Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 56, Issue -, Pages 45-51Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2020.06.007
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Funding
- National Institute of General Medical Sciences of the National Institutes of Health [K12GM081259]
- NIH [DP2AG067511]
- University of Pennsylvania Institute for Immunology, Center for Molecular Studies in Digestive and Liver Diseases
- Institute on Aging and Alzheimer's Disease
- Center for Excellence in Environmental Toxicology
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The biogeography of the mammalian intestine is remarkable in that a vast microbial consortium exists inside the organism, surrounded by intestinal epithelial cells. The microbiome and the intestinal epithelium have developed a complex network of interactions that maintain intestinal homeostasis. We now recognize that functions of the epithelium are compartmentalized in specific intestinal epithelial cell subtypes. Furthermore, we are beginning to understand the ways in which microbes and their metabolic products impact the specific epithelial subsets. Here, we survey the mechanisms utilized by the microbiome to regulate intestinal epithelial function, and inversely, how different epithelial cell subtypes cooperate in regulating the microbiome.
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