Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 63, Issue -, Pages 67-76Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2020.03.011
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Funding
- N.I.H. [U01MH109107, R01NS109947, P30EY012196]
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [ZIADE000757] Funding Source: NIH RePORTER
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Characterizing neuronal cell types demands efficient strategies for specific labeling and manipulation of individual subtypes to dissect their connectivity and functions. Recombinant viral technology offers a powerful toolbox for targeted transgene expression in specific neuronal populations. In order to achieve cell type-specific targeting, exciting progress has been made to: alter viral tropisms, design rational delivery strategies, and drive selective expression patterns with engineered DNA sequences in viral genomes. For the latter case, emerging single-cell genomic analyses provide rich databases. In this review, we will summarize current status, and point out challenges, of using viral vectors for neuronal cell type-specific visualization and manipulations. With concerted efforts, progress will continue to be made toward developing viral vectors for the vast array of neuronal subtypes in the mammalian nervous system.
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