Editorial Material
Oncology
Raphael Colle, Thierry Andre, Yves Menu
Summary: The article highlights that early tumor shrinkage and depth of response predict prognosis in colorectal cancer patients treated with immune checkpoint inhibitors, but no cases of pseudoprogression were observed. Discrepancies with other studies may be due to differences in radiological evaluation criteria and timing of imaging.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Letter
Oncology
Sarah Badaoui, Andrew Rowland, Michael J. Sorich, Ashley M. Hopkins
Summary: This letter to the editor emphasizes additional analyses needed to supplement the study by Rugo et al. on Abemaciclib treatment for HR+/HER2- breast cancer.
Letter
Environmental Sciences
Davy Vanham, Mesfin M. Mekonnen
Summary: The reliability of the scarcity-weighted water footprint (WSF) and its counterproductivity for achieving SDG target 6.4 is questioned. The analysis shows that unsustainably produced wheat may receive better ranking than sustainably produced wheat based on WSF. The suggestion is to use the water stress indicator instead of WSF in the LCA framework.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Neurosciences
Jing-Jing Zhou, Jian-Ying Shao, Shao-Rui Chen, De-Pei Li, Hui-Lin Pan
Summary: The study reveals that chronic stress-induced persistent hypertension is mediated by enhanced sympathetic outflow via alpha 2 delta-1-bound NMDARs in the paraventricular nucleus. This provides a cellular and molecular basis for understanding how genetic and environmental factors interact to cause persistent hypertension.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Peripheral Vascular Disease
Ailsa F. Ralph, Celine Grenier, Hannah M. Costello, Kevin Stewart, Jessica R. Ivy, Neeraj Dhaun, Matthew A. Bailey
Summary: High salt intake leads to hypertension, affecting renal and vascular function in C57BL6/J mice, with a rapid increase in blood pressure observed in male mice within 4 days of dietary switch. The high-salt diet also increases renal artery sensitivity and urinary excretion of adrenaline in these mice.
Article
Cardiac & Cardiovascular Systems
Zhao-Fu Sheng, Hua Zhang, PeiRu Zheng, Shanyan Chen, Zezong Gu, Jing-Jing Zhou, Jeffery G. Phaup, Hui-Ming Chang, Edward T. H. Yeh, Hui-Lin Pan, De-Pei Li
Summary: This study found that decreased Kv7 channel activity in the central amygdala (CeA) contributes to heightened sympathetic outflow in hypertension. This novel information provides new mechanistic insight into the pathogenesis of neurogenic hypertension.
CARDIOVASCULAR RESEARCH
(2022)
Article
Peripheral Vascular Disease
Yusuke Sata, Sandra L. Burke, Nina Eikelis, Anna M. D. Watson, Cindy Gueguen, Kristy L. Jackson, Gavin W. Lambert, Kyungjoon Lim, Kate M. Denton, Markus P. Schlaich, Geoffrey A. Head
Summary: Renal denervation, whether total or afferent, can effectively reduce hypertension and sympathetic activity in chronic kidney disease (CKD) rabbits, suggesting that renal afferents play a significant role in driving elevated blood pressure in this model.
Review
Peripheral Vascular Disease
Baojian Xue, Alan Kim Johnson
Summary: Hypertension affects over 1 billion individuals worldwide, and the cause is largely unknown. Increased sympathetic nervous system activity is common in hypertensive patients, but the root cause is still unclear. Recent research has found that the neural network controlling sympathetic drive becomes more reactive after exposure to mild challenges, leading to a sensitized hypertensive response. Plasticity in the neural network and the involvement of various factors are necessary for the induction and maintenance of this state. This review discusses the induction and expression of this sensitized hypertensive response in adult animals and the offspring of mothers with prenatal obesity/overnutrition or maternal gestational hypertension, as well as interventions to reverse the effects of stressor-induced sensitization.
Article
Cardiac & Cardiovascular Systems
Felix Mahfoud, Markus P. Schlaich, Melvin D. Lobo
Summary: Efforts to improve blood pressure control have shifted towards interventional therapies targeting the sympathetic nervous system, with renal denervation being the most mature technology. Other emerging technologies like baroreflex activation therapy require more human data support. Central nervous system control of circulation remains poorly understood yet vital component, with deep brain stimulation of key cardiovascular control territories showing promise for blood pressure control. Technology targeting hemodynamics of circulation may also be worth exploring for patients with less relevant sympathetic drive to hypertension perpetuation.
CIRCULATION RESEARCH
(2021)
Article
Nutrition & Dietetics
Shohei Yamaguchi, Yuzumi Hayasaka, Miho Suzuki, Wenhao Wang, Masahiro Koyama, Yasuko Nagasaka, Kozo Nakamura
Summary: This study demonstrates that low-dose orally administered ACh can lower blood pressure in spontaneously hypertensive rats by acting on gastrointestinal M3 muscarinic ACh receptors to increase afferent vagal nerve activity, resulting in decreased sympathetic nervous activity and noradrenaline release.
Article
Peripheral Vascular Disease
Guido Grassi, Fosca Quarti-Trevano, Gino Seravalle, Raffaella Dell'Oro, Jennifer Vanoli, Gianluca Perseghin, Giuseppe Mancia
Summary: The study investigated the differences in blood pressure values when measured with or without a doctor present. The results showed that there were significant increases in blood pressure and sympathetic nerve traffic when BP was measured in the presence of a doctor, while there were modest decreases in these values during unattended BP measurement. This suggests that the presence of a doctor during BP measurement may affect cardiovascular and neural responses.
Article
Urology & Nephrology
Anna M. Zemke, Roger A. Rodby, Martin Hertl, Ali Waleed, George L. Bakris
Summary: This case suggests that BLN treatment should be considered in some rHTN patients before they develop ESKD, rather than only using RDN.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Neurosciences
Kokwin Ooi, Li Hu, Yi Feng, Chenzhi Han, Xiaorong Ren, Xinyi Qian, Haofeng Huang, Sijia Chen, Qi Shi, Hong Lin, Jijiang Wang, Danian Zhu, Rui Wang, Chunmei Xia
Summary: Exposure to stress can lead to hypertension through neuroinflammation pathways, but sigma-1R exerts a protective role by regulating ER-mitochondria contact and mitochondrial functions, thus suppressing neuroinflammation in stress-induced hypertension.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Peripheral Vascular Disease
Roland E. Schmieder, Felix Mahfoud, Giuseppe Mancia, Michael Azizi, Michael Boehm, Kyriakos Dimitriadis, Kazuomi Kario, Abraham A. Kroon, Melvin D. Lobo, Christian Ott, Atul Pathak, Alexandre Persu, Filippo Scalise, Markus Schlaich, Reinhold Kreutz, Costas Tsioufis
Summary: This paper presents updated recommendations based on new pivotal sham-controlled randomized clinical trials, demonstrating the efficacy and safety of endovascular device-based renal denervation for hypertension treatment. Meta-analyses show a significant reduction in blood pressure and a decreased incidence of cardiovascular events with this treatment option.
JOURNAL OF HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
Jing-Jing Zhou, Jian-Ying Shao, Shao-Rui Chen, Hui-Lin Pan
Summary: This study revealed that calcineurin inhibitor-induced hypertension may be caused by the modulation of NMDA receptor activity in the paraventricular nucleus of the hypothalamus, leading to increased sympathetic output. Therefore, targeting NMDA receptor activity could be a potential therapeutic approach for treating this type of hypertension.
CIRCULATION RESEARCH
(2022)
