Review
Medicine, General & Internal
Deepak L. Bhatt, Renato D. Lopes, Robert A. Harrington
Summary: This review discusses the current evidence on the epidemiology, pathophysiology, clinical presentation, diagnosis, management, and prognosis of acute coronary syndromes (ACS). ACS is a sudden reduction in blood supply to the heart and includes ST-segment elevation myocardial infarction (STEMI), non-STEMI (NSTEMI), and unstable angina. Each year, more than 7 million people are diagnosed with ACS worldwide. Prompt intervention, such as primary percutaneous coronary intervention (PCI) for STEMI patients and invasive coronary angiography with revascularization for high-risk NSTE-ACS patients, is associated with reduced mortality.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Christian Zanchin, Stefan Ledwoch, Sarah Bar, Yasushi Ueki, Tatsuhiko Otsuka, Jonas D. Haner, Thomas Zanchin, Fabien Praz, Lukas Hunziker, Stefan Stortecky, Thomas Pilgrim, Sylvain Losdat, Stephan Windecker, Lorenz Raber, George C. M. Siontis
Summary: The prevalence of acute coronary syndromes (ACS) among young individuals is increasing, with atherosclerosis being the main cause. Compared to older ACS patients, young patients have a lower risk for future events and lower mortality rates.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Se Hun Kang, Jae Youn Moon, Sang Hoon Kim, Jung Hoon Sung, In Jai Kim, Sang Wook Lim, Dong Hun Cha, Won-Jang Kim
Summary: This study retrospectively evaluated the prevalence and prognostic consequences of anemia in patients with acute coronary syndrome (ACS) treated with percutaneous coronary intervention in Korea. The results showed that anemia is prevalent in ACS patients and is strongly associated with increased mortality and cardiovascular events.
Article
Cardiac & Cardiovascular Systems
Tatsuhiko Otsuka, Sarah Baer, Sylvain Losdat, Raminta Kavaliauskaite, Yasushi Ueki, Christian Zanchin, Jonas Lanz, Fabien Praz, Jonas Haener, George C. M. Siontis, Thomas Zanchin, Stefan Stortecky, Thomas Pilgrim, Stephan Windecker, Lorenz Raeber
Summary: In patients with ACS, early and late staged non-target-vessel PCI showed similar rates of major adverse cardiac events at 1 year follow-up.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Medicine, General & Internal
Brian A. Bergmark, Njambi Mathenge, Piera A. Merlini, Marilyn B. Lawrence-Wright, Robert P. Giugliano
Summary: Although progress has been made in diagnosing and treating acute coronary syndromes, cardiovascular disease remains a leading cause of death globally. High-sensitivity troponin assays have allowed for rapid diagnosis in suspected cases. Dual antiplatelet therapy and additional preventive measures are recommended. The diagnosis and management of acute coronary syndromes continue to evolve, especially in response to the COVID-19 pandemic.
Article
Cardiac & Cardiovascular Systems
Giulia Magnani, Serena Bricoli, Maddalena Ardissino, Giuseppe Maglietta, Adam Nelson, Caterina Disisto, Patrizia Celli, Maurizio Ferrario, Umberto Canosi, Carlo Cernetti, Francesco Negri, Marco Tubaro, Carlo Berzuini, Chiara Manzalini, Gianfranco Ignone, Carlo Campana, Luigi Moschini, Elisabetta Ponte, Roberto Pozzi, Raffaela Fetiveau, Silvia Buratti, Elvezia Paraboschi, Rosanna Asselta, Andrea Botti, Domenico Tuttolomondo, Federico Barocelli, Andrea Biagi, Rosario Bonura, Tiziano Moccetti, Antonio Crocamo, Giorgio Benatti, Giorgia Paoli, Emilia Solinas, Elisabetta Moscarella, Paolo Calabr, Stefano Duga, Giampaolo Niccoli, Diego Ardissino
Summary: MINOCA is common in patients with early-onset MI, and although there is a lower rate of cardiovascular death, the long-term risk is not significantly different from that of patients with obstructive coronary artery disease.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Matthew G. L. Williams, Amardeep Dastidar, Kate Liang, Thomas W. Johnson, Anna Baritussio, Julian Strange, Nikhil Joshi, Stephen Dorman, Estefania De Garate, Lucrezia Spagnoli, Emiliano Fiori, Christopher Lawton, Giovanni Biglino, Sven Plein, Chiara Bucciarelli-Ducci
Summary: This study evaluates the impact of sex on clinical presentation and outcome in patients with suspected ACS and non-obstructive coronary arteries. The results show that sex does not have a significant effect on all-cause mortality, but men are more likely to have non-ischemic causes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Toshimitsu Tsugu, Kaoru Tanaka, Dries Belsack, Yuji Nagatomo, Mayuko Tsugu, Jean-Francois Argacha, Bernard Cosyns, Nico Buls, Michel De Maeseneer, Johan De Mey
Summary: In non-obstructive coronary artery disease, the decline of CT-derived fractional flow reserve (FFRCT) depends not only on vessel length but also on the lumen volume. A new marker, the ratio of lumen volume to vessel length (V/L ratio), was found to be the strongest predictor of distal FFRCT.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ewelina A. Dziedzic, Jakub S. Gasior, Agnieszka Tuzimek, Justyna Paleczny, Miroslaw Kwasny, Marek Dabrowski, Piotr Jankowski
Summary: This study assessed the zinc nutritional status in patients with coronary artery disease using inductively coupled plasma optical emission spectrometry. The results showed no association between zinc and the severity of coronary artery disease, and there were no significant differences in zinc levels between patients with acute coronary syndrome and stable coronary artery disease. However, a significant negative correlation was observed between zinc content and serum triglyceride concentration, and patients with type 2 diabetes mellitus had lower hair zinc content.
Article
Cardiac & Cardiovascular Systems
Nooraldaem Yousif, David Niederseer, Allan Davies, Meidi El Issa, Besma Sidia, Husam A. Noor, Haitham Amin, Lorenz Raber, Baris Gencer, Roland Klingenberg, Stephan Windecker, Francois Mach, Christian M. Matter, David Nanchen, Thomas F. Luscher, Slayman Obeid
Summary: This study investigated the prevalence and prognostic influence of cancer in patients with acute coronary syndrome, finding that patients with cancer, especially those with solid tumors, had a higher rate of major cardiovascular events and mortality at one-year follow-up compared to non-cancer patients. Cancer was identified as an independent risk factor for poor outcomes in ACS patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Biology
Sarena La, Rosanna Tavella, Jing Wu, Sivabaskari Pasupathy, Christopher Zeitz, Matthew Worthley, Ajay Sinhal, Margaret Arstall, John A. Spertus, John F. Beltrame
Summary: Angina and Non-Obstructive Coronary Artery (ANOCA) patients often lack a clear explanation for their symptoms, despite the available functional coronary angiography to identify potential underlying coronary vasomotor disorders. This study found that ANOCA patients diagnosed with coronary vasomotor disorders post elective coronary angiography were more likely to have emergency department visits and readmissions for chest pain compared to patients discharged with unspecified chest pain.
Article
Biology
Jin Jung, Su-Nam Lee, Sung-Ho Her, Ki-Dong Yoo, Keon-Woong Moon, Donggyu Moon, Won-Young Jang
Summary: Little is known about the long-term clinical impact of multi-vessel non-obstructive coronary artery disease (CAD). This study found that multi-vessel non-obstructive CAD, especially in patients with three diseased vessels, is strongly associated with poor long-term clinical outcomes.
Review
Cardiac & Cardiovascular Systems
Adam Timmis, Denis Kazakiewicz, Nick Townsend, Radu Huculeci, Victor Aboyans, Panos Vardas
Summary: This review provides an overview of global mortality from acute coronary syndromes (ACS) and examines the regional and temporal changes in the epidemiology of ACS over the past 20 years. It shows that mortality from ACS is higher in men than in women, and highest in lower-income global regions. High-income regions have seen progressive reductions in mortality from ACS, while Asia and Latin America have stable levels of mortality. There is a need for more complete epidemiological data to identify countries with the greatest burden of death from ACS and the need for preventive strategies.
NATURE REVIEWS CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Sharaf Eldeen S. Mahmoud, Mohammady Shahin, Nooraldaem Yousif, Andrea Denegri, Lotfy H. Abo Dahab, Thomas F. Luscher
Summary: This study aimed to investigate the cardiovascular risk profile, clinical presentations, angiographic findings, management strategies, and outcomes of patients with previous coronary artery bypass grafting (CABG) presenting with acute coronary syndromes (ACS). The findings showed that structural changes and atherosclerotic plaques in bypass grafts, especially venous grafts, were the main causes of ACS. Most patients presented with unstable angina, followed by non-ST segment elevation myocardial infarction (NSTEMI), and a small percentage presented with ST segment elevation myocardial infarction (STEMI). The majority of events occurred after one year, particularly in patients with saphenous vein grafts. Hypertensive and obese patients, as well as those with myocardial infarction or ACS before discharge or during the first year after CABG, had higher rates of major adverse cardiovascular and cerebrovascular events (MACCE).
CURRENT PROBLEMS IN CARDIOLOGY
(2022)
Article
Critical Care Medicine
Morgan Roue, Alexis F. Guedon, Nathanael Lapidus, Keyvan Razazi, Geoffroy Hariri, Elise Morawiec, Cyrielle Desnos, Stephane Ederhy, Ariel Cohen, Armand Mekontso Dessap, Muriel Fartoukh, Vincent Labbe
Summary: In patients with AMI and obstructive coronary artery disease during an ICU stay for non-cardiac disease, there is a significant risk of severe ischemia, major bleeding, and death. A history of arterial hypertension and high SOFA scores are independent hazards for poor prognosis.
ANNALS OF INTENSIVE CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Cristina Aurigemma, Maria Benedetta Giannico, Francesco Burzotta, Enrico Romagnoli, Stefano Cangemi, Francesco Bianchini, Piergiorgio Bruno, Antonio Maria Leone, Achille Gaspardone, Filippo Crea, Carlo Trani
Summary: This study investigated the impact of the extent of jeopardized myocardium on clinical outcomes in patients with concomitant coronary artery disease (CAD) and severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI). The results showed that patients with less extensive revascularization had better survival free from major adverse cardiovascular and cerebrovascular events (MACCE). Therefore, adequate myocardial revascularization before TAVI is crucial for patients with CAD and severe AS.
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Correction
Cardiac & Cardiovascular Systems
Rocco Antonio Montone, Giampaolo Niccoli, Michele Russo, Marta Giaccari, Marco Giuseppe Del Buono, Maria Chiara Meucci, Filippo Gurgoglione, Rocco Vergallo, Domenico D'Amario, Antonino Buffon, Antonio M. Leone, Francesco Burzotta, Cristina Aurigemma, Carlo Trani, Giovanna Liuzzo, Gaetano A. Lanza, Filippo Crea
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Stefania Rizzo, Andrea Cozzi, Miriam Dolciami, Filippo Del Grande, Angela L. Scarano, Andrea Papadia, Benedetta Gui, Nicoletta Gandolfo, Carlo Catalano, Lucia Manganaro
Summary: Pelvic MRI interpreted with the Ovarian-Adnexal Reporting and Data System (O-RADS) MRI lexicon had high diagnostic performance for the characterization of US-indeterminate adnexal lesions. Summary estimates of malignancy rates in the O-RADS MRI 4 and O-RADS MRI 5 categories were higher than predicted ones.
Article
Radiology, Nuclear Medicine & Medical Imaging
Alessandro Napoli, Alessandro De Maio, Giulia Alfieri, Chiara Gasperini, Roberto Scipione, Laura Campanacci, Giambattista Siepe, Francesca De Felice, Benedetta Siniscalchi, Lorenzo Chiurchioni, Vincenzo Tombolini, Davide Maria Donati, Alessio Giuseppe Morganti, Pejman Ghanouni, Carlo Catalano, Alberto Bazzocchi
Summary: This study compared the safety and effectiveness of MRI-guided focused ultrasound and external beam radiation therapy in the treatment of bone metastases. The results showed that both treatments achieved similar improvements in pain palliation and quality of life, with low adverse event rates.
Article
Cardiac & Cardiovascular Systems
Daixin Ding, Shengxian Tu, Yingguang Li, Chunming Li, Wei Yu, Xun Liu, Antonio Maria Leone, Cristina Aurigemma, Enrico Romagnoli, Rocco Vergallo, Carlo Trani, William Wijns, Francesco Burzotta
Summary: This study evaluates the potential of a novel method for fast computation of Murray law-based quantitative flow ratio (mu QFR) from coregistered optical coherence tomography (OCT) and angiography (OCT-modulated mu QFR, OCT-mu QFR) in predicting the physiological efficacy of percutaneous coronary intervention (PCI). The results show that simulated residual OCT-mu QFR has good correlation, agreement, and diagnostic concordance with actual post-PCI OCT-mu QFR. In OCT-guided procedures, the pressure drop of OCT-mu QFR in the stent is low and can be predicted by pre-PCI vessel/plaque characteristics.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Francesco Bianchini, Stefano Cangemi, Amanda DeVos, Michael Bielecki, Cristina Aurigemma, Enrico Romagnoli, Carlo Trani, Paul Anthony Iaizzo, Francesco Burzotta
Summary: This study compared two optimization techniques for side branch treatment after stent implantation, and found that the PKP technique performed better in terms of minimum stent expansion, while the PSP technique performed better in terms of stent eccentricity index and side branch scaffold length.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Schaefer, Oliver D. Bhadra, Lenard Conradi, Dirk Westermann, Caroline Kellner, Ole De Backer, Vilhelmas Bajoras, Lars Sondergaard, Waqas T. Qureshi, Nikolaos Kakouros, Summer Aldrugh, Ignacio Amat-Santos, Tsuyoshi Kaneko, Morgan Harloff, Rui Teles, Tiago Nolasco, Jose Pedro Neves, Miguel Abecasis, Nikos Werner, Michael Lauterbach, Jerzy Sacha, Krzysztof Krawczyk, Carlo Trani, Enrico Romagnoli, Antonio Mangieri, Francesco Condello, Ander Regueiro, Salvatore Brugaletta, Fausto Biancari, Matti Niemela, Francesco Giannini, Marco Toselli, Rossella Ruggiero, Andrea Buono, Diego Maffeo, Francesco Bruno, Federico Conrotto, Fabrizio D'Ascenzo, Mikko Savontaus, Jouni Pykari, Alfonso Ielasi, Maurizio Tespili, Michele Cimmino, Michele Albanese, Giuseppe Biondi-Zoccai, Nicola Corcione, Alberto Morello, Arturo Giordano
Summary: This study compared the procedural success of different types of transcatheter heart valves (THV) in Trans-AXillary Intervention (TAXI) registry. It was found that both self-expanding (SE) and balloon-expandable (BE) THV can be safely used in TAx-TAVI, but SE THV were associated with higher device success, while BE THV were more often used in challenging anatomical circumstances.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Michele Russo, Riccardo Rinaldi, Massimiliano Camilli, Alice Bonanni, Andrea Caffe, Mattia Basile, Carmine Salzillo, Michele Colucci, Ilaria Torre, Tommaso Sanna, Giovanna Liuzzo, Francesco Burzotta, Carlo Trani, Giampaolo Niccoli, Filippo Crea, Rocco A. Montone
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Giacomo Pambianchi, Martina Giannetti, Livia Marchitelli, Giulia Cundari, Viviana Maestrini, Massimo Mancone, Marco Francone, Carlo Catalano, Nicola Galea
Summary: This study aimed to assess the diagnostic performance of nT1 and PPM-ls in the identification of iPPM, which is associated with increased risk of mitral valve regurgitation or PPM rupture after myocardial infarction. The study found that higher nT1 values and lower PPM-ls were effective indicators for identifying iPPM.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Antonella Borrelli, Martina Pecoraro, Francesco Del Giudice, Leonardo Cristofani, Emanuele Messina, Ailin Dehghanpour, Nicholas Landini, Michela Roberto, Stefano Perotti, Maurizio Muscaritoli, Daniele Santini, Carlo Catalano, Valeria Panebianco
Summary: Artificial intelligence (AI)-driven software utilizing CT images can automatically assess body composition and diagnose sarcopenia. The combination of standardized CT staging methods with sarcopenia analysis can aid in identifying patients with advanced urothelial tumors who may benefit from customized nutritional therapies, leading to improved outcomes and quality of life. The AI tool has the potential to enhance the clinical value of CT imaging reports and promote precision medicine.
Article
Cardiac & Cardiovascular Systems
Natalia Pavone, Laura Manfredonia, Francesco Burzotta, Federico Cammertoni, Luisa Vicchio, Claudio Spalletta, Francesca Graziani, Gabriella Locorotondo, Cristina Aurigemma, Enrico Romagnoli, Piergiorgio Bruno, Niccolo Del Zanna, Emanuele Marzetti, Maria Calabrese, Maria Grandinetti, Marialisa Nesta, Antonella Lombardo, Carlo Trani, Massimo Massetti
Summary: This study provides a comprehensive assessment of an original heart valve clinic model. By standardizing access criteria, the team made progress in patient complexity and severity of valve disease, resulting in an increased rate of intervention and no compromise in operative mortality.
MINERVA CARDIOLOGY AND ANGIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Luigi Natale, Rozemarijn Vliegenthart, Rodrigo Salgado, Jens Bremerich, Riccardo P. J. Budde, Jean-Nicholas Dacher, Marco Francone, Karl-Friedrich Kreitner, Christian Loewe, Konstantin Nikolaou, Charles Peebles, Birgitta K. Velthuis, Carlo Catalano
Summary: Cardiac computed tomography (CT) and cardiac magnetic resonance imaging (MRI) are important radiological examinations for diagnosing and predicting cardiac diseases. The expected growth in cardiac radiology exceeds the current capacity and workforce, leading to the need for support and strengthening of this field. The European Society of Cardiovascular Radiology (ESCR) aims to improve and optimize the quality and availability of cardiac imaging and experienced radiologists in Europe.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nicola Galea, Giulia Cundari, Emanuele Di Dedda, Cristina Chimenti, Giovanni Donato Aquaro, Andrea Barison, Riccardo Cau, Ernesto Di Cesare, Paolo Di Renzi, Antonio Esposito, Riccardo Faletti, Marco Gatti, Carlo Liguori, Luigi Lovato, Cesare Mantini, Caterina Beatrice Monti, Anna Palmisano, Silvia Pradella, Fabrizio Ricci, Luca Saba, Francesco Secchi, Carlo Catalano, Marco Francone
Summary: This study retrospectively analyzed the short-term follow-up of clinical and cardiac magnetic resonance (CMR) in patients with vaccine-associated myocarditis, pericarditis or myo-pericarditis (VAMP) following COVID-19 vaccination. The results showed that most of the cases had symptom relief and a reduction in CMR signs of active inflammation during short-term follow-up.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Federica Catapano, Nicola Galea, Giacomo Pambianchi, Laura D'Erasmo, Cristian Borrazzo, Giulia Cundari, Livia Marchitelli, Marianna Maranghi, Ilenia Minicocci, Alessia Di Costanzo, Iacopo Carbone, Marco Francone, Marcello Arca, Carlo Catalano
Summary: The performance of clinical scoring systems, including MFHS, SAFEHEART-RE, FHRS, and DLCN, in predicting the extent and severity of CAD in asymptomatic FH patients was investigated. The results showed that MFHS had the best discriminatory power, followed by FHRS and SAFEHEART-RE.
Article
Respiratory System
Arianna Sanna, Daniela Pellegrino, Emanuele Messina, Leonardo Maria Siena, Valentina Baccolini, Letizia D'Antoni, Nicholas Landini, Pia Baiocchi, Paolo Villari, Carlo Catalano, Valeria Panebianco, Paolo Palange
Summary: This study evaluated the incidence and risk factors of Post-COVID-19 Interstitial Lung Disease (PC-ILD) in 100 patients with moderate to critical COVID-19. It found that 8% of patients showed residual radiological and functional signs consistent with PC-ILD at the 15-month follow-up. Aging, severity of COVID-19, and degree of pulmonary involvement during acute infection were identified as significant risk factors for developing PC-ILD.