Article
Peripheral Vascular Disease
In-Chang Hwang, Chee Hae Kim, Jae-Young Kim, Hong-Mi Choi, Yeonyee E. Yoon, Goo-Yeong Cho
Summary: The incremental 10-year risk of atherosclerotic cardiovascular disease (ASCVD) is associated with the risk of future ASCVD events, indicating the success or failure in controlling major cardiovascular risk factors. Effective control of risk factors leads to lower ASCVD event rates, whereas failure to control these risk factors results in higher ASCVD event rates.
Review
Cardiac & Cardiovascular Systems
Nisha I. Parikh, Juan M. Gonzalez, Cheryl A. M. Anderson, Suzanne E. Judd, Kathryn M. Rexrode, Mark A. Hlatky, Erica P. Gunderson, Jennifer J. Stuart, Dhananjay Vaidya
Summary: This statement summarizes the impact of adverse pregnancy outcomes on women's risk of cardiovascular disease and highlights the importance of recognizing this impact. Lifestyle interventions such as adopting a heart-healthy diet and increasing physical activity can help reduce CVD risk. Further research on non-White women is needed to address health disparities and inform recommendations for primary CVD prevention.
Article
Public, Environmental & Occupational Health
Lily D. Yan, Jean Lookens Pierre, Vanessa Rouzier, Michel Theard, Alexandra Apollon, Stephano St Preux, Justin R. Kingery, Kenneth A. Jamerson, Marie Deschamps, Jean W. Pape, Monika M. Safford, Margaret L. McNairy
Summary: In this study conducted in Haiti, six existing cardiovascular disease (CVD) risk prediction models were compared, showing significant variation in identifying high-risk groups and statin eligibility. The findings suggest a need to develop and validate CVD risk prediction tools for low-middle income countries that incorporate locally relevant risk factors. The results have important implications for making appropriate treatment recommendations and public health policies.
Article
Medicine, Research & Experimental
Jiayi Yi, Lili Wang, Xinli Guo, Xiangpeng Ren
Summary: This study analyzed data from seven community-based prospective cohort studies to investigate the influence of historical cardiovascular risk status on future risk of atherosclerotic cardiovascular disease (ASCVD). The results showed that individuals with different historical cardiovascular disease (CVD) risks but the same current CVD risk status exhibited varying risks of future ASCVD incidents. Therefore, incorporating historical risk status into cardiovascular risk stratification can enable more accurate risk evaluation and inform decision-making regarding preventive interventions.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Anurag Mehta, Nestor Vasquez, Colby R. Ayers, Jaideep Patel, Ananya Hooda, Amit Khera, Roger S. Blumenthal, Michael D. Shapiro, Carlos J. Rodriguez, Michael Y. Tsai, Laurence S. Sperling, Salim S. Virani, Michael J. Blaha, Parag H. Joshi
Summary: Elevated lipoprotein(a) and coronary artery calcium are independently associated with ASCVD risk, and may be concurrently useful in guiding primary prevention therapy decisions, as demonstrated in the MESA and DHS cohorts.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Clinical Neurology
Ralph K. Akyea, Yana Vinogradova, Nadeem Qureshi, Riyaz S. Patel, Evangelos Kontopantelis, George Ntaios, Folkert W. Asselbergs, Joe Kai, Stephen F. Weng
Summary: The study found that in the UK, the incidence of initial stroke and subsequent major adverse outcomes is higher in women, older populations, and people living in socially deprived areas.
Article
Cardiac & Cardiovascular Systems
Katrina K. Poppe, Sue Wells, Rod Jackson, Robert N. Doughty, Andrew J. Kerr
Summary: This study developed a CVD risk score for individuals with ASCVD to complement existing scores for primary prevention. The median CVD risk for those with ASCVD is eight times higher than those without, but there is overlap and the widest distribution of CVD risk is among individuals with ASCVD.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sadiya S. Khan, Lucia C. Petito, Xiaoning Huang, Katharine Harrington, Rebecca B. McNeil, Natalie A. Bello, C. Noel Bairey Merz, Eliza C. Miller, Rupa Ravi, Christina Scifres, Janet M. Catov, Victoria L. Pemberton, Jasmina Varagic, Phyllis C. Zee, Lynn M. Yee, Mitali Ray, Jin Kyung Kim, Abbi D. Lane-Cordova, Jennifer Lewey, Lauren H. Theilen, George R. Saade, Philip Greenland, William A. Grobman
Summary: This study found a significant association between early pregnancy obesity and postpartum hypertension, hyperlipidemia, and diabetes risk. Adverse pregnancy outcomes were related to increased incidence of postpartum hypertension and hyperlipidemia. However, these adverse pregnancy outcomes only partially mediated the association between early pregnancy obesity and postpartum hypertension.
CIRCULATION RESEARCH
(2023)
Article
Medicine, General & Internal
In Sun Ryou, Ju Young Kim, Hwa Yeon Park, Sohee Oh, Sehun Kim, Hwa Jung Kim
Summary: The study found that the risk of MACE incidence decreased in statin users, but increased for low-risk statin users, with no significant relationship identified for intermediate and borderline risk groups. The risk of MACE incidence decreased only in the high CVD risk group among statin users.
FRONTIERS IN MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Aardra Rajendran, Anum S. Minhas, Brigitte Kazzi, Bhavya Varma, Eunjung Choi, Aarti Thakkar, Erin D. Michos
Summary: Cardiovascular disease is the leading cause of mortality for women globally, and there are sex differences in the relative risks conferred by traditional risk factors as well as female-specific risk factors. Assessing both traditional and female-specific factors is important for a comprehensive overview of cardiovascular risk and guiding preventive interventions.
Article
Cardiac & Cardiovascular Systems
Fang Zhu, Banafsheh Arshi, Maarten J. G. Leening, Elif Aribas, M. Arfan Ikram, Eric Boersma, M. Kamran Ikram, Maryam Kavousi
Summary: This study aimed to evaluate the sex-specific predictive value of NT-proBNP, hs-cTnT, and CK-MB for 10-year risk prediction of CHD, stroke, HF, and composite outcomes. The results showed that NT-proBNP and hs-cTnT provided added predictive value for various cardiovascular outcomes above traditional risk factors and there were sex differences in the predictive performance of these biomarkers.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Alexandre Vallee
Summary: The objective of this study was to investigate the sex correlations of particulate matters (PM2.5, PM10, PM2.5-10), NO2 and NOx with ASCVD risk in the UK Biobank population. The findings showed that males had a higher ASCVD risk than females, and air pollutants such as particulate matters and nitrogen oxides were positively associated with ASCVD risk, while PM2.5-10 showed no significant association with ASCVD risk.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
EIena I. Usova, Asiiat S. Alieva, Alexey N. Yakovlev, Madina S. Alieva, Alexey A. Prokhorikhin, Alexandra O. Konradi, Evgeny V. Shlyakhto, Paolo Magni, Alberico L. Catapano, Andrea Baragetti
Summary: Genetics, environmental and lifestyle factors greatly impact cardiovascular diseases, with atherosclerosis as the etiopathological factor. Novel omic approaches can enhance accurate prediction and risk assessment of ACVD, with the use of genomics expanding therapeutic potential and omics presenting a forward step in this direction. AI/ML strategies are essential for analyzing data and developing predictive models for ACVD diagnosis and prediction.
Article
Peripheral Vascular Disease
Sukainah Al Khalaf, Lucy C. C. Chappell, Ali S. S. Khashan, Fergus P. P. McCarthy, Eilis J. O'Reilly
Summary: There is a strong association between chronic hypertension and the risk of cardiovascular disease (CVD) in mothers, especially those with adverse pregnancy outcomes (APOs). This risk can lead to premature CVD, thus intervention programs targeting these high-risk groups might reduce their risk of subsequent CVD.
Article
Cardiac & Cardiovascular Systems
Steven Hageman, Lisa Pennells, Francisco Ojeda, Stephen Kaptoge, Kari Kuulasmaa, Tamar de Vries, Zhe Xu, Frank Kee, Ryan Chung, Angela Wood, John William McEvoy, Giovanni Veronesi, Thomas Bolton, Paul Dendale, Brian A. Ference, Martin Halle, Adam Timmis, Panos Vardas, John Danesh, Ian Graham, Veikko Salomaa, Frank Visseren, Dirk De Bacquer, Stefan Blankenberg, Jannick Dorresteijn, Emanuele Di Angelantonio, Stephan Achenbach, Krasimira Aleksandrova, Pilar Amiano, Philippe Amouyel, Jonas Andersson, Stephan J. L. Bakker, Rui Bebiano Da Providencia Costa, Joline W. J. Beulens, Michael Blaha, Martin Bobak, Jolanda M. A. Boer, Catalina Bonet, Fabrice Bonnet, Marie-Christine Boutron-Ruault, Tonje Braaten, Hermann Brenner, Fabian Brunner, Eric J. Brunner, Mattias Brunstrom, Julie Buring, Adam S. Butterworth, Nadezda Capkova, Giancarlo Cesana, Christina Chrysohoou, Sandra Colorado-Yohar, Nancy R. Cook, Cyrus Cooper, Christina C. Dahm, Karina Davidson, Elaine Dennison, Augusto Di Castelnuovo, Chiara Donfrancesco, Marcus Doerr, Agnieszka Dorynska, Mats Eliasson, Gunnar Engstrom, Pietro Ferrari, Marco Ferrario, Ian Ford, Michael Fu, Ron T. Gansevoort, Simona Giampaoli, Richard F. Gillum, Agustin Gomez de la Camara, Guido Grassi, Per-Olof Hansson, Radu Huculeci, Kristian Hveem, Licia Iacoviello, M. Kamran Ikram, Torben Jorgensen, Bijoy Joseph, Pekka Jousilahti, J. Wouter Jukema, Rudolf Kaaks, Verena Katzke, Maryam Kavousi, Stefan Kiechl, Jens Klotsche, Wolfgang Koenig, Richard A. Kronmal, Ruzena Kubinova, Anna Kucharska-Newton, Kristi Lall, Nils Lehmann, David Leistner, Allan Linneberg, David Lora Pablos, Thiess Lorenz, Wentian Lu, Dalia Luksiene, Magnus Lyngbakken, Christina Magnussen, Sofia Malyutina, Alejandro Marin Ibanez, Giovanna Masala, Ellisiv B. Mathiesen, Kuni Matsushita, Tom W. Meade, Olle Melander, Haakon E. Meyer, Karel G. M. Moons, Conchi Moreno-Iribas, David Muller, Thomas Muenzel, Yury Nikitin, Borge G. Nordestgaard, Torbjorn Omland, Charlotte Onland, Kim Overvad, Chris Packard, Andrzej Pajak, Luigi Palmieri, Demosthenes Panagiotakos, Salvatore Panico, Aurora Perez-Cornago, Annette Peters, Arto Pietila, Hynek Pikhart, Bruce M. Psaty, Fosca Quarti-Trevano, J. Ramon Quiros Garcia, Elio Riboli, Paul M. Ridker, Beatriz Rodriguez, Miguel Rodriguez-Barranco, Annika Rosengren, Ronan Roussel, Carlotta Sacerdote, Susana Sans, Naveed Sattar, Catarina Schiborn, Boerge Schmidt, Ben Schoettker, Matthias Schulze, Joseph E. Schwartz, Randi Marie Selmer, Steven Shea, Martin J. Shipley, Sabina Sieri, Stefan Soderberg, Reecha Sofat, Abdonas Tamosiunas, Barbara Thorand, Taavi Tillmann, Anne Tjonneland, Tammy Y. N. Tong, Antonia Trichopoulou, Rosario Tumino, Hugh Tunstall-Pedoe, Anne Tybjaerg-Hansen, Joanna Tzoulaki, Amber van der Heijden, Yvonne T. van der Schouw, W. M. Monique Verschuren, Henry Voelzke, Christoph Waldeyer, Nicholas J. Wareham, Elisabete Weiderpass, Franz Weidinger, Philipp Wild, Johann Willeit, Peter Willeit, Tom Wilsgaard, Mark Woodward, Tanja Zeller, Dudan Zhang, Bin Zhou
Summary: The study aimed to develop, validate, and demonstrate an updated prediction model (SCORE2) to estimate 10-year cardiovascular disease risk in individuals without previous history of CVD or diabetes in Europe. The new algorithm, SCORE2, enhances the identification of individuals at higher risk of developing CVD across Europe by predicting first-onset CVD risk in European populations.
EUROPEAN HEART JOURNAL
(2021)
Article
Medicine, General & Internal
Peter A. Glynn, Hongyan Ning, Aakash Bavishi, Priya M. Freaney, Sanjiv Shah, Clyde W. Yancy, Donald M. Lloyd-Jones, Sadiya S. Khan
Summary: The study found that the average predicted 10-year heart failure risk in the US population significantly increased from 1999 to 2016, particularly among non-Hispanic black and white men. In 2013-2016, 17.6% of the studied population were at high predicted 10-year heart failure risk, with non-Hispanic black men having the highest prevalence.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Arjun Sinha, Yinan Zheng, Drew Nannini, Yishu Qu, Lifang Hou, Sanjiv J. Shah, Clyde W. Yancy, Elizabeth M. McNally, Myriam Fornage, Joao Lima, Donald M. Lloyd-Jones, Laura J. Rasmussen-Torvik, Sadiya S. Khan
Summary: This study focused on 875 Black participants from the Coronary Artery Risk Development in Young Adults cohort to investigate the association between the V122I TTR genetic variant and cardiac structure and function in middle age individuals without heart failure. The findings revealed a significant link between the TTR V122I variant and worse left ventricular structure and cardiac mechanics at an average age of 54 years, suggesting that early screening with echocardiography in Black middle-aged adults carrying the TTR V122I variant can help guide the use of novel therapies and risk factor modification to prevent or delay heart failure.
Article
Gastroenterology & Hepatology
Lisa B. VanWagner, Blessing Aghaulor, Tasmeen Hussain, Megan Kosirog, Patrick Campbell, Stewart Pine, Amna Daud, Daniel J. Finn, Josh Levitsky, Donald M. Lloyd-Jones, Jane L. Holl
Summary: The Northwestern Method (c) is a mixed-methods approach used for developing clinical-practice guidance in the absence of condition-specific evidence. This method involves adaptation of existing guidelines, expert consensus, identification of barriers, and recommendations for implementation, with a focus on the needs and limitations of all end users. This user-centered approach aims to achieve sustainable implementation of guidance statements into clinical practice by involving end users in the guidance-development process.
GASTROENTEROLOGY REPORT
(2021)
Review
Peripheral Vascular Disease
Michael C. Wang, Donald M. Lloyd-Jones
Summary: Hypertension, a leading risk factor for cardiovascular disease, can be effectively managed through quantitative cardiovascular risk assessment and global risk prediction equations. Both short-term and long-term blood pressure patterns are associated with incident CVD, and adjunctive biomarkers show promise in refining risk assessment strategies. Implementation of quantitative risk assessment for CVD is facilitated by tools and electronic health record integrations, emphasizing the need for ongoing innovation in risk assessment methods.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
Arjun Sinha, Hongyan Ning, Mercedes R. Carnethon, Norrina B. Allen, John T. Wilkins, Donald M. Lloyd-Jones, Sadiya S. Khan
Summary: By studying race and sex groups, it was found that hypertension had the highest population attributable fraction (PAF) for HF in Black men and women, while obesity had the highest PAF in White men and women. Diabetes contributed disproportionately to HF in Black women. The cumulative PAF of all 5 risk factors was the highest in Black women.
CIRCULATION-HEART FAILURE
(2021)
Article
Endocrinology & Metabolism
Kyeezu Kim, Brian T. Joyce, Yinan Zheng, Pamela J. Schreiner, David R. Jacobs, Janet M. Catov, James M. Shikany, Mercedes R. Carnethon, Philip Greenland, Linda V. Van Horn, Norrina B. Allen, Donald M. Lloyd-Jones, Erica P. Gunderson, Lifang Hou
Summary: The study found that DNA methylation-based biological age is positively associated with the risk of type 2 diabetes, particularly among obese individuals. Additionally, GrimAge partially mediates the association between cumulative obesity and diabetes or prediabetes.
Article
Peripheral Vascular Disease
Hokyou Lee, Yuichiro Yano, So Mi Jemma Cho, Ji Eun Heo, Dong-Wook Kim, Sungha Park, Donald M. Lloyd-Jones, Hyeon Chang Kim
Summary: Treatment and control rates for high blood pressure are unsatisfactory among young adults, with poor adherence to pharmacological treatment associated with higher risk for future cardiovascular events.
Editorial Material
Cardiac & Cardiovascular Systems
Priya M. Freaney, Donald M. Lloyd-Jones, Sadiya S. Khan
Letter
Cardiac & Cardiovascular Systems
Hokyou Lee, Yuichiro Yano, So Mi Jemma Cho, Hyeok-Hee Lee, Dong-Wook Kim, Donald M. Lloyd-Jones, Hyeon Chang Kim
Summary: Supplemental digital content is available within the text.
Editorial Material
Cardiac & Cardiovascular Systems
Keith Churchwell, Donald M. Lloyd-Jones, Allyson L. Frazier
Article
Medicine, General & Internal
Nilay S. Shah, Michael C. Wang, Priya M. Freaney, Amanda M. Perak, Mercedes R. Carnethon, Namratha R. Kandula, Erica P. Gunderson, Kai McKeever Bullard, William A. Grobman, Matthew J. O'Brien, Sadiya S. Khan
Summary: The gestational diabetes rates increased among individuals with a singleton first live birth in the US from 2011 to 2019, with differences observed across racial and ethnic subgroups. This cross-sectional study used data from the National Center for Health Statistics to analyze these trends.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Transplantation
Patrick T. Campbell, Megan Kosirog, Blessing Aghaulor, Dyanna Gregory, Stewart Pine, Amna Daud, Arighno Das, Daniel J. Finn, Josh Levitsky, Jane L. Holl, Donald M. Lloyd-Jones, Lisa B. VanWagner
Summary: This study found that in liver transplant recipients, the prevalence of CKD or CKD risk increased annually while the management by nephrologists decreased yearly. Results suggest that nephrology comanagement may help reduce the occurrence of cardiovascular events.
TRANSPLANTATION DIRECT
(2021)
Article
Genetics & Heredity
Anna Mikhaylova, Caitlin P. McHugh, Linda M. Polfus, Laura M. Raffield, Meher Preethi Boorgula, Thomas W. Blackwell, Jennifer A. Brody, Jai Broome, Nathalie Chami, Ming-Huei Chen, Matthew P. Conomos, Corey Cox, Joanne E. Curran, Michelle Daya, Lynette Ekunwe, David C. Glahn, Nancy Heard-Costa, Heather M. Highland, Brian D. Hobbs, Yann Ilboudo, Deepti Jain, Leslie A. Lange, Tyne W. Miller-Fleming, Nancy Min, Jee-Young Moon, Michael H. Preuss, Jonathon Rosen, Kathleen Ryan, Albert Smith, Quan Sun, Praveen Surendran, Paul S. de Vries, Klaudia Walter, Zhe Wang, Marsha Wheeler, Lisa R. Yanek, Xue Zhong, Goncalo R. Abecasis, Laura Almasy, Kathleen C. Barnes, Terri H. Beaty, Lewis C. Becker, John Blangero, Eric Boerwinkle, Adam S. Butterworth, Sameer Chavan, Michael H. Cho, Helene Choquet, Adolfo Correa, Nancy Cox, Dawn L. DeMeo, Nauder Faraday, Myriam Fornage, Robert E. Gerszten, Lifang Hou, Andrew D. Johnson, Eric Jorgenson, Robert Kaplan, Charles Kooperberg, Kousik Kundu, Cecelia A. Laurie, Guillaume Lettre, Joshua P. Lewis, Bingshan Li, Yun Li, Donald M. Lloyd-Jones, Ruth J. F. Loos, Ani Manichaikul, Deborah A. Meyers, Braxton D. Mitchell, Alanna C. Morrison, Debby Ngo, Deborah A. Nickerson, Suraj Nongmaithem, Kari E. North, Jeffrey R. O'Connell, Victor E. Ortega, Nathan Pankratz, James A. Perry, Bruce M. Psaty, Stephen S. Rich, Nicole Soranzo, Jerome Rotter, Edwin K. Silverman, Nicholas L. Smith, Hua Tang, Russell P. Tracy, Timothy A. Thornton, Ramachandran S. Vasan, Joe Zein, Rasika A. Mathias, Alexander P. Reiner, Paul L. Auer
Summary: Through imputation on large-scale reference panels, this study discovered various common and rare variants associated with hematologic traits, including some affecting leukocyte counts. GWAS on different types of leukocytes revealed new associations, such as potential links between certain variants and reduced risk of allergic diseases.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Rheumatology
Kaveh Ardalan, Donald M. Lloyd-Jones, Laura E. Schanberg
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2022)
Review
Cardiac & Cardiovascular Systems
Philip Greenland, Donald M. Lloyd-Jones
Summary: Coronary artery calcium testing is best utilized in selected patients at intermediate risk of ASCVD, where it can help reclassify risk effectively and improve the targeting of drug therapy.