Article
Biochemistry & Molecular Biology
Mathieu Uzzan, Jerome C. Martin, Luka Mesin, Alexandra E. Livanos, Tomas Castro-Dopico, Ruiqi Huang, Francesca Petralia, Giuliana Magri, Shashi Kumar, Qing Zhao, Adam K. Rosenstein, Minami Tokuyama, Keshav Sharma, Ryan Ungaro, Roman Kosoy, Divya Jha, Jeremy Fischer, Harpriya Singh, Mary E. Keir, Nandhini Ramamoorthi, William E. O' Gorman, Benjamin L. Cohen, Adeeb Rahman, Francesca Cossarini, Akihiro Seki, Louise Leyre, Sonia Tejedor Vaquero, Sakteesh Gurunathan, Emilie K. Grasset, Bojan Losic, Marla Dubinsky, Alexander J. Greenstein, Zoe Gottlieb, Peter Legnani, James George, Haritz Irizar, Aleksandar Stojmirovic, Carrie Brodmerkel, Andrew Kasarkis, Bruce E. Sands, Glaucia Furtado, Sergio A. Lira, Zewen K. Tuong, Huaibin M. Ko, Andrea Cerutti, Charles O. Elson, Menna R. Clatworthy, Miriam Merad, Mayte Suarez-Farinas, Carmen Argmann, Jason A. Hackney, Gabriel D. Victora, Gwendalyn J. Randolph, Ephraim Kenigsberg, Jean Frederic Colombel, Saurabh Mehandru
Summary: The study revealed highly dysregulated B cell response in UC patients, with major alterations in colonic B cells, reduced clonal diversity of plasma cells, and the potential of circulating gut-homing plasmablasts as a biomarker for disease activity.
Review
Cell Biology
Lingfeng Qiu, Yixi Zhang, Xun Zeng
Summary: The purpose of this review is to discuss the role of gamma delta T cells in humoral immune responses. Accumulating evidence indicates that gamma delta T cells, independent of alpha beta T cells, participate in multiple steps of humoral immunity, including B cell maturation, activation and differentiation, antibody production and class switching. Gamma delta T cells affect B cell function by directly interacting with B cells, secreting cytokines, or modulating alpha beta T cells.
INFLAMMATION RESEARCH
(2023)
Article
Immunology
Marta Sanz, Brendan T. Mann, Paul L. Ryan, Alberto Bosque, Daniel J. Pennington, Holger Hackstein, Natalia Soriano-Sarabia
Summary: Under non-pathological conditions, human ?d T cells represent a small fraction of CD3(+) T cells in peripheral blood (1-10%). They constitute a unique subset of T lymphocytes that recognize stress ligands or non-peptide antigens through MHC-independent presentation. Major human ?d T cell subsets, Vd1 and Vd2, expand in response to microbial infection or malignancy, but possess distinct tissue localization, antigen recognition, and effector responses. By comparing highly purified Vd1 and Vd2 cells, this study found distinct genetic and phenotypic signatures that define functional differences in ?d T cell populations, suggesting that Vd1 and Vd2 T cells are different lineages. These findings will facilitate further investigation into the ligand specificity and unique role of Vd1 and Vd2 cells in early immune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Carmen de Jesus-Gil, Lidia Sans-de San Nicolas, Ester Ruiz-Romeu, Marta Ferran, Laura Soria-Martinez, Irene Garcia-Jimenez, Anca Chiriac, Josep Manel Casanova-Seuma, Josep Manel Fernandez-Armenteros, Sherry Owens, Antonio Celada, Michael D. Howell, Ramon Maria Pujol, Luis Francisco Santamaria-Babi
Summary: The study found that patients with plaque psoriasis have higher levels of anti-CA IgA and IgG in their plasma, and the cellular response to Candida albicans primarily occurs in CLA(+) T cells, particularly Th17 cells. In plaque psoriasis, the levels of anti-CA IgA are directly associated with the CLA(+) Th17 response. Proteomic analysis revealed distinct profiles in psoriasis patients with high anti-CA IgA levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jeremy Wee Kiat Ng, Kar Wai Tan, Dian Yan Guo, Joey Jia Hui Lai, Xiubo Fan, Zhiyong Poon, Tse Hui Lim, Alvin Soon Tiong Lim, Tony Kiat Hon Lim, William Ying Khee Hwang, Shang Li, Connie J. Eaves, Yeow Tee Goh, Alice Man Sze Cheung
Summary: Human cord blood-derived γ6 T cells (CB γ6) have a diverse TCR γ6 repertoire and unique subtype composition. In vitro expansion of CB γ6 revealed their differentiation into neoantigen-reactive tumor-infiltrating lymphocytes, tissue-resident memory precursor-like cells, and antigen-presenting cell-like cells. These differentiation dynamics were observed in both primary and secondary nonviral antigen stimulations.
Review
Immunology
Hai Qi, Bo Liu, Xinquan Wang, Linqi Zhang
Summary: This review summarizes key observations of humoral immune responses in people with COVID-19, discusses key features of infection- and vaccine-induced neutralizing antibodies, and explores vaccine designs for inducing broadly protective antibodies against different variants of the SARS-CoV-2 virus.
Article
Multidisciplinary Sciences
Yongjian Wu, Manni Wang, Huan Yin, Siqi Ming, Xingyu Li, Guanmin Jiang, Ye Liu, Peihui Wang, Guangde Zhou, Lei Liu, Sitang Gong, Haibo Zhou, Hong Shan, Xi Huang
Summary: Limited understanding of T cell responses against SARS-CoV-2 has hindered vaccine development and drug discovery for COVID-19. This study reveals an previously unknown role for TREM-2 in SARS-CoV-2 infection, suggesting potential strategies for drug discovery and clinical management of COVID-19.
Article
Immunology
Folayemi Olayinka-Adefemi, Chukwunonso Onyilagha, Nipun Jayachandran, Sen Hou, Ping Jia, Jude Uzonna, Aaron J. Marshall
Summary: PI3K delta plays a critical role in immunity to Trypanosoma congolense, promoting immune regulatory responses and antibody generation while also inhibiting early parasite control. Furthermore, the essentiality of PI3K delta for humoral immunity highlights its significant role in protection against systemic trypanosome infection.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Cameron R. Bastow, Ervin E. Kara, Timona S. Tyllis, Carola G. Vinuesa, Shaun R. McColl, Iain Comerford
Summary: Follicular T cells, including T follicular helper (T-FH) and T follicular regulatory (T-FR) cells, play essential roles in supporting and regulating antibody responses. This study found that follicular T cells express not only CXCR5 and CXCR4, but also CCR6, CCR2 and CXCR3. CCR6 is particularly highly expressed in T-FR cells and gating on CCR6(+)CXCR5(hi)PD-1(hi) T cells enriches for T-FR cells. However, CCR6 is not essential for development of the germinal center response and does not affect T-FR cell development and localization during splenic humoral responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Alexandria Gillespie, Maria Gracia Gervasi, Thillainayagam Sathiyaseelan, Timothy Connelley, Janice C. Telfer, Cynthia L. Baldwin
Summary: The WC1 cell surface molecules function as TCR co-receptors and pattern recognition receptors. Following cellular activation, WC1 and TCR colocalize, allowing signaling to occur. WC1 and TCR exist in separate protein domains in quiescent cells, but merge after activation and bind pathogens like Leptospira.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Robert J. Mallis, Jonathan S. Duke-Cohan, Dibyendu Kumar Das, Aoi Akitsu, Adrienne M. Luoma, Debasis Banik, Hannah M. Stephens, Paul W. Tetteh, Caitlin D. Castro, Sophie Krahnke, Rebecca E. Hussey, Brian Lawney, Kristine N. Brazin, Pedro A. Reche, Wonmuk Hwang, Erin J. Adams, Matthew J. Lang, Ellis L. Reinherz
Summary: Research shows that the human DP10.7 gamma delta TCR does not require mechanosensing for ligand recognition, in contrast to alpha beta TCRs. Furthermore, a chimeric gamma delta-alpha beta TCR signals more robustly than the wild-type gamma delta TCR, indicating a different mechanism of ligand recognition for gamma delta T cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Hong -Yin Wang, Sze Ham Chan, Simli Dey, Ivan Castello-Serrano, Michael K. Rosen, Jonathon A. Ditlev, Kandice R. Levental, Ilya Levental
Summary: During T cell activation, LAT forms condensates with Grb2 and Sos1, inducing lipid domains and stabilizing raft-like membrane domains. The coupling of lipid and protein assembly is functionally important, as uncoupling them abrogates T cell activation.
Article
Immunology
Federica Dominelli, Maria Antonella Zingaropoli, Matteo Tartaglia, Eeva Tortellini, Mariasilvia Guardiani, Valentina Perri, Patrizia Pasculli, Federica Ciccone, Leonardo Malimpensa, Viola Baione, Anna Napoli, Aurelia Gaeta, Miriam Lichtner, Antonella Conte, Claudio Maria Mastroianni, Maria Rosa Ciardi
Summary: The study evaluated the humoral and specific T-cell response in people with MS under DMTs before and after vaccination. The results showed that DMTs may influence the immune response to vaccination in MS patients. The understanding of T-cell quality dynamic is important for determining the best vaccination strategy for MS patients under different DMTs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Caroline Stienne, Richard Virgen-Slane, Lisa Elmen, Marisol Veny, Sarah Huang, Jennifer Nguyen, Elizabeth Chappell, Mary Olivia Balmert, Jr-Wen Shui, Michelle A. Hurchla, Mitchell Kronenberg, Scott N. Peterson, Kenneth M. Murphy, Carl F. Ware, John R. Sedy
Summary: The Btla inhibitory receptor is involved in regulating metabolism and cytokine signaling, and plays a role in humoral immunity. It affects the numbers of Tfh cells and GC B cells in lymphocytes, and loss of Btla leads to altered Treg homeostasis and microbial imbalance in the intestine.
Article
Pharmacology & Pharmacy
Jian Wang, Run-Ze Li, Wen-Jun Wang, Hu-Dan Pan, Chun Xie, Lee-Fong Yau, Xing-Xia Wang, Wei-Li Long, Rui-Hong Chen, Tu-Liang Liang, Lin-Rui Ma, Jia-Xin Li, Ju-Min Huang, Qi-Biao Wu, Liang Liu, Jian-Xing He, Elaine Lai-Han Leung
Summary: Non-small cell lung cancer (NSCLC) is a highly lethal malignant tumor. Immunotherapy has become the standard treatment for advanced NSCLC, but drug resistance and low response rates remain challenges. This study found that the sphingolipid metabolism enzyme CERS4 is positively correlated with the efficacy of anti-PD-1 therapy for NSCLC. Upregulating CERS4 expression can improve the effectiveness of anti-PD-1 therapy. The study also revealed the role of sphingolipid metabolites in regulating the immunotherapeutic function of NSCLC and provided potential targets for predicting and improving the efficacy of ICIs for NSCLC.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Infectious Diseases
Anais Corma-Gomez, Luis M. Real, Marta Fernandez-Fuertes, Alejandro Gonzalez-Serna, Noemi Oliver, Jesus Ortega, Pilar Rincon, Elena Rodriguez-Pineda, Marta Santos, Marta Trigo-Rodriguez, Juan Macias, Juan A. Pineda
Summary: This study aimed to assess HAV serologic and vaccination status among people who live with HIV (PLWH) and evaluate the impact of a vaccination-based strategy on HAV-negative patients in Seville, Spain. The results showed that a considerable proportion of PLWH remained susceptible to HAV infection despite the vaccine delivery program, highlighting the need for new strategies to increase HAV vaccination coverage.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2023)
Article
Biochemistry & Molecular Biology
Marta Marquie, Fernando Garcia-Gutierrez, Adelina Orellana, Laura Montrreal, Itziar de Rojas, Pablo Garcia-Gonzalez, Raquel Puerta, Claudia Olive, Amanda Cano, Isabel Hernandez, Maitee Rosende-Roca, Liliana Vargas, Juan Pablo Tartari, Ester Esteban-De Antonio, Urszula Bojaryn, Mario Ricciardi, Diana M. Ariton, Vanesa Pytel, Montserrat Alegret, Gemma Ortega, Ana Espinosa, Alba Perez-Cordon, Angela Sanabria, Nathalia Munoz, Nuria Lleonart, Nuria Aguilera, Ainhoa Garcia-Sanchez, Emilio Alarcon-Martin, Lluis Tarraga, Agustin Ruiz, Merce Boada, Sergi Valero
Summary: This study found that the association between Alzheimer's disease biomarkers and neuropsychiatric symptoms has a significant impact on the conversion to dementia in patients with mild cognitive impairment. A total of 500 individuals with MCI were followed-up yearly, and it was found that certain AT(N) profiles and the presence of depression and apathy were associated with a higher risk of conversion. The additive combination of AT(N) profile with depression exacerbates the risk of conversion, and a synergic effect of prodromal AD profile with depressive symptoms is evidenced.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pablo Garcia-Gonzalez, Itziar de Rojas, Sonia Moreno-Grau, Laura Montrreal, Raquel Puerta, Emilio Alarcon-Martin, Ines Quintela, Adela Orellana, Victor Andrade, Pamela V. Martino Adami, Stefanie Heilmann-Heimbach, Pilar Gomez-Garre, Maria Teresa Perinan, Ignacio Alvarez, Monica Diez-Fairen, Raul Nunez Llaves, Claudia Olive Roig, Guillermo Garcia-Ribas, Manuel Menendez-Gonzalez, Carmen Martinez, Miquel Aguilar, Mariateresa Buongiorno, Emilio Franco-Macias, Maria Eugenia Saez, Amanda Cano, Maria J. Bullido, Luis Miguel Real, Eloy Rodriguez-Rodriguez, Jose Luis Royo, Victoria Alvarez, Pau Pastor, Gerard Pinol-Ripoll, Pablo Mir, Miguel Calero Lara, Miguel Medina Padilla, Pascual Sanchez-Juan, Angel Carracedo, Sergi Valero, Isabel Hernandez, Lluis Tarraga, Alfredo Ramirez, Merce Boada, Agustin Ruiz
Summary: Mosaic loss of chromosome Y (mLOY) is a common somatic event associated with Alzheimer's disease (AD) and can be age-confounded in genome-wide association studies. This study used Mendelian randomisation to construct an age-independent mLOY polygenic risk score (mloy-PRS) and found that higher genetic risk for mLOY was associated with faster progression to AD in men with mild cognitive impairment. The study suggests that mLOY is involved in AD pathogenesis and shows associations with cerebrospinal fluid biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Clinical Neurology
Antonio Boza-Serrano, Rocio Ruiz, Raquel Sanchez-Varo, Juan Garcia-Revilla, Yiyi Yang, Itzia Jimenez-Ferrer, Agnes Paulus, Malin Wennstroem, Anna Vilalta, David Allendorf, Jose Carlos Davila, John Stegmayr, Sebastian Jimenez, Maria A. Roca-Ceballos, Victoria Navarro-Garrido, Maria Swanberg, Christine L. Hsieh, Luis M. Real, Elisabet Englund, Sara Linse, Hakon Leffler, Ulf J. Nilsson, Guy C. Brown, Antonia Gutierrez, Javier Vitorica, Jose Luis Venero, Tomas Deierborg
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Donghe Li, John J. Farrell, Jesse Mez, Eden R. Martin, William S. Bush, Agustin Ruiz, Merce Boada, Itziar de Rojas, Richard Mayeux, Jonathan L. Haines, Margaret A. Pericak Vance, Li-San Wang, Gerard D. Schellenberg, Kathryn L. Lunetta, Lindsay A. Farrer
Summary: This study identified several gene loci associated with Alzheimer's disease, including APOE, TREM2 R47H, rs541586606, and rs760573036, through the use of principal component analysis and Ashkenazi Jewish reference genome-wide association study data.
ALZHEIMERS & DEMENTIA
(2023)
Article
Infectious Diseases
Ines Suarez-Garcia, Belen Alejos, Victoria Hernando, Laura Vinuela, Mar Vera Garcia, David Rial-Crestelo, Maria Jesus Perez Elias, Helena Albendin Iglesias, Joaquim Peraire, Juan Tiraboschi, Asuncion Diaz, Santiago Moreno, Inma Jarrin
Summary: The study assessed the effectiveness and tolerability of DTG/3TC in treatment-naive and virologically suppressed treatment-experienced individuals. The results showed that 91.4% and 93.8% of treatment-naive individuals achieved viral suppression at 24 and 48 weeks, respectively, after starting DTG/3TC. Among treatment-experienced individuals, 97.4% and 95.5% maintained viral suppression at 24 and 48 weeks, respectively, after switching to DTG/3TC.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Virology
Anais Corma-Gomez, Marta Fernandez-Fuertes, Laura Vinuela, Carmen Dominguez, Marta Santos, Ana Fuentes-Lopez, Almudena Rojas, Nieves Fernandez-Perez, Jessica Martin-Carmona, Esther Serrano-Conde, Luis M. Real, Joaquin Mendoza, Juan Macias, Juan A. Pineda, Federico Garcia
Summary: The aim of this study was to assess the immunogenicity of SARS-CoV-2 vaccines among people living with HIV with severe immunosuppression. The findings showed that patients with CD4 cell count <200 cells/mm(3) had reduced immune response after vaccination.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Emily Baker, Ganna Leonenko, Karl Michael Schmidt, Matthew Hill, Amanda J. Myers, Maryam Shoai, Itziar de Rojas, Niccolo Tesi, Henne Holstege, Wiesje M. van der Flier, Yolande A. L. Pijnenburg, Agustin Ruiz, John Hardy, Sven van der Lee, Valentina Escott-Price
Summary: Late-onset Alzheimer's disease has a strong genetic component, and the heritability estimates range from 38% to 66%. The APOE region and microglial-related genes play important roles in the genetic architecture of the disease.
Article
Biochemistry & Molecular Biology
Alvaro Esteban-Martos, Ana Maria Brokate-Llanos, Luis Miguel Real, Sonia Melgar-Locatelli, Itziar de Rojas, Adriana Castro-Zavala, Maria Jose Bravo, Maria del Carmen Manas-Padilla, Pablo Garcia-Gonzalez, Maximiliano Ruiz-Galdon, Beatriz Pacheco-Sanchez, Rocio Polvillo, Fernando Rodriguez de Fonseca, Irene Gonzalez, Estela Castilla-Ortega, Manuel J. Munoz, Patricia Rivera, Armando Reyes-Engel, Agustin Ruiz, Jose Luis Royo
Summary: Genome-wide association studies (GWAS) are a powerful tool for identifying disease-related biochemical pathways and facilitating drug repurposing. DAGGER is a pipeline used to find approved drugs with repurposing potential by analyzing GWAS and gene expression data. Using this pipeline, we identified midostaurin as a protective drug for Alzheimer's disease and confirmed its effect in both C. elegans and 3xTg AD transgenic mice models. Our pipeline has the potential to be a useful tool for drug repurposing in complex diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris Jansen, Eric Yu, Aude Nicolas, Itziar de Rojasj, Thiago Peixoto Leal, Akinori Miyashita, Celine Bellenguez, Michelle Mulan Lian, Kayenat Parveen, Takashi Morizono, Hyeonseul Park, Benjamin Grenier-Boley, Tatsuhiko Naito, Fahri Kucukali, Seth D. Talyansky, Selina Maria Yogeshwar, Vicente Sempere, Wataru Satake, Victoria Alvarez, Beatrice Arosio, Michael E. Belloy, Luisa Benussi, Anne Boland, Barbara Borroni, Maria J. Bullido, Paolo Caffarra, Jordi Clarimon, Antonio Daniele, Daniel Darling, Stephanie Debette, Jean-Francois Deleuze, Martin Dichgans, Carole Dufouil, Emmanuel During, Emrah Duzel, Daniela Galimberti, Guillermo Garcia-Ribas, Jose Maria Garcia-Alberca, Pablo Garcia-Gonzalez, Vilmantas Giedraitis, Oliver Goldhardt, Caroline Graff, Edna Grunblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Heimbach, Henne Holstege, Jakub Hort, Yoo Jin Jung, Deckert Jurgen, Silke Kern, Teemu Kuulasmaa, Kun Ho Lee, Ling Lin, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre de Mendonca, Merce Boada, Pablo Mir, Susanne Moebus, Fermin Moreno, Benedetta Nacmias, Gael Nicolas, Shumpei Niida, Borge G. Nordestgaard, Goran Papenberg, Janne Papma, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Oliver Peters, Yolande A. L. Pijnenburg, Gerard Pinol-Ripoll, Julius Popp, Laura Molina Porcel, Raquel Puertaj Jordi Perez-Tur, Innocenzo Rainero, Inez Ramakers, Luis M. Real, Steffi Riedel-Heller, Eloy Rodriguez-Rodriguez, Owen A. Ross, Jose Luis Royo, Dan Rujescu, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Ingmar Skoog, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John van Swieten, Raquel Sanchez-Valle, Eng-King Tan, Thomas Tegos, Charlotte Teunissen, Jesper Qvist Thomassen, Lucio Tremolizzo, Martin Vyhnalek, Frans Verhey, Margda Waern, Jens Wiltfang, Jing Zhangc, Henrik Zetterberg, Kaj Blennow, Zihuai He, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick G. Kehoe, Ole A. Andreassen, Cornelia Van Duin, Magda Tsolaki, Pascual Sanchez-Juan, Ruth Frikke-Schmidt, Kristel Sleegers, Tatsushi Todau, Anna Zettergren, Martin Ingelsson, Yukinori Okada, Giacomina Rossi, Mikko Hiltunen, Jungsoo Gim, Kouichi Ozaki, Rebecca Sims, Jia Nee Foo, Wiesje van der Fliere, Takeshi Ikeuchi, Alfredo Ramirez, Ignacio Mata, Agustin Ruiz, Ziv Gan-Or, Jean-Charles Lambert, Michael D. Greicius, Emmanuel Mignot
Summary: We analyzed the HLA associations in individuals with Parkinson's disease and Alzheimer's disease across different ancestry groups and found that these two diseases share a common protective association at the HLA locus. Fine-mapping showed that specific subtypes of HLA-DRB1*04 were responsible for this association, with HLA-DRB1*04:04 and HLA-DRB1*04:07 showing the strongest association. This protective effect was also associated with decreased neurofibrillary tangles in the brain and reduced levels of tau protein in cerebrospinal fluid.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Mathematics
Angela Jimenez-Casas, Mario Castro, Manuel Villanueva-Pesqueira
Summary: This study investigates the influence of elasticity on the dynamics of chaotic systems by examining various models derived from mechanics, immunology, ecology, and rheology. The findings reveal that elasticity profoundly alters the chaotic dynamics of these systems, highlighting the non-trivial and non-monotonic role of elasticity in controlling or lack of control of chaotic behavior across different scales.
Article
Multidisciplinary Sciences
Luis Miguel Real, Maria E. Saez, Anais Corma-Gomez, Antonio Gonzalez-Perez, Christian Thorball, Rocio Ruiz, Maria Reyes Jimenez-Leon, Alejandro Gonzalez-Serna, Carmen Gasca-Capote, Maria Jose Bravo, Jose Luis Royo, Alberto Perez-Gomez, Maria Ines Camacho-Sojo, Isabel Gallego, Joana Vitalle, Sara Bachiller, Alicia Gutierrez-Valencia, Francisco Vidal, Jacques Fellay, Mathias Lichterfeld, Ezequiel Ruiz-Mateos, Swiss HIV Cohort Study
Summary: Some HIV controllers experience immunologic progression with CD4(+) T cell decline. Genetic factors associated with CD4(+) T cell decline in HIV controllers were identified. Specific genetic factors were found to be associated with the long-term non-progressor HIV spontaneous control phenotype.
Article
Computer Science, Information Systems
Jaime Perez, Mario Castro, Gregorio Lopez
Summary: The gaming industry plays a crucial role in entertainment, but serious games have also been used for language learning, value conveyance, and skill training. The resurgence of AI and data science provides an opportunity for integrating them into video games. This paper aims to explore the intersection of serious games, AI, and computational social science as novel research tools to understand human behavior and society.