Review
Pharmacology & Pharmacy
Pratima Kumari, Priyanka Debta, Anshuman Dixit
Summary: Oral cancer is a critical health issue, with the majority of new cases occurring in Asia. Various factors, such as genetics and lifestyle, are closely associated with its occurrence and progression. Early signs of oral cancer include oral lesions, genetic mutations, and viral infections. Lesions with dysplastic features have a high risk of malignancy, and OPMDs have a high prevalence in South Asian countries. Early detection, prevention, and treatment of OPMDs are crucial.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Saman Warnakulasuriya, Omar Kujan, Jose M. Aguirre-Urizar, Jose Bagan, Miguel Angel Gonzalez-Moles, Alexander R. Kerr, Giovanni Lodi, Fernanda Weber Mello, Luis Monteiro, Graham R. Ogden, Philip Sloan, Newell W. Johnson
Summary: Oral potentially malignant disorders (OPMDs) are associated with an increased risk of oral cancer, and an expert group updated the nomenclature and classification of OPMDs, adding oral lichenoid lesions and oral manifestations of 'chronic graft-versus-host disease' to the list. It is recommended to establish a global research consortium to study the natural history of OPMDs based on the proposed classification.
Article
Otorhinolaryngology
Marko Tarle, Danko Muller, Marina Raguz, Ivica Luksic
Summary: This study investigated the expression of nuclear EGFR (nEGFR) and the stem cell marker ABCG2 in oral leukoplakia and oral erythroplakia, and found that co-expression of both biomarkers was associated with an increased risk of malignant transformation.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Medicine, General & Internal
Sheng-Fu Chiu, Chung-Han Ho, Yi-Chen Chen, Li-Wha Wu, Yuh-Ling Chen, Jer-Horng Wu, Wei-Sheng Wu, Hui-Kun Hung, Wei-Fan Chiang
Summary: The study aimed to analyze the malignant transformation rate of oral potentially malignant disorders (OPMDs) and found that oral verrucous hyperplasia (OVH) had the highest malignant transformation possibility, with female OPMD patients having a relatively high malignant transformation rate.
Article
Engineering, Biomedical
Xing Wang, Zuoying Yuan, Anqi Tao, Pudi Wang, Wenyue Xie, Shuo Yang, Jianyong Huang, Ning Wen
Summary: This study introduces a novel hydrogel patch that effectively treats oral potentially malignant disorders and improves patient comfort. Through experiments and modeling, the feasibility and clinical value of this hydrogel patch have been demonstrated.
Article
Biochemistry & Molecular Biology
Lucas de Villalain, Saul Alvarez-Teijeiro, Tania Rodriguez-Santamarta, Alvaro Fernandez del Valle, Eva Allonca, Juan P. Rodrigo, Juan Carlos de Vicente, Juana M. Garcia-Pedrero
Summary: This study aimed to evaluate the expression of senescence markers DcR2 and DEC1 in oral potentially malignant disorders and found a significant association with oral cancer risk. The increased expression of DcR2 and DEC1 was correlated with increased risk of oral cancer and higher-grade dysplasia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Gerardo Gilligan, Rene Panico, Jeronimo Lazos, Rosana Morelatto, Paola Belardinelli, Ines Criscuolo, Nicolas Bolesina, Ignacio Molina Avila, Juan Martin Pimentel Sola, Emilce Rivarola, Maria Jimena Morgante, Maria Eugenia Ingrassia Tonelli, Javier Gimenez, Pablo Doratti, Laura Cecilia Werner, Ana Carolina Prado-Ribeiro, Thais Bianca Brandao, Aljomar Jose Vechiato-Filho, Maria Claudia Cuzzullin, Cristina Saldivia-Siracusa, Marcio Ajudarte Lopes, Michelle Agostini, Mario Jose Romanach, Aline Correa Abrahao, Thamyres Campos Fonseca, Estela Kaminagakura, Ana Lia Anbinder, Kamilla Santos Alves, Maria Leticia de Almeida Lanca, Sonia Sacsaquispe-Contreras, Karem Rodriguez Ibazetta, Roberto Gerber-Mora, Saray Aranda Romo, Francisco Javier Tejeda Nava, Karina Cordero-Torres, Ricardo Moreno Silva, Wilfredo Gonzalez-Arriagada, Raiza Toro, Felipe Martins Silveira, Natalia Gonzalez, Pablo Agustin Vargas, Alan Roger Santos-Silva, Ronell Bologna-Molina, Mariana Villarroel-Dorrego, Benjamin Martinez, Eduardo Piemonte
Summary: This study aims to investigate the frequency, epidemiological profile, and traditional risk factors of oral squamous cell carcinoma (OSCC) associated or not with oral potentially malignant disorders (OPMD) in Latin America. The results suggest that OSCC-dn is more frequent in Latin America, with regional variations in some clinical and histopathological features.
Article
Oncology
Jebrane Bouaoud, Jean-Philippe Foy, Antonin Tortereau, Lucas Michon, Vincent Lavergne, Nicolas Gadot, Sandrine Boyault, Julie Valantin, Genevieve De Souza, Philippe Zrounba, Chloe Bertolus, Nathalie Bendriss-Vermare, Pierre Saintigny
Summary: This study utilized RNA sequencing to investigate the dynamics of the immune microenvironment during oral carcinogenesis, highlighting the significant gene expression changes in the stromal compartment related to immune biological processes. The infiltration of macrophages was identified as the most quantitatively important, especially during the dysplasia stage. Additionally, three M2 macrophages signatures were found to be independently associated with improved oral cancer-free survival in patients with oral leukoplakia.
Article
Oncology
Ya-Qin Tan, Zheng-Tao Li, Gang Zhou
Summary: Oral potentially malignant disorders (OPMDs) are associated with an increased risk of oral cavity or lip cancers. The primary objective of OPMDs management is to prevent cancer development. Current strategies for OPMDs management include non-surgical and surgical interventions, disease monitoring, and preventive strategies. However, there is a need for improved treatment options and predictive markers for OPMDs treatment.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Pablo Ramos-Garcia, Maria del Mar Roca-Rodriguez, Manuel Aguilar-Diosdado, Miguel Angel Gonzalez-Moles
Summary: The study revealed that patients with diabetes mellitus have a higher prevalence and greater chance of developing oral cancer and potentially malignant oral disorders compared to non-diabetic patients, with higher mortality rates for diabetic patients with oral cancer.
Article
Oncology
John Adeoye, Mohamad Koohi-Moghadam, Anthony Wing Ip Lo, Raymond King-Yin Tsang, Velda Ling Yu Chow, Li-Wu Zheng, Siu-Wai Choi, Peter Thomson, Yu-Xiong Su
Summary: Machine learning models were used to predict malignancy from oral white lesions with satisfactory performance and stability. DeepSurv and RSF were the top-performing models in terms of discrimination and calibration in internal validation. DeepSurv was more stable than RSF in cross-validation, with external validation confirming their utility for discrimination and individual survival estimates.
Article
Biochemistry & Molecular Biology
Alejandro Herreros-Pomares, David Hervas, Leticia Bagan-Debon, Eloisa Jantus-Lewintre, Concepcion Gimeno-Cardona, Jose Bagan
Summary: This study aims to compare and describe the composition and diversity of the oral microbiome in patients with homogeneous leucoplakia, proliferative verrucous leukoplakia, oral squamous cell carcinoma, and OSCC preceded by PVL. The number of bacterial species was lower in cancer patients, with Fusobacteriota being the dominant group. PVL and PVL-OSCC patients had a higher abundance of Campilobacterota and lower Proteobacteria compared to other groups. This is the first study comparing oral microbiome alterations in these groups, and further research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Xinjia Cai, Jianyun Zhang, Ying Han, Qian Tang, Heyu Zhang, Tiejun Li
Summary: This study developed a novel nomogram model to assess the risks of malignant transformation of oral potentially malignant disorders. The model showed high predictive value and clinical relevance, although not applicable to all cases.
Article
Oncology
Gizem Tanriver, Merva Soluk Tekkesin, Onur Ergen
Summary: Oral cancer is the most common type of head and neck cancer worldwide, with early detection leading to high survival rates. However, lack of public awareness and delays in referrals contribute to late-stage diagnoses. This study explores the use of deep learning and computer vision techniques for automated detection and classification of oral potentially malignant disorders, offering a low-cost and non-invasive tool to improve screening processes and detection outcomes.
Review
Health Care Sciences & Services
Jewel Kai Lin See, Xinyao Liu, Federica Canfora, Caroline Moore, Michael Mccullough, Tami Yap, Rita Paolini, Antonio Celentano
Summary: This study systematically reviewed the evidence on the therapeutic effects of vitamin supplementation for oral potentially malignant disorders (OPMDs) and oral cancer (OC). The results showed that vitamin K, vitamin C, vitamin A, vitamin B, and vitamin D all had therapeutic benefits. The research on oral cancer was extensive, with a focus on oral lichen planus and oral leukoplakia among the OPMDs. However, standardizing the study design and outcomes is needed to enhance future research.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
