Article
Multidisciplinary Sciences
Luanfeng Lin, Xiaoling Chen, Junnian Chen, Xiaobin Pan, Pincang Xia, Hailong Lin, Houwei Du
Summary: By using ROC curve analysis and a COX proportional hazards regression model, it was found that COVID-19 patients with higher levels of sCys C are more likely to develop severe illness.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Urology & Nephrology
Sho Hasegawa, Masaomi Nangaku
Summary: This study suggests that SGLT2 inhibitors, such as dapagliflozin, may reduce the risk of abrupt declines in kidney function in patients with chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Editorial Material
Urology & Nephrology
Maurice Laville
Summary: Nephroprotective treatments may lead to a drop in glomerular filtration rate, which could be related to the intensity of baseline glomerular anomalies and potential treatment benefits. The study by Oshima et al. further confirms this relationship in diabetic patients with chronic kidney disease under sodium-glucose cotransporter 2 inhibition.
KIDNEY INTERNATIONAL
(2021)
Article
Environmental Sciences
Teresa Dalla Zuanna, David A. Savitz, Giulia Barbieri, Gisella Pitter, Maryam Zare Jeddi, Francesca Dapra, Aline S. C. Fabricio, Francesca Russo, Tony Fletcher, Cristina Canova
Summary: The study found that the associations between PFAS concentrations and lipid profiles in pregnant women may differ by trimesters of pregnancy, suggesting a possible influence of PFAS on lipid metabolism in pregnant women, especially showing differences between late pregnancy and non-pregnant women.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Multidisciplinary Sciences
Sam O. Kleeman, Mattia Cordioli, Paul R. H. J. Timmers, Atlas Khan, Pinkus Tober-Lau, Florian Kurth, Vadim Demichev, Hannah Meyer, James F. Wilson, Markus Ralser, Krzysztof Kiryluk, Andrea Ganna, Kenneth Baillie, Tobias Janowitz
Summary: This study found a significant association between cystatin C production and the severity and mortality of COVID-19 in patients, suggesting its potential use in stratifying patients and its functional role in the host response to COVID-19.
Article
Environmental Sciences
Yufen Liang, Han Zhou, Jiachen Zhang, Shuangjing Li, Weitong Shen, Lijian Lei
Summary: This study aimed to investigate the relationships between perfluoroalkyl and polyfluoroalkyl substances (PFASs) and estimated glomerular filtration rate (eGFR) using univariate exposure and multivariate co-exposure models. The results showed significant associations between PFOS and PFHxS with eGFR in the total population, and a significant joint effect between PFHxS and PFDeA/PFNA/PFUA. Future cohort studies are needed to explore the association between multiple PFASs and health.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lucas M. Wiggenhauser, Lena Metzger, Katrin Bennewitz, Silas Soleymani, Mike Boger, Christoph T. Tabler, Ingrid Hausser, Carsten Sticht, Paulus Wohlfart, Nadine Volk, Elena Heidenreich, Michael Buettner, Hans-Peter Hammes, Jens Kroll
Summary: This study identified the pdx1 mutant as a novel model for the study of DKD, showing signs of the early disease progression already in the larval stage and several selective features of later DKD in adult mutants.
Article
Medicine, General & Internal
H. Pottel, J. Bjork, A. D. Rule, N. Ebert, B. O. Eriksen, L. Dubourg, E. Vidal-Petiot, A. Grubb, M. Hansson, E. J. Lamb, K. Littmann, C. Mariat, T. Melsom, E. Schaeffner, P. -O. Sundin, A. Akesson, A. Larsson, E. Cavalier, J. B. Bukabau, E. K. Sumaili, E. Yayo, D. Monnet, M. Flamant, U. Nyman, P. Delanaye
Summary: The study developed a cystatin C-based equation (EKFC eGFRcys) to estimate glomerular filtration rate (GFR). This equation had similar accuracy to a creatinine-based equation (EKFC eGFRcr) and outperformed other commonly used equations. Furthermore, taking the arithmetic mean of EKFC eGFRcr and EKFC eGFRcys further improved the accuracy of GFR estimation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Editorial Material
Urology & Nephrology
Lesley A. Inker, Andrew S. Levey
Summary: Developing and validating equations for estimating glomerular filtration rate in diverse populations, including different age groups, races, and clinical conditions, is essential. Two newly developed equations for children and young adults showed better performance than recommended equations, but require further evaluation for generalizability in diverse populations.
KIDNEY INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Jane Ha, Cheol Woong Jung, Sunkyu Choi, Myung-Gyu Kim, Jun Gyo Gwon, Joong Kyung Kim, Chan-Duck Kim, Ji Won Min, Jaeseok Yang, Curie Ahn
Summary: Comparing kidney transplantations from donors with acute kidney injury to those from non-AKI donors through matching, it was found that although transplantations from AKI donors had a higher incidence of delayed graft function, the overall graft function was comparable.
Article
Medicine, General & Internal
Ping Liu, Rob R. Quinn, Ngan N. Lam, Huda Al-Wahsh, Manish M. Sood, Navdeep Tangri, Marcello Tonelli, Pietro Ravani
Summary: This study found that with advancing age, CKD regression and death were more likely than CKD progression or kidney failure. These findings have important implications for patient care and for assessing the potential effect of population aging on the burden of CKD.
Article
Biochemistry & Molecular Biology
Kao Wu, Ying Fang, Huaxin Wu, Yi Wan, Hong Qian, Fatang Jiang, Sheng Chen
Summary: The pore size distribution of konjac glucomannan (KGM)-based aerogels plays a key role in air filtration efficiency and resistance. Increasing the total solid concentration leads to smaller pore size and decreased porosity in the aerogels. By preparing aerogel stacks with different pore size distributions, filtration efficiency can be improved while reducing air resistance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Gastroenterology & Hepatology
Carlos Gonzalez-Alayon, Esteban Porrini, Sergio Luis-Lima, Natalia Negrin-Mena, Miguel Moreno, Dalia Morales-Arraez, Federico Gonzalez-Rinne, Laura Diaz-Martin, Flavio Gaspari, Alejandra Gonzalez-Delgado, Carmen Ferrer-Moure, Alberto Ortiz-Arduan, Manuel Hernandez-Guerra
Summary: In patients with cirrhosis, formulas for estimating renal function, whether specific to this population or classic equations, have not been proven to be reliable. The study found poor agreement between estimated and measured glomerular filtration rate in cirrhotic patients, indicating caution should be exercised when using eGFR in this population.
LIVER INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Mads Hornum, Morten Baltzer Houlind, Esben Iversen, Esteban Porrini, Sergio Luis-Lima, Peter Oturai, Martin Iversen, Pia Bredahl, Jorn Carlsen, Christian Holdflood Moller, Mads Jonsson Andersen, Bo Feldt-Rasmussen, Michael Perch
Summary: Patients undergoing lung transplantation (LTx) experience a rapid decline in glomerular filtration rate (GFR) in the acute postoperative period. This study compared different equations for estimating GFR in LTx patients and found that equations based on plasma creatinine underestimated GFR decline, while equations based on plasma cystatin C overestimated GFR decline after LTx. The 2021 CKD-EPI combination equation had the most accurate estimation of GFR in both pre-LTx and post-LTx periods. Therefore, caution should be exercised when interpreting renal function based on GFR estimation equations in the acute postoperative period following LTx.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Medicine, General & Internal
Jonathan R. Genzen, Rhona J. Souers, Lauren N. Pearson, David M. Manthei, Allison B. Chambliss, Zahra Shajani-Yi, W. Greg Miller
Summary: This study examines the awareness and adoption of new equations for estimated glomerular filtration rate (eGFR) in clinical laboratories that participated in the first general chemistry proficiency testing survey in 2022. The new equations, proposed by the Chronic Kidney Disease Epidemiology Collaboration, eliminate race-adjustment factors and include equations based on creatinine alone or a combination of creatinine and cystatin C.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Respiratory System
Jessica Y. Islam, Jane Hoppin, Ana M. Mora, Manuel E. Soto-Martinez, Leonel Cordoba Gamboa, Jorge Ernesto Penaloza Castaneda, Brian Reich, Christian Lindh, Berna van Wendel de Joode
Summary: This study evaluated the effects of pesticide exposure on respiratory and allergic outcomes in children. By measuring urinary metabolite concentrations and collecting medical history information, it was found that pesticide exposure was associated with respiratory and allergic symptoms.
Article
Public, Environmental & Occupational Health
Karin Loven, Anders Gudmundsson, Eva Assarsson, Monica Karedal, Aneta Wierzbicka, Camilla Dahlqvist, Catarina Nordander, Yiyi Xu, Christina Isaxon
Summary: This study investigated the effects of cleaning spray on the upper airways and physical workload of cleaning workers. The results show that cleaning workers using spray had a higher risk of experiencing symptoms in the eyes, airways, and musculoskeletal pain compared to using other methods. Switching from spray to foam can reduce the concentration of airborne particles and volatile organic compounds, thereby reducing eye and airway symptoms and without increasing the physical workload.
Article
Environmental Sciences
Annelise J. Blomberg, Line S. Haug, Christian Lindh, Azemira Sabaredzovic, Daniela Pineda, Kristina Jakobsson, Christel Nielsen
Summary: The concentrations of PFAS in human milk change over the course of lactation, with different PFAS showing different concentration trajectories and being influenced by colostrum levels. Models for cumulative infant exposure from breastfeeding need to take these differences into account.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Gunnar Johanson, Irina Gyllenhammar, Carl Ekstrand, Andrei Pyko, Yiyi Xu, Ying Li, Karin Norstrom, Karl Lilja, Christian Lindh, Jonathan P. Benskin, Antonios Georgelis, Karl Forsell, Kristina Jakobsson, Anders Glynn, Carolina Vogs
Summary: This study aimed to investigate the quantitative relationships between concentrations of perfluoroalkyl acids (PFAAs) in drinking water and serum of Swedish adults living near contamination hotspots. The study found that the concentration of PFAAs in drinking water is the most significant factor affecting serum concentrations.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Yiyi Xu, Kristina Jakobsson, Florencia Harari, Eva M. Andersson, Ying Li
Summary: This register-based study examined the risk of type 2 diabetes among Swedish adults exposed to high levels of per- and polyfluoroalkyl substances (PFAS) in drinking water. The study found that long-term exposure to high levels of PFAS increases the risk of developing diabetes, particularly among younger individuals. These findings suggest increased susceptibility to PFAS-related health effects at a younger age.
ENVIRONMENTAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Gunilla Malm, Christian Lindh, Stefan Hansson, Karin Kaellen, Johan Malm, Lars Rylander
Summary: This case-control study in Sweden found that low serum vitamin D concentrations in early pregnancy may be a risk factor for the development of preeclampsia, particularly in cases that are early-onset and/or born small-for-gestational age (SGA).
Article
Medicine, General & Internal
Christel Nielsen, Kristofer Andreasson, H. Olsson, Malin Engfeldt, Anna Joud
Summary: The Swedish Tattoo and Body Modifications Cohort (TABOO) cohort was established to study the role of tattoos and body modifications as risk factors for adverse health outcomes. It is the first population-based cohort with detailed exposure assessment of various types of body modifications. Currently, the cohort is being used to investigate the incidence of health complaints after tattooing and the risk of immune-mediated diseases.
Article
Environmental Sciences
Arash Derakhshan, Huan Shu, Maarten A. C. Broeren, Andreas Kortenkamp, Christian H. Lindh, Barbara Demeneix, Robin P. Peeters, Carl-Gustaf Bornehag, Tim I. M. Korevaar
Summary: This study investigated the association between concentrations of endocrine disrupting chemicals (EDCs) in urine and blood during pregnancy and serum human chorionic gonadotropin (hCG) concentrations. The results showed that higher exposure to bisphenol A was associated with lower hCG concentrations, while higher triclosan exposure was associated with higher hCG concentrations. Higher exposure to certain phthalates and polychlorinated biphenyls (PCBs) was also associated with lower hCG concentrations. These findings suggest that EDC exposure may have negative effects on placental hCG production and secretion, warranting further experimental studies.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Eva Gorrochategui, Marc Le Vee, Habiba Selmi, Anne Gerard, Jade Chaker, Annette M. Krais, Christian Lindh, Olivier Fardel, Cecile Chevrier, Pierre Le Cann, Gary W. Miller, Robert Barouki, Bernard Jegou, Thomas Gicquel, David M. Kristensen, Arthur David
Summary: This study demonstrates that APAP thiomethyl metabolite conjugates can serve as stable biomarkers for monitoring APAP ingestion history and diagnosing acute intoxication. The study also reveals a previously overlooked pathway for the production of the toxic NAPQI metabolites. These findings have implications for improving APAP human biomonitoring and understanding the underlying causes of APAP-induced hepatotoxicity.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Katherine Svensson, Chris Gennings, Christian Lindh, Hannu Kiviranta, Panu Rantakokko, Sverre Wikstrom, Carl-Gustaf Bornehag
Summary: This study found an association between prenatal exposure to a mixture of EDCs and lower BMI and overweight in girls, with non-significant associations among boys. Chemicals of concern for girls included phthalates, non-phthalate plasticizers, bisphenols, PAHs, and PFAS.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Axel G. Andersson, Anna Lundgren, Yiyi Xu, Christel Nielsen, Christian H. Lindh, Daniela Pineda, Julia Cederlund, Elisavet Pataridou, Sandra Sogaard Tottenborg, Kajsa Ugelvig Petersen, Tony Fletcher, Martin Lagging, Mats Bemark, Kristina Jakobsson, Ying Li
Summary: This study aimed to evaluate the association between PFAS exposure levels and antibody responses after SARS-CoV-2 vaccination in adults. The results showed no negative correlation between PFAS exposure and antibody levels 5 weeks and 6 months after COVID-19 vaccination.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Environmental Sciences
Andreas Vilhelmsson, Lars Rylander, Anna Joud, Christian H. Lindh, Kristina Mattsson, Zeyan Liew, Pengfei Guo, Beate Ritz, Karin Kallen, Jesse D. Thacher
Summary: This study investigated the association between prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and cerebral palsy (CP) in Swedish children. The results showed a positive association between PFAS exposure and CP in preterm infants, but no consistent evidence of associations in the overall group. Further research is needed to explore this issue.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Medicine, General & Internal
Anna Zettergren, Shanzina Sompa, Lena Palmberg, Petter Ljungman, Goran Pershagen, Niklas Andersson, Christian Lindh, Antonios Georgelis, Inger Kull, Erik Melen, Sandra Ekstrom, Anna Bergstrom
Summary: This study investigated the prevalence of tobacco use and validated self-reported tobacco use among young adults in Sweden. It found higher rates of smoking, snus use, and e-cigarette use among men compared to women. The study also confirmed the high validity of self-reported tobacco use.
Article
Andrology
Katia Keglberg Haervig, Kajsa Ugelvig Petersen, Mette Moller Dornfeldt, Jens Peter Bonde, Karin Sorig Hougaard, Cecilia Host Ramlau-Hansen, Gunnar Toft, Christian Lindh, Aleksander Giwercman, Sandra Sogaard Tottenborg
Summary: The effects of paternal pre-conceptional smoking on offspring semen quality are still uncertain due to challenges in isolating paternal exposure from other factors and the limitations of current studies.
Article
Environmental Sciences
Ellen Malm, Andreas Vilhelmsson, Hannah Hogfeldt, Isabelle Deshayes, Karin Kallen, Stefan R. Hansson, Christian H. Lindh, Lars Rylander
Summary: This study investigated the association between maternal PFAS levels in early pregnancy and the risk of SGA birth. The overall results showed no significant association between elevated PFAS concentrations and SGA birth risk, except for a subgroup of women of Nordic origin where PFHxS was significantly associated with SGA birth risk.
