Article
Respiratory System
Erika B. Rosenzweig, Angela Bates, Mary P. Mullen, Steven H. Abman, Eric D. Austin, Allen Everett, Jeffrey Fineman, Jeffery Feinstein, Rachel K. Hopper, John P. Kinsella, Usha S. Krishnan, Minmin Lu, Kenneth D. Mandl, J. Usha Raj, Nidhy Varghese, Delphine Yung, Stephanie S. Handler, Lynn A. Sleeper
Summary: This study analyzed the hemodynamic findings and safety of catheterization in children with WSPH group 1 and 3 subtypes. The results showed that diagnostic RHC was performed safely in experienced pediatric pulmonary hypertension centers for WSPH group 1 and 3 patients. Additionally, hemodynamic differences were noted between group 1 and 3 subjects.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Medicine, General & Internal
Giulia Elena Mandoli, Federico Landra, Benedetta Chiantini, Carlotta Sciaccaluga, Maria Concetta Pastore, Marta Focardi, Luna Cavigli, Flavio D'Ascenzi, Sonia Bernazzali, Massimo Maccherini, Serafina Valente, Matteo Cameli, Michael Henein
Summary: This study evaluated the predictive accuracy of peak TRV for PH based on the new and old cutoff values for mPAP, and compared it with the mean RV-RA pressure gradient. The results showed that peak TRV performed better than mean RV-RA pressure gradient in predicting PH, regardless of the hemodynamic definitions, and had higher sensitivity and equal positive predictive value.
Review
Cardiac & Cardiovascular Systems
Simina Crisan, Ruxandra-Maria Baghina, Silvia Ana Luca, Alina-Ramona Cozlac, Alina-Gabriela Negru, Cristina Vacarescu, Mihai-Andrei Lazar, Constantin-Tudor Luca, Dan Gaita
Summary: Currently, various imaging techniques play a crucial role in the comprehensive evaluation of patients with suspected pulmonary hypertension (PH), providing important diagnostic information and facilitating early detection of the disease. Transthoracic echocardiography is the primary method for assessing right ventricle pressure overload and dysfunction, while right heart catheterisation is considered the gold standard assessment. Other imaging modalities such as chest radiography, CT, and CT pulmonary angiography are equally important for evaluating lung parenchyma and pulmonary arteries. Advanced techniques like dual-energy CT and cardiac MRI provide accurate diagnostic information for specific subtypes of PH.
Review
Cardiac & Cardiovascular Systems
Aleksandra Bartnik, Joanna Pepke-Zaba, Stephen P. Hoole, Paul White, Madalina Garbi, John G. Coghlan, Fouad Taghavi, Steven Tsui, Jonathan Weir-McCall
Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is a condition that occurs in some patients with prior acute pulmonary embolism, characterized by shortness of breath, persistently elevated pulmonary pressures, and right heart failure. Surgical pulmonary endarterectomy (PEA) is effective for patients with proximal disease distribution, while balloon pulmonary angioplasty (BPA) and medical therapy are options for those with inoperable disease. Current evaluation of pulmonary hemodynamics does not accurately reflect patient symptoms, and further research is needed on how to manage symptomatic patients without pulmonary hypertension.
Article
Medicine, General & Internal
Gian M. Rosa, Riccardo Scagliola, Gabriele Zoppoli, Valentina Perna, Angelo Buscaglia, Alessandro Berri, Roberta Della Bona, Italo Porto, Rinaldo Pellicano, Gianni Testino
Summary: This study has demonstrated that standard echocardiography can predict cardiac dysfunction in asymptomatic alcoholics, and sex-related differences may be identified in this regard. These findings should be confirmed by larger population studies.
Article
Health Care Sciences & Services
Igor Volodarsky, Katerina Kerzhner, Dan Haberman, Valeri Cuciuc, Lion Poles, Alex Blatt, Elena Kirzhner, Jacob George, Gera Gandelman
Summary: Right heart catheterization is a diagnostic procedure used to diagnose pulmonary hypertension. It includes measuring blood pressure in heart chambers, estimating cardiac output, and calculating pulmonary vascular resistance. The thermodilution and indirect Fick methods are commonly used to evaluate cardiac output, but there is a discrepancy between the values obtained by the two methods.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Rong Jiang, Lan Wang, Qin-Hua Zhao, Cheng Wu, Ping Yuan, Shang Wang, Rui Zhang, Su-Gang Gong, Wen-Hui Wu, Jing He, Hong-Ling Qiu, Ci-Jun Luo, Jin-Ming Liu, Zhi-Cheng Jing
Summary: We established and validated a novel nomogram using echocardiographic parameters to predict all-cause death in patients with severe CLD-PH.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Veterinary Sciences
Tomoya Morita, Kensuke Nakamura, Tatsuyuki Osuga, Sei Kawamoto, Shingo Miki, Mitsuyoshi Takiguchi
Summary: This study validated the relationship between echocardiographic indices and right heart catheterization variables in dogs with acute pulmonary embolism, and identified a useful echocardiographic index for diagnosing acute pulmonary embolism.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Dilia Giuggioli, Valeria Riccieri, Edoardo Cipolletta, Nicoletta Del Papa, Francesca Ingegnoli, Amelia Spinella, Greta Pellegrino, Anna Maria Risa, Marco de Pinto, Silvia Papa, Giuseppe Armentaro, Rossella De Angelis
Summary: Systemic sclerosis (SSc) is a connective tissue disease characterized by immune-system alterations, fibrosis, and microangiopathy. Pulmonary arterial hypertension (PAH) is a severe complication affecting about 10-15% of SSc patients, and appropriate screening programs are necessary. Nail fold videocapillaroscopy (NVC) studies show more severe microvascular dysfunction in SSc patients with PAH, suggesting a correlation with pulmonary microangiopathy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Micha T. Maeder, Lukas Weber, Hans Rickli
Summary: In patients with severe aortic stenosis, pulmonary hypertension is a sign of decompensated cardiac function and heart failure resulting from AS-related cardiac injury. This review article discusses the pathophysiology of AS-induced PH, its prognostic impact, and options for prevention and treatment. The study emphasizes the importance of invasive hemodynamics in evaluating AS patients for aortic valve replacement, particularly the relevance of combined pre-and post-capillary PH. Comprehensive assessment, including right heart catheterization and non-invasive imaging, is crucial for accurately evaluating AS-related cardiac injury and distinguishing PH forms unrelated to AS.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Critical Care Medicine
Ryan W. Morgan, Adam S. Himebauch, Heather Griffis, William O. Quarshie, Timothy Yeung, Todd J. Kilbaugh, Alexis A. Topjian, Danielle Traynor, Vinay M. Nadkarni, Robert A. Berg, Akira Nishisaki, Robert M. Sutton
Summary: This study aimed to determine the prevalence of pulmonary hypertension (PH) among children with in-hospital cardiac arrest (IHCA) and its relation to survival. Results showed that children with pre-existing documented PH were less likely to survive to hospital discharge compared to those without PH.
Article
Cardiac & Cardiovascular Systems
Vladislav Chubuchny, Nicola Riccardo Pugliese, Claudia Taddei, Elisa Poggianti, Valentina Spini, Andrea Barison, Bruno Formichi, Edoardo Airo, Carolina Bauleo, Renato Prediletto, Luigi Emilio Pastormerlo, Michele Coceani, Marco Ciardetti, Christina Petersen, Emilio Pasanisi, Carlo Lombardi, Michele Emdin, Alberto Giannoni
Summary: The novel quantitative echocardiographic approach for the estimation of PAWP and PVR has high diagnostic accuracy in patients with heart failure and pulmonary hypertension, showing superior performance compared to previous recommendations and equations.
Article
Critical Care Medicine
Franck F. Rahaghi, Nicholas A. Kolaitis, Ayodeji Adegunsoye, Joao A. de Andrade, Kevin R. Flaherty, Lisa H. Lancaster, Joyce S. Lee, Deborah J. Levine, Ioana R. Preston, Zeenat Safdar, Rajan Saggar, Sandeep Sahay, Mary Beth Scholand, Oksana A. Shlobin, David A. Zisman, Steven D. Nathan
Summary: This study identifies triggers and screening tools for pulmonary hypertension (PH) in patients with interstitial lung disease (ILD) through expert consensus. Due to the lack of standardized approaches, this consensus statement aims to aid physicians in the identification of ILD patients with possible PH and provide guidance for timely right heart catheterization.
Article
Critical Care Medicine
Gabor Kovacs, Alexander Avian, Gerhard Bachmaier, Natascha Troester, Adrienn Tornyos, Philipp Douschan, Vasile Foris, Teresa Sassmann, Katarina Zeder, Joerg Lindenmann, Luka Brcic, Michael Fuchsjaeger, Alvar Agusti, Horst Olschewski
Summary: By combining echocardiography, NT-proBNP level, and PA to Ao diameter ratio, severe PH in patients with COPD can be predicted with high sensitivity and specificity. The contribution of severe airflow limitation and severe PH to impaired survival is comparable.
Article
Cardiac & Cardiovascular Systems
Nobuhide Yamakawa, Norihiko Kotooka, Tomoyuki Kato, Tatsuhiko Kuroda, Koichi Node
Summary: In this study, non-invasive cardiac acoustic biomarkers (CABs) were used to classify pulmonary hypertension (PH) phenotypes and compared with echocardiography. The results showed a significant correlation between CABs and RHC measurements, providing a convenient method for identifying PH and its phenotypes.
Article
Cardiac & Cardiovascular Systems
Alejandro A. Floh, Shubhadeep Das, Maruti Haranal, Peter C. Laussen, Lynn Crawford-Lean, Chun-Po S. Fan, Luc L. Mertens, Kyle Runeckles, Osami Honjo
Summary: The use of Del Nido cardioplegia (DNc) during pediatric cardiopulmonary bypass (CPB) was not associated with an increase in reported systemic ventricle dysfunction (sVD). However, DNc may potentially impact right ventricular function.
Editorial Material
Cardiac & Cardiovascular Systems
Dawn M. Park, Bruce F. Landeck, Dale A. Burkett, Richard M. Friesen, Karrie L. Villavicencio, Sonali S. Patel, K. Scott Kirby, Brittany E. Hoefener, Casey M. Gau, Lindsay M. Provenzano, Adel K. Younoszai
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Letter
Cardiac & Cardiovascular Systems
Rahna Rasouli, Jerome Baranger, Cameron Slorach, Minh Nguyen, Patrick Segers, Vitor Guerra, Mathieu Pernot, Wei Hui, Luc Mertens, Olivier Villemain
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Article
Gastroenterology & Hepatology
Isani Singh, Gillian Noel, Jennifer M. Barker, Kathryn C. Chatfield, Anna Furniss, Amber D. Khanna, Natalie J. Nokoff, Sonali Patel, Laura Pyle, Leena Nahata, Francis S. Cole, Chijioke Ikomi, Vaneeta Bamba, Patricia Y. Fechner, Shanlee M. Davis
Summary: This study investigates liver abnormalities in children with Turner Syndrome (TS) and finds a higher prevalence of elevated liver enzymes and liver diseases compared to matched controls. These findings highlight the importance of early and consistent liver function screening in TS and the need for further research on the etiology and treatment of liver disease in this population.
LIVER INTERNATIONAL
(2022)
Review
Pediatrics
Maelys Venet, Mark K. Friedberg, Luc Mertens, Jerome Baranger, Zakaria Jalal, Ghoufrane Tlili, Olivier Villemain
Summary: Nuclear imaging plays a unique role in pediatric and congenital cardiology, allowing assessment of various parameters and providing different information compared to echocardiography or magnetic resonance imaging.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cardiac & Cardiovascular Systems
Sofie Dannesbo, Elisabeth Blixenkrone-Moeller, Christian A. Pihl, Anne-Sophie Sillesen, Ruth O. Voegg, Agnes S. Davidsen, Louise E. Lind, Dorthe L. Jeppesen, Charlotte Kruse, Betina Noerager, James K. Dodd, Finn S. Jorgensen, Anna A. Raja, Steven D. Colan, Luc Mertens, Vibeke E. Hjortdal, Niels Vejlstrup, Robert H. Anderson, Henning Bundgaard, Kasper Iversen
Summary: This study developed a new classification algorithm for interatrial communications in newborns using echocardiographic criteria. The algorithm showed high interobserver and intraobserver agreement in distinguishing between patency of the oval foramen and atrial septal defects. This algorithm may be valuable for both research and clinical practice.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Cardiac & Cardiovascular Systems
Kristian Sorensen, Solveig Fadnes, Luc Mertens, Matthew Henry, Patrick Segers, Lasse Lovstakken, Siri Ann Nyrnes
Summary: This study developed and validated the calculation of intraventricular pressure difference (IVPD) using blood speckle-tracking (BST) in children and investigated its potential role in assessing diastolic function. The results showed that BST is highly feasible and provides information on diastolic suction and early filling in children with heart disease. The IVPD was significantly reduced in children with dilated cardiomyopathies (DCMs) and hypertrophic cardiomyopathies (HCMs) compared to controls.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Neurosciences
Julien Aguet, Nikan Fakhari, Minh Nguyen, Luc Mertens, Elod Szabo, Birgit Ertl-Wagner, Lynn Crawford, Christoph Haller, David Barron, Jerome Baranger, Olivier Villemain
Summary: Newborns with congenital heart disease undergoing cardiac surgery are at risk of neurodevelopmental impairment. This study used ultrafast power Doppler to assess cerebral blood volume (CBV) variations in neonates with hypoplastic left heart syndrome during surgery. The results showed that global CBV did not differ significantly before and after surgery. However, regional differences in CBV were observed during hypothermia, and CBV was correlated with cardiopulmonary bypass (CPB) flow rate. Patients with higher CBV variation had brain injury on post-operative imaging. This suggests that the measurement of CBV using ultrafast power Doppler can optimize cerebral perfusion during neonatal cardiac surgery.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Cardiac & Cardiovascular Systems
Safwat Aly, Luc Mertens, Mark K. Friedberg, Andreea Dragulescu
Summary: After the Fontan operation, there is a progressive decrease in myocardial deformation parameters. The progressive decrease in SV torsion is related to a decrease in apical rotation, which is more pronounced in single RVs. Decreased torsion is associated with increased markers of myocardial fibrosis and lower maximal exercise capacity.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Aimen Malik, Jerome Baranger, Minh Bao Nguyen, Cameron Slorach, Wei Hui, Jose Carlos Villalobos Lizardi, Maelys Venet, Mark K. Friedberg, Luc Mertens, Olivier Villemain
Summary: This study aims to determine the normal range of myocardial stiffness in healthy children and young adults using shear-wave elastography (SWE) and explore the impact of left ventricular geometric characteristics on SWE. The results show that diastolic myocardial stiffness increases linearly with age and has a weaker correlation with myocardial and left ventricular geometric characteristics.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Yohei Akazawa, Tao Fujioka, Kana Yazaki, Martina Strbad, Juergen Hoerer, Andreas Kuehn, Wei Hui, Cameron Slorach, Christoph Roehlig, Luc Mertens, Bart H. Bijnens, Manfred Vogt, Mark K. Friedberg
Summary: A study published in the Journal of the American Society of Echocardiography showed that mechanical dyssynchrony in the right ventricle is associated with remodeling, dysfunction, and impaired exercise capacity in Ebstein anomaly patients. Therefore, mechanical dyssynchrony may be a therapeutic target in selected patients.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Rahna Rasouli, Jerome Baranger, Cameron Slorach, Wei Hui, Maelys Venet, Minh B. Nguyen, Matthew Henry, Josh Gopaul, Paul C. Nathan, Luc Mertens, Olivier Villemain
Summary: This study assessed the effect of anthracycline treatment on arterial stiffness in childhood cancer survivors using ultrafast ultrasound imaging. The results showed that there was no significant difference in demographic parameters, blood biomarkers, cardiovascular parameters, or pulse wave velocity between the survivors and healthy controls. Therefore, anthracycline treatment did not have a significant impact on local arterial stiffness in the left common carotid artery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Computer Science, Interdisciplinary Applications
Nikan Fakhari, Julien Aguet, Minh Nguyen, Luc Mertens, David Barron, Christoph Haller, John G. Sled, Olivier Villemain, Jeirome Baranger
Summary: In this study, the variations of cerebral blood volume (CBV) in human neonates during cardiac surgery were measured using Ultrafast Power Doppler and freehand scanning. The study found significant variations of CBV during bypass and demonstrated the clinical translation of ultrafast power Doppler with diverging-waves and freehand scanning.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Correction
Pediatrics
Yingping Deng, Xiang Cao, Luc L. L. Mertens, Patrick J. J. McNamara
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Yingping Deng, Xiang Cao, Luc L. Mertens, Patrick J. McNamara
Summary: This study investigated the attitudes, training, and accreditation regarding targeted neonatal echocardiography (TnEcho) among Chinese neonatologists. The survey revealed that 35.1% of respondents used TnEcho in their neonatal intensive care units (NICUs). Most respondents valued the role of TnEcho in providing timely and longitudinal hemodynamic information. However, the lack of experienced practitioners and accredited training programs were perceived as major barriers to implementation.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)