Review
Medicine, General & Internal
David G. Armstrong, Tze-Woei Tan, Andrew J. M. Boulton, Sicco A. Bus
Summary: Approximately 18.6 million people worldwide are affected by diabetic foot ulcers each year, with 1.6 million people in the United States. These ulcers precede 80% of lower extremity amputations among people with diabetes and are associated with an increased risk of death.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Rebecca Voelker
Summary: This article describes diabetic foot ulcers and their evaluation and treatment.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Jean-Baptiste Bonnet, Valerie Macioce, Abdulkader Jalek, Karim Bouchdoug, Cecile Elleau, Marie-Francoise Gras-Vidal, Julie Pochic, Antoine Avignon, Ariane Sultan
Summary: This study analyzed the evolution of diabetic foot ulcers (DFU) in outpatient settings during the Covid-19 epidemic and 1 month after the lockdown ended. The findings suggest that lockdown had a positive effect on DFU if patients continued to receive care from wound centers. Better compliance with offloading, possibly facilitated by tele-medicine, may have contributed to this effect.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Mayland Chang, Trung T. Nguyen
Summary: Diabetic foot ulcers (DFUs) are chronic wounds that affect 30% of diabetic patients, with dysregulation of the normal wound healing process. Infection in DFUs increases inflammation and delays wound healing. Selective inhibition of MMP-9 may be a promising strategy for treatment of DFUs.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Georgios Theocharidis, Beena E. Thomas, Debasree Sarkar, Hope L. Mumme, William J. R. Pilcher, Bhakti Dwivedi, Teresa Sandoval-Schaefer, Ruxandra F. Sirbulescu, Antonios Kafanas, Ikram Mezghani, Peng Wang, Antonio Lobao, Ioannis S. Vlachos, Biraja Dash, Henry C. Hsia, Valerie Horsley, Swati S. Bhasin, Aristidis Veves, Manoj Bhasin
Summary: This study utilizes single-cell RNA sequencing to reveal the distribution of specific populations of fibroblasts and macrophages in diabetic foot ulceration (DFU) patients and identifies their crucial roles in wound healing.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Qian Yu, Guo-hong Qiao, Min Wang, Li Yu, Yaoxiang Sun, Hui Shi, Tie-liang Ma
Summary: Diabetic foot ulcer poses a worldwide challenge in clinical medicine due to the ineffective traditional treatments. Researching the pathogenesis and molecular mechanisms of stem cell therapy for diabetic foot is of great importance in maximizing the repair properties of stem cells. Additionally, effective application modalities are crucial for improving stem cell survival and viability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Dermatology
David Dayya, Owen J. O'Neill, Tania B. Huedo-Medina, Nusrat Habib, Joanna Moore, Kartik Iyer
Summary: Diabetic foot ulcerations can lead to severe complications, and debridement is a common treatment method involving both nonmechanical and mechanical approaches. These methods help promote wound healing and reduce complications.
ADVANCES IN WOUND CARE
(2022)
Article
Biotechnology & Applied Microbiology
Yi Xu, Kang Han, Yongming Zhou, Jian Wu, Xin Xie, Wei Xiang
Summary: Diabetic foot ulcers (DFUs) are common complications of diabetes. Recent advancements in computerized classification based on deep learning methods have shown promising results for identifying infection and ischemia in DFUs. This study proposes the use of class knowledge banks (CKBs) to improve the performance of DFU infection and ischemia classifications by effectively extracting and representing class knowledge.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Malakai Sovaki Ranuve, Masoud Mohammadnezhad
Summary: This study examines the perception of healthcare workers in Rotuma, Fiji on diabetic foot ulcers and foot care, revealing a lack of significant in-depth knowledge and challenges in practice. Insufficient resources and professional development opportunities negatively impact the quality of foot care services provided by healthcare workers.
Review
Health Care Sciences & Services
Alvaro Astasio-Picado, Alba angel Babiano, Miriam Lopez-Sanchez, Rocio Ruiz Lozano, Paula Cobos-Moreno, Beatriz Gomez-Martin
Summary: This article provides evidence on the effectiveness and safety of ozone therapy in the treatment of wounds in patients with diabetic foot. It compares ozone therapy with other treatment methods and presents the findings of a literature review.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Danielle Dixon, Michael Edmonds
Summary: Recent evidence-based treatments for diabetic foot ulcers have emerged from multicentre, randomised, controlled trials, highlighting new advances in wound therapy. The overview of current and future pharmacotherapies includes proposed mechanisms of action and supporting evidence for various treatments. Looking forward, novel therapies utilizing nanotechnology and bioactive agents may provide possibilities for pharmacotherapy in the future.
Article
Pharmacology & Pharmacy
Yanling Wang, Bang Liu, Yinzhen Pi, Li Hu, Yeling Yuan, Jiao Luo, Yixiao Tao, Ping Li, Shan Lu, Wei Song
Summary: The purpose of this study was to assess the risk factors for morbidity and mortality of diabetic foot ulcers (DFUs). The study also investigated the effectiveness of negative pressure wound therapy (NPWT) combined with platelet-rich plasma-fibrin glue (PRP) in the treatment of diabetic foot ulcers. They found new risk factors for DFUs and concluded that the combination therapy could accelerate wound healing and reduce mortality rate.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dermatology
David G. Armstrong, Michael E. Edmonds, Thomas E. Serena
Summary: Elevated bacterial levels increase the risk of chronic wound infection and hinder healing. This study examined the role of fluorescence imaging in detecting bacteria in wounds. The results show that imaging can improve the detection of bacteria across different loads. A new terminology, chronic inhibitory bacterial load (CIBL), is introduced to describe asymptomatic high bacterial loads in diabetic ulcers, which require clinical intervention.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Lawrence Sena Tuglo, Felix Kwasi Nyande, Percival Delali Agordoh, Eunice Berko Nartey, Zhongqin Pan, Lydia Logosu, Atsu Eyram Dei-Hlorlewu, Desire Koku Haligah, Linda Osafo, Simon Taful, Minjie Chu
Summary: The study found that 63% of diabetic patients had good knowledge of DFC, while 49% competently practiced it. There was a negative correlation between knowledge and practice levels of DFC. The prevalence of DFUs was 8.7%, and male diabetic patients were 3.4 times more likely to develop DFUs than female diabetic patients.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Timothy Olukunle Aladelusi, Foluso Ayobami Atiba, Shakeerah Olaide Gbadebo, Yewande Isabella Adeyemo, Adeola Adenike Olusanya, Oladimeji Adeniyi Akadiri
Summary: Dental healthcare providers in Nigeria have a good understanding of the symptoms and preventive measures of COVID-19, with fever being the most common symptom and aerosol generating procedures identified as the main transmission risk in clinics. However, there is still room for improvement in their knowledge of less common features. The study suggests the utilization of teledentistry, clinical triage, preprocedural 1% hydrogen peroxide oral rinses, and proper Personal Protective Equipment to prevent transmission in dental practice settings.
Article
Dermatology
Jiaxing You, Chao Liu, Yixin Chen, Weifen Zhu, Hongye Li, Lin Li
Summary: The aim of this study was to identify the most cited articles in the field of diabetic foot ulcer (DFU) research. The study conducted a bibliometric analysis using Boolean search terms in two databases. The findings revealed the characteristics of the top-cited articles, such as publication year, country of origin, and level of evidence. The majority of the articles were clinical studies, providing valuable insights into the history and development of DFU research.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2023)
Article
Green & Sustainable Science & Technology
Xiang Wang, Si-Fen Liu, Zhen-Yao Wang, Yao Wang, Ting-Bin Hao, Srinivasan Balamurugan, Da-Wei Li, Yuhe He, Hong-Ye Li, Carol Sze Ki Lin
Summary: The research on sustainable alternatives for producing valuable polyunsaturated fatty acids (PUFAs) has been promoted due to the limited supply of wild deep-sea fish and the potential accumulation of toxic pollutants. In this study, an evolved strain of Phaeodactylum tricornutum microalgae was generated through adaptive evolution, resulting in enhanced biomass and PUFA production capabilities. The use of food waste hydrolysate as a carbon source further improved biomass yield and PUFA production. This study provides novel insights into sustainable microalgal-based waste valorisation for PUFA production.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Microbiology
Yunpeng Gai, Lei Li, Bing Liu, Haijie Ma, Yanan Chen, Fang Zheng, Xuepeng Sun, Mingshuang Wang, Chen Jiao, Hongye Li
Summary: This study identifies the crucial role of bZIP transcription factors in fungal morphogenesis, abiotic stress response, and pathogenesis in phytopathogenic fungus Alternaria alternata. The findings expand our understanding of how microbial pathogens utilize these genes to cope with environmental stresses and achieve successful infection in the host plant.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Microbiology
Pu-Dong Li, Zeng-Rong Zhu, Yunzeng Zhang, Jianping Xu, Hongkai Wang, Zhengyi Wang, Hongye Li
Summary: By studying the impact of Diaporthe citri on the phyllosphere microbiome of citrus, we found that infection caused changes in the phyllosphere microbiome. After infection, there was a significant decrease in community evenness, the emergence of new microbes, and an intense microbial network. We also identified potential beneficial microbes and enriched microbial functions that could help plants cope with D. citri challenge.
Article
Engineering, Environmental
Yuhan Ma, Wasiqi Yuan, Wenjie Kan, Changyue Huang, Jiawei Zhu, Guilong Zhang, Hongye Li, Srinivasan Balamurugan, Lifang Wu
Summary: Microalgae are being investigated as green cell factories for biochemistry and pollution control. This study focuses on enhancing the synthesis of selenium nanoparticles (SeNPs) in microalgae and understanding the molecular mechanisms involved. Chlorella vulgaris was fortified with quercetin to promote SeNPs biotransformation. Quercetin facilitated the formation of SeNPs within 72 hours, converting almost 97% of inorganic selenite to SeNPs. Electron microscopy confirmed the biogenic ability of the algal system. Quercetin fortification protected C. vulgaris from selenite-induced impairment and improved its growth rate, while also altering the fatty acid profile.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Agronomy
Bei Liu, Xingxing Liang, Jinchao Kong, Chen Jiao, Hongye Li, Yunpeng Gai
Summary: In this study, the genetic structure and diversity of Colletotrichum gloeosporioides, the dominant species causing citrus anthracnose, were analyzed using the Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene. A total of 19 GAPDH haplotypes were identified, with the main haplotype (haplotype 5) distributed widely among isolates from different Citrus species and locations. The genetic differentiation index (Fst) revealed significant genetic differentiation between populations from different regions and host species. The results suggest that genetic differentiation in C. gloeosporioides is mainly influenced by gene mutation, recombination, or migration within native populations rather than natural selection caused by geography or host variety.
Article
Agriculture, Multidisciplinary
Li-Gong Zou, Yi-Tong Yao, Fu-Fang Wen, Xiao Zhang, Bo-Tao Liu, Da-Wei Li, Yu-Feng Yang, Wei-Dong Yang, Srinivasan Balamurugan, Hong-Ye Li
Summary: The excessive accumulation of catechol in the environment due to its burgeoning commercial applications poses a severe ecological threat. This study investigated the potential of the microalga Crypthecodinium cohnii to degrade catechol and utilize the byproduct as a carbon source. Results showed that catechol significantly increased the growth of C. cohnii and was rapidly catabolized within 60 hours. Transcriptomic analysis identified key genes involved in catechol degradation, and real-time polymerase chain reaction (RT-PCR) analysis revealed a remarkable increase in the transcription of these genes. The study also demonstrated altered primary metabolite content and the ability of C. cohnii to tolerate catechol treatment without adverse effects.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Green & Sustainable Science & Technology
Zi-Hao Qin, Xiaomeng Hu, Jin-Hua Mou, Guo-Hui He, Guang-Bin Ye, Hong-Ye Li, Shauhrat Singh Chopra, Liang Dong, Carol Sze Ki Lin, Xiang Wang
Summary: This study conducted Life Cycle Assessments (LCA) to evaluate the environmental impact of laboratory-scale EPA production by Phaeodactylum tricornutum. The results showed that technical advancements, particularly metabolic engineering, significantly reduced the global warming potential and cumulative energy demand associated with EPA production. Electricity consumption and extraction solvents were identified as the main contributors to the environmental impact. The study suggests future directions should focus on increasing EPA productivity, adopting alternative cultivation approaches with less energy input, and implementing environmentally friendly methods for EPA recovery.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Chemistry, Medicinal
Kuan-Kuan Yuan, Zi-Min Chen, Ya-Xin Liu, Hong-Ye Li, Wei-Dong Yang
Summary: This study found that docosahexaenoic acid (DHA) can enhance the response of Perna viridis to diarrhetic shellfish toxins (DSTs) produced by Prorocentrum lima. The addition of DHA increased the esterification level of DSTs, activated the Nrf2 signaling pathway, and alleviated the damage to the digestive glands. These findings provide insights into the role of DHA in the environmental adaptation of bivalves.
Article
Agronomy
Yunpeng Gai, Qichen Niu, Jinchao Kong, Lei Li, Xingxing Liang, Yuwei Cao, Xianqi Zhou, Xuepeng Sun, Haijie Ma, Mingshuang Wang, Neeraj Shrivastava, Hongye Li, Chen Jiao
Summary: A comparative transcriptome analysis was performed to study the gene expression patterns of Alternaria alternata during infection of citrus. Significant gene expression differences were found between the early and late stages of infection. Several novel genes related to plant-pathogen interaction were identified. RT-qPCR analysis confirmed the expression patterns of selected genes from the peroxisome pathway.
Article
Microbiology
Wen Wang, Tao Xiong, Yating Zeng, Wenwen Li, Chen Jiao, Jianping Xu, Hongye Li
Summary: This study conducted an extensive survey of Phyllosticta species across 11 citrus-producing provinces in southern China and identified five Phyllosticta species with pathogenicity on different citrus species. The findings have important implications for the control and management of Citrus Black Spot and related diseases.
Article
Engineering, Environmental
Jin-Hua Mou, Zi-Hao Qin, Yu-Feng Yang, Si-Fen Liu, Wei Yan, Lan Zheng, Ya-Hui Miao, Hong-Ye Li, Patrick Fickers, Carol Sze Ki Lin, Xiang Wang
Summary: This study investigated the characteristics of four types of food waste and their hydrolysates, and explored their potential application in biorefineries. The results showed that the characteristics of food waste and their hydrolysates varied based on their origins, and the origin and storage conditions of food waste affected microalgal growth and paramylon production.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Marine & Freshwater Biology
Jian-Wei Zheng, Guo-Hui He, Rui-Xia Xu, Xiang Wang, Hong-Ye Li, Wei-Dong Yang
Summary: Studies have found that there are reciprocal inhibitory effects between Karenia mikimotoi and Prorocentrum shikokuense under co-cultures. RNA sequencing analysis revealed that genes involved in photosynthesis, carbon fixation, energy metabolism, nutrients absorption and assimilation were up-regulated in K. mikimotoi after co-cultured with P. shikokuense, while genes involved in DNA replication and cell cycle were down-regulated. In contrast, genes involved in energy metabolism, cell cycle, and nutrients uptake and assimilation were down-regulated in P. shikokuense under co-culture with K. mikimotoi. Additionally, the expression of PLA2G12 and nitrate reductase, which may play important roles in the allelopathy of K. mikimotoi, was significantly increased. These findings provide new insights into the interspecies competition between K. mikimotoi and P. shikokuense and offer a novel strategy for studying interspecific competition in complex systems.
Article
Public, Environmental & Occupational Health
Jinping Zhang, Peng Liu, Morong Wang, Jie Wang, Jie Chen, Wenling Yuan, Mei Li, Zhijuan Xie, Wangping Dong, Hongye Li, Yan Zhao, Lun Wan, Tian Chu, Lu Wang, Hui Zhang, Ting Tao, Jing Ma
Summary: This study analyzed the clinical features and diagnostic methods of 19 patients with COVID-19. The findings showed that there were more male than female critically ill patients, and they often had symptoms such as fever and dry cough. Chest computed tomography revealed ground-glass changes in all cases. Significant changes were observed in clinical laboratory indices, especially in the D-dimer level of non-survivors.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2022)
