Article
Clinical Neurology
Ettore Beghi, Benedict D. Michael, Tom Solomon, Erica Westenberg, Andrea S. Winkler
Summary: There is a growing body of research on neurological manifestations of COVID-19, but issues with study quality and comparability exist. To facilitate research development, the global COVID-19 Neuro Research Coalition has collaborated with the World Health Organization to harmonize clinical measures.
ANNALS OF NEUROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Inayat Ur Rahman, Niaz Ali, Farhana Ijaz, Aftab Afzal, Elsayed Fathi Abd Allah
Summary: The rapid spread of COVID-19 has raised concerns about global capacity limitations and lack of unified responses, especially from the world's most developed countries. Lockdowns and social distancing measures have helped prevent further infection, but the development of effective vaccines and therapies is critical in stopping the pandemic.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Review
Microbiology
Olivier Vandenberg, Delphine Martiny, Olivier Rochas, Alex van Belkum, Zisis Kozlakidis
Summary: In this review, Vandenberg et al. explore the crucial role of diagnostic tests during the early phase of the COVID-19 pandemic, addressing technical and implementation issues encountered and suggesting future directions for improved diagnostics in potential future outbreaks.
NATURE REVIEWS MICROBIOLOGY
(2021)
Review
Acoustics
R. D'Souza, R. Ashraf, H. Rowe, J. Zipursky, L. Clarfield, C. Maxwell, C. Arzola, S. Lapinsky, K. Paquette, S. Murthy, M. P. Cheng, I Malhame
Summary: This review summarizes evidence on the use of routine and investigational pharmacologic interventions for pregnant and lactating patients with COVID-19. Individualized decision-making is crucial, such as for antenatal corticosteroids and magnesium sulfate use. Dexamethasone is the only proven experimental treatment for mechanically ventilated pregnant patients with COVID-19.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Review
Health Care Sciences & Services
Afroditi K. Boutou, Andreas Asimakos, Eleni Kortianou, Ioannis Vogiatzis, Argyris Tzouvelekis
Summary: The COVID-19 pandemic and ARDS have caused a severe global health crisis, with evidence showing that survivors may develop long-term consequences known as the long-COVID-19 syndrome, which affect multiple organs with a variety of symptoms. Management strategies, including corticosteroids, antifibrotic treatment, and pulmonary rehabilitation, are key in improving outcomes for these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Medicine, General & Internal
Huifen Wang, Haiyu Wang, Ying Sun, Zhigang Ren, Weiwei Zhu, Ang Li, Guangying Cui
Summary: The COVID-19 pandemic has caused a major crisis worldwide, with significant changes in the gut and airway microbiomes of patients being observed. The dysregulation of intestinal microecology may play a role in the progression of the disease, and interventions such as probiotics, prebiotics, and fecal bacteria transplantation (FMT) could potentially aid in the treatment of COVID-19.
FRONTIERS IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Zixin Cai, Jiaxin Zhong, Yingling Jiang, Jingjing Zhang
Summary: This study summarizes the correlation between sex hormone levels and COVID-19. The findings suggest that COVID-19 patients have lower levels of T/LH, FSH/LH, and SHBG, and higher levels of LH and E-2/T. These findings may be helpful in evaluating the severity of COVID-19.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Ancha Baranova, Yuqing Song, Hongbao Cao, Fuquan Zhang
Summary: The study finds that basal metabolic rate (BMR) is associated with the susceptibility to and severity of COVID-19. Genetic correlation and Mendelian randomization analyses reveal a causal relationship between BMR and COVID-19 outcomes. The effect of BMR on COVID-19 severity may be mediated by BMI and type 2 diabetes.
Article
Endocrinology & Metabolism
Ancha Baranova, Yuqing Song, Hongbao Cao, Fuquan Zhang
Summary: This study found that basal metabolic rate (BMR) is associated with the susceptibility to and severity of COVID-19. BMR has significant genetic correlations and causal effects on SARS-CoV-2 infection, hospitalized COVID-19, and critical COVID-19. The causal effect of BMR on the severity of COVID-19 may be mediated by BMI and type 2 diabetes.
Review
Immunology
Wael Alturaiki
Summary: Mucosal surfaces serve as the initial contact sites for SARS-CoV-2, and current vaccines offer limited protection to mucosal immunity. This article reviews the roles of BAFF, APRIL, CXCL13, CCL19, and CCL21 in activating local B-cell responses and antibody production, as well as the formation of iBALT. The authors suggest that a mucosal vaccine using BAFF/APRIL or CXCL13 as immunostimulants, combined with spike protein-encoding mRNA, may enhance local immune response efficiency and prevent early viral replication and clearance.
Article
Medicine, General & Internal
Jakub Udzik, Pawel Jakubowski, Malgorzata Niekrasz, Adrian Barczyszyn, Milosz Parczewski
Summary: Neurological manifestations are common in patients with SARS-CoV-2 infection, and in some cases, it can lead to severe encephalopathy. This case series provides a detailed description of three cases with severe encephalopathy complicating SARS-CoV-2 infection, including neurological status changes, imaging findings, and clinical outcomes. The authors highlight common features in the disease course and test results, and hope that these experiences will contribute to the diagnostic and therapeutic process for COVID-19-associated encephalopathy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Nina S. Hsu, Saskia Hendriks, Khara M. Ramos, Christine Grady
Summary: Participating in clinical trials during COVID-19 may bring unexpected risks that investigators and institutional review boards are unsure how to investigate. The question of how to apply existing guidance and ethical frameworks in a pandemic setting has emerged as a key issue.
Review
Immunology
Qian He, Qunying Mao, Jialu Zhang, Lianlian Bian, Fan Gao, Junzhi Wang, Miao Xu, Zhenglun Liang
Summary: The world is facing the second wave of the COVID-19 pandemic, with a higher intensity than the first wave of early 2020. Multiple COVID-19 vaccine candidates have been developed and are undergoing clinical testing to rapidly respond to the global pandemic. Evaluating and defining effective vaccine candidates is crucial for prioritizing vaccination programs against COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Psychiatry
Ju-Wan Kim, Hee-Ju Kang, Min Jhon, Seunghyong Ryu, Ju-Yeon Lee, Seung-Ji Kang, Sook-In Jung, Il-Seon Shin, Sung-Wan Kim, Robert Stewart, Jae-Min Kim
Summary: Hospital isolation for COVID-19 can lead to significant psychological stress. Patients with COVID-19 often experience anxiety, depression, insomnia, and suicidal ideation. Early intervention is crucial to improve mental health outcomes.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Oncology
Muna Almasri, Khalifa Bshesh, Wafa Khan, Malik Mushannen, Mohammad A. Salameh, Ameena Shafiq, Ahamed Lazim Vattoth, Nadine Elkassas, Dalia Zakaria
Summary: This review explores the immune response rates and safety of COVID-19 vaccination in patients with cancer. The findings suggest that cancer patients, especially those with hematologic cancers and those receiving chemotherapy, radiotherapy, or immunosuppressants, have lower immune response rates. However, many patients still generate sufficient immune response, and vaccination is described as safe and well-tolerated. Therefore, vaccination should be encouraged for cancer patients. Further research is needed to address the lack of guidelines for COVID-19 vaccination in this population.
Article
Anesthesiology
E. Li
Summary: Surgical patients with peri-operative or recent SARS-CoV-2 infection are at increased risk of postoperative venous thromboembolism compared to those without a history of SARS-CoV-2. However, the optimal prophylaxis and treatment for venous thromboembolism in this patient population remains unknown. Venous thromboembolism is independently associated with 30-day mortality.
Article
Clinical Neurology
Keiko Wada, Masaki Sonoda, Ethan Firestone, Kazuki Sakakura, Naoto Kuroda, Yutaro Takayama, Keiya Iijima, Masaki Iwasaki, Takahiro Mihara, Takahisa Goto, Eishi Asano, Tomoyuki Miyazaki
Summary: This study observed the effect of sevoflurane anesthesia on the epileptogenic zone. The results showed a positive correlation between the anesthetic stage and the phase-amplitude coupling modulation index (MI) of high-frequency and delta oscillations before reaching a certain concentration of sevoflurane, and this phenomenon was more pronounced in brain regions with higher initial MI values.
CLINICAL NEUROPHYSIOLOGY
(2022)
Letter
Behavioral Sciences
Naoto Kuroda, Nozomi Akatsu, Keisuke Hatano, Naoki Ikegaya, Kazuto Katsuse, Satoshi Kodama, Yutaro Takayama, Ayataka Fujimoto
EPILEPSY & BEHAVIOR
(2022)
Article
Behavioral Sciences
Takafumi Kubota, Naoto Kuroda, Toru Horinouchi, Naoki Ikegaya, Yu Kitazawa, Satoshi Kodama, Izumi Kuramochi, Teppei Matsubara, Naoto Nagino, Shuichiro Neshige, Temma Soga, Yutaro Takayama, Daichi Sone
Summary: The study in Japan identified that the unwillingness of physicians in epilepsy care to continue telemedicine during the COVID-19 pandemic was mainly associated with workload. Other factors included age, psychiatrist profession, type of hospital, number of COVID-19 risk factors, epidemic area, consultation time, and workload related to telemedicine.
EPILEPSY & BEHAVIOR
(2022)
Letter
Behavioral Sciences
Izumi Kuramochi, Naoto Kuroda, Naoto Nagino, Daichi Sone, Mao Fujioka, Ayataka Fujimoto
EPILEPSY & BEHAVIOR
(2022)
Article
Clinical Neurology
Naoto Kuroda, Hiroshi Kawaji, Yoshifumi Arai, Yoshiro Otsuki, Katsutoshi Miura, Hiroshi Minato, Kento Kuroda, Hirokazu Nakatogawa, Tomohiro Yamazoe, Tokutaro Tanaka, Chikanori Inenaga
Summary: The case involved a 69-year-old male patient with HPV-related HMSC, who died on day 41 after receiving radiotherapy. Both biopsy and autopsy confirmed the tumor's HPV-related nature and immunoreactivity to p16. The effectiveness of radiotherapy in treating HMSC may depend on the histopathological components and location of the lesion.
Article
Medicine, General & Internal
Naoto Kuroda, Anna Suzuki, Kai Ozawa, Nobuhiro Nagai, Yurika Okuyama, Kana Koshiishi, Masafumi Yamada, Yoshihiko Raita, Yosuke Kakisaka, Nobukazu Nakasato, Makoto Kikukawa
Summary: This cross-sectional national study identifies the educational approaches associated with the effectiveness of online clerkship for medical students. The results show that observation and practical experience have a positive impact on students' satisfaction, motivation, knowledge acquisition, and skill acquisition.
Review
Infectious Diseases
Naoto Kuroda, Tadashi Shimizu, Daishi Hirano, Masahiro Ishikane, Yuki Kataoka
Summary: Since May 2022, several human monkeypox cases have been reported in non-endemic countries. This systematic review summarized the research on the efficacy and safety of tecovirimat, brincidofovir, and cidofovir for treating monkeypox. Only five studies were included, with limited assessment on efficacy and adverse events. Tecovirimat showed positive results with no adverse events reported, while brincidofovir had increased alanine transaminase levels and some side effects. There were no studies on cidofovir. Overall, further studies are needed to determine the efficacy and safety of these treatments for human monkeypox.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Article
Medicine, General & Internal
James C. Glasbey, Tom E. F. Abbott, Adesoji Ademuyiwa, Adewale Adisa, Ehab AlAmeer, Sattar Alshryda, Alexis P. Arnaud, Brittany Bankhead-Kendall, M. K. Abou Chaar, Daoud Chaudhry, Ainhoa Costas-Chavarri, Miguel F. Cunha, Justine I. Davies, Anant Desai, Muhammed Elhadi, Marco Fiore, J. Edward Fitzgerald, Maria Fourtounas, Alex James Fowler, Kay Futaba, Gaetano Gallo, Dhruva Ghosh, Rohan R. Gujjuri, Rebecca Hamilton, Parvez Haque, Ewen M. Harrison, Peter Hutchinson, Gabriella Hyman, Arda Isik, Umesh Jayarajah, Haytham M. A. Kaafarani, Bryar Kadir, Ismail Lawani, Hans Lederhuber, Elizabeth Li, Markus W. Loffler, Maria Aguilera Lorena, Harvinder Mann, Janet Martin, Dennis Mazingi, Craig D. McClain, Kenneth A. McLean, John G. Meara, Antonio Ramos-De La Medina, Mengistu Mengesha, Ana Minaya, Maria Marta Modolo, Rachel Moore, Dion Morton, Dmitri Nepogodiev, Faustin Ntirenganya, Francesco Pata, Rupert Pearse, Maria Picciochi, Thomas Pinkney, Peter Pockney, Gabrielle H. van Ramshorst, Toby Richards, April Camilla Roslani, Sohei Satoi, Raza Sayyed, Richard Shaw, Joana Filipa Ferreira Simoes, Neil Smart, Richard Sulliva, Malin Sund, Sudha Sundar, Stephen Tabiri, Elliott H. Taylor, Mary L. Venn, Dakshitha Wickramasinghe, Naomi Wright, Sebastian Bernardo Shu Yip, Aneel Bhangu
Summary: This study developed and validated a novel index (SPI) to support the strengthening of local elective surgical systems and address growing backlogs. The findings showed that hospitals with a higher SPI were associated with an increased planned surgical volume ratio, independent of income status, COVID-19 burden, and hospital type. Annual self-assessment of surgical preparedness is recommended to identify areas for improvement and enhance the resilience of local surgical systems.
Review
Clinical Neurology
Takafumi Kubota, Naoto Kuroda, Daichi Sone
Summary: This review provides an update on the neuropsychiatric dimensions of long COVID, including fatigue, cognitive impairment, sleep disorders, depression, anxiety, and post-traumatic stress disorder. The possible mechanisms of long COVID include inflammation, ischemic effects, direct viral invasion, and social and environmental changes. Some patient characteristics and the severity of acute COVID-19 infection may be associated with an increased risk of neuropsychiatric symptoms.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Computer Science, Information Systems
Jeong-Won Jeong, Min-Hee Lee, Naoto Kuroda, Kazuki Sakakura, Nolan O'Hara, Csaba Juhasz, Eishi Asano
Summary: The present study investigates the effectiveness of a deep learning neural network for non-invasively localizing the seizure onset zone (SOZ) using multi-modal MRI data that are clinically acquired from children with drug-resistant epilepsy. The proposed MRI marker provided a very large effect size between SOZ and non-SOZ and improved the localization of epileptogenic foci for successful pediatric epilepsy surgery.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Clinical Neurology
Ethan Firestone, Masaki Sonoda, Naoto Kuroda, Kazuki Sakakura, Jeong-Won Jeong, Min-Hee Lee, Keiko Wada, Yutaro Takayama, Keiya Iijima, Masaki Iwasaki, Tomoyuki Miyazaki, Eishi Asano
Summary: This study investigated the effects of sevoflurane anesthesia on intraoperative epilepsy biomarkers, including high-frequency oscillation (HFO) effective connectivity (EC). The results showed that HFO EC increased with increasing sevoflurane concentration, particularly in epileptogenic sites. The classification ability of HFO EC was optimized at a sevoflurane concentration of 2 MAC. The HFO EC could be visualized on major white matter tracts using diffusion-weighted imaging and dynamic tractography. These findings support the hypothesis that sevoflurane-activated HFO biomarkers may help localize the epileptogenic zone during surgery.
CLINICAL NEUROPHYSIOLOGY
(2023)
Letter
Clinical Neurology
Takafumi Kubota, Satoshi Kodama, Naoto Kuroda
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Article
Clinical Neurology
Naoto Kuroda, Takafumi Kubota, Toru Horinouchi, Naoki Ikegaya, Yu Kitazawa, Satoshi Kodama, Izumi Kuramochi, Teppei Matsubara, Naoto Nagino, Shuichiro Neshige, Temma Soga, Yutaro Takayama, Daichi Sone
Summary: This multicenter retrospective cohort study investigated the impact of the COVID-19 pandemic on epilepsy care in Japan. Results showed that outpatient EEG studies and telemedicine for epilepsy were significantly affected by the pandemic. COVID-19 cases and a state of emergency were independently associated with epilepsy admission and EEG monitoring.
Article
Surgery
Group Author Only
Summary: This study reports the 30-day outcomes of patients with perioperative SARS-CoV-2 infection undergoing surgery in the USA. The results show a significantly high risk for postoperative complications, especially in elderly males. Postponing elective surgery and adopting non-operative management should be considered during the pandemic peaks.
Article
Behavioral Sciences
Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
Summary: The study aimed to evaluate the safety and impact of Dexmedetomidine Hydrochloride (DH) administration during pediatric invasive intracranial electroencephalography (IEEG). The results showed that DH administration was not associated with adverse events and did not significantly affect the frequency of seizures captured on the IEEG and the duration of hospitalization.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Sabra Zaraa, H. Steve White, Andy Stergachis, Edward Novotny Jr, Chris Protos, Grant Simic, Jennifer L. Bacci
Summary: This study used design thinking to develop a community pharmacist-led intervention for people living with epilepsy. Four features - pharmacist-patient consultations, care plan development, regular check-ins, and care coordination with other health care providers - were identified as desirable, feasible, and viable for the intervention. The study highlights the importance of involving pharmacists in epilepsy care and provides evidence-based features for such interventions.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Bofei Tan, Qiang Liu, Yameng Qin, Qiuyan Chen, Rong Chen, Yanzi Jin, Mengyun Li, Xiaodan Jia, Xianrui Xu, Qing Zhang
Summary: The purpose of this study was to identify factors associated with insomnia in patients with epilepsy. The results showed that nocturnal seizures and anxiety were independently associated with insomnia in these patients. Patients with epilepsy and insomnia were more likely to experience depression and excessive daytime sleepiness.
EPILEPSY & BEHAVIOR
(2024)
