Article
Critical Care Medicine
Tatsuma Fukuda, Naoko Ohashi-Fukuda, Ryota Inokuchi, Yutaka Kondo, Takayuki Taira, Ichiro Kukita
Summary: This study analyzed nationwide registry data in Japan and found that delayed epinephrine administration was associated with lower 1-month neurologically favorable survival among out-of-hospital cardiac arrest patients.
Article
Critical Care Medicine
Deborah Wagner, S. L. Kronick, H. Nawer, J. A. Cranford, S. M. Bradley, R. W. Neumar
Summary: This retrospective cohort study compared the use of amiodarone and lidocaine in adult patients with in-hospital cardiac arrest from VT/VF. The study found that compared to amiodarone, lidocaine therapy was associated with significantly higher rates of ROSC, 24 h survival, survival to hospital discharge, and favorable neurologic outcome.
Review
Medicine, General & Internal
Wachira Wongtanasarasin, Karan Srisurapanont, Daniel K. Nishijima
Summary: Current guidelines recommend administering 1 mg of epinephrine every 3-5 min for cardiac arrest treatment. This study aimed to investigate the impact of different epinephrine administration intervals on resuscitation outcomes in adult patients. Three high-quality studies were included in the systematic review. The results showed that the administration interval of epinephrine during CPR was not associated with better hospital outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Ryan Morgan, Robert S. Berg, Ron M. Reeder, Todd Carpenter, Deborah M. Franzon, Aisha Frazier, Kathryn Graham, Kathleen P. Meert, Vinay Nadkarni, Maryam Naim, Bradley Tilford, Heather Wolfe, Andrew R. Yates, Robert F. Sutton
Summary: The change in diastolic blood pressure (DBP) following epinephrine administration during pediatric CPR was found to be associated with return of spontaneous circulation (ROSC) in responders, but not in non-responders.
Article
Medicine, General & Internal
Deborah Jaeger, Jonathan Koger, Helene Duhem, Caroline Fritz, Victor Jeangeorges, Kevin Duarte, Bruno Levy, Guillaume Debaty, Tahar Chouihed
Summary: The study compared the effects of reduced doses of adrenaline with the recommended 1 mg dose on CPP in a pig model of cardiac arrest. The results showed that the 0.25 mg dose did not achieve the threshold of 35 mmHg, while the 0.5 mg dose and the standard 1 mg dose did not have significant differences in CPP.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jun Nakajima, Yusuke Sawada, Yuta Isshiki, Yumi Ichikawa, Kazunori Fukushima, Yuto Aramaki, Kiyohiro Oshima
Summary: The prehospital administered dosage of epinephrine influences the plasma levels of Ep, but does not contribute to the plasma levels of norepinephrine (Nep), dopamine (DOA) and vasopressin (ADH) in patients with out-of-hospital cardiac arrest (OHCA).
Review
Critical Care Medicine
Amy Hooper, Jerry Nolan, Nigel Rees, Alison Walker, Gavin Perkins, Keith Couper
Summary: Recent evidence has sparked renewed interest in the optimal route for drug administration in adult out-of-hospital cardiac arrest. While current guidelines support the intravenous route, extensive variation exists in the use of the intraosseous route. Early administration of cardiac arrest drugs is associated with improved patient outcomes, but the time from administration to central circulation remains unclear. Comparative studies on intravenous and intraosseous drug administration are challenging due to potential bias and confounders, and randomized controlled trials are urgently needed.
Letter
Medicine, General & Internal
Olivier C. Manintveld, Stefan Roest, Yannick J. H. J. Taverne
Summary: In the study by Suverein et al., the use of extracorporeal cardiopulmonary resuscitation (CPR) in patients with refractory out-of-hospital cardiac arrest was examined. The results showed similar survival rates with a favorable neurologic outcome between extracorporeal CPR and conventional CPR. This raises questions about the role of extracorporeal CPR as an adjunct to conventional CPR.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Tomoaki Hashida, Nanami Hata, Akiko Higashi, Yoshito Oka, Shunsuke Otani, Eizo Watanabe
Summary: REBOA is used to treat hemorrhagic shock, but its use in patients with gastrointestinal hemorrhage is relatively rare. Appropriate patient selection and early use may improve survival in patients with upper gastrointestinal hemorrhage.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yunke Tan, Kai Yu, Lian Liang, Yuanshan Liu, Fengqing Song, Qiulin Ge, Xiangshao Fang, Tao Yu, Zitong Huang, Longyuan Jiang, Peng Wang
Summary: Empagliflozin, a newly developed antidiabetic drug, positively affects cardiac function in non-diabetic rats with acute myocardial dysfunction after cardiac arrest by reducing glucose levels and promoting ketone body oxidation metabolism. The study found that Empagliflozin can improve cardiac function, reduce myocardial damage, and increase cardiac energy metabolism.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Critical Care Medicine
Gavin D. Perkins, Keith Couper
Summary: The Chain of Survival emphasizes the importance of early recognition, calling for help, performing CPR, and early defibrillation in cardiac arrest cases. Despite these interventions, many patients still remain in cardiac arrest. Adrenaline is highly effective in achieving return of spontaneous circulation, but its effectiveness on long-term outcomes and neurological outcome remains uncertain. Vasopressin and high-dose adrenaline have not shown evidence of improved long-term outcomes. Trials to evaluate the interaction between steroids and vasopressin are needed. The use of other vasopressors is not supported by sufficient evidence. Routine use of intravenous calcium chloride is not beneficial and may cause harm. The optimal route for vascular access is still being studied.
Article
Cardiac & Cardiovascular Systems
Sebastian Wolfrum, Kevin Roedl, Alexia Hanebutte, Rudiger Pfeifer, Volkhard Kurowski, Reimer Riessen, Anne Daubmann, Stephan Braune, Gerold Soffker, Eric Bibiza-Freiwald, Karl Wegscheider, Heribert Schunkert, Holger Thiele, Stefan Kluge
Summary: This study found that hypothermic temperature control after IHCA did not improve survival nor functional outcome. The study may have been underpowered to detect clinically important differences between hypothermic temperature control and normothermia.
Article
Medicine, General & Internal
Masashi Okubo, Sho Komukai, Clifton W. Callaway, Junichi Izawa
Summary: This study investigated the association between timing of epinephrine administration and patient outcomes after out-of-hospital cardiac arrest (OHCA). The findings showed that delayed administration of epinephrine resulted in decreased survival rates for both shockable and nonshockable rhythms.
Article
Cardiac & Cardiovascular Systems
Martin Jonsson, Ellinor Berglund, Enrico Baldi, Maria Luce Caputo, Angelo Auricchio, Marieke T. Blom, Hanno L. Tan, Remy Stieglis, Linn Andelius, Fredrik Folke, Jacob Hollenberg, Leif Svensson, Mattias Ringh, ESCAPE NET Investigators
Summary: Activation of a volunteer responder system in cases of out-of-hospital cardiac arrest (OHCA) was associated with higher rates of bystander CPR, bystander defibrillation, and 30-day survival compared to no system activation. A randomized controlled trial is necessary to determine the causal effect of volunteer responder systems.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Critical Care Medicine
Rongrong Shen, Dong Pan, Zhengquan Wang, Xiaohong Jin, Zilong Li, Haojie Wang
Summary: Dexmedetomidine post-conditioning demonstrated significant improvement in cardiac and neurological outcomes post-resuscitation by reducing tissue inflammation, oxidative stress, and cell apoptosis and necroptosis. The protective effects were dose-dependent, with the high-dose group showing greater benefits compared to the low-dose group.
Article
Pediatrics
Myra H. Wyckoff, Robert Greif, Peter T. Morley, Kee-Chong Ng, Theresa M. Olasveengen, Eunice M. Singletary, Jasmeet Soar, Adam Cheng, Ian R. Drennan, Helen G. Liley, Barnaby R. Scholefield, Michael A. Smyth, Michelle Welsford, David A. Zideman, Jason Acworth, Richard Aickin, Lars W. Andersen, Diane Atkins, David C. Berry, Farhan Bhanji, Joost Bierens, Vere Borra, Bernd W. Bottiger, Richard N. Bradley, Janet E. Bray, Jan Breckwoldt, Clifton W. Callaway, Jestin N. Carlson, Pascal Cassan, Maaret Castren, Wei-Tien Chang, Nathan P. Charlton, Sung Phil Chung, Julie Considine, Daniela T. Costa-Nobre, Keith Couper, Thomaz Bittencourt Couto, Katie N. Dainty, Peter G. Davis, Maria Fernanda de Almeida, Allan R. de Caen, Charles D. Deakin, Therese Djarv, Michael W. Donnino, Matthew J. Douma, Jonathan P. Duff, Cody L. Dunne, Kathryn Eastwood, Walid El-Naggar, Jorge G. Fabres, Joe Fawke, Judith Finn, Elizabeth E. Foglia, Fredrik Folke, Elaine Gilfoyle, Craig A. Goolsby, Asger Granfeldt, Anne-Marie Guerguerian, Ruth Guinsburg, Karen G. Hirsch, Mathias J. Holmberg, Shigeharu Hosono, Ming-Ju Hsieh, Cindy H. Hsu, Takanari Ikeyama, Tetsuya Isayama, Nicholas J. Johnson, Vishal S. Kapadia, Mandira Daripa Kawakami, Han-Suk Kim, Monica Kleinman, David A. Kloeck, Peter J. Kudenchuk, Anthony T. Lagina, Kasper G. Lauridsen, Eric J. Lavonas, Henry C. Lee, Yiqun (Jeffrey) Lin, Andrew S. Lockey, Ian K. Maconochie, R. John Madar, Carolina Malta Hansen, Siobhan Masterson, Tasuku Matsuyama, Christopher J. D. McKinlay, Daniel Meyran, Patrick Morgan, Laurie J. Morrison, Vinay Nadkarni, Firdose L. Nakwa, Kevin J. Nation, Ziad Nehme, Michael Nemeth, Robert W. Neumar, Tonia Nicholson, Nikolaos Nikolaou, Chika Nishiyama, Tatsuya Norii, Gabrielle A. Nuthall, Brian J. O'Neill, Yong-Kwang Gene Ong, Aaron M. Orkin, Edison F. Paiva, Michael J. Parr, Catherine Patocka, Jeffrey L. Pellegrino, Gavin D. Perkins, Jeffrey M. Perlman, Yacov Rabi, Amelia G. Reis, Joshua C. Reynolds, Giuseppe Ristagno, Antonio Rodriguez-Nunez, Charles C. Roehr, Mario Rudiger, Tetsuya Sakamoto, Claudio Sandroni, Taylor L. Sawyer, Steve M. Schexnayder, Georg M. Schmolzer, Sebastian Schnaubelt, Federico Semeraro, Markus B. Skrifvars, Christopher M. Smith, Takahiro Sugiura, Janice A. Tijssen, Daniele Trevisanuto, Patrick Van de Voorde, Tzong-Luen Wang, Gary M. Weiner, Jonathan P. Wyllie, Chih-Wei Yang, Joyce Yeung, Jerry P. Nolan, Katherine M. Berg
Summary: This is the sixth annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. This summary addresses the most recent resuscitation evidence reviewed by the International Liaison Committee on Resuscitation Task Force science experts. Various topics, such as resuscitation during transport and after drowning, were covered and consensus treatment recommendations were generated based on the quality of evidence.
Editorial Material
Medicine, General & Internal
Asger Granfeldt, Mathias J. Holmberg, Lars W. Andersen
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Emergency Medicine
Cecilie Munch Johannsen, Casper Norholt, Cecilie Baltsen, Mark A. Eggertsen, Andreas Magnussen, Lasse Vormfenne, Signe ostergaard Mortensen, Esben Sovso Szocska Hansen, Lauge Vammen, Lars W. Andersen, Asger Granfeldt
Summary: This study evaluated the effect of methylene blue as a bolus on a clinically relevant pig model of cardiac arrest. The results showed that a bolus of methylene blue did not significantly improve hemodynamic function and did not have neuroprotective effects.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Review
Critical Care Medicine
Asger Granfeldt, Mathias J. Holmberg, Jerry P. Nolan, Jasmeet Soar, Lars W. Andersen
Summary: This article presents an updated systematic review and meta-analysis on temperature control in adult patients with cardiac arrest. The study found no improvement in survival or neurological outcomes with a target temperature control of 32-34°C compared to normothermia or 36°C. However, important knowledge gaps exist in areas such as temperature targets, rewarming rate, and fever control.
Article
Critical Care Medicine
Mathias J. Holmberg, Asger Granfeldt, Lars W. Andersen
Summary: In this study, the use of bicarbonate, calcium, and magnesium in in-hospital cardiac arrest patients and their association with survival rate were analyzed. The results showed that due to wide confidence intervals and inconsistencies in estimates across instrumental variables, the effects of these drugs are still uncertain, and randomized trials are needed for further investigation.
Correction
Critical Care Medicine
Mathias J. Holmberg, Asger Granfeldt, Spyros D. Mentzelopoulos, Lars W. Andersen
Article
Critical Care Medicine
Lars W. Andersen, Mathias J. Holmberg, Maria Hoybye, Dan Isbye, Jesper Kjaergaard, Soren Darling, Stine T. Zwisler, Jacob M. Larsen, Bodil S. Rasmussen, Kasper Iversen, Martin Schultz, Birthe Sindberg, Mikael Fink Valentin, Asger Granfeldt
Summary: The study aimed to evaluate the hemodynamic effects of vasopressin and methylprednisolone during the first 24 hours after return of spontaneous circulation (ROSC). The results showed no significant difference in mean arterial blood pressure, vasopressor use, or arterial blood gases between the group that received vasopressin and methylprednisolone and the placebo group within the first 24 hours after ROSC.
Article
Critical Care Medicine
Noa Berlin, Rahul Pawar, Xiaowen Liu, Lakshman Balaji, Andrea C. Morton, Jeremy Silverman, Franklin Li, Mahmoud S. Issa, Lara L. Roessler, Mathias J. Holmberg, Aditya C. Shekhar, Michael W. Donnino, Ari Moskowitz, Anne Grossestreuer
Summary: This study aimed to evaluate the performance of kidney-specific biomarkers in early detection of acute kidney injury (AKI) following cardiac arrest (CA). The results showed that creatinine, NGAL, and cystatin-C can predict AKI development better than KIM-1.
Article
Critical Care Medicine
Anne Kirstine Hoeyer-Nielsen, Mathias J. Holmberg, Anne V. Grossestreuer, Tuyen Yankama, Katherine M. Berg, Michael W. Donnino
Summary: This study assessed whether changes in oxygen consumption and other metabolic parameters could be used as an early warning system for clinical deterioration in mechanically ventilated patients. The results showed that the respiratory quotient increased significantly before an increase in lactate, suggesting its potential as an early marker. However, further studies are needed to evaluate its use in critical care settings.
Article
Critical Care Medicine
Carsten Meilandt, Mikael Fink Vallentin, Kristian Blumensaadt Winther, Allan Bach, Thomas H. Dissing, Steffen Christensen, Christian Juhl Terkelsen, Thomas Lass Klitgaard, Soren Mikkelsen, Fredrik Folke, Asger Granfeldt, Lars W. Andersen
Summary: This article describes the design of the IVIO trial in Denmark, which aims to compare the effectiveness of intravenous access and intraosseous access in patients with out-of-hospital cardiac arrest. The trial started in March 2022 and is expected to finish in the spring of 2024, with primary results anticipated in mid-2024.
RESUSCITATION PLUS
(2023)
Article
Cardiac & Cardiovascular Systems
Katherine M. Berg, Janet E. Bray, Kee-Chong Ng, Helen G. Liley, Robert Greif, Jestin N. Carlson, Peter T. Morley, Ian R. Drennan, Michael Smyth, Barnaby R. Scholefield, Gary M. Weiner, Adam Cheng, Therese Djaerv, Cristian Abelairas-Gomez, Jason Acworth, Lars W. Andersen, Dianne L. Atkins, David C. Berry, Farhan Bhanji, Joost Bierens, Thomaz Bittencourt Couto, Vere Borra, Bernd W. Boettiger, Richard N. Bradley, Jan Breckwoldt, Pascal Cassan, Wei-Tien Chang, Nathan P. Charlton, Sung Phil Chung, Julie Considine, Daniela T. Costa-Nobre, Keith Couper, Katie N. Dainty, Vihara Dassanayake, Peter G. Davis, Jennifer A. Dawson, Maria Fernanda de Almeida, Allan R. De Caen, Charles D. Deakin, Bridget Dicker, Matthew J. Douma, Kathryn Eastwood, Walid El-Naggar, Jorge G. Fabres, Joe Fawke, Nino Fijacko, Judith C. Finn, Gustavo E. Flores, Elizabeth E. Foglia, Fredrik Folke, Elaine Gilfoyle, Craig A. Goolsby, Asger Granfeldt, Anne-Marie Guerguerian, Ruth Guinsburg, Tetsuo Hatanaka, Karen G. Hirsch, Mathias J. Holmberg, Shigeharu Hosono, Ming-Ju Hsieh, Cindy H. Hsu, Takanari Ikeyama, Tetsuya Isayama, Nicholas J. Johnson, Vishal S. Kapadia, Mandira Daripa Kawakami, Han-Suk Kim, Monica E. Kleinman, David A. Kloeck, Peter Kudenchuk, Amy Kule, Hiroshi Kurosawa, Anthony T. Lagina, Kasper G. Lauridsen, Eric J. Lavonas, Henry C. Lee, Yiqun Lin, Andrew S. Lockey, Finlay Macneil, Ian K. Maconochie, R. John Madar, Carolina Malta Hansen, Siobhan Masterson, Tasuku Matsuyama, Christopher J. D. Mckinlay, Daniel Meyran, Vix Monnelly, Vinay Nadkarni, Firdose L. Nakwa, Kevin J. Nation, Ziad Nehme, Michael Nemeth, Robert W. Neumar, Tonia Nicholson, Nikolaos Nikolaou, Chika Nishiyama, Tatsuya Norii, Gabrielle A. Nuthall, Shinchiro Ohshimo, Theresa M. Olasveengen, Yong-Kwang Gene Ong, Aaron M. Orkin, Michael J. Parr, Catherine Patocka, Gavin D. Perkins, Jeffrey M. Perlman, Yacov Rabi, James Raitt, Shalini Ramachandran, Viraraghavan V. Ramaswamy, Tia T. Raymond, Amelia G. Reis, Joshua C. Reynolds, Giuseppe Ristagno, Antonio Rodriguez-Nunez, Charles C. Roehr, Mario Ruediger, Tetsuya Sakamoto, Claudio Sandroni, Taylor L. Sawyer, Steve M. Schexnayder, Georg M. Schmoelzer, Sebastian Schnaubelt, Federico Semeraro, Eunice M. Singletary, Markus B. Skrifvars, Christopher M. Smith, Jasmeet Soar, Willem Stassen, Takahiro Sugiura, Janice A. Tijssen, Alexis A. Topjian, Daniele Trevisanuto, Christian Vaillancourt, Myra H. Wyckoff, Jonathan P. Wyllie, Chih-Wei Yang, Joyce Yeung, Carolyn M. Zelop, David A. Zideman, Jerry P. Nolan, Roberto Barcala-Furelos, Stephen B. Beerman, Maaret Castren, Shuling Chong, Andreas Claesson, Cody L. Dunne, Hege L. Ersdal, Emer Finan, Janene Fuerch, Tatsuma Fukuda, Saptharishi Lalgudi Ganesan, Callum Gately, Seth Gray, Louis P. Halamek, Amber V. Hoover, Louise Kollander, C. Omar Kamlin, Mirjam Koo, Lei Li, Tina A. Leone, S. Mecrow, William Montgomery, Patrick Ristau, Muralidharan Jayashree, Bin Huey Quek, Andrew Schmidt, Tommaso Scquizzato, Jeroen Seesink, Justin Sempsrott, Birju A. Shah, Marya L. Strand, David Szpilman, Edgardo Szyld, Marta Thio, Ogilvie Thom, Joshua M. Tobin, Enrique Udaeta, Jonathon Webber, Hannah K. Webster, Michelle Wellsford, Nicole K. Yamada
Summary: The International Liaison Committee on Resuscitation conducts continuous reviews of new, peer-reviewed, published CPR and first aid science. They provide annual summaries of the Consensus on Science With Treatment Recommendations, covering a variety of topics and highlighting areas for further research.