Article
Peripheral Vascular Disease
Christian Adolf, Veronika Goerge, Daniel A. Heinrich, Eva Hoster, Holger Schneider, Laura Handgriff, Heike Kuenzel, Lisa Sturm, Felix Beuschlein, Martin Reincke
Summary: The study found that patients with PA exhibit significantly impaired NaCl taste perception, but both surgical and medical treatments significantly improved NaCl taste sensitivity in these patients.
Article
Endocrinology & Metabolism
Alessio Pecori, Fabrizio Buffolo, Jacopo Burrello, Giulio Mengozzi, Francesca Rumbolo, Valeria Avataneo, Antonio D'Avolio, Franco Rabbia, Chiara Bertello, Franco Veglio, Paolo Mulatero, Silvia Monticone
Summary: In patients with primary aldosteronism, mineralocorticoid receptor antagonists can cause a significant increase in renin and potassium levels, as well as a significant decrease in the aldosterone to renin ratio. This effect becomes more pronounced with higher doses of canrenone and longer treatment periods.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Alessio Pecori, Fabrizio Buffolo, Jacopo Burrello, Giulio Mengozzi, Francesca Rumbolo, Valeria Avataneo, Antonio D'Avolio, Franco Rabbia, Chiara Bertello, Franco Veglio, Paolo Mulatero, Silvia Monticone
Summary: The study found that mineralocorticoid receptor antagonists significantly impact the screening results of primary aldosteronism, leading to increased false negative rates.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Medicine, Research & Experimental
Jordana B. Cohen, Irina Bancos, Jenifer M. Brown, Harini Sarathy, Adina F. Turcu, Debbie L. Cohen
Summary: Primary aldosteronism (PA) is frequently overlooked and undertreated, despite being the most common cause of secondary hypertension. PA patients are at high risk for heart and kidney damage. While surgical treatment is an option for unilateral PA, many patients are not suitable or do not want surgery. Steroidal mineralocorticoid receptor antagonists (MRAs) effectively treat PA but are often underprescribed due to side effects. Nonsteroidal MRAs, on the other hand, reduce adverse renal and cardiovascular outcomes and are better tolerated. Their potential role in reducing target organ damage in PA patients, however, is still uncertain.
ANNUAL REVIEW OF MEDICINE
(2023)
Review
Endocrinology & Metabolism
Wei-Chieh Huang, Ying-Ying Chen, Yen-Hung Lin, Jeff S. Chueh
Summary: Meta-analyses confirmed the superior performance of surgical treatment over medical treatment in terms of lower incidences of composite cardiovascular outcomes and non-cure of hypertension among patients with primary aldosteronism (PA). Therefore, adrenalectomy can now be concluded as the treatment of choice for lateralized PA.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Namki Hong, Kyoung Jin Kim, Min Heui Yu, Seong Ho Jeong, Seunghyun Lee, Jung Soo Lim, Yumie Rhee
Summary: This study examined the risk of dementia in patients with primary aldosteronism (PA) compared to patients with essential hypertension (EH). The findings revealed that treated PA patients were more likely to develop all-cause dementia compared to EH patients. Among PA patients, those using mineralocorticoid receptor antagonists (MRA) had a higher risk, especially for vascular dementia.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Multidisciplinary Sciences
Oskar Ragnarsson, Andreas Muth, Gudmundur Johannsson, Eleftheria Gkaniatsa, Eva Jakobsson Ung, Sofie Jakobsson
Summary: This study aimed to describe the most troublesome symptoms for patients with PA and explore health-related worries and expectations following treatment. The findings highlight the need for improving patient care by reducing diagnostic delay, providing comprehensive disease information, and implementing structured long-term follow-up for all patients with PA.
Article
Peripheral Vascular Disease
Ryo Nakamaru, Koichi Yamamoto, Hiroshi Akasaka, Hiromi Rakugi, Isao Kurihara, Takashi Yoneda, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Tetsuya Yamada, Hiroki Kobayashi, Kouichi Tamura, Yoshihiro Ogawa, Junji Kawashima, Nobuya Inagaki, Megumi Fujita, Kenji Oki, Kohei Kamemura, Akiyo Tanabe, Mitsuhide Naruse
Summary: The study found that female patients with bilateral primary aldosteronism have worse renal outcomes compared to male patients after receiving mineralocorticoid receptor antagonist treatment. Despite similar systolic blood pressure levels between the sexes, women experienced a greater decline in estimated glomerular filtration rate, especially during the late phase of 6 to 60 months post-treatment initiation.
Review
Biochemistry & Molecular Biology
Xurong Mai, Mitsuhiro Kometani, Takashi Yoneda
Summary: This review summarizes previous studies on autonomous aldosterone production. It discusses the inhibitory effects of mineralocorticoid receptor antagonists (MRAs) on steroid synthesis and considers the possible factors of cytochrome P-450 reduction. Clinical research reveals the association between aldosterone-producing adenoma and cells containing spironolactone bodies. Furthermore, long-term treatment with MRAs has been reported to lead to spontaneous remission of primary aldosteronism in some cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Jun Yang, Morag J. Young, Timothy J. Cole, Peter J. Fuller
Summary: Primary aldosteronism, or Conn syndrome, is the most common endocrine cause of hypertension. It is associated with a higher risk of cardiovascular, metabolic, and renal diseases and leads to a lower quality of life compared to hypertension caused by other reasons. The multi-systemic effects of primary aldosteronism can be attributed to aldosterone-mediated activation of the mineralocorticoid receptor in various tissues. Recognizing primary aldosteronism as a multi-system disease with tissue-specific pathophysiology may result in more vigilant testing and earlier targeted interventions.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Peripheral Vascular Disease
Hiroko Ogata, Yuto Yamazaki, Yuta Tezuka, Xin Gao, Kei Omata, Yoshikiyo Ono, Yoshihide Kawasaki, Tomoaki Tanaka, Hidekazu Nagano, Norio Wada, Yutaka Oki, Akira Ikeya, Kenji Oki, Yoshiyu Takeda, Mitsuhiro Kometani, Kazunori Kageyama, Ken Terui, Celso E. Gomez-Sanchez, Shujun Liu, Ryo Morimoto, Kensuke Joh, Hiroshi Sato, Mariko Miyazaki, Akihiro Ito, Yoichi Arai, Yasuhiro Nakamura, Sadayoshi Ito, Fumitoshi Satoh, Hironobu Sasano
Summary: Research found that patients with hyperaldosteronism have more pronounced renal damage, characterized by global and segmental glomerulosclerosis, interstitial fibrosis, arteriosclerosis, and arteriolar hyalinization. These results suggest the potential clinical significance of early intervention using mineralocorticoid receptor antagonists or blockers.
Article
Endocrinology & Metabolism
Yen Kheng Tan, Yu Heng Kwan, David Choon Liang Teo, Marieke Velema, Jaap Deinum, Pei Ting Tan, Meifen Zhang, Joan Joo Ching Khoo, Wann Jia Loh, Linsey Gani, Thomas F. J. King, Eberta Jun Hui Tan, Shui Boon Soh, Vanessa Shu Chuan Au, Tunn Lin Tay, Lily Mae Quevedo Dacay, Keng Sin Ng, Kang Min Wong, Andrew Siang Yih Wong, Foo Cheong Ng, Tar Choon Aw, Yvonne Hui Bin Chan, Khim Leng Tong, Sheldon Shao Guang Lee, Siang Chew Chai, Troy Hai Kiat Puar
Summary: Both surgical and medical therapy improve health-related quality of life and psychological symptoms in patients with primary aldosteronism, with surgery providing better outcomes. This highlights the importance of early diagnosis and appropriate treatment.
ENDOCRINE CONNECTIONS
(2021)
Review
Pharmacology & Pharmacy
Piotr Jedrusik, Bartosz Symonides, Jacek Lewandowski, Zbigniew Gaciong
Summary: Primary aldosteronism (PA) is a potentially curable form of secondary hypertension that requires measuring renin and aldosterone, followed by confirmatory tests. Various antihypertensive drug classes interfere with PA evaluation, with calcium antagonists and alpha-blockers being the least interfering drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Sho Katsuragawa, Atsushi Goto, Satoru Shinoda, Kosuke Inoue, Kazuki Nakai, Jun Saito, Tetsuo Nishikawa, Yuya Tsurutani
Summary: The study suggests that reversing renin suppression with optimal mineralocorticoid receptor antagonist titration may help mitigate adverse renal outcomes in medically treated primary aldosteronism patients.
Article
Endocrinology & Metabolism
Alejandra Tapia-Castillo, Cristian A. Carvajal, Jorge A. Perez, Carlos E. Fardella
Summary: This study identified adult subjects with a combined condition of nonclassic apparent mineralocorticoid excess (NCAME) and primary aldosteronism (PA), who had higher blood pressure and increased markers of renal and endothelial damage. Additionally, certain miRNA expressions were associated with this novel combined phenotype.
Article
Endocrinology & Metabolism
Satoshi Higuchi, Hideki Ota, Yuta Tezuka, Kazumasa Seiji, Hidenobu Takagi, Jongmin Lee, Yi-Wei Lee, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Fumitoshi Satoh, Kei Takase
Summary: This study found that APA is associated with greater LV volumetric parameters and higher native T1 values, indicating a higher risk of volume overload and myocardial damage.
ENDOCRINE CONNECTIONS
(2021)
Article
Endocrinology & Metabolism
Yuta Tezuka, Nanako Atsumi, Amy R. Blinder, Juilee Rege, Thomas J. Giordano, William E. Rainey, Adina F. Turcu
Summary: Unlike the ZG and ZR, the ZF and the total adrenal cortex areas enlarge with aging. An abrupt decline of the ZG occurs with age in men only, possibly contributing to sexual dimorphism in cardiovascular risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Xin Gao, Yuto Yamazaki, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hironobu Sasano
Summary: PA is the most common cause of secondary hypertension, classified into unilateral and bilateral types. APMs may be precursors of APAs, and aging plays a pivotal role in the development of aldosterone-producing lesions.
ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Cell Biology
Xin Gao, Yuto Yamazaki, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hironobu Sasano
Summary: The gender differences in the human adrenal cortex mainly manifest in the developing stage, where females have more activated stem cells and higher renewal capacity, resulting in divergent structures and functions of cortical zonations. Females generally exhibit lower blood pressure, renin levels, ACE activities, and more activated HPA axis compared to males.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yuta Tezuka, Adina F. Turcu
Summary: This study found that only a small percentage of patients with PA and LRH treated with MRAs in an academic outpatient practice were evaluated for target renin, and less than half of them achieved target renin. Lower baseline serum potassium, lower MRA doses, and beta-blocker use were associated with lower odds of achieving target renin in PA, while male sex was associated with target renin in LRH.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yuta Tezuka, Yuto Yamazaki, Yasuhiro Nakamura, Hironobu Sasano, Fumitoshi Satoh
Summary: Primary aldosteronism (PA) has been recognized as a leading cause of secondary hypertension, with two major subtypes clinically identified as surgically curable and uncurable, requiring time-consuming and labor-intensive diagnostic procedures. Recent research has focused on PA prevalence, histopathological classification, diagnostic biomarkers, and prediction scores, aiming to improve early detection and decrease complications through better understanding of its epidemiology and pathology.
Article
Biochemistry & Molecular Biology
Jacopo Pieroni, Yuto Yamazaki, Xin Gao, Yuta Tezuka, Hiroko Ogata, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hironobu Sasano
Summary: The study revealed that in aldosterone-producing adenomas and idiopathic hyperaldosteronism, cells in the zona glomerulosa exhibited significantly higher levels of senescence compared to other regions. Additionally, laboratory findings of primary aldosteronism were significantly correlated with specific gene mutations.
Article
Urology & Nephrology
Yoshihide Kawasaki, Shigeto Ishidoya, Ryo Morimoto, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Naoki Kawamorita, Shinichi Yamashita, Koji Mitsuzuka, Fumitoshi Satoh, Akihiro Ito
Summary: Middle-aged patients with primary aldosteronism (PA) who undergo laparoscopic adrenalectomy (LADX) may experience limited antihypertensive effects, particularly in older patients. However, LADX can lead to significant improvements in mental health-related quality of life (HRQoL) in older patients, despite lower rates of antihypertensive drug use post-surgery.
UROLOGIA INTERNATIONALIS
(2023)
Article
Biochemistry & Molecular Biology
Naoki Motomura, Yuto Yamazaki, Daiki Koga, Shogo Harashima, Xin Gao, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh, Yasuhiro Nakamura, Go Eun Kwon, Man Ho Choi, Akihiro Ito, Hironobu Sasano
Summary: Cortisol-producing adenomas consist of clear and compact cells, with compact cells showing higher expression of cholesterol uptake receptors and synthetic enzymes. The study found that both cholesterol uptake and biosynthesis were more pronounced in compact cells, and that PRKACA mutation could contribute to more pronounced clinical symptoms through increased hormone-sensitive lipase expression in compact cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Hiroyuki Sakakibara, Kazumasa Seiji, Sota Oguro, Kenji Mori, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Ryo Morimoto, Takuya Masuda, Hisao Miyamoto, Takuya Hirao, Yuki Niwa, Yohei Suzuki, Yasutaka Baba, Fumitoshi Satoh, Kei Takase
Summary: This study evaluated a flexible device for transvenous adrenal gland radiofrequency ablation in vitro and in an in vivo animal model. The results showed that the device could be successfully inserted into the left adrenal vein and achieved effective ablation of the adrenal gland without causing thermal damage to surrounding organs. This method has the potential as a therapeutic option for primary aldosteronism.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Review
Peripheral Vascular Disease
Yuta Tezuka, Sadayoshi Ito
Summary: This review explores the advantages of nonsteroidal mineralocorticoid receptor blockers (MRBs) in the management of hypertension and cardiovascular and renal diseases compared to conventional MRBs. The unique structures of nonsteroidal MRBs result in higher selectivity for mineralocorticoid receptors (MRs) and no agonist activity for major steroid hormone receptors. Clinical trials have shown that nonsteroidal MRBs achieve similar MR blockade with smaller doses and have fewer off-target side effects.
CURRENT HYPERTENSION REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Naoki Motomura, Yuto Yamazaki, Xin Gao, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh, Yasuhiro Nakamura, Jaeyoon Shim, Man Ho Choi, Akihiro Ito, Hironobu Sasano
Summary: This study demonstrates that amlodipine, an anti-hypertensive medication, can directly affect aldosterone biosynthesis in aldosterone-producing adenoma (APA) patients, potentially through its targeting of CaV1.2 and suppression of HSD3B activity.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shogo Harashima, Yuto Yamazaki, Naoki Motomura, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hiroyoshi Suzuki, Go Eun Kwon, Man Ho Choi, Hironobu Sasano
Summary: This study analyzed the histological characteristics, cholesterol metabolism, and differences related to gene mutations in aldosterone-producing adenomas (APAs). The results showed that mutated KCNJ5 genes in APAs were associated with higher plasma aldosterone concentration and more lipid droplets in compact tumor cells compared to non-mutated APAs. Additionally, cholesterol uptake and synthesis were found to be different between clear and compact tumor cells, with mutated KCNJ5 APAs showing enhanced cholesterol ester uptake and de novo synthesis.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Sota Oguro, Ryo Morimoto, Kazumasa Seiji, Hideki Ota, Tomo Kinoshita, Masahiro Kawabata, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Fumitoshi Satoh, Sadayoshi Ito, Nobukazu Moriya, Seishi Matsui, Tetsuo Nishikawa, Masao Omura, Kazuki Nakai, Seishi Nakatsuka, Isao Kurihara, Kazutoshi Miyashita, Wataru Koda, Tetsuya Minami, Yoshiyu Takeda, Mitsuhiro Kometani, Yutaka Oki, Toshihiro Oishi, Takasuke Ushio, Satoshi Goshima, Kei Takase
Summary: This study evaluated the feasibility and safety of percutaneous radiofrequency ablation (RFA) using bipolar radiofrequency devices for patients with benign aldosterone-producing adenoma (APA). The results showed that the treatment was successful in 94.6% of patients, with a clinical success rate of 86.5% after 84 days. The procedure was deemed safe with low adverse event rates.
SCIENTIFIC REPORTS
(2022)
Letter
Endocrinology & Metabolism
Tracy Ann Williams, Siyuan Gong, Yuya Tsurutani, Yuta Tezuka, Moe Thuzar, Jacopo Burrello, Vin-Cent Wu, Yuto Yamazaki, Paolo Mulatero, Hironobu Sasano, Michael Stowasser, Tetsuo Nishikawa, Fumitoshi Satoh, Martin Reincke
LANCET DIABETES & ENDOCRINOLOGY
(2022)
