☆ 4.7 Editorial Material

Plasticity of Arterial and Venous Endothelial Cell Identity: Some Nerve!

CIRCULATION RESEARCH (2016)

Journal

CIRCULATION RESEARCH

Volume 119, Issue 5, Pages 574-576

Publisher

LIPPINCOTT WILLIAMS & WILKINS

DOI: 10.1161/CIRCRESAHA.116.309442

Keywords

Editorials; arteries; endothelial cells; pulmonary embolism; thrombosis; veins

Categories

Cardiac & Cardiovascular Systems Hematology Peripheral Vascular Disease

Funding

NHLBI NIH HHS [R01 HL115141, R01 HL117994] Funding Source: Medline
NIGMS NIH HHS [R01 GM115605] Funding Source: Medline

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Biochemistry & Molecular Biology

Pulmonary Endothelial Dysfunction and Thrombotic Complications in Patients with COVID-19

Cristina Rodriguez, Neus Luque, Isabel Blanco, Laura Sebastian, Joan Albert Barbera, Victor Peinado, Olga Tura-Ceide

Summary: SARS-CoV-2, causing COVID-19, poses a major threat to global public health with severe respiratory and multiorgan complications. The complications of COVID-19, including cytokine storm and thrombi formation, involve the pulmonary endothelium in regulating vascular homeostasis and coagulation.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Neutrophils Mediate Pulmonary Artery Thrombosis In Situ

Olga Porembskaya, Vsevolod Zinserling, Vladimir Tomson, Yana Toropova, Eleonora A. Starikova, Vitaliy V. Maslei, Nika Bulavinova, Olga Kirik, Marina A. Syrtsova, Leonid Laberko, Maxim Galchenko, Vyacheslav Kravchuk, Sergey Saiganov, Alexander Brill

Summary: This study demonstrated that thrombi in the lung vasculature can form in situ by mechanisms that require local neutrophil recruitment taking place in the deep vein thrombosis (DVT) setting.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Health Care Sciences & Services

Pulmonary Embolism Risk Assessment Using Blood Copeptin Concentration and Pulmonary Arteries Thrombotic Burden Evaluated by Computer Tomography

Mihai Stefan Cristian Haba, Ionut Tudorancea, Radu Stefan Miftode, Irene Paula Popa, Ovidiu Mitu, Cosmin Teodor Mihai, Raluca Maria Haba, Viviana Aursulesei Onofrei, Antoniu Octavian Petris, Irina Iuliana Costache, Danisia Haba, Laurentiu Sorodoc

Summary: This study aimed to evaluate the diagnostic and prognostic role of copeptin in patients with acute PE and to analyze the relationship between copeptin and the Mastora score. The findings suggest that both copeptin and the Mastora score are correlated with adverse cardiovascular events and mortality in PE patients.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Add to Collection

Review Medicine, General & Internal

SARS-CoV-2 Infection: Modulator of Pulmonary Embolism Paradigm

Mohammad Suhail Akhter, Hassan A. Hamali, Abdullah A. Mobarki, Hina Rashid, Johannes Oldenburg, Arijit Biswas

Summary: The incidence of PE in COVID-19 patients has significantly increased, possibly due to the viral impact on hypercoagulability. The diagnosis and management of this complication are highly challenging due to overlapping symptoms and a lack of clear predisposing factors.

JOURNAL OF CLINICAL MEDICINE (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Late outcomes of surgical reconstruction of peripheral pulmonary arteries

Abdulaziz Al-Khaldi, Ahmad D. Abuzaid, Omar Tamimi, Atif Alsahari, Abdulmajeed Alotay, Tarek Momenah, Juan J. Alfonso

Summary: This study retrospectively analyzed the late outcomes of peripheral pulmonary artery reconstruction in 91 patients. The results showed excellent and durable late outcomes, with significant reductions in right ventricular to aortic systolic pressure ratio and low mortality rates. No reinterventions were necessary.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2022)

Add to Collection

Article Hematology

Pulmonary embolism at autopsy in cancer patients

Inge A. Gimbel, Frits I. Mulder, Floris T. M. Bosch, Jan Erik Freund, Noori Guman, Nick van Es, Pieter W. Kamphuisen, Harry R. Buller, Saskia Middeldorp

Summary: The study found that 12.4% of cancer patients had pulmonary embolism at autopsy, with 90.2% being thrombotic embolism. Venous thromboembolism occurred in 12.8% of the patients.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

Add to Collection

Article Medicine, General & Internal

Clinical Significance and Outcome in Patients with Asymptomatic Versus Symptomatic Subsegmental Pulmonary Embolism

Ana Rodriguez-Cobo, Carmen Fernandez-Capitan, Yale Tung-Chen, Giorgina Salgueiro-Origlia, Aitor Ballaz, Cristiano Bortoluzzi, Gabrielle Sarlon-Bartoli, Maria Lourdes Pesce, Dally Najib, Manuel Monreal

Summary: The clinical significance and optimal therapy of patients with subsegmental pulmonary embolism (SSPE) remain controversial. This study compared the baseline characteristics, treatment, and outcomes of patients with asymptomatic vs. symptomatic SSPE, revealing that patients with asymptomatic SSPE had similar rates of symptomatic PE recurrences, DVT, and major bleeding to those with symptomatic SSPE, but had a higher mortality rate. The unexpectedly high rate of major bleeding highlights the need for further research.

JOURNAL OF CLINICAL MEDICINE (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Tocilizumab Use among Patients Who Developed Pulmonary Embolism in the Course of Cytokine Release Storm and COVID-19 Pneumonia-A Retrospective Study

Daniel Chober, Bogusz Aksak-Was, Jolanta Niscigorska-Olsen, Malgorzata Niekrasz, Milosz Parczewski

Summary: Thromboembolic events, including pulmonary embolisms and ischemic strokes, are common in COVID-19 patients. This study aimed to investigate the efficacy of tocilizumab (TCZ) in patients with acute pulmonary embolism. The results showed that the use of TCZ was associated with increased mortality in patients with COVID-19 pneumonia, cytokine release storm, and acute pulmonary embolism.

BIOMEDICINES (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Occurrence of pulmonary embolism related to COVID-19

Marie Hauguel-Moreau, Mostafa El Hajjam, Quentin De Baynast, Antoine Vieillard-Baron, Anne-Sophie Lot, Thierry Chinet, Hazrije Mustafic, Celine Begue, Robert Yves Carlier, Guillaume Geri, Olivier Dubourg, Sebastien Beaune, Nicolas Mansencal

Summary: The COVID-19 pandemic has led to a significant increase in the incidence of pulmonary embolism (PE), with patients experiencing symptoms such as dyspnea, decreased arterial oxygen saturation, elevated C-reactive protein and white blood cell count, and a higher in-hospital mortality rate. Diagnosis of PE in COVID-19 patients may occur at admission or after several days of hospitalization, presenting with different clinical, CT, and biological features.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

Add to Collection

Review Cardiac & Cardiovascular Systems

Review of Acute Leukemia as a New Cause of Dual Thrombosis (Pulmonary Vein Thrombosis and Pulmonary Embolism)

Guillermo Cueto-Robledo, Hector-Daniel Cueto-Romero, Diana-Laura Carrillo-Rocha, Ernesto Roldan-Valadez

Summary: Pulmonary vein thrombosis is rare and usually not seen in medical pathologies. However, a case of dual thrombosis involving both pulmonary thromboembolism and pulmonary vein thrombosis was reported in a patient with acute leukemia. This is the first reported case of dual thrombosis secondary to acute leukemia, as there are no similar cases reported in the English medical literature.

CURRENT PROBLEMS IN CARDIOLOGY (2023)

Add to Collection

Article Cardiac & Cardiovascular Systems

Varicose Veins and Risk of Venous Thromboembolic Diseases: A Two-Sample-Based Mendelian Randomization Study

Ruihao Li, Zuoguan Chen, Liang Gui, Zhiyuan Wu, Yuqing Miao, Qing Gao, Yongpeng Diao, Yongjun Li

Summary: This study used Mendelian randomization methods and found a potential causal effect of varicose veins on deep vein thrombosis (DVT), but no causal association with pulmonary embolism (PE) and venous thromboembolism (VTE). Additionally, it was discovered that obesity and taller height may be factors that predispose to varicose veins and DVT.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

Add to Collection

Article Plant Sciences

3′-Oxo-tabernaelegantine A (OTNA) selectively relaxes pulmonary arteries by inhibiting AhR

Pei Long, Yong Li, Qing Wen, Maohua Huang, Songtao Li, Yuning Lin, Xiaojun Huang, Minfeng Chen, Jie Ouyang, Yunlin Ao, Qi Qi, Haipeng Zhang, Wencai Ye, Guohua Cheng, Xiaoqi Zhang, Dongmei Zhang

Summary: The study shows that OTNA relaxes pulmonary arteries by antagonizing AhR, providing a potential therapeutic mechanism for PAH.

PHYTOMEDICINE (2021)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Identification of pulmonary embolism: diagnostic accuracy of venous-phase dual-energy CT in comparison to pulmonary arteries CT angiography

Giovanni Foti, Ronaldo Silva, Niccolo Faccioli, Alessandro Fighera, Rossella Menghini, Arianna Campagnola, Giovanni Carbognin

Summary: In a selected, high-prevalence population, VP-DECT is considered an accurate imaging tool for diagnosing PE compared to CTPA. The sensitivity of VP-DECT images in per-patient analysis was 90.0%, with 100% specificity; while in per-lobe analysis, sensitivity ranged from 100% for the right lower lobe to 50% for the left upper lobe.

EUROPEAN RADIOLOGY (2021)

Add to Collection

Article Hematology

Prognosis of incidental pulmonary embolism vs. symptomatic pulmonary embolism in cancer patients: a single-center retrospective cohort study in China

Yanfei Wang, Zhongfen Liu, Qiuyu Li, Lina Xia, Yunyi Wang, Danfeng Jiang, Xiaoyan Chen, Yanqun Zheng, Wei Liu, Dan Wang, Dong Xue

Summary: This study compared the clinical characteristics and outcomes between cancer patients with incidental pulmonary embolism (IPE) and symptomatic pulmonary embolism (SPE). The results showed that IPE was more common in central locations, isolated, and unilateral distribution compared to SPE, and patients with IPE had better prognosis. Therefore, with active anticoagulation treatment, IPE is expected to have better survival rates than SPE.

THROMBOSIS JOURNAL (2023)

Add to Collection

Article Infectious Diseases

Incidence, risk factors, and thrombotic load of pulmonary embolism in patients hospitalized for COVID-19 infection

Alberto Garcia-Ortega, Grace Oscullo, Pilar Calvillo, Raquel Lopez-Reyes, Raul Mendez, Jose Daniel Gomez-Olivas, Amina Bekki, Carles Fonfria, Laura Trilles-Olaso, Enrique Zaldivar, Ana Ferrando, Gabriel Anguera, Andres Briones-Gomez, Juan Pablo Reig-Mezquida, Laura Feced, Paula Gonzalez-Jimenez, Soledad Reyes, Carlos F. Munoz-Nunez, Ainhoa Carreres, Ricardo Gil, Carmen Morata, Nuria Toledo-Pons, Luis Marti-Bonmati, Rosario Menendez, Miguel Angel Martinez-Garcia

Summary: The study revealed a high incidence of pulmonary embolism in hospitalized COVID-19 patients, with heart rate, spO2, D-dimer, and CRP levels at admission serving as predictors of PE during hospitalization.

JOURNAL OF INFECTION (2021)

Add to Collection

Article Chemistry, Multidisciplinary

MicroRNA-17-3p suppresses NF-κB-mediated endothelial inflammation by targeting NIK and IKKβ binding protein

Yin Cai, Yu Zhang, Hui Chen, Xing-hui Sun, Peng Zhang, Lu Zhang, Meng-yang Liao, Fang Zhang, Zheng-yuan Xia, Ricky Ying-keung Man, Mark W. Feinberg, Susan Wai-Sum Leung

Summary: miR-17-3p inhibits LPS-induced NF-kappa B activation by targeting NIBP, thereby effectively suppressing pro-inflammatory responses in vascular endothelium.

ACTA PHARMACOLOGICA SINICA (2021)

Add to Collection

Article Hematology

Novel Lesional Transcriptional Signature Separates Atherosclerosis With and Without Diabetes in Yorkshire Swine and Humans

Stefan Haemmig, Ali Hashemi Gheinani, Marina Zaromytidou, Gerasimos Siasos, Ahmet Umit Coskun, Michelle A. Cormier, David A. Gross, A. K. M. Khyrul Wara, Antonios P. Antoniadis, Xinghui Sun, Galina K. Sukhova, Fred G. P. Welt, Ioannis Andreou, Carl Whatling, Li-Ming Gan, Johannes Wikstrom, Elazer R. Edelman, Peter Libby, Peter H. Stone, Mark W. Feinberg

Summary: This study identified evolutionarily conserved gene signatures and signaling pathways that distinguish diabetes-related and non-diabetes-related atherosclerosis. By utilizing genome-wide transcriptomics, the research successfully differentiated between atherosclerosis associated with diabetes and that not associated with diabetes, providing new insights and therapeutic opportunities.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

Add to Collection

Article Hematology

Gene Expression Signature in Patients With Symptomatic Peripheral Artery Disease

Jonathan D. Newman, MacIntosh G. Cornwell, Hua Zhou, Caron Rockman, Adriana Heguy, Yajaira Suarez, Henry S. Cheng, Mark W. Feinberg, Judith S. Hochman, Kelly Ruggles, Jeffrey S. Berger

Summary: A transcriptomic signature identified patients with symptomatic PAD and those at increased risk of major adverse cardiac or limb events (MACLE). A specific microRNA, microRNA-4477b, was found to be overexpressed in prevalent PAD, incident MACLE, and in a mouse hindlimb ischemia model. This novel signature provides insights into potential mechanisms of severe symptomatic PAD.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity

Xiao Cheng, Mohamed Sham Shihabudeen Haider Ali, Matthew Moran, Martonio Ponte Viana, Sarah L. Schlichte, Matthew C. Zimmerman, Oleh Khalimonchuk, Mark W. Feinberg, Xinghui Sun

Summary: The study found that the lncRNA Meg3 plays a role in obesity-induced insulin resistance by inducing cellular senescence of endothelial cells. Knockdown of Meg3 exacerbates the disease progression by promoting cellular senescence in hepatic endothelium.

REDOX BIOLOGY (2021)

Add to Collection

Article Hematology

A Smooth Muscle Cell-Enriched Long Noncoding RNA Regulates Cell Plasticity and Atherosclerosis by Interacting With Serum Response Factor

Huaner Ni, Stefan Haemmig, Yihuan Deng, Jingshu Chen, Viorel Simion, Dafeng Yang, Galina Sukhova, Eugenia Shvartz, A. K. M. Khyrul Wara, Henry S. Cheng, Daniel Perez-Cremades, Carmel Assa, Grasiele Sausen, Rulin Zhuang, Qiuyan Dai, Mark W. Feinberg

Summary: The lncRNA CARMN plays a critical role in regulating VSMC plasticity and atherosclerosis by interacting with SRF, which enhances SRF occupancy on VSMC target gene promoters. These findings provide important implications for chronic vascular occlusive diseases.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

MicroRNA-mediated control of myocardial infarction in diabetes

Daniel Perez-Cremades, Jingshu Chen, Carmel Assa, Mark W. Feinberg

Summary: Diabetes mellitus is a global public health problem that is expected to continue increasing due to the rise in obesity and aging population. Individuals with diabetes have a higher risk of cardiovascular complications, particularly myocardial infarction (MI). In the past two decades, studies have revealed the role of stage-specific miRNAs in the hearts of people with diabetes and MI, impacting cardiomyocyte death, angiogenesis, inflammatory response, myocardial remodeling, and myocardial lipotoxicity. Understanding the significance of these miRNAs and their targets may lead to novel RNA-based therapeutic interventions for managing the increased risk of MI in diabetes.

TRENDS IN CARDIOVASCULAR MEDICINE (2023)

Add to Collection

Article Medicine, Research & Experimental

Deficiency of lncRNA SNHG12 impairs ischemic limb neovascularization by altering an endothelial cell cycle pathway

David A. Gross, Henry S. Cheng, Rulin Zhuang, Michael G. McCoy, Daniel Perez-Cremades, Zachary Salyers, A. K. M. Khyrul Wara, Stefan Haemmig, Terence E. Ryan, Mark W. Feinberg

Summary: SNHG12 is a dysregulated long noncoding RNA (lncRNA) in atherosclerosis, and it plays a significant role in the regulation of vascular senescence and angiogenic response. The deficiency of SNHG12 reduces cell proliferation, migration, and endothelial sprouting, while overexpression promotes these angiogenic functions. SNHG12 may exert its effects through interacting with proteins like IGF2BP3, and it is involved in cell cycle regulation and signaling pathways related to Wnt, Notch, and angiopoietin signaling pathways.

JCI INSIGHT (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Isolation and culture of murine aortic cells and RNA isolation of aortic intima and media: Rapid and optimized approaches for atherosclerosis research

Jingshu Chen, Rulin Zhuang, Henry S. Cheng, Anurag Jamaiyar, Carmel Assa, Michael McCoy, Shruti Rawal, Daniel Perez-Cremades, Mark W. Feinberg

Summary: A new method for isolating and culturing diverse cell types from the mouse aorta simultaneously has been developed, allowing for the extraction of highly pure cells for studying the function and mechanisms of various vascular diseases.

ATHEROSCLEROSIS (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Endothelial cell-specific deletion of a microRNA accelerates atherosclerosis

Dafeng Yang, Stefan Haemmig, Jingshu Chen, Michael McCoy, Henry S. Cheng, Haoyang Zhou, Xiao Cheng, Xinghui Sun, Jorge Haneo-Mejia, Shamsudheen K. Vellarikkal, Rajat M. Gupta, Victor Barrera, Mark W. Feinberg

Summary: In this study, the researchers investigated the role of miRNA deficiency in vascular endothelial cells during atherogenesis using a mouse model. They found that the specific deletion of miR-181a2b2 in endothelial cells promoted atherosclerotic lesion formation, cell adhesion molecule expression, and the influx of macrophages in the vessel wall. However, the deletion of miR-181a2b2 did not affect body weight, lipid metabolism, or inflammation levels in circulating peripheral blood mononuclear cells. The study suggests that miR-181a2b2 deficiency in endothelial cells plays a crucial role in regulating key pathways involved in endothelial inflammation and atherosclerosis development.

ATHEROSCLEROSIS (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Perivascular Fibrosis Is Mediated by a KLF10-IL-9 Signaling Axis in CD4+T Cells

Rulin Zhuang, Jingshu Chen, Henry S. Cheng, Carmel Assa, Anurag Jamaiyar, Arvind K. Pandey, Daniel Perez-Cremades, Bofang Zhang, Aspasia Tzani, Akm Khyrul Wara, Jorge Plutzky, Victor Barrera, Preetida Bhetariya, Richard N. Mitchell, Zhongmin Liu, Mark W. Feinberg

Summary: Transcription factor KLF10 is upregulated in CD4+ T cells of hypertensive individuals and Ang II-treated mice. Deficiency of Klf10 exacerbates perivascular fibrosis and multi-organ dysfunction in response to Ang II. Klf10 or IL-9 may represent novel therapeutic targets for the treatment of vascular or fibrotic diseases.

CIRCULATION RESEARCH (2022)

Add to Collection

Article Biochemistry & Molecular Biology

A miRNA cassette reprograms smooth muscle cells into endothelial cells

Michael G. McCoy, Daniel Perez-Cremades, Nathan Belkin, Wenhui Peng, Bofang Zhang, Jingshu Chen, Madhur Sachan, A. K. M. Khyrul Wara, Rulin Zhuang, Henry S. Cheng, Mark W. Feinberg

Summary: This study demonstrates that a 4-miRNA cassette can reprogram vascular smooth muscle cells into endothelial cells, and these induced cells exhibit high similarity to native endothelial cells. Injected induced cells even restore blood flow faster than conventional endothelial cells in a mouse model, suggesting the potential of this approach for vascular disease therapy.

FASEB JOURNAL (2022)

Add to Collection

Article Biochemistry & Molecular Biology

miR-181b regulates vascular endothelial aging by modulating an MAP3K3 signaling pathway

Haoyang Zhou, Dafeng Yang, Henry S. Cheng, Michael G. McCoy, Daniel Perez-Cremades, Stefan Haemmig, Danny Wong, Lei Chen, Mark W. Feinberg

Summary: The study uncovers an important role of miR-181b in regulating vascular endothelial aging through the MAP3K3-MAPK signaling pathway, revealing potential therapeutic targets for anti-aging therapy in cardiovascular disease.

FASEB JOURNAL (2022)

Add to Collection

Article Multidisciplinary Sciences

Antirheumatic therapy is associated with reduced complement activation in rheumatoid arthritis

Thao H. P. Nguyen, Ingrid Hokstad, Morten Wang Fagerland, Tom Eirik Mollnes, Ivana Hollan, Mark W. Feinberg, Gunnbjorg Hjeltnes, Gro O. Eilertsen, Knut Mikkelsen, Stefan Agewall

Summary: This study found that patients with active RA had elevated levels of complement activation, and TCC levels decreased after anti-rheumatic treatment within 6 weeks, but only TNFi +/- MTX treatment led to sustained reduction in TCC during the 6-month follow-up period. RA patients with endothelial dysfunction had higher baseline TCC compared to those without, indicating the potential involvement of complement in the atherosclerotic process in RA.

PLOS ONE (2022)

Add to Collection

Article Peripheral Vascular Disease

MicroRNA-375 repression of Kruppel-like factor 5 improves angiogenesis in diabetic critical limb ischemia

Michael G. McCoy, Anurag Jamaiyar, Grasiele Sausen, Henry S. Cheng, Daniel Perez-Cremades, Rulin Zhuang, Jingshu Chen, Philip P. Goodney, Mark A. Creager, Marc S. Sabatine, Marc P. Bonaca, Mark W. Feinberg

Summary: Peripheral artery disease (PAD) is a serious condition that can lead to limb loss and death, especially in subjects with diabetes. In this study, researchers identified miR-375 as a potential therapeutic target for critical limb ischemia (CLI), an advanced form of PAD. They found that miR-375, when overexpressed, promotes angiogenesis and arteriogenesis, improving blood flow recovery in diabetic mice. Further investigation revealed that miR-375 regulates the NF-kB signaling pathway by targeting Kruppel-like factor 5 (KLF5). These findings suggest that targeting the miR-375-KLF5-NF-kB signaling axis may be an effective strategy for treating CLI in diabetes.

ANGIOGENESIS (2023)

Add to Collection

Article Cardiac & Cardiovascular Systems

KLF10 deficiency in CD4+T cells promotes atherosclerosis progression by altering macrophage dynamics

Akm Khyrul Wara, Shruti Rawal, Xilan Yang, Daniel Perez-Cremades, Madhur Sachan, Jingshu Chen, Mark W. Feinberg

Summary: This study identifies a critical role for the transcription factor KLF10 in regulating the interactions between CD4+ Tregs and macrophages in atherosclerosis. Knockout of KLF10 in CD4+ T cells leads to exaggerated plaque progression due to defects in the immunosuppressive functions of Tregs on macrophages. Adoptive cellular therapy with WT Tregs reverses the accelerated lesion progression and deleterious effects in KLF10 knockout mice.

ATHEROSCLEROSIS (2022)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.