Article
Cardiac & Cardiovascular Systems
Pablo Diez-Villanueva, Cesar Jimenez-Mendez, Clara Bonanad, Carolina Ortiz-Cortes, Eduardo Barge-Caballero, Josebe Goirigolzarri, Alberto Esteban-Fernandez, Angel Perez-Rivera, Marta Cobo, Ancor Sanz-Garcia, Francesc Formiga, Albert Ariza-Sole, Manuel Martinez-Selles, Fernando Alfonso
Summary: Frailty is more common in elderly women with heart failure compared to men. However, frailty is only associated with mortality in men.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sadiya S. Khan, Lauren B. Beach, Clyde W. Yancy
Summary: Sex-based differences in risk, symptoms, and management of heart failure exist, with women having a higher incidence of HF with preserved ejection fraction compared to men. However, there are gaps in understanding gender-based differences in HF and inadequate representation of women and gender minorities in clinical trials.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Emilie Dubois-Deruy, Yara El Masri, Annie Turkieh, Philippe Amouyel, Florence Pinet, Jean-Sebastien Annicotte
Summary: Lysine acetylation is a conserved mechanism that affects various biological processes, and its dysregulation is associated with cardiac dysfunction. This review summarizes the regulation of cardiac acetylation and its roles in both physiological and pathological conditions, highlighting its importance in cardiovascular diseases and suggesting KATs and KDACs as potential therapeutic targets for heart failure.
Article
Cardiac & Cardiovascular Systems
Yohei Sotomi, Shungo Hikoso, Daisaku Nakatani, Hiroya Mizuno, Katsuki Okada, Tomoharu Dohi, Tetsuhisa Kitamura, Akihiro Sunaga, Hirota Kida, Bolrathanak Oeun, Taiki Sato, Sho Komukai, Shunsuke Tamaki, Masamichi Yano, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Yoshio Yasumura, Takahisa Yamada, Yasushi Sakata
Summary: In patients with HFpEF, female sex is independently associated with a higher prevalence of diastolic dysfunction and worse clinical outcomes compared to male sex. Despite differences in diastolic dysfunction, there was no significant difference in the incidence of clinical endpoints between women and men.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, General & Internal
Federica Moscucci, Susanna Sciomer, Silvia Maffei, Antonella Meloni, Ilaria Lospinuso, Myriam Carnovale, Andrea Corrao, Ilaria Di Diego, Cristina Caltabiano, Martina Mezzadri, Anna Vittoria Mattioli, Sabina Gallina, Pietro Rossi, Damiano Magri, Gianfranco Piccirillo
Summary: This study aims to evaluate possible differences between men and women in ECG repolarization markers for the telemonitoring of CHF patients. The results show that Te-SD can be considered a risk factor for CHF worsening and complications for both female and male patients, but different cutoffs should be taken into account.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Tobias Taeger, Jennifer Franke, Norbert Frey, Lutz Frankenstein, Hanna Froehlich
Summary: Obesity is associated with better outcomes in heart failure patients, while cachexia is linked to higher mortality. The prognostic impact of gradual, long-term weight changes in stable heart failure patients is not well understood.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Cardiac & Cardiovascular Systems
Alessia Argiro, Carolyn Ho, Sharlene M. Day, Jolanda van der Velden, Elisabetta Cerbai, Sara Saberi, Jil C. Tardiff, Neal K. Lakdawala, Iacopo Olivotto
Summary: Cardiomyopathies are diseases characterized by primary functional and structural abnormalities of the heart muscle. The most effective classification is based on the presenting phenotype. Sex modulates the prevalence, clinical manifestations, and course of cardiomyopathies. Differences in ion channel expression and left ventricular remodeling exist between male and female patients. Societal and environmental factors may also contribute to clinical differences between sexes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Nutrition & Dietetics
Liang-Jen Wang, Chih-Lang Lin, Yi-Chih Chen, Chemin Lin, Yu-Chiau Shyu, Chih-Ken Chen
Summary: This study investigated the sex differences in the relationship between excessive drinking and the risk of metabolic abnormalities. It found that males were at higher risks of certain metabolic abnormalities, while females were more likely to develop hypertension. Both males and females who engaged in hazardous drinking had a greater risk of metabolic abnormalities compared to those who did not drink excessively. However, after controlling for demographics and lifestyle-related habits, there was no interaction effect of sex and excessive drinking on the risks of metabolic abnormalities.
Article
Cardiac & Cardiovascular Systems
Daichi Maeda, Yuya Matsue, Nobuyuki Kagiyama, Kentaro Jujo, Kazuya Saito, Kentaro Kamiya, Hiroshi Saito, Yuki Ogasahara, Emi Maekawa, Masaaki Konishi, Takeshi Kitai, Kentaro Iwata, Hiroshi Wada, Masaru Hiki, Taishi Dotare, Tsutomu Sunayama, Takatoshi Kasai, Hirofumi Nagamatsu, Tetsuya Ozawa, Katsuya Izawa, Shuhei Yamamoto, Naoki Aizawa, Kazuki Wakaume, Kazuhiro Oka, Shin-ichi Momomura, Tohru Minamino
Summary: Frailty and sarcopenia are common in elderly patients with heart failure and have a negative impact on prognosis, with no clear gender differences.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Camilla C. S. van Der Hoef, Eva M. M. Boorsma, Johanna E. E. Emmens, Bart J. J. van Essen, Marco Metra, Leong L. L. Ng, Stefan D. D. Anker, Kenneth Dickstein, Ify R. R. Mordi, Adel Dihoum, Chim C. C. Lang, Dirk J. J. van Veldhuisen, Carolyn S. P. Lam, Adriaan A. A. Voors
Summary: This study investigated the clinical and biomarker correlates of metabolic syndrome in patients with heart failure. It found that metabolic syndrome is associated with obesity, lipid metabolism, and chronic inflammation-related biomarkers and pathways underlying heart failure.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Longjian Liu, Joao A. C. Lima, Wendy S. Post, Moyses Szklo
Summary: This study examined the associations of time-varying obesity and metabolic syndrome with heart failure, finding that time-varying obesity and MetSyn were significantly associated with HF risk, with a stronger association with HFpEF than with HFrEF. Continued efforts to control these risk factors are recommended.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Anne-Mar van Ommen, Ernest Diez Benavente, N. Charlotte Onland-Moret, Gideon B. Valstar, Maarten J. Cramer, Frans H. Rutten, Arco J. Teske, Roxana Menken, Leonard Hofstra, Igor I. Tulevski, Nancy Sweitzer, G. Aernout Somsen, Hester M. den Ruijter
Summary: This study reveals that concentric remodeling (cRM) precedes heart failure with preserved ejection fraction (HFpEF), which is more prevalent in women. Age, heart rate, and hypertension are risk factors for relative wall thickness, and higher levels of IFNA5 are associated with increased relative wall thickness in women. Differential biological pathway activation by sex in cRM may contribute to the female predominance of HFpEF and provide new therapeutic avenues for prevention and treatment of HFpEF.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Danielle J. Beetler, Katelyn A. Bruno, Damian N. Di Florio, Erika J. Douglass, Swikriti Shrestha, Carsten Tschoepe, Madeleine W. Cunningham, Jan Krejci, Julie Bienertova-Vasku, Sabine Pankuweit, Dennis M. McNamara, Eun-Seok Jeon, Sophie van Linthout, Lori A. Blauwet, Leslie T. Cooper, DeLisa Fairweather
Summary: This study aimed to investigate the sex and age differences in soluble ST2 (sST2) levels for various cardiovascular diseases (CVDs). Using ELISA kit, sST2 levels were measured in patients with myocarditis, cardiomyopathy, coronary artery disease (CAD), myocardial infarct (MI), and congestive heart failure (CHF) and compared to controls without CVDs. The results showed that myocarditis occurred in younger patients around the age of 40, while other CVDs were more common in individuals around the age of 60. There were significant differences in sST2 levels between sexes in myocarditis and cardiomyopathy, but not in other CVDs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Endocrinology & Metabolism
Ionel Sandovici, Denise S. Fernandez-Twinn, Antonia Hufnagel, Miguel Constancia, Susan E. Ozanne
Summary: Early-life exposures can affect long-term metabolic health, and male and female fetuses have different responses to these exposures, which may contribute to sex differences in metabolic health in adulthood.
Article
Cardiac & Cardiovascular Systems
Joshua R. Smith, Randal J. Thomas, Amanda R. Bonikowske, Shane M. Hammer, Thomas P. Olson
Summary: This article reviews the sex differences in outpatient phase II cardiac rehabilitation (CR) programming, including CR participation rates, core components, and barriers to participation. Strategies to mitigate these disparities are discussed, along with areas for future research.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Tomoyuki Tobushi, Kazuya Hosokawa, Ko Abe, Satomi Kon-no, Toshiaki Kadokami, Ryo Nakamura, Hiroyuki Tsutsui, Shin-ichi Ando
Summary: The study aimed to investigate changes in lung to fingertip circulation time (LFCT) during the clinical course of heart disease patients, and its response to treatment. The results suggest that LFCT values can reflect cardiac function and may serve as an important indicator for evaluating the effectiveness of heart disease treatment.
Article
Cardiac & Cardiovascular Systems
Kyoshiro Fukasawa, Koji Fukuda, Nobuyoshi Mori, Masateru Kondo, Takahiko Chiba, Keita Miki, Yuhi Hasebe, Makoto Nakano, Hiroaki Shimokawa
Summary: The study shows that maintaining sinus rhythm with ablation can improve exercise tolerance in patients with paroxysmal atrial fibrillation, especially in those with reduced exercise tolerance.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Akira Suda, Andreas Seitz, Yuji Odaka, Anastasios Athanasiadis, Giancarlo Pirozzolo, Koichi Sato, Kiyotaka Hao, Raffi Bekeredjian, Jun Takahashi, Udo Sechtem, Hiroaki Shimokawa, Peter Ong
Summary: This study compared contemporary German and Japanese patients with coronary spasm, finding similarities in types of spasm and frequency of multivessel spasm between the two populations.
Article
Radiology, Nuclear Medicine & Medical Imaging
Tomohisa Fukunaga, Kenichi Sanui, Toshiaki Kadokami, Masayuki Sasaki
Summary: Objective phase analysis combined with myocardial perfusion and wall motion imaging is expected to enhance the accuracy of myocardial ischemia diagnosis. Different radionuclides may have varying influences on stress-induced left ventricular mechanical dyssynchrony detection, with Tc-99m-MPS considered more useful compared to Tl-201-MPS.
ANNALS OF NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Hideo Arai, Masateru Kawakubo, Toshiaki Kadokami
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Multidisciplinary Sciences
Tomoyuki Tobushi, Takatoshi Kasai, Masayuki Hirose, Kazuhiro Sakai, Manabu Akamatsu, Chizuru Ohsawa, Yasuko Yoshioka, Shoko Suda, Nanako Shiroshita, Ryo Nakamura, Toshiaki Kadokami, Takeshi Tohyama, Kouta Funakoshi, Kazuya Hosokawa, Shin-ichi Ando
Summary: The new method to measure LFCT is highly stable and feasible for any type of heart failure patients, achieving excellent reliability with an ICC of 0.85. The overall measurability reached 95.7% in the study, demonstrating the efficacy and safety of the device.
SCIENTIFIC REPORTS
(2021)
Letter
Endocrinology & Metabolism
Atsushi Tanaka, Takumi Imai, Makoto Suzuki, Shinya Hiramitsu, Naohiko Takahashi, Toshiaki Kadokami, Arihiro Kiyosue, Masami Nishino, Yasushi Sakata, Koichi Node
DIABETES OBESITY & METABOLISM
(2022)
Article
Medicine, General & Internal
Ryo Nakamura, Shin-ichi Ando, Seiya Kato, Toshiaki Kadokami
Summary: An elderly patient developed acute heart failure shortly after receiving influenza vaccination. Treatment with conventional heart failure drugs resulted in rapid recovery. Experimental data and clinical course suggested that influenza vaccination may have caused acute lymphocyte myocarditis leading to heart failure.
Article
Environmental Sciences
Hideo Arai, Masateru Kawakubo, Kenichi Sanui, Ryoji Iwamoto, Hiroshi Nishimura, Toshiaki Kadokami
Summary: This study evaluated the use of deep learning based on a U-Net convolutional neural network for fully automated segmentation of the four cardiac chambers in four-chamber cine cardiovascular magnetic resonance imaging. The results showed that the automated segmentation method achieved high accuracy and strong agreement with manual segmentation, enabling simultaneous evaluation and detection of enlargement of the cardiac chambers.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Hideo Arai, Masateru Kawakubo, Toshiaki Kadokami
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Endocrinology & Metabolism
Satoshi Yamaguchi, Michio Shimabukuro, Atsushi Tanaka, Takumi Imai, Shinya Hiramitsu, Naohiko Takahashi, Toshiaki Kadokami, Masayoshi Ajioka, Makoto Suzuki, Koichi Node
Summary: The aim of this study was to investigate factors associated with proteinuria regression in patients with type 2 diabetes treated with canagliflozin. The results showed that the rate of proteinuria regression was higher and the rate of progression was lower in the canagliflozin group compared to the glimepiride group. In the regression subclass, insulin level, beta-cell function, insulin resistance, and estimated plasma volume were decreased at 24 weeks. Baseline insulin level was associated with proteinuria regression in the multivariate logistic regression model.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Hiroki Teragawa, Atsushi Tanaka, Yuichi Fujii, Hisako Yoshida, Tomohiro Ueda, Shuichi Nomura, Toshiaki Kadokami, Hisashi Koide, Makoto Saito, Hiroaki K. Sano, Yasuko Bando, Toyoaki Murohara, Koichi Node, PRIZE Study Investigators
Summary: This study aimed to assess the effect of febuxostat on the level of malondialdehyde-modified low-density lipoprotein (MDA-LDL). The results showed that the febuxostat group had a significantly lower MDA-LDL/LDL-C ratio compared to the control group, while there were no differences in MDA-LDL and LDL-C levels between the two groups. These findings suggest a potential of febuxostat in reducing atherosclerosis and oxidative stress in asymptomatic hyperuricemic patients with carotid atherosclerosis.
CLINICAL CARDIOLOGY
(2023)
Article
Peripheral Vascular Disease
Yasuhiro Nakano, Mitsutaka Yamamoto, Tetsuya Matoba, Shunsuke Katsuki, Soichi Nakashiro, Susumu Takase, Yusuke Akiyama, Takuya Nagata, Yasushi Mukai, Shujiro Inoue, Keiji Oi, Taiki Higo, Masao Takemoto, Nobuhiro Suematsu, Kenichi Eshima, Kenji Miyata, Makoto Usui, Kenji Sadamatsu, Toshiaki Kadokami, Kiyoshi Hironaga, Ikuyo Ichi, Koji Todaka, Junji Kishimoto, Hiroyuki Tsutsui
Summary: This study investigated the effect of combining ezetimibe with statin therapy on coronary plaque composition and molecular mechanisms. The results showed that the combination therapy resulted in greater plaque regression compared to statin monotherapy.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Nutrition & Dietetics
Yusuke Akiyama, Shunsuke Katsuki, Tetsuya Matoba, Yasuhiro Nakano, Susumu Takase, Soichi Nakashiro, Mitsutaka Yamamoto, Yasushi Mukai, Shujiro Inoue, Keiji Oi, Taiki Higo, Masao Takemoto, Nobuhiro Suematsu, Kenichi Eshima, Kenji Miyata, Makoto Usui, Kenji Sadamatsu, Toshiaki Kadokami, Kiyoshi Hironaga, Ikuyo Ichi, Koji Todaka, Junji Kishimoto, Hiroyuki Tsutsui
Summary: Oxysterols are believed to contribute to the development of cardiovascular diseases, and their serum levels are positively associated with cholesterol absorption and synthesis. However, the regulation of different oxysterols in the body is largely unknown. This study aimed to investigate the relationship between clinical factors and cholesterol metabolism markers, as well as identify oxysterols associated with cholesterol absorption and synthesis in patients with coronary artery disease.
Article
Radiology, Nuclear Medicine & Medical Imaging
Masateru Kawakubo, Daichi Moriyama, Yuzo Yamasaki, Kohtaro Abe, Kazuya Hosokawa, Tetsuhiro Moriyama, Pandji Triadyaksa, Adi Wibowo, Michinobu Nagao, Hideo Arai, Hiroshi Nishimura, Toshiaki Kadokami
Summary: In this study, a deep learning-based fully automatic RV segmentation technique targeting RLA images showed higher accuracy compared to conventional SA methods in terms of RV strain parameter measurements. The proposed RLA method achieved accurate full automatic extraction of the entire RV region from available CMR cine images without additional imaging, overcoming limitations in RV visualization in echocardiography.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)