Article
Multidisciplinary Sciences
Brunda Ganneru, Harsh Jogdand, Vijaya Kumar Daram, Dipankar Das, Narasimha Reddy Molugu, Sai D. Prasad, Srinivas Kannappa, Krishna M. Ella, Rajaram Ravikrishnan, Amit Awasthi, Jomy Jose, Panduranga Rao, Deepak Kumar, Raches Ella, Priya Abraham, Pragya D. Yadav, Gajanan N. Sapkal, Anita Shete-Aich, Gururaj Desphande, Sreelekshmy Mohandas, Atanu Basu, Nivedita Gupta, Krishna Mohan Vadrevu
Summary: The study reports the development and evaluation of a whole virion inactivated COVID-19 vaccine, showing high antigen-binding and neutralizing antibody titers in mice, rats, and rabbits, with excellent safety profiles.
Article
Immunology
Grace Chung-Yan Lui, Terry Cheuk-Fung Yip, Vincent Wai-Sun Wong, Viola Chi-Ying Chow, Tracy Hang-Yee Ho, Timothy Chun-Man Li, Yee-Kit Tse, Henry Lik-Yuen Chan, David Shu-Cheong Hui, Grace Lai-Hung Wong
Summary: A territory-wide cohort study in Hong Kong compared the case-fatality ratios of COVID-19 and SARS, finding a much lower CFR for COVID-19 at 0.4% compared to 17.1% for SARS. Age and diabetes were associated with worse outcomes in COVID-19 patients, while antiviral treatments showed no significant association with the primary endpoint.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Virology
Charles W. Stratton, Yi-Wei Tang, Hongzhou Lu
Summary: COVID-19 is considered a global public health emergency and therapy should be based on the pathogenic mechanisms, including testing and treatment, correcting hypoxia, reducing viral load, addressing hyperinflammation, and hypercoagulability, among six major therapeutic goals identified.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Public, Environmental & Occupational Health
Wojciech Malchrzak, Agnieszka Mastalerz-Migas, Zbigniew Sroka, Maciej Spiegel
Summary: This review aims to summarize the most relevant scientific discoveries on SARS-CoV-2 virus infection, focusing on its pathophysiology and treatment. Through manual examination of research articles, it was found that further studies are crucial to find accurate treatment methods and halt the spread of the disease.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2021)
Article
Immunology
Sheng-Chieh Lin, Hsiao-Chin Wang, Wen-Chuan Lin, Yung-Ting Kuo, Yi-Hsiang Hsu, Yin-Tai Tsai, Shou-Cheng Lu, Yuan-Hung Wang, Shih-Yen Chen
Summary: This study analyzed the viral pathogens causing pneumonia among hospitalized patients during the COVID-19 pandemic in Taiwan. The results showed that rhinovirus and respiratory syncytial virus were the most common viral pathogens in children, while the viral diversity was higher in adults. Coronavirus was most commonly detected in elderly patients during autumn, but not in children or adults during summer.
Review
Virology
Xiaojian Cui, Zhihu Zhao, Tongqiang Zhang, Wei Guo, Wenwei Guo, Jiafeng Zheng, Jiayi Zhang, Cuicui Dong, Ren Na, Lisheng Zheng, Wenliang Li, Zihui Liu, Jia Ma, Jinhu Wang, Sijia He, Yongsheng Xu, Ping Si, Yongming Shen, Chunquan Cai
Summary: This study provides a comprehensive analysis of demographic characteristics, clinical symptoms, laboratory findings, and imaging features of COVID-19 in pediatric patients. It revealed that children with COVID-19 tend to have mild illness with typical manifestations of fever and cough, normal white blood cell counts, and common imaging features of normal or ground-glass opacity. However, the high incidence of critical cases and vomiting symptoms in children under 1 year old should be given attention.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, Research & Experimental
Ting Wang, Minghui Zhao, Pingping Ye, Qian Wang, Yongshan Zhao
Summary: This study investigated key molecules involved in SARS-CoV-2 infection through bioinformatics analysis and identified potential therapeutic targets. Several significant pathways were found to contribute to COVID-19 development, and potential drugs for viral treatment were screened, providing new insights for clinical treatment options.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Surgery
Peter Sparwasser, Maximillian P. Brandt, Maximillian Haack, Robert Dotzauer, Katharina Boehm, Mohammed Kamal Gheith, Rene Mager, Wolfgang Jaeger, Alexander Ziebart, Thomas Hoefner, Igor Tsaur, Axel Haferkamp, Hendrik Borgmann
Summary: The safety of robotic surgery during the COVID-19 pandemic was investigated, with one patient acquiring COVID-19 infection while healthcare workers remained unaffected. Elective surgery is recommended only for verified COVID-19 negative patients based on the findings.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2021)
Review
Nutrition & Dietetics
Zhaoping Li, Vijaya Surampudi, David Heber
Summary: The COVID-19 pandemic has shown that individuals with obesity are more susceptible to infection and severe disease, leading to higher rates of hospitalization and mortality. There is a link between obesity and immunity that could contribute to the spread of future pandemics, highlighting the importance of addressing obesity as part of global response efforts.
Article
Virology
Aylin O. Alpaydin, Naciye S. Gezer, Gokcen O. Simsek, Kemal C. Tertemiz, Oya O. E. Kutsoylu, Arzu N. Zeka, Irmak Guzel, Mujde Soyturk, Ayca A. Sayiner, Vildan A. Oguz
Summary: The study identified distinct clinical and laboratory features between COVID-19 and pneumonia caused by other viruses, but did not rule out the possibility of coinfections. Some clinical, laboratory, and radiological findings may assist in differentiating COVID-19 from other viral infections.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Microbiology
Paolo Calistri, Nicola Decaro, Alessio Lorusso
Summary: The common trait among the betacoronaviruses that emerged in the past two decades is their likely animal origin from bats. Bats as potential hosts of emerging viruses have drawn attention from the scientific community. Human activities may facilitate viral transmission from bats to humans, and globalization of trade and human mobility accelerate the spread of these viruses.
Review
Medicine, Research & Experimental
Miribane Dermaku-Sopjani, Mentor Sopjani
Summary: COVID-19 is a new public health crisis caused by SARS-CoV-2 virus originating from bats and spreading to humans through intermediary animals in China. The virus has resulted in over 43.4 million confirmed cases and approximately 1.16 million deaths worldwide, posing a serious threat to global public health. The disease is transmitted through inhalation or direct contact, with an incubation period of 1 to 14 days and symptoms including cough and fatigue, potentially leading to multi-organ dysfunction in severe cases.
CURRENT MOLECULAR MEDICINE
(2021)
Review
Virology
Sana Shabbir, Muhammad Hassan Raza, Muhammad Arshad, Muhammad Jawad Khan
Summary: The global population has been significantly impacted by COVID-19, caused by SARS-CoV-2 with no effective treatment options available. Research has shown that patients exhibit active immune responses, potentially leading to issues like cytokine storm syndrome.
ARCHIVES OF VIROLOGY
(2021)
Review
Microbiology
Ben Hu, Hua Guo, Peng Zhou, Zheng-Li Shi
Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.
NATURE REVIEWS MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Milton Severo, Ana Isabel Ribeiro, Raquel Lucas, Teresa Leao, Henrique Barros
Summary: In the Lisbon Metropolitan Area, parishes near Sintra railway stations had higher SARS-CoV-2 infection rates, while parishes near other railway stations (Sado and Fertagus lines) had significantly lower infection rates compared to those farther away. Infection rates varied with epidemic stage and mitigation measures, and socioeconomic deprivation increasingly influenced SARS-CoV-2 infections.
FRONTIERS IN PUBLIC HEALTH
(2021)