Review
Cell Biology
Andreja Figurek, Merita Rroji, Goce Spasovski
Summary: Fibroblast growth factor 23 (FGF23) is a hormone that is mainly produced in osteocytes and has a significant role in disturbed bone and mineral metabolism in chronic kidney disease (CKD). Current research has found that FGF23 is also expressed in cardiac myocytes, fibroblasts, and endothelial cells, suggesting its primary role in cardiac remodeling in CKD patients. Recent discoveries have shown a link between increased FGF23 levels and the development of anemia in CKD. This review discusses the role of FGF23 in cardiac hypertrophy and anemia in CKD and suggests possible therapeutic approaches for lowering FGF23 levels.
Article
Nutrition & Dietetics
Juan F. Navarro-Gonzalez, Carmen Mora-Fernandez, Juan Miguel Diaz-Tocados, Milica Bozic, Marcelino Bermudez-Lopez, Marisa Martin, Jose Manuel Valdivielso
Summary: This study found that elevated serum phosphate and intact FGF23 levels were closely associated with an increased risk of anemia in patients with chronic kidney disease. Low phosphate levels amplified the effect of intact FGF23 concentration on anemia.
Article
Medicine, General & Internal
Hirotaka Fukasawa, Ryuichi Furuya, Mai Kaneko, Daisuke Nakagami, Yuri Ishino, Shuhei Kitamoto, Kyosuke Omata, Hideo Yasuda
Summary: Zinc is essential for various physiological processes in humans, and its deficiency can lead to impaired growth, immune function, taste maintenance, and neurological function. Patients with chronic kidney disease are at risk of zinc deficiency, which is associated with anemia, nutritional problems, cardiovascular diseases, and non-specific symptoms. Zinc supplementation may be beneficial, but it can cause copper deficiency and severe disorders. This review focuses on the roles of zinc and its association with complications in CKD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Lukas Lanser, Dietmar Fuchs, Hubert Scharnagl, Tanja Grammer, Marcus E. Kleber, Winfried Marz, Gunter Weiss, Katharina Kurz
Summary: The study found that anemia is associated with the severity and outcome of coronary artery disease, particularly in patients with elevated inflammatory markers.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Transplantation
Ahmed A. Awan, Carl P. Walther, Peter A. Richardson, Maulin Shah, Wolfgang C. Winkelmayer, Sankar D. Navaneethan
Summary: In patients with chronic kidney disease and anemia, absolute and functional iron deficiency anemia were associated with various clinical covariates. Functional IDA was linked to an increased risk of mortality and cardiovascular hospitalization, while absolute IDA was only associated with a higher risk of hospitalization.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Medicine, General & Internal
Tomas Ganz, Francesco Locatelli, Mustafa Arici, Tadao Akizawa, Michael Reusch
Summary: Roxadustat has a distinct impact on iron parameters and hemoglobin levels compared to erythropoiesis-stimulating agents (ESAs). It decreases serum ferritin levels to a greater extent and increases serum iron levels instead of decreasing them. The decrease in transferrin saturation in patients treated with Roxadustat is relatively small and is not observed in non-dialysis or dialysis-dependent chronic kidney disease (CKD) patients by Week 52. Roxadustat improves iron availability, increases erythropoiesis, and requires less intravenous iron use compared to placebo and ESA. Hepcidin levels generally decrease more significantly with Roxadustat than with ESA or placebo. The mechanisms underlying the effects of Roxadustat and ESAs on iron availability, stores, and erythropoiesis differ and should be considered holistically when treating CKD anemia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Kuo-Hua Lee, Yang Ho, Der-Cherng Tarng
Summary: Anemia is a common issue in patients with chronic kidney disease, and novel iron replacement therapies have shown to be effective in reducing medical costs and improving anemia in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Patricia Garcia-Ortega, Ines Jimenez-Lozano, Alejandro Cruz, Aurora Fernandez Polo, Mercedes Lopez, Gema Ariceta
Summary: This study retrospectively evaluated the safety and effectiveness of FCM treatment in pediatric patients with CKD non-dependent of hemodialysis. The results showed that FCM can improve anemia and is well-tolerated in pediatric patients with CKD, with a low incidence of adverse effects.
FRONTIERS IN PEDIATRICS
(2022)
Article
Transplantation
Evgeny Shutov, Wladyslaw Sulowicz, Ciro Esposito, Avtandil Tataradze, Branislav Andric, Michael Reusch, Udaya Valluri, Nada Dimkovic
Summary: The study demonstrated that Roxadustat is more effective than placebo in treating anemia in patients with chronic kidney disease. The treatment group showed significantly higher Hb response rate and Hb change from baseline compared to the placebo group.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Urology & Nephrology
Orlando M. Gutierrez
Summary: Iron deficiency is common in individuals with chronic kidney disease and can lead to the development of anemia. Oral iron agents may not be effective, and consideration should be given to using intravenous formulations. Recent studies suggest that more aggressive repletion of iron may provide benefits for anemia management and severe clinical outcomes such as cardiovascular disease.
KIDNEY INTERNATIONAL REPORTS
(2021)
Letter
Medicine, General & Internal
H. Franklin Bunn
Summary: The trials show convincing evidence that vadadustat is effective in treating anemia in patients with chronic kidney disease, compared to darbepoetin alfa which has prolonged life span in circulation.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Ashton C. Lai, Solomon W. Bienstock, Raman Sharma, Karl Skorecki, Frans Beerkens, Rajeev Samtani, Andrew Coyle, Tonia Kim, Usman Baber, Anton Camaj, David Power, Valentin Fuster, Martin E. Goldman
Summary: Cardiovascular disease is the leading cause of death in end-stage renal disease patients, exacerbated by dialysis treatment. Multimodality imaging may offer additional prognostication and risk stratification for these patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Pediatrics
Kelly Meza, Sharmi Biswas, Chantal Talmor, Kanza Baqai, Dmitry Samsonov, Sonia Solomon, Oleh Akchurin
Summary: Around 30% of children with chronic kidney disease do not respond to oral iron therapy for anemia. The severity of anemia at baseline is correlated with treatment response, suggesting the need for further studies to improve iron therapy outcomes and identify predictors of treatment response in children with anemia of CKD.
PEDIATRIC NEPHROLOGY
(2023)
Article
Health Care Sciences & Services
Pei-Hua Yu, Yu-Lin Chao, I-Ching Kuo, Sheng-Wen Niu, Yi-Wen Chiu, Jer-Ming Chang, Chi-Chih Hung
Summary: Iron deficiency is associated with poor renal outcomes in male or non-anemic patients with CKD stage 1-4. Iron status is not only related to anemia but also contributes to adverse consequences for the kidney. The study found that male patients with normal iron had a significantly decreased risk of renal outcomes, while female patients and anemic patients did not exhibit this association.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Yang Xu, Marie Evans, Faizan Mazhar, Johan Arnlov, Elinor Cockburn, Peter Barany, Juan-Jesus Carrero
Summary: Chinese patients with chronic kidney disease (CKD) receiving primary care often face limited awareness and treatment options for managing anemia, a common complication. This study found that a significant number of patients did not receive timely treatment after developing anemia, and anemia was associated with adverse cardiovascular events and death.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Barbara Olmeda, Begona Garcia-Alvarez, Manuel J. Gomez, Marta Martinez-Calle, Antonio Cruz, Jesus Perez-Gil
Article
Biochemistry & Molecular Biology
Marta Martinez-Calle, Barbara Olmeda, Paul Dietl, Manfred Frick, Jesus Perez-Gil
Article
Biochemistry & Molecular Biology
Elisa J. Cabre, Marta Martinez-Calle, Manuel Prieto, Alexander Fedorov, Barbara Olmeda, Luis M. S. Loura, Jesus Perez-Gil
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Biotechnology & Applied Microbiology
Laura Cervera, Sonia Gutierrez-Granados, Marta Martinez, Julia Blanco, Francesc Godia, Maria Mercedes Segura
JOURNAL OF BIOTECHNOLOGY
(2013)
Article
Biochemical Research Methods
Marta Martinez-Calle, Alejandro Alonso, Jesus Perez-Gil, Barbara Olmeda
JOURNAL OF PROTEOMICS
(2019)
Article
Biochemistry & Molecular Biology
Marta Martinez-Calle, Manuel Prieto, Barbara Olmeda, Aleksander Fedorov, Luis M. S. Loura, Jesus Perez-Gil
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2020)
Article
Biochemistry & Molecular Biology
Marta Martinez-Calle, Elisa Parra-Ortiz, Antonio Cruz, Barbara Olmeda, Jesus Perez-Gil
Summary: SP-B and SP-C play important roles in the permeability of surfactant membranes, with SP-C and anionic phospholipids identified as essential modulators for maintaining native-like permeability features. Proper permeability through membrane assemblies is crucial for the overall role of surfactant in maintaining alveolar equilibrium.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Meeting Abstract
Endocrinology & Metabolism
Marta Martinez-Calle, Guillaume Courbon, Connor Francis, Xueyan Wang, Bridget Hunt-Tobey, Jadeah Spindler, Sana Lynch, Aline Martin, Valentin David
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Biophysics
Marta Martinez-Calle, Elisa Parra, Barbara Olmeda, Jesus Perez-Gil
BIOPHYSICAL JOURNAL
(2017)
Article
Anatomy & Morphology
Barbara Olmeda, Marta Martinez-Calle, Jesus Perez-Gil
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2017)