Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 62, Issue -, Pages 58-64Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2020.05.028
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Funding
- Burroughs Wellcome Fund Careers at the Scientific Interface
- Sloan Research fellowship
- Koret-UC Berkeley-Tel Aviv University Initiative in Computational Biology and Bioinformatics
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Germline mutations are the source of all heritable variation. In the past few years, whole genome sequencing has allowed direct and comprehensive surveys of mutation patterns in humans and other species. These studies have documented substantial variation in both mutation rates and spectra across primates, the causes of which remain unclear. Here, we review what is currently known about mutation rates in primates, highlight the factors proposed to explain the variation across species, and discuss some implications of these findings on our understanding of the chronology of primate evolution and the process of mutagenesis.
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