Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 50, Issue 9, Pages 1412-1414Publisher
WILEY
DOI: 10.1002/eji.202048724
Keywords
CCL5/RANTES; COVID-19; CXCL9/MIG; SARS-CoV-2; T-cell activation
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Funding
- University of Brescia, Brescia, Italy
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Study of immunological features of immune response in 14 children (aged from 12 days up to 15 years) and of 10 adults who developed COVID-19 show increased number of activated CD4 and CD8 cells expressing DR and higher plasmatic levels of IL-12 and IL-1 beta in adults with COVID-19, but not in children. In addition, plasmatic levels of CCL5/RANTES are higher in children and adults with COVID-19, while CXCL9/MIG was only increased in adults. Higher number of activated T cells and expression of IL-12 and CXCL9 suggest prominent Th1 polarization of immune response against SARS-CoV2 in infected adults as compared with children.(#)
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