Journal
ENVIRONMENTAL POLLUTION
Volume 262, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2020.114668
Keywords
Air pollution; Lipidomics; Liver; Plasma
Categories
Funding
- Zhejiang Provincial National Science Fund for Distinguished Young Scholars [LR17H260001]
- National Natural Science Foundation of China [81973001, 91643103, 81770847]
- Drug Innovation Major Project [2018ZX09711001-003-005]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2017-I2M-1-010]
- National Key R&D Program of China [2018YFA0506902, 2018YFA0800901]
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More recent evidences are supportive of air pollution exposure on diabetes risk, including worsening of whole-body insulin sensitivity, enhancement of hepatic lipogenesis and nonalcoholic fatty liver disease after fine particulate matter (PM2.5) exposure. Therefore, we aimed to explore the lipidomics to get a comprehensive insight about ambient real-world PM2.5 exposure on lipid metabolism in blood and liver. After ambient PM2.5 exposure for 6 months, excess triglyceride accumulation in the liver was observed. Remarkable metabolic alterations including neutral lipids, glycerophospholipids and sphingolipids were noticed. Lipidomic signatures in liver is different from plasma in response to PM2.5 exposure. Lipids including species of ceramide, sphingomyeline and triglyceride may become potential biomarkers of lipotoxicity contributing to PM2.5-induced metabolic dysfunction, and the present study may serve as a reference lipid bank for further studies. (C) 2020 Elsevier Ltd. All rights reserved.
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