Article
Dentistry, Oral Surgery & Medicine
Rafaela D. Parolina de Carvalho, Jessica de Andrade Moreno, Sindy Magri Roque, Daniel Cheuk Hong Chan, Willy Bustillos Torrez, Rafael Nobrega Stipp, Bruno Bueno-Silva, Patricia Oliveira de Lima, Karina Cogo-Muller
Summary: Simvastatin showed strong antimicrobial activity against oral bacteria, especially against Porphyromonas gingivalis. It also exhibited synergistic interaction with amoxicillin against Streptococcus oralis and Streptococcus sanguinis. Simvastatin inhibited biofilm formation of P. gingivalis and reduced the metabolic activity and total counts of multispecies biofilm.
Article
Cardiac & Cardiovascular Systems
Ciaran N. Kohli-Lynch, James Lewsey, Kathleen A. Boyd, Dustin D. French, Neil Jordan, Andrew E. Moran, Naveed Sattar, David Preiss, Andrew H. Briggs
Summary: This study evaluates the cost-effectiveness of expanding preventive statin eligibility and novel approaches to prioritization from a Scottish health sector perspective. The findings suggest that generic pricing has made preventive statin therapy cost-effective for many adults. Additionally, an approach using absolute risk reduction (ARR)-guided therapy is more effective and cost-effective than the traditional method based on 10-year risk assessment.
Article
Health Care Sciences & Services
Armando Chaure-Pardos, Isabel Aguilar-Palacio, Ma Jose Rabanaque, Ma Jesus Lallana, Lina Maldonado, Sara Castel-Feced, Julian Librero, Jose Antonio Casasnovas, Sara Malo
Summary: This study analyzed the effectiveness of statin therapy for primary prevention of cardiovascular disease in low- and medium-risk patients. The results suggest that statin treatment for primary prevention in individuals with low and medium cardiovascular risk may be inefficient, but improves with better adherence and in patients with higher risk.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
You-Bin Lee, Minji Koo, Eunjin Noh, Soon Young Hwang, Jung A. Kim, Eun Roh, So-Hyeon Hong, Kyung Mook Choi, Sei Hyun Baik, Geum Joon Cho, Hye Jin Yoo
Summary: This study explored the relationship between low-density lipoprotein cholesterol (LDL-C) levels and the risks of myocardial infarction (MI), stroke, and all-cause death among older adults. The findings indicate that lower LDL-C is associated with reduced risks of MI and stroke. However, the risk of all-cause death follows an inverted J-shaped pattern with LDL-C levels. Intensive statin therapy, which lowers LDL-C, is beneficial for older adults with cardiovascular risk factors like diabetes.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Eline M. Lambert, Wim A. Wuyts, Jonas Yserbyt, Laurens J. De Sadeleer
Summary: This study found that statin users exhibited significantly slower progression of IPF, while the effects of antiaggregant therapy were inconclusive. Anticoagulant use showed a trend towards worsened DLCO decline, and metformin therapy did not affect IPF progression or survival.
RESPIRATORY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Andrey Sivkov, Natalya Chernus, Roman Gorenkov, Sergey Sivkov, Svetlana Sivkova, Tamara Savina
Summary: The study revealed that Rosuvastatin had a better lipid-lowering effect, while patients with the SLCO1B1 521CC genotype were more likely to experience a decrease in the lipid-lowering effect of statins. MDR1 polymorphism had no significant effect on statin efficacy.
LIPIDS IN HEALTH AND DISEASE
(2021)
Review
Clinical Neurology
Jong S. Kim
Summary: Hyperlipidemia is an important risk factor for ischemic stroke, and statins have been shown to benefit stroke patients. Guidelines now emphasize high-intensity statins and low LDL-C target strategies for stroke patients, but the benefits of lipid-lowering therapy vary among patients with different levels of cerebral arterial diseases.
Article
Clinical Neurology
Geert J. Lefeber, Wilma Knol, Patrick C. Souverein, Marcel L. Bouvy, Anthonius de Boer, Huiberdina L. Koek
Summary: In patients aged 65 and older, those aged 80 and older who were prescribed statins for 2 years after a first ischemic stroke had a lower risk of recurrent stroke, myocardial infarction, and cardiovascular mortality, as well as reduced all-cause mortality.
Article
Health Care Sciences & Services
Tak Kyu Oh, In-Ae Song, Young-Tae Jeon
Summary: Statin therapy may have potential benefits for the prevention of COVID-19 in South Korea, but it does not affect the hospital mortality of patients diagnosed with COVID-19.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Bom Lee, Sung-Jin Hong, Seung-Woon Rha, Jung Ho Heo, Seung-Ho Hur, Hyun Hee Choi, Kyung-Jin Kim, Ju Han Kim, Hyun Kuk Kim, Ung Kim, Yu Jeong Choi, Yong-Joon Lee, Seung-Jun Lee, Chul-Min Ahn, Young-Guk Ko, Byeong-Keuk Kim, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: The combination therapy of moderate-intensity statin plus ezetimibe showed consistent effectiveness in reducing cardiovascular outcomes for patients with atherosclerotic cardiovascular disease (ASCVD), regardless of their baseline low-density lipoprotein cholesterol (LDL-C) levels.
Article
Dentistry, Oral Surgery & Medicine
Sebastian-Edgar Baumeister, Birte Holtfreter, Stefan Lars Reckelkamm, Thomas Kocher, Zoheir Alayash, Benjamin Ehmke, Hansjorg Baurecht, Michael Nolde
Summary: Genetically proxied inhibition of NCP1L1 and PCSK9 was associated with lower odds of periodontitis, while genetically proxied HMGCR inhibition was not associated with periodontitis.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Luis Fernando Valladales-Restrepo, Diego Alejandro Medina-Morales, Claudia Giraldo-Giraldo, Jorge Enrique Machado-Alba
Summary: The study in Colombia found that pharmacokinetic interactions between statins and other medications were common, especially in adults over 65 years of age and those with endocrine comorbidities or HIV infection. This knowledge should aid in proposing solutions to reduce the risk of adverse reactions.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Urology & Nephrology
Sunjae Bae, JiYoon B. Ahn, Corey Joseph, Ryan Whisler, Mark A. Schnitzler, Krista L. Lentine, Bernard S. Kadosh, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: Statins appear to be well tolerated in kidney transplant recipients, but their use may be associated with a slightly higher risk of post-transplant diabetes mellitus, cataract, and rhabdomyolysis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zhen Zhou, Joanne Ryan, Michael E. Ernst, Sophia Zoungas, Andrew M. Tonkin, Robyn L. Woods, John J. McNeil, Christopher M. Reid, Andrea J. Curtis, Rory Wolfe, Jo Wrigglesworth, Raj C. Shah, Elsdon Storey, Anne Murray, Suzanne G. Orchard, Mark R. Nelson
Summary: The study found that statin therapy in adults aged 65 and older was not associated with incident dementia, MCI, or declines in individual cognition domains. The impact of statin lipophilicity and baseline neurocognitive ability on these associations was also explored. Further confirmation from ongoing randomized trials is needed.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Neurosciences
Guangshuo Li, Shang Wang, Yunyun Xiong, Hongqiu Gu, Kaixuan Yang, Xin Yang, Chunjuan Wang, Chuanying Wang, Zixiao Li, Xingquan Zhao
Summary: This study aimed to compare in-hospital mortality and evacuation rates of intracranial hematoma in patients with primary intracerebral hemorrhage who were prior statin users and nonusers. The results showed that prior statin use was not associated with in-hospital mortality but reduced the proportion of patients undergoing evacuation of intracranial hematoma.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
