Journal
DYES AND PIGMENTS
Volume 177, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2020.108290
Keywords
Coumarin; Ratiometric fluorescent probe; Mercury ions; DL-Dithiothreitol; Bioimaging application
Funding
- National Natural Science Foundation of China [21777053, 21607053]
- Shandong Provincial Natural Science Foundation [ZR2017MB014, ZR2018PC013]
- Project of Shandong Province Higher Educational Science and Technology Support Program for Young Innovation [2019KJD005]
- Youth Fund of Shandong Academy of Science [2019QN001]
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It is very important to determine mercury owing to its complex biological poisonousness that could cause various physical diseases and even death. In this study, we designed a novel coumarin-based ratiometric fluorescent probe, CR-Hg, with DL-dithiothreitol moiety as the recognition receptor to detect mercury ions (Hg2+). CR-Hg could realize the quantitative detection of Hg2+ between 0 and 1.4 mu M with low detection limit (1.6 nM). Furthermore, CR-Hg could react quickly with Hg2+ in a few seconds and accompanied by color changes from pale yellow to orange. In the end, the applications of CR-Hg in the water samples, living cells and zebrafish more deeply indicated that the probe could serve as a novel promising tool for revealing mercury distribution in the environment and organisms.
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