Article
Cell Biology
Nian Zhang, Yunwei Hua, Yunfeng Li, Jian Pan
Summary: This study demonstrated that local administration of Sema3A significantly accelerated bone regeneration, improved angiogenesis, and enhanced the biomechanical strength of callus during distraction osteogenesis. Sema3A showed directional effects on angiogenesis in in vivo and in vitro experiments, making it a potential therapeutic option for DO.
CONNECTIVE TISSUE RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Yanshi Liu, Feiyu Cai, Kai Liu, Jialin Liu, Xiaoxu Zhang, Aihemaitijiang Yusufu
Summary: The CDC technique has been found to improve bone regeneration during distraction osteogenesis, with better outcomes achieved by increasing the amplitude and slowing down the rate of the technique. The mechanism may involve the activation of the HIF pathway and enhancement of the osteogenic-angiogenic coupling.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell Biology
Ze Liu, Qi Liu, Hongbin Guo, Jieyu Liang, Yi Zhang
Summary: Distraction osteogenesis (DO) is a bone regeneration technology that promotes new bone formation through continuous and stable traction force. However, the long consolidation course of DO can lead to complications. Current treatment strategies include gene, growth factor, stem-cell, physical, and pharmacological therapies, with physical and pharmacological therapies being considered safe and effective. Recent research provides evidence for the effectiveness of physical and pharmacological therapies in promoting bone healing during DO.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Orthopedics
Narisaku Inada, Tetsuya Ohata, Hideto Maruno, Takeshi Morii, Naobumi Hosogane, Shoichi Ichimura
Summary: This study aimed to determine the optimal timing of PTH (1-34) administration in a rabbit distraction osteogenesis model. The results showed that PTH (1-34) administration during the consolidation phase led to the best outcomes.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Engineering, Biomedical
Cheol Hee Jeong, Song-Yi Lim, Jo Eun Um, Hyo Won Lim, Kyu Ho Hwang, Kyeong-Mee Park, Jun Seop Yun, Dohun Kim, Jong-Ki Huh, Hyun Sil Kim, Jong In Yook, Nam Hee Kim, Yoon Hae Kwak
Summary: This study introduces micellized bone morphogenetic protein-2 (mPTD-BMP-2), a next-generation osteogenic supplement that combines protein transduction domain (PTD) and nano-sized micelle formulation technique to improve transduction efficiency and stability. The use of PTD represents a novel approach, and our results demonstrate the superiority of mPTD-BMP-2 over rh-BMP-2 in terms of in vivo pharmacokinetic profile and osteogenic potential, particularly in a rat tibial model of distraction osteogenesis.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Ting Pan, Wenjing Song, Hongbao Xin, Haiyue Yu, He Wang, Dandan Ma, Xiaodong Cao, Yingjun Wang
Summary: Bone defects pose a major threat to human health and the demand for bone tissue regeneration is increasing worldwide. This study highlights the importance of finding a balance between the degradation behavior of scaffolds and the release profile of miRNA for successful bone repair. The findings provide valuable insights for designing bioactive scaffolds for tissue regeneration.
BIOACTIVE MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Qi Liu, Haibo Mei, Guanghui Zhu, Ze Liu, Hongbin Guo, Min Wang, Jieyu Liang, Yi Zhang
Summary: The early PVR gradually increases in the first 3 months after osteotomy, which is significantly influenced by chronological age, sex, and the lengthening site. The early PVR may reflect the potential clinical outcome for bone lengthening.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Physiology
Yanshi Liu, Jialin Liu, Feiyu Cai, Kai Liu, Xiaoxu Zhang, Aihemaitijiang Yusufu
Summary: Hypoxia therapy during the consolidation phase of distraction osteogenesis enhances bone regeneration by accelerating bone formation and remodeling.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Engineering, Biomedical
Kazuhiro Imoto, Kensuke Yamauchi, Kenji Odashima, Shinnosuke Nogami, Yoshinaka Shimizu, Peter Kessler, Bernd Lethaus, Hidero Unuma, Tetsu Takahashi
Summary: The study evaluated the use of a polyethylene terephthalate (PET) membrane as an activation device for periosteal expansion osteogenesis (PEO), showing that membrane activation in the experimental group led to more new bone formation compared to the control group. Bone formation progressed to adjacent areas histologically, and no PET membrane-associated complications were observed in the study.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Cell & Tissue Engineering
Qi Chang, Masahito Fujio, Makoto Tsuboi, Huiting Bian, Masashi Wakasugi, Hideharu Hibi
Summary: This study evaluated high-mobility group box 1 (HMGB1) as a novel therapeutic target for distraction osteogenesis (DO) treatment. The results showed that HMGB1 promotes bone regeneration by recruiting PDGFRa and Sca-1 positive cells and endothelial progenitor cells, as well as accelerating angiogenesis. Therefore, HMGB1 may be a new therapeutic target for the acceleration of DO-driven bone regeneration.
Article
Orthopedics
Tao Zhang, Weidong Jiang, Fengchun Liao, Peiqi Zhu, Lina Guo, Zhenchen Zhao, Yan Liu, Xuanping Huang, Nuo Zhou
Summary: This study aimed to investigate whether exosomes derived from distraction osteogenesis (DO) and bone fracture (BF) serum could stimulate osteogenic differentiation and identify the relevant genes involved. The results showed that exosomes accelerated osteogenesis in DO, possibly through co-expression of MSTRG.532277.1 and FBXL14, providing new therapeutic targets for bone regeneration.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Shuo Wu, Lijie Zhang, Ruidan Zhang, Kang Yang, Qin Wei, Qiyu Jia, Jian Guo, Chuang Ma
Summary: Injecting bone marrow mesenchymal stem cells and recombinant rat platelet-derived growth factor BB (rrPDGF-BB) into the distraction area can promote the formation and differentiation of new bone tissue, thereby promoting bone regeneration and healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Shahrokh Hatefi, Milad Sh Etemadi, Javad Alizargar, Venous Behdadipour, Khaled Abou-El-Hossein
Summary: The application of Distraction Osteogenesis (DO) techniques in reconstruction surgeries is advantageous with fewer side effects. However, the development of automatic devices for controlled continuous force still requires further research. A two-axis continuous distractor is proposed for mandibular reconstruction, meeting the current requirements.
BIOENGINEERING-BASEL
(2022)
Article
Computer Science, Interdisciplinary Applications
Ruisen Fu, Yili Feng, Yang Liu, Xing Gao, David T. Bertrand, Tianming Du, Youjun Liu, Bettina M. Willie, Haisheng Yang
Summary: This study investigated the effects of different AT modes on DO outcomes using computer simulation. The results showed that applying AT during the early consolidation phase significantly enhanced bone formation and reduced the overall healing time. However, the effects of AT depended on its duration and rate. Moderate durations and rates of AT promoted blood perfusion recovery and bone regeneration, while high rates and longer durations of AT adversely affected bone regeneration and delayed bone bridging.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Immunology
Duchenhui Li, Xiao Li, Jie Zhang, Zhenglong Tang, Ai Tian
Summary: This study found that IL-4 injection can promote bone regeneration at the site of bone defects in aged rats by reducing inflammation and regulating macrophage polarization.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Orthopedics
Shin Osawa, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Hiroyuki Tsuchiya, Takahiro Niikura
JOURNAL OF ORTHOPAEDIC SCIENCE
(2023)
Article
Orthopedics
Masanori Tsubosaka, Hirotsugu Muratsu, Naoki Nakano, Tomoyuki Kamenaga, Yuichi Kuroda, Takao Inokuchi, Hidetoshi Miya, Ryosuke Kuroda, Tomoyuki Matsumoto
Summary: This study compared the medial preserving gap technique (MPGT) with the measured resection technique (MRT) in terms of postoperative knee stability after posterior-stabilized total knee arthroplasty (PS-TKA). The results showed that MPGT provided better postoperative medial knee stability, especially at 3 years after PS-TKA.
JOURNAL OF KNEE SURGERY
(2023)
Article
Orthopedics
Yoshinori Takashima, Tomoyuki Matsumoto, Naoki Nakano, Tomoyuki Kamenaga, Yuichi Kuroda, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda
Summary: The study aimed to investigate whether the transplantation of human cells from a non-reattached injured anterior cruciate ligament (ACL) remnant could enhance tendon-bone healing. The results showed that the non-reattachment group exhibited higher and earlier healing, with induction of endochondral ossification-like integration and mature bone ingrowth. This enhanced healing potential was attributed to increased intrinsic angiogenesis/osteogenesis. In comparison, the reattachment group showed poorer tendon-bone healing.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Tomoyuki Matsumoto, Naoki Nakano, Kazunari Ishida, Yoshinori Takashima, Toshihisa Maeda, Yuichi Kuroda, Shinya Hayashi, Tekehiko Matsushita, Takahiro Niikura, Hirotsugu Muratsu, Ryosuke Kuroda
Summary: This study aimed to compare intraoperative soft-tissue balance and clinical outcomes of kinematically aligned total knee arthroplasty (KA-TKA) using single-radius (SR) or multiradius (MR) prostheses. The results showed that joint component gaps differed between the two groups during flexion, with the SR group having significantly larger gaps at 60 to 120 degrees. However, there were no significant differences in varus/valgus balance and postoperative clinical outcomes between the two groups.
JOURNAL OF KNEE SURGERY
(2023)
Article
Orthopedics
Yoshinori Takashima, Naoki Nakano, Kazunari Ishida, Tomoyuki Kamenaga, Masanori Tsubosaka, Yuichi Kuroda, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto
Summary: The study aims to compare the differences in trochlear shape and knee anatomy between four types of prostheses and preoperative native knee. It was found that the prostheses had a deeper and more medial trochlear groove compared to the native knee under kinematic alignment.
JOURNAL OF KNEE SURGERY
(2023)
Article
Orthopedics
Tomoyuki Matsumoto, Naoki Nakano, Kazunari Ishida, Yuichi Kuroda, Shinya Hayashi, Hirotsugu Muratsu, Ryosuke Kuroda
Summary: This study aimed to compare kinematically aligned total knee arthroplasty (KA-TKA) targeting the neutral ground mechanical axis (MA) with tibia-restricted modified KA-TKA. The study found that the ground KA-TKA group achieved a significantly deeper postoperative flexion angle compared to the modified KA-TKA group.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Orthopedics
Tomoyuki Matsumoto, Naoki Nakano, Shinya Hayashi, Koji Takayama, Toshihisa Maeda, Kazunari Ishida, Yuichi Kuroda, Takehiko Matsushita, Takahiro Niikura, Hirotsugu Muratsu, Ryosuke Kuroda
Summary: This study compared the prosthetic orientation, limb alignment, soft tissue balance, and early clinical outcomes between the use of a handheld robot and a conventional alignment guide for TKA. Results showed that the robot group had better accuracy in prosthetic orientation, stable soft tissue balance, and higher patient-reported scores for early clinical outcomes compared to the control group.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Orthopedics
Tomoyuki Matsumoto, Naoki Nakano, Kazunari Ishida, Toshihisa Maeda, Shotaro Tachibana, Yuichi Kuroda, Shinya Hayashi, Takehiko Matsushita, Ryosuke Kuroda
Summary: This study aimed to present a ground kinematically aligned (KA)-total knee arthroplasty (TKA) technique, which targets the hip-to-calcaneus axis as an alternative to the conventional hip-to-talus axis. The results showed that using ground KA-TKA can achieve individual physiological alignment and may provide a more similar alignment to the native knee compared to other kinematic alignment techniques.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Orthopedics
Kenichi Kikuchi, Naoki Nakano, Kazunari Ishida, Yuichi Kuroda, Shinya Hayashi, Masanori Tsubosaka, Tomoyuki Kamenaga, Takehiko Matsushita, Ryosuke Kuroda, Tomoyuki Matsumoto
Summary: This study investigated the influence of different surgical techniques on lower limb alignment after total knee arthroplasty. The results showed that there were no significant changes in alignment parameters between the mechanically aligned TKA group and the kinematically aligned TKA group after surgery. However, preoperative varus deformity was associated with a change in alignment deviation after surgery.
JOURNAL OF KNEE SURGERY
(2023)
Article
Cell & Tissue Engineering
Kensuke Anjiki, Tomoyuki Matsumoto, Yuichi Kuroda, Masahiro Fujita, Shinya Hayashi, Naoki Nakano, Masanori Tsubosaka, Tomoyuki Kamenaga, Yoshinori Takashima, Kenichi Kikuchi, Kenmei Ikuta, Yuma Onoi, Shotaro Tachibana, Yoshihito Suda, Kensuke Wada, Takehiko Matsushita, Ryosuke Kuroda
Summary: This study aimed to investigate the therapeutic effects of heterogeneous cells in rabbit stromal-vascular fraction (SVF) on rabbit chondrocytes. It was found that the SVF group showed superior therapeutic effects compared to the low-dose adipose-derived stromal cells (lADSC) group. The SVF group mainly consisted of M2 macrophages, which secreted growth factors and chondrocyte-protective cytokines, benefiting chondrocytes and knee joint homeostasis.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cell & Tissue Engineering
Masahiro Fujita, Tomoyuki Matsumoto, Satoshi Sobajima, Masanori Tsubosaka, Takehiko Matsushita, Hideki Iwaguro, Ryosuke Kuroda
Summary: This study aimed to compare the clinical and radiological outcomes of single and double stromal vascular fraction (SVF) cell injections in patients with knee osteoarthritis (OA). The results showed that the total WOMAC score improved significantly in the single injection group from 3 to 24 months, while the double injection group showed significant improvement at 24 months. In conclusion, double injections may provide better treatment outcomes for patients with severe varus knee alignment.
CELL TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Takahiro Furukawa, Takashi Kurosawa, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Yasuhiro Ueda, Takeshi Kataoka, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Issei Shinohara, Tatsuo Kato, Shuya Tanaka, Masaya Kusunose, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda
Summary: This study aims to evaluate the in vitro effects of apocynin on human rotator cuff-derived cells. The results showed that apocynin can effectively reduce AGE-induced oxidative stress by inhibiting NOX activation. Thus, apocynin is a potential prodrug in preventing degenerative changes of the rotor cuff.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Koji Nukuto, Takehiko Matsushita, Kohei Kamada, Kyohei Nishida, Kanto Nagai, Noriyuki Kanzaki, Yuichi Hoshino, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda
Summary: This study successfully developed the first MMPRT mouse model, which can be used to investigate the pathological changes of MMPRT.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Orthopedics
Kohei Kamada, Takehiko Matsushita, Kanto Nagai, Yuichi Hoshino, Daisuke Araki, Noriyuki Kanzaki, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda
Summary: This study comprehensively evaluated the risk factors of residual pivot-shift after anatomic double-bundle ACL reconstruction. The results showed that patients younger than 20 years of age, with high-grade preoperative pivot-shift, or hyperextended knees had a higher risk of residual postoperative pivot-shift.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)