Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 57, Issue -, Pages 75-81Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2020.04.020
Keywords
CRISPR/dCas; Epigenome editing; Targeted DNA methylation; Targeted histone modifications; Expression reprogramming
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Funding
- COST ACTION [CM1406]
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Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. Here, we review the current applications of these epigenetic editing tools in mammals and shed light on biochemical improvements that facilitate versatile applications.
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