Journal
EMBO MOLECULAR MEDICINE
Volume 12, Issue 7, Pages -Publisher
WILEY
DOI: 10.15252/emmm.201708662
Keywords
humanized mice; infections; PDX; immuno-oncology; regenerative medicine
Categories
Funding
- German Center for Infections Research [DZIF-TTU07.803, DZIF-TTU07.805]
- German Research Council [DFG/SFB738]
- Swiss National Science Foundation [310030B_182827, CRSII5_180323]
- Swiss Vaccine Research Institute
- Cancer Research Switzerland [KFS-4091-02-2017]
- Roche
- Novartis
- National Heart Lung and Blood Institute (NHLBI) [HL134510]
- National Institute of Diabetes and Digestive and Kidney Disease (NIDDK) [DK115461]
- National Institute of Allergy and Infectious Diseases (NIAID) [AI32963]
- NIDDK [DK104218]
- National Cancer Institute (NCI) [CA23707, CA224013]
- NIH Office of the Director (OD) [OD026440]
- The Jackson Laboratory (JAX)
- European Molecular Biology Organization (EMBO)
- Jackson Laboratory (JAX)
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Mice xenotransplanted with human cells and/or expressing human gene products (also known as humanized mice) recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevantin vivocontext for understanding of human-specific physiology and pathologies. Humanized mice have advanced toward mainstream preclinical models and are now at the forefront of biomedical research. Here, we considered innovations and challenges regarding the reconstitution of human immunity and human tissues, modeling of human infections and cancer, and the use of humanized mice for testing drugs or regenerative therapy products. As the number of publications exploring different facets of humanized mouse models has steadily increased in past years, it is becoming evident that standardized reporting is needed in the field. Therefore, an international community-driven resource called Minimal Information for Standardization of Humanized Mice (MISHUM) has been created for the purpose of enhancing rigor and reproducibility of studies in the field. WithinMISHUM, we propose comprehensive guidelines for reporting critical information generated using humanized mice.
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