Review
Immunology
Christopher J. Peterson, Benjamin Lee, Kenneth Nugent
Summary: The COVID-19 pandemic and its associated vaccine have brought attention to vaccine hesitancy among healthcare workers. Reasons for hesitancy include concerns about safety and efficacy, mistrust of government and institutions, waiting for more data, and feeling that personal rights are being infringed upon. Being a physician, having more advanced education, and previous vaccination habits are frequently associated with vaccine acceptance.
Article
Public, Environmental & Occupational Health
Young E. Choi, Seung H. Lee, Yun J. Kim, Jeong G. Lee, Yu H. Yi, Young J. Tak, Gyu L. Kim, Young J. Ra, Sang Y. Lee, Young H. Cho, Eun J. Park, Young Lee, Jung Choi, Sae R. Lee, Ryuk J. Kwon, Soo M. Son, Yea J. Lee, Min J. Kang
Summary: This study aimed to compare the level of burnout among nurses in general wards and COVID-19-dedicated wards in a national university hospital, and identify the risk factors. The results showed that nurses in general wards had a higher emotional impairment score than those in COVID-19 wards, and were at a higher risk of presenting with total-core symptoms. Short career length and presence of an underlying disease were identified as risk factors for mental distance.
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Psychiatry
Rony Cleper, Nimrod Hertz-Palmor, Mariela Mosheva, Ilanit Hasson-Ohayon, Rachel Kaplan, Yitshak Kreiss, Arnon Afek, Itai M. Pessach, Doron Gothelf, Raz Gross
Summary: This study aimed to investigate the relationship between sleep difficulties and work-related stressors and negative experiences in COVID-19 frontline healthcare workers (HCWs), as well as the role of depression and traumatic stress in this association. The results showed that COVID-19 HCWs were more likely to report sleep difficulties, particularly difficulty maintaining sleep, compared to non-COVID-19 HCWs. Negative patient-care related experiences partially explained this association.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Minggang Jiang, Xu Shao, Shengyi Rao, Yu Ling, Zhilian Pi, Yongqiang Shao, Shuaixiang Zhao, Li Yang, Huiming Wang, Wei Chen, Jinsong Tang
Summary: This study investigated the emotional and psychological state of healthcare workers in China and explored the association between sociodemographic factors/profession-related condition and emotional state. The results showed that gender, educational level, department category, job title, experience of workplace violence, job enthusiasm, and professional self-identity are the most important influencing factors of physician's anxiety and depression.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Elsa Tesfa Berhe, Adisu Tafari Shama, Mohammed Musa Ahmed, Hailay Abrha Gesesew, Paul R. Ward, Teferi Gebru Gebremeskel
Summary: This study investigated the acceptance/refusal of COVID-19 vaccination among healthcare workers in Ethiopia and identified predictors for refusal. The study found that approximately 38.5% of healthcare workers refused vaccination, with younger age groups and medical doctors more likely to refuse.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Sharon Amit, Sharon Alexsandra Beni, Asaf Biber, Amir Grinberg, Eyal Leshem, Gili Regev-Yochay
Summary: Symptoms of COVID-19 can be mistaken for vaccine-related side effects, highlighting the importance of promptly testing for COVID-19 after vaccination. In a study of healthcare workers in Israel, a small percentage developed COVID-19 within 10 days of vaccination, emphasizing the need for vigilance in monitoring post-vaccination symptoms.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Esmee Bosma, Verena Feenstra, Sandra H. van Oostrom, Karin I. Proper
Summary: This study found no significant differences in perceived anxiety levels during the COVID-19 pandemic between healthcare workers and non-healthcare workers.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Immunology
Juliet Otiti-Sengeri, Omaido Blair Andrew, Rebecca Claire Lusobya, Immaculate Atukunda, Caroline Nalukenge, Abubakar Kalinaki, John Mukisa, Damalie Nakanjako, Robert Colebunders
Summary: The study revealed a high acceptance rate of the COVID-19 vaccine among eye healthcare workers in Uganda. High perceived susceptibility and high perceived benefits were significantly associated with vaccine acceptance. There is a need to provide vaccines to developing countries.
Review
Infectious Diseases
Mandana Gholami, Iman Fawad, Sidra Shadan, Rashed Rowaiee, HedaietAllah Ghanem, Amar Hassan Khamis, Samuel B. Ho
Summary: This study aimed to describe the clinical outcomes and risk factors for SARS-CoV-2 infection in healthcare workers, finding that 51.7% of healthcare workers tested positive for COVID-19, with a hospitalization rate of 15.1% and a mortality rate of 1.5%. Healthcare workers who were infected with COVID-19 had increased relative risks related to personal protective equipment, workplace setting, profession, exposure, contacts, and testing compared to those without infection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Public, Environmental & Occupational Health
Carlo Giacomo Leo, Saverio Sabina, Maria Rosaria Tumolo, Antonella Bodini, Giuseppe Ponzini, Eugenio Sabato, Pierpaolo Mincarone
Summary: Healthcare workers are facing burnout during the current global public health crisis, necessitating measures at individual, organizational, and cultural levels to prevent and reduce work-related stress. In addition to implementing various solutions, a cultural shift is needed to eliminate the stigma associated with mental illness.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Health Care Sciences & Services
Adriana Cotel, Florinda Golu, Anca Pantea Stoian, Mihai Dimitriu, Bogdan Socea, Catalin Cirstoveanu, Ana Maria Davitoiu, Florentina Jacota Alexe, Bogdan Oprea
Summary: This study aimed to identify predictors of burnout in healthcare workers during the COVID-19 pandemic. Job demands, job resources, and personal resources were found to be significant predictors of burnout, explaining 37% of the variance. Psychological interventions during the pandemic should focus primarily on addressing these demands and resources.
Article
Health Care Sciences & Services
Hui-Ting Huang, Chung-Hung Tsai, Chia-Fen Wang, Tzu-Chao Chien, Shu-Hao Chang
Summary: Since the outbreak of COVID-19, compliance with preventive behaviors has become crucial for reducing the rapid spread of the pandemic. This study proposed an integrative model that explained and predicted COVID-19 preventive behaviors among healthcare workers. The study found that workplace safety climate influenced health belief factors, which in turn influenced safety attitudes. Safety attitudes affected safety compliance, and safety compliance further affected safety satisfaction. The findings highlight the importance of workplace safety climate in strengthening healthcare workers' health beliefs and promoting their adherence to preventive measures.
Article
Psychology, Multidisciplinary
Rebeca Robles, Sara Infante, Miriam Feria, Ivan Arango, Elsa Tirado, Andres Rodriguez-Delgado, Edgar Miranda, Ana Fresan, Claudia Becerra, Raul Escamilla, Eduardo Angel Madrigal de Leon
Summary: This study describes and evaluates the implementation process and clinical impact of brief, remote, manualized evidence-based practices (EBP) for crisis intervention and suicide risk management among healthcare workers attending patients with COVID-19 in Mexico.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Pawel Holas, Natalia Wojtkowiak, Malgorzata Gambin, Karolina Hansen, Grazyna Kmita, Ewa Pisula, Kamilla Bargiel-Matusiewicz, Emilia Lojek
Summary: The COVID-19 pandemic has caused increased psychological distress among healthcare workers (HCWs) and previous studies have found a high prevalence of burnout among HCWs. This study aimed to investigate whether the economic status of HCWs and experiencing negative and positive emotions contribute to burnout. The results suggest that negative emotions are the strongest predictor of burnout, while positive emotions are associated with reduced burnout levels.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Immunology
Sohail Agha, Adaobi Chine, Mathias Lalika, Samikshya Pandey, Aparna Seth, Alison Wiyeh, Alyssa Seng, Nandan Rao, Akhtar Badshah
Summary: The study found that high motivation and high practical ability were important predictors of healthcare workers being fully vaccinated against COVID-19, but only a minority of healthcare workers possessed both characteristics. Healthcare workers generally believed that getting vaccinated against COVID-19 was important, but faced challenges in terms of practical ability.
Article
Medicine, Research & Experimental
Daniel Stone, Kelly R. Long, Michelle A. Loprieno, Harshana S. De Silva Feelixge, Elizabeth J. Kenkel, R. Matt Liley, Stephen Rapp, Pavitra Roychoudhury, Thuy Nguyen, Laurence Stensland, Rossana Colon-Thillet, Lindsay M. Klouser, Nicholas D. Weber, Connie Le, Jessica Wagoner, Erin A. Goecker, Alvason Zhenhua Li, Karsten Eichholz, Lawrence Corey, D. Lorne Tyrrell, Alexander L. Greninger, Meei-Li Huang, Stephen J. Polyak, Martine Aubert, John E. Sagartz, Keith R. Jerome
Summary: The study utilized AAV and CRISPR-SaCas9 for gene editing therapy in liver-humanized FRG mice chronically infected with HBV, showing improved treatment efficacy by enhancing gene editing levels, which significantly impacted HBV infection.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2021)
Article
Immunology
Abbye E. McEwen, Seth Cohen, Chloe Bryson-Cahn, Catherine Liu, Steven A. Pergam, John Lynch, Adrienne Schippers, Kathy Strand, Estella Whimbey, Nandita S. Mani, Allison J. Zelikoff, Vanessa A. Makarewicz, Elizabeth R. Brown, Shah A. Mohamed Bakhash, Noah R. Baker, Jared Castor, Robert J. Livingston, Meei-Li Huang, Keith R. Jerome, Alexander L. Greninger, Pavitra Roychoudhury
Summary: Among 20 vaccine breakthrough cases at the institution, all infections were caused by variants of concern, with a median Ct value of 20.2. Variants of concern were significantly more prevalent in breakthrough infections compared to contemporaneous samples sequenced in the laboratory.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Nursing
Margaret L. Lind, Mirta Maravilla Rosas, Lindsay McFarland, Lenise Taylor, Sandra Olson, Steven A. Pergam
Summary: The Glasgow Coma Scale (GCS) score, as an indicator of acute mental status, is infrequently collected among allogeneic hematopoietic cell transplant recipients with suspected infections, and has moderate sensitivity in this population. If sepsis screening tools inclusive of acute mental status changes are to be used, nursing teams need to increase measurement of GCS scores among high sepsis risk patients or identify a standard alternative indicator.
Article
Pathology
Dustin E. Bosch, Stephen J. Salipante, Rodney A. Schmidt, Paul E. Swanson, Andrew Bryan, Dhruba J. SenGupta, Camtu D. Truong, Matthew M. Yeh
Summary: In this study, a high number of tumor-associated neutrophils in gallbladder carcinoma patients was associated with shorter survival, independent of patient age and cancer stage. Inflammation response may have prognostic significance in gallbladder carcinoma patients, and further studies with larger case numbers are needed to confirm these findings.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2022)
Article
Virology
Kate B. Juergens, John Huckabee, Alexander L. Greninger
Summary: In this study, the complete genomes of two novel viruses in the Iflaviridae family were obtained from bat guano in Washington State using metagenomic deep sequencing and RACE techniques. These viruses, named King virus and Rolda virus, share some nucleotide identity with deformed wing virus. The presence of these viruses in guano suggests a possible ecological relationship between the viruses, insectivores, and plant reproduction.
Article
Virology
Diana Avetyan, Siras Hakobyan, Maria Nikoghosyan, Lilit Ghukasyan, Gisane Khachatryan, Tamara Sirunyan, Nelli Muradyan, Roksana Zakharyan, Andranik Chavushyan, Varduhi Hayrapetyan, Anahit Hovhannisyan, Shah A. Mohamed Bakhash, Keith R. Jerome, Pavitra Roychoudhury, Alexander L. Greninger, Lyudmila Niazyan, Mher Davidyants, Gayane Melik-Andreasyan, Shushan Sargsyan, Lilit Nersisyan, Arsen Arakelyan
Summary: The sequencing of SARS-CoV-2 in Armenia revealed six clades and their transmission routes, with each clade being responsible for different waves of positive case increase. The study also showed that mutations did not affect PCR testing accuracy and that nanopore sequencing is a viable alternative for large-scale molecular epidemiology research.
Article
Virology
Jaydee Sereewit, Nicole A. P. Lieberman, Hong Xie, Shah A. K. Mohamed Bakhash, B. Ethan Nunley, Benjamin Chung, Margaret G. Mills, Pavitra Roychoudhury, Alexander L. Greninger
Summary: Using viral whole genome sequencing, the study identified gene inactivating mutations in monkeypox virus. These mutations may be a result of selective pressure in humans, and they pose limitations in therapeutics and diagnostic testing.
Editorial Material
Medical Laboratory Technology
Hannah Marie Brown, Christopher W. Farnsworth, Andrew Bryan, Jonathan R. Genzen, Ann Gronowski, Jamie Philips Deeter, Melanie Yarbrough
CLINICAL CHEMISTRY
(2023)
Article
Immunology
Jason D. Goldman, Kai Wang, Katharina Roltgen, Sandra C. A. Nielsen, Jared C. Roach, Samia N. Naccache, Fan Yang, Oliver F. Wirz, Kathryn E. Yost, Ji-Yeun Lee, Kelly Chun, Terri Wrin, Christos J. Petropoulos, Inyoul Lee, Shannon Fallen, Paula M. Manner, Julie A. Wallick, Heather A. Algren, Kim M. Murray, Jennifer Hadlock, Daniel Chen, Chengzhen L. Dai, Dan Yuan, Yapeng Su, Joshua Jeharajah, William R. Berrington, George P. Pappas, Sonam T. Nyatsatsang, Alexander L. Greninger, Ansuman T. Satpathy, John S. Pauk, Scott D. Boyd, James R. Heath
Summary: Recovery from COVID-19 does not guarantee immunity, as reinfection with a different strain can occur. In this study, we present a case of reinfection with a variant strain carrying the D614G mutation. By analyzing antibodies, B cells, and T cells, we provide evidence of adaptive immunity during reinfection. Our findings have implications for vaccine programs and establishing benchmarks for protection against SARS-CoV-2 reinfection.
Article
Public, Environmental & Occupational Health
Matthew Triplette, Meagan C. Brown, Madison Snidarich, Jehan Z. Budak, Nicholas Giustini, Nicholas Murphy, Perrin E. Romine, Bryan J. Weiner, Kristina Crothers
Summary: This study aimed to understand the attitudes and barriers to lung cancer screening among people with HIV and their providers. The results showed that both people with HIV and providers had overall enthusiasm for lung cancer screening, particularly with a tailored and evidence-based approach. However, this population may face barriers such as medical comorbidities and competing issues, so tailored interventions may be needed to overcome these barriers.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Virology
Linhui Hao, Tien-Ying Hsiang, Ronit R. Dalmat, Renee Ireton, Jennifer F. Morton, Caleb Stokes, Jason Netland, Malika Hale, Chris Thouvenel, Anna Wald, Nicholas M. Franko, Kristen Huden, Helen Y. Chu, Alex Sigal, Alex L. Greninger, Sasha Tilles, Lynn K. Barrett, Wesley C. Van Voorhis, Jennifer Munt, Trevor Scobey, Ralph S. Baric, David J. Rawlings, Marion Pepper, Paul K. Drain, Michael Gale
Summary: New variants of SARS-CoV-2 continue to emerge and evade immunity. Convalescence from the ancestral virus provides limited protection against variants. Vaccination enhances immunity against viral variants, but the protection is weaker against Omicron BA.1, and a three-dose vaccine regimen provides significantly better protection against it compared to a two-dose.
Article
Infectious Diseases
Wondimagegn Adissu, Marcelo Brito, Eduardo Garbin, Marcela Macedo, Wuelton Monteiro, Sandip Kumar Mukherjee, Jane Myburg, Mohammad Shafiul Alam, Germana Bancone, Pooja Bansil, Sampa Pal, Abhijit Sharma, Stephanie Zobrist, Andrew Bryan, Cindy S. Chu, Santasabuj Das, Gonzalo J. Domingo, Amanda Hann, James Kublin, Marcus V. G. Lacerda, Mark Layton, Benedikt Ley, Sean C. Murphy, Francois Nosten, Dhelio Pereira, Ric N. Price, Arunansu Talukdar, Daniel Yilma, Emily Gerth-Guyette
Summary: The study pooled data from clinical studies conducted in different countries to evaluate the performance of the STANDARD G6PD Test. The test showed high sensitivity and specificity in capillary and venous specimens, making it a reliable tool to guide the treatment of antimalarial drugs.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Pathology
Rebecca S. Treger, Patrick C. Mathias, Andrew J. Cowan, Damian Green, Kathleen Hutchinson, Andrew Bryan, Anu Chaudhary, Susan L. Fink, Mark H. Wener, Chihiro Morishima
Summary: Our study evaluates the real-world performance and reference intervals of the Binding Site Freelite serum free light chain (SFLC) assay and highlights the impact of assay drift and other potential factors on the kappa/lambda ratio (KLR) distribution. We propose a revised reference interval for KLR that improves assay interpretation and should prompt the reconsideration of Freelite reference intervals worldwide.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Immunology
Evann E. Hilt, James Boocock, Marisol Trejo, Catherine Q. Le, Longhua Guo, Yi Zhang, Laila Sathe, Valerie A. Arboleda, Yi Yin, Joshua S. Bloom, Pin-Chieh Wang, Joann G. Elmore, Leonid Kruglyak, Lasata Shrestha, Shah A. Mohamed Bakhash, Michelle Lin, Hong Xie, Meei-Li Huang, Pavitra Roychoudhury, Alexander Greninger, Sukantha Chandrasekaran, Shangxin Yang, Omai B. Garner
Summary: This study found evidence of the early community spread of SARS-CoV-2 in the Los Angeles area, well before widespread diagnostic testing was being conducted in early 2020. The virus was introduced into the area from both domestic and international sources as early as January.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Microbiology
Garrett A. Perchetti, Meei-Li Huang, Margaret G. Mills, Keith R. Jerome, Alexander L. Greninger
Summary: This study evaluated the analytical sensitivity of the Abbott BinaxNOW COVID-19 Ag card, finding detection limits of approximately 4.04 x 10(4) to 8.06 x 10(4) copies/swab, and good detection performance for samples with SARS-CoV-2 viral loads above 40,000 copies/swab.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)