Article
Endocrinology & Metabolism
Paola Caruso, Maria Ida Maiorino, Margherita Macera, Giuseppe Signoriello, Laura Castellano, Lorenzo Scappaticcio, Miriam Longo, Maurizio Gicchino, Ferdinando Campitiello, Giuseppe Bellastella, Nicola Coppola, Katherine Esposito
Summary: During the COVID-19 pandemic in 2020, the prevalence of antibiotic resistance in patients with diabetic foot infection was significantly higher compared to 2019, with more patients admitted due to recent or current antibiotic therapy. Various factors such as previous hospitalization, self-administration of antibiotics, and antibiotic prescription by general practitioners were identified as independent predictors of antibiotic resistance.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Urology & Nephrology
Giovanni Motterle, Alessandro Morlacco, Massimo Lafrate, Marta Bianco, Giuliano Federa, Orest Xhafka, Filiberto Zattoni, Tommaso Prayer-Galetti
Summary: The COVID-19 pandemic had a significant impact on urgent urological consultations, with a remarkable reduction in 2020 and a higher risk of admissions compared to 2019. The potential consequences of delayed diagnoses remain to be determined.
WORLD JOURNAL OF UROLOGY
(2021)
Review
Medicine, General & Internal
Jingui Yan, Yiqing Xiao, Rui Cao, Yipeng Su, Dan Wu, Yanjin Wang
Summary: In the context of the COVID-19 pandemic, finding effective treatment approaches for diabetic foot has become an urgent issue. This study proposes a new protocol for treating diabetic foot patients, including home treatment and hospital treatment, with emphasis on COVID-19 screening and isolation measures.
Letter
Oncology
Shanmugam Subbiah, Syed Afroze Hussain, M. Samanth Kumar
Summary: The COVID-19 pandemic has led to changes in the care of cancer patients worldwide, with the experience of the evolving COVID-19 protocol at Royapettah cancer hospital highlighting the importance of adherence to institutional protocols based on general hygiene measures such as masking, hand washing, and social distancing in minimizing disease spread.
Review
Medicine, General & Internal
Andrew J. M. Boulton
Summary: The COVID-19 pandemic has posed challenges for the care of diabetic foot worldwide, especially with the difficulties of telemedicine for hands-on treatment. By addressing the challenges through the COVID-19 experience, our approach to managing diabetic foot disease might be transformed, particularly in the areas of digital health and smart technology.
MEDICINA-LITHUANIA
(2021)
Article
Endocrinology & Metabolism
Brian M. Schmidt, Laura Shin
Summary: This study evaluated changes in care delivery for diabetic foot ulcer patients during the COVID-19 pandemic. The ratio of major to minor lower extremity amputations decreased after implementing novel strategies to combat access restrictions. Strategic planning and rapid implementation of diabetic foot ulcer triage resulted in accessible care and a reduction in amputations during the pandemic.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Emergency Medicine
Eric Murakami, Aditi Ghatak-Roy, Margarita Popova, Carin Gannon, Daniel E. Park, Jack Villani, Cindy Liu, Ian Toma, John Lafleur
Summary: In this study, 138 emergency department healthcare providers were tested for exposure to COVID-19, with a 5% seroconversion rate one month after the first wave of the pandemic. There were no significant differences in demographic/ethnic variables, medical history, hours worked, PPE use, or exposures between seropositive and seronegative individuals.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Medicine, General & Internal
Eleonora Carlicchi, Maria Eugenia Di Sabato, Antonino Cincotta, Riccardo Accetta, Alberto Aliprandi, Domenico Albano, Luca Maria Sconfienza, Carmelo Messina
Summary: Italy was the first European country to face the COVID-19 pandemic, and this study evaluated the effects of COVID-19 on an orthopedic emergency department. The results showed a decrease in ED admissions, but an increase in more severe triage codes and diagnosed fractures during the pandemic.
Article
Health Care Sciences & Services
Yasmine Samir Galal, Walaa Ahmed Khairy, Ahmed Ali Taha, Tarek Tawfik Amin
Summary: This study investigated the predictors of foot ulcers among Egyptian diabetic patients, revealing that having three or more comorbidities, two or more diabetic complications, callus, and flatfoot are significant positive predictors of DFUs, while managing diabetes through diet, oral hypoglycemic drugs, and insulin, as well as intact vibration sense, were found to be protective predictors against DFUs. Close monitoring of diabetic patients with comorbidities and complications is recommended to reduce the risk of DFUs.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Pediatrics
Giorgio Cozzi, Idoya Molina Ruiz, Fabiola Giudici, Sara Romano, Veronica Grigoletto, Egidio Barbi, Alessandro Amaddeo
Summary: This study evaluated the impact of the COVID-19 pandemic on pediatric emergency cases in a tertiary-level children's hospital in Italy. The results showed no significant changes in the number and proportion of pediatric emergency cases during the pandemic, but there was a significant decrease in the proportion of emergency cases related to respiratory diseases.
FRONTIERS IN PEDIATRICS
(2022)
Article
Ophthalmology
Hasenin Al-Khersan, Meghana A. Kalavar, Rebecca Tanenbaum, Thomas A. Lazzarini, Nimesh A. Patel, Nicolas A. Yannuzzi, Jayanth Sridhar, Justin H. Townsend, Audina M. Berrocal, Zubair A. Ansari
Summary: During the COVID-19 pandemic in April 2020, there was a significant decrease in surgical volume compared to the previous year, leading to changes in the types of procedures performed and a decrease in the age of both surgeons and patients. Broad preoperative screening resulted in only 1 positive COVID-19 test in an asymptomatic patient.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Infectious Diseases
Michal Leibovitch, Avivit Cahn, Yechiel N. Gellman, Amir Haze, Shahar Peled, Sharon Amit, Ofer Elishoov, Karen Olshtain-Pops
Summary: This study found that ESBL-producing bacteria are common in patients with acute DFI, particularly in older patients with PVD, advanced ulcers, and recent hospitalization. Patients infected with ESBL-producing bacteria are more likely to undergo major amputations.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Dermatology
Guy Rubin, Guy Feldman, Inon Dimri, Arthur Shapiro, Nimrod Rozen
Summary: The outbreak of COVID-19 had significant impacts on the treatment and management of patients with chronic diabetes. This study examined the short-term effects of the pandemic on patients with chronic diabetes who suffered from contaminated diabetic ulcers. The results did not show a clear worsening trend in the condition of patients during the COVID-19 outbreak.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Medicine, Research & Experimental
Yuxia Cheng, Ping Zu, Jie Zhao, Lintao Shi, Hongyan Shi, Mei Zhang, Aihong Wang
Summary: The study found that diabetes duration, callus, history of vascular intervention, and amputation were independent risk factors for recurrent DFUs in a cohort of Chinese patients with active DFU.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Pediatrics
Fabienne Carre, Nicolas Leboulanger, Briac Thierry, Francois Simon, Vincent Couloigner, Francoise Denoyelle, Romain Luscan
Summary: A retrospective study evaluated the impact of COVID-19 lockdown on pediatric otolaryngology emergency activity, revealing a significant decrease in consultations and surgeries, as well as a reduction in surgery rates for infections of any type.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Cardiac & Cardiovascular Systems
Dario Giugliano, Miriam Longo, Simona Signoriello, Maria Ida Maiorino, Bruno Solerte, Paolo Chiodini, Katherine Esposito
Summary: According to the results of network meta-analysis, GLP-1RA and SGLT-2 inhibitors are superior to DPP-4 inhibitors in reducing the risk of cardiorenal outcomes. Compared with DPP-4 inhibitors, SGLT-2 inhibitors have a more significant effect in reducing cardiovascular and overall mortality, while GLP-1RA only reduces overall mortality. There is no significant difference between GLP-1RA and SGLT-2 inhibitors in the risks of MACE, nonfatal MI, nonfatal stroke, cardiovascular, and overall mortality. SGLT-2 inhibitors are superior to GLP-1RA in reducing the risk of hospitalization for heart failure and renal outcomes. Only GLP-1RA can reduce the risk of nonfatal stroke.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Paola Caruso, Maria Ida Maiorino, Lorenzo Scappaticcio, Chiara Porcellini, Rita Matrone, Paolo Cirillo, Margherita Macera, Maurizio Gicchino, Maria Teresa Vietri, Giuseppe Bellastella, Nicola Coppola, Katherine Esposito
Summary: This study aimed to evaluate PTH levels in individuals with diabetic foot ulcers (DFU) and investigate the relationship between PTH levels and osteomyelitis (OM) in this population. The results showed that PTH levels were lower in DFU patients with OM compared to those without OM, and alkaline phosphatase levels were higher in the OM group. OM and alkaline phosphatase levels were independent predictors of PTH levels in this selected population.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Bellastella, Paolo Cirillo, Carla Carbone, Lorenzo Scappaticcio, Antonietta Maio, Graziella Botta, Maria Tomasuolo, Miriam Longo, Alessandro Pontillo, Antonio Bellastella, Katherine Esposito, Annamaria De Bellis
Summary: This review discusses the neuroimmune endocrinological aspects of SARS-CoV-2 infection. The virus targets the central nervous system, affecting the hypothalamic-pituitary axis and potentially causing autoimmune processes and satellite gland disorders. However, further research is needed to understand the short- and long-term effects on the endocrine system.
Article
Endocrinology & Metabolism
Miriam Longo, Irene Di Meo, Paola Caruso, Maria Francesca Muscio, Lorenzo Scappaticcio, Antonietta Maio, Maria Ida Maiorino, Giuseppe Bellastella, Giuseppe Signoriello, Filip K. Knop, Maria Rosaria Rizzo, Katherine Esposito
Summary: This study aimed to evaluate cognitive function in type 2 diabetes patients treated with GLP-1RA plus metformin compared to metformin alone, and its association with endothelial progenitor cells (EPCs). The results showed that patients in the GLP-1RA + MET group had better cognitive function and higher levels of circulating EPCs compared to the MET group. Further studies are needed to understand the relationship between EPCs, GLP-1RA treatment, and cognitive health.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Editorial Material
Endocrinology & Metabolism
Paola Caruso, Maria Ida Maiorino, Giuseppe Bellastella, Katherine Esposito, Dario Giugliano
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Michele Cerasuolo, Irene Di Meo, Maria Chiara Auriemma, Francesca Trojsi, Maria Ida Maiorino, Mario Cirillo, Fabrizio Esposito, Rita Polito, Anna Maria Colangelo, Giuseppe Paolisso, Michele Papa, Maria Rosaria Rizzo
Summary: Neurodegeneration is a complex process involving multiple mechanisms, with diseases like Parkinson's, multiple sclerosis, Alzheimer's, prion diseases, and ALS being examples. Iron overload has been identified as a potential cause of neurodegeneration, with dysregulated iron metabolism and increased oxidative stress being common in these diseases. Alzheimer's, in particular, shows increased iron content in vulnerable brain regions, leading to mitochondrial alterations and lack of antioxidant defenses. Iron metabolism and ferroptosis play a significant role in diabetes-induced cognitive decline, and iron chelators offer a promising therapeutic approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Dario Giugliano, Miriam Longo, Lorenzo Scappaticcio, Paola Caruso, Maurizio Gicchino, Michela Petrizzo, Giuseppe Bellastella, Maria Ida Maiorino, Katherine Esposito
Summary: The study aimed to assess the metabolic benefits of simplifying complex insulin regimens in patients with inadequately controlled type 2 diabetes. Results showed that simplification of treatment might be a durable option for at least half of patients.
Meeting Abstract
Public, Environmental & Occupational Health
G. D. Mauro, A. Mascolo, M. Longo, M. I. Maiorino, L. Scappaticcio, G. Bellastella, K. Esposito, A. Capuano
