Review
Neurosciences
Kathleen Forero, Raghad Buqaileh, Clare Sunderman, Wissam Aboualaiwi
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a newly emerged coronavirus, has caused a global pandemic due to its airborne transmission and ability to infect asymptomatic patients. The binding of angiotensin converting enzyme 2 (ACE2) receptors in various body organs is believed to be the key in its pathophysiology. This article reviews the symptoms of COVID-19, with a focus on neurological symptoms, and discusses the possible mechanisms of SARS-CoV-2 virus infection in the body.
Article
Clinical Neurology
Ettore Beghi, Elena Moro, Eugenia Irene Davidescu, Bogdan Ovidiu Popescu, Oxana Grosu, Franco Valzania, Maria Sofia Cotelli, Gordana Kiteva-Trenchevska, Maria Zakharova, Tibor Kovacs, Carmel Armon, Waldemar Brola, Clarissa Lin Yasuda, Luis F. Maia, Arijana Lovrencic-Huzjan, Mafalda Maria Laracho de Seabra, Rafael Avalos-Pavon, Anne Hege Aamodt, Sara Meoni, Victoria Gryb, Serefnur Ozturk, Omer Karadas, Ingomar Krehan, Maurizio A. Leone, Maria Lolich, Elisa Bianchi, Verena Rass, Raimund Helbok, Claudio L. A. Bassetti
Summary: The study aims to assess the neurological complications of SARS-CoV-2 infection and compare phenotypes and outcomes in infected patients with and without neurological manifestations. Data from a registry established by the European Academy of Neurology during the first wave of the COVID-19 pandemic were analyzed. Results showed that 79.6% of COVID-19-infected patients had neurological manifestations, with cognitive dysfunction and stroke being the most common. These manifestations were associated with age, comorbidities, and infection severity.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Jaeseok Park, Yong-Shik Kwon, Hyun-Ah Kim, Doo-Hyuk Kwon, Jihye Hwang, Seong-Hwa Jang, Hyungjong Park, Sung-Il Sohn, Huimahn Alex Choi, Jeong-Ho Hong
Summary: Neurological problems in COVID-19 ICU patients, both preexisting conditions and new-onset complications, are associated with increased mortality risk and medical complications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Critical Care Medicine
Ghazal Aghagoli, Benjamin Gallo Marin, Nicole J. Katchur, Franz Chaves-Sell, Wael F. Asaad, Sarah A. Murphy
Summary: This review synthesizes the literature on the neurological impact of COVID-19, highlighting potential neurologic manifestations and mechanisms, and emphasizes the importance of understanding and mitigating SARS-CoV-2-associated neurologic injury.
NEUROCRITICAL CARE
(2021)
Article
Medicine, General & Internal
Dicle Sener Okur
Summary: There is limited evidence on the neurological effects of SARS-CoV-2 in children. This study aimed to identify and manage neurological symptoms in pediatric patients with COVID-19 and plan future follow-ups. Headache, seizure, and anosmia/hyposmia were the major neurological manifestations. Girls and older children were more likely to experience anosmia and headache. Pulmonary and hematologic involvement was more common in children with anosmia and headache. This study provides valuable insights into the neurological involvement in COVID-19 in children.
Article
Neurosciences
Avindra Nath, Bryan Smith
Summary: COVID-19 has significantly impacted the healthcare system, with neurological manifestations being common among infected patients. While the pathophysiology is not well understood, many clinical manifestations seem to be immune mediated.
NEUROSCIENCE LETTERS
(2021)
Article
Medicine, General & Internal
Jan Van Slambrouck, Mona Khan, Erik Verbeken, Sumin Choi, Vincent Geudens, Cedric Vanluyten, Simon Feys, Emiel Vanhulle, Elke Wollants, Kurt Vermeire, Charlotte De Fays, Lucia Aversa, Janne Kaes, Dirk Van Raemdonck, Robin Vos, Bart Vanaudenaerde, Gert De Hertogh, Els Wauters, Joost Wauters, Laurens J. Ceulemans, Peter Mombaerts
Summary: A study introduces a methodology for visualizing the replication of SARS-CoV-2 in the lungs at single-cell resolution. The method utilizes fluorescence staining and confocal imaging to observe viral replication in histological sections. This technique can be valuable for studying SARS-CoV-2 variants and other respiratory viruses.
Review
Biochemistry & Molecular Biology
Michael J. Strong
Summary: As the world continues to battle the COVID-19 pandemic, there is growing evidence suggesting that the long-term neurological sequelae of the viral infection will be significant and enduring. This pandemic is unique due to its impact on an aging population, putting survivors at increased risk of developing neurodegenerative conditions. The SARS-CoV-2 virus itself, as well as its key proteins, have been implicated in potential neurodegenerative processes.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Clinical Neurology
Alberto Romagnolo, Roberta Balestrino, Gabriele Imbalzano, Giovannino Ciccone, Franco Riccardini, Carlo Alberto Artusi, Marco Bozzali, Bruno Ferrero, Elisa Montalenti, Elisa Montanaro, Mario Giorgio Rizzone, Giovanna Vaula, Maurizio Zibetti, Leonardo Lopiano
Summary: This study evaluated the prevalence of neurological comorbidities in COVID-19 patients and found that neurological comorbidity is associated with COVID-19 severity. Patients with cerebrovascular diseases and cognitive impairment are particularly at higher risk for severe COVID-19.
JOURNAL OF NEUROLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Gabor Tamas Szabo, Azita Josefine Mahiny, Irena Vlatkovic
Summary: Since the discovery of the advantages of mRNA vaccines nearly 30 years ago, significant progress has been made in this field. The development of COVID-19 vaccines using mRNA technology has achieved unprecedented success globally, demonstrating the safety and effectiveness of mRNA vaccines in combating COVID-19 and highlighting their potential for other infectious diseases and medical conditions.
Article
Behavioral Sciences
Nahid Abbasi Khoshsirat, Mostafa Qorbani, Ali Mokhtari Farivar, Sahar Mohammadpoor Nami, Nami Mohammadian Khonsari
Summary: During the COVID-19 pandemic, in-hospital mortality caused by neurological disorders significantly increased, with higher mortality rates seen in patients infected with COVID-19. Patients with minor strokes and other non-life-threatening ailments avoiding hospital care led to a significantly higher rate of critical conditions. Increased incidence of strokes and intracerebral hemorrhages during the pandemic also contributed to a significant rise in in-hospital mortality.
BRAIN AND BEHAVIOR
(2021)
Review
Clinical Neurology
David Garcia-Azorin, Katrin M. Seeher, Charles R. Newton, Njideka U. Okubadejo, Andrea Pilotto, Deanna Saylor, Andrea Sylvia Winkler, Chahnez Charfi Triki, Matilde Leonardi
Summary: This rapid review found that the COVID-19 pandemic had a significant impact on neurological services, with cross-sectoral neurological services being most severely disrupted. The study highlights the need for effective mitigation strategies, such as telemedicine, to address the negative effects of the pandemic on neurological care.
JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, General & Internal
Giacomo Tondo, Davide Aprile, Fabiana Tesser, Cristoforo Comi
Summary: During the COVID-19 pandemic, there was a significant increase in neuropsychiatric disorders in non-deferrable neurological evaluations, indicating a need for more complex management. Meanwhile, the number of patients seeking evaluation for cerebrovascular disorders, headache, and vertigo decreased noticeably during the lockdown period.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Javier Molina-Gil, Lucia Gonzalez-Fernandez, Carmen Garcia-Cabo
Summary: A 65-year-old man presented with general malaise and respiratory symptoms of COVID-19, along with paroxysmal lancinating pain in the trigeminal territory. Blood tests and neuroimaging were normal, with positive IgG and IgM for SARS-CoV-2. The patient was diagnosed with TN secondary to the viral infection.
Article
Clinical Neurology
Shivam Bhola, Jhillika Trisal, Vikram Thakur, Parneet Kaur, Saurabh Kulshrestha, Shashi Kant Bhatia, Pradeep Kumar
Summary: This review focuses on the various neurological disorders associated with the central nervous system and peripheral nervous system in relation to the COVID-19 disease caused by the SARS-CoV-2 virus. It examines disorders such as cytokine release syndrome, encephalitis, acute stroke, Bell's palsy, as well as psychological manifestations. The review also explores cognitive impairment, drug addiction disorders, mood and anxiety disorders, and post-traumatic stress disorder. The exact association and mechanism of the SARS-CoV-2 virus with neurological disorders are yet to be clarified, highlighting the need for further research to understand the neurological impact of COVID-19.
NEUROLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hanin Abdulbaset Abo Taleb, Badrah Saeed Alghamdi
JOURNAL OF MOLECULAR NEUROSCIENCE
(2020)
Article
Public, Environmental & Occupational Health
Badrah S. Alghamdi, Yasser Alatawi, Fahad S. Alshehri, Haythum O. Tayeb, Hanin AboTaleb, Amal Binsalman
Summary: This study investigates the effects of strict national regulations related to the COVID-19 pandemic on mental health among Saudi residents. The results indicate that the COVID-19 outbreak has led to psychological distress, with healthcare workers experiencing higher levels of stress. Variables such as age, gender, and history of contact with confirmed COVID-19 cases are significantly associated with higher psychological distress scores. Urgent public health interventions are needed to disseminate sufficient and targeted health information in order to mitigate the psychological impact of the COVID-19 pandemic.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Neurosciences
Hanin Abdulbaset AboTaleb, Majed Mohammad Al-Hayani, Badrah Saeed Alghamdi
Summary: The study evaluated disability in Saudi migraine patients and its relation to social factors, finding that most migraineurs in Saudi Arabia had severe disability according to the MIDAS score. Gender, regular exercise, disease severity, and attack frequency were significantly associated with migraine-related disabilities.
ARCHIVES OF NEUROSCIENCE
(2021)
Article
Neurosciences
Badrah Saeed Alghamdi, Hanin Abdulbaset AboTaleb
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2020)
Review
Respiratory System
Hanin Abdulbaset Abo Taleb
CURRENT RESPIRATORY MEDICINE REVIEWS
(2019)
