Journal
ENVIRONMENTAL POLLUTION
Volume 263, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2020.114474
Keywords
Triphenyl phosphate (TPHP); Lipidome; Endoplasmic reticulum (ER) stress; Inflammation
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Funding
- International S&T Cooperation Program of China [2016YFE0117800]
- National Natural Science Foundation of China [21737001, 21577001, 41821005]
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Although triphenyl phosphate (TPHP) has been reported to disrupt lipid metabolism, the effect of TPHP on lipid saturation remains unexplored. In this study, a lipidomic analysis demonstrated decreases in the levels of poly-unsaturated phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS) in RAW264.7 murine macrophage cells exposed to 10 mM TPHP. The expression of the gene encoding lysophosphatidylcholine acyltransferase 3 (Lpcat3) was significantly downregulated by 0.76 +/- 0.03 and 0.70 +/- 0.08-fold in 10 and 20 mu M TPHP exposure groups, relative to the control group. This finding explains the observed decrease in lipid saturation. Correspondingly, exposure to 10 and 20 mu M TPHP induced endoplasmic reticulum (ER) stress and inflammatory responses, which have been linked to metabolic dysfunction such as insulin resistance and hypertriglyceridemia. Therefore, TPHP may pose a risk to human health by promoting metabolic diseases. (c) 2020 Elsevier Ltd. All rights reserved.
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