Article
Virology
Brian Mondeja, Odalys Valdes, Sonia Resik, Ananayla Vizcaino, Emilio Acosta, Adelmo Montalvan, Amira Paez, Mayra Mune, Roberto Rodriguez, Juan Valdes, Guelsys Gonzalez, Daisy Sanchez, Viviana Falcon, Yorexis Gonzalez, Vivian Kouri, Angelina Diaz, Maria Guzman
Summary: The study collected nasopharyngeal swabs from 12 Cuban individuals, processed them with various microscopy techniques, and found that positive samples showed characteristic coronavirus-like particles with evident destruction of microvilli, potentially explaining anosmia in some patients.
Article
Immunology
Adnan Qureshi, William Baskett, Wei Huang, Iryna Lobanova, S. Hasan Naqvi, Chi-Ren Shyu
Summary: Reinfection with SARS-CoV-2 is rare but has been associated with mortality. The severity of reinfection appears to be milder, with fewer cases of severe illness compared to primary infection. Risk factors for reinfection include asthma and nicotine dependence/tobacco use.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Ridhima Kaul, Pradipta Paul, Sanjay Kumar, Dietrich Buesselberg, Vivek Dhar Dwivedi, Ali Chaari
Summary: This review summarizes the activities and structure-activity relationships of flavonoids in combating SARS-CoV-2 from in vitro studies to clinical research. The study found that flavonoids such as quercetin and myricetin derivatives, baicalein, baicalin, EGCG, and tannic acid show promising activities against SARS-CoV-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Nandan Gautam, Shyam Madathil, Natascia Tahani, Shaun Bolton, Dhruv Parekh, James Stockley, Shraddha Goyal, Hannah Qureshi, Sadhika Yasmin, Brendan G. Cooper, Jennifer Short, Tarekegn Geberhiwot
Summary: A study found that a significant proportion of severely ill COVID-19 patients still experience symptoms such as breathlessness, fatigue, pain, reduced mobility, depression, and decreased quality of life 4-7 months after disease onset, with symptomatic patients having more residual chest radiographic and LFT abnormalities.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fernanda de Paula Eduardo, Leticia Mello Bezinelli, Carlos Ariel Rodrigues de Araujo, Joao Vitor Vanderlan Moraes, Alexander Birbrair, Joao Renato Rebello Pinho, Nelson Hamerschlak, Ibtisam Al-Hashimi, Debora Heller
Summary: The study found that self-collected unstimulated saliva samples have a higher agreement (87.3%) with nasopharyngeal swab samples in detecting the SARS-CoV-2 virus compared to oral swab samples (65.9% agreement with nasopharyngeal swab and 73% with self-collected unstimulated saliva).
CLINICAL ORAL INVESTIGATIONS
(2022)
Review
Microbiology
Yu-An Kung, Kuo-Ming Lee, Huan-Jung Chiang, Sheng-Yu Huang, Chung-Jung Wu, Shin-Ru Shih
Summary: This review discusses the molecular mechanisms of SARS-CoV-2 and related coronaviruses, with a focus on host factors or pathways identified through genome-wide CRISPR screening that can be targeted for the development of effective antiviral agents.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2022)
Article
Multidisciplinary Sciences
Viviane Fongaro Botosso, Soraia Attie Calil Jorge, Renato Mancini Astray, Ana Marcia de Sa Guimaraes, Monica Beatriz Mathor, Patricia dos Santos de Carneiro, Edison Luiz Durigon, Dimas Covas, Danielle Bruna Leal de Oliveira, Ricardo das Neves Oliveira, Durvanei Augusto Maria, Silas Fernandes Eto, Neuza Maria Frazatti Gallina, Giselle Pidde, Carla Cristina Squaiella-Baptistao, Dilza Trevisan Silva, Isadora Maria Villas-Boas, Dayanne Carla Fernandes, Aline Vivian Vatti Auada, Alexandre Campos Banari, Antonio Francisco de Souza Filho, Camila Bianconi, Carla Lilian de Agostini Utescher, Denise Cristina Andre Oliveira, Douglas Oscar Ceolin Mariano, Flavia Ferreira Barbosa, Giuliana Rondon, Josana Kapronezai, Juliana Galvao da Silva, Mauricio Barbugiani Goldfeder, Priscila Comone, Regis Edgar Castilho Junior, Taiana Taina Silva Pereira, Fan Hui Wen, Denise Tambourgi, Ana Marisa Chudzinski-Tavassi
Summary: The new outbreak of COVID-19 has caused millions of deaths worldwide. Efforts are being made to find effective treatments, such as using immunoglobulin from immunized animals or plasma from convalescent patients. Clinical trials using anti-SARS-CoV-2 immunoglobulins from horses immunized with spike protein are underway. Researchers have developed an anti-SARS-CoV-2 equine F(ab ')(2) immunoglobulin that successfully neutralizes the virus, is safe in animal models, and reduces the severity of the disease in a hamster model of SARS-CoV-2 infection.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Analytical
Rabia Asghar, Madiha Rasheed, Jalees ul Hassan, Mohsin Rafique, Mashooq Khan, Yulin Deng
Summary: This review discusses the diagnostic platforms for COVID-19, including imaging, molecular-based detection, serological testing, and biosensors. Each platform's principle, advancement, and challenges are discussed in detail, along with an overview of the impact of variants on detection, commercially available kits, and readout signal analysis.
Article
Virology
Florence Carrouel, Martine Valette, Herve Perrier, Maude Bouscambert-Duchamp, Claude Dussart, Paul Tramini, Denis Bourgeois
Summary: The study showed that self-collected pure saliva samples are comparable to nasopharyngeal swabs in detecting SARS-CoV-2 viral load in asymptomatic, mild COVID-19 patients, with a significant correlation in viral load between the two sample collection methods.
Article
Microbiology
Maria Paz Ventero, Rafael R. C. Cuadrat, Inmaculada Vidal, Bruno G. N. Andrade, Carmen Molina-Pardines, Jose M. Haro-Moreno, Felipe H. Coutinho, Esperanza Merino, Luciana C. A. Regitano, Cynthia B. Silveira, Haithem Afli, Mario Lopez-Perez, Juan Carlos Rodriguez
Summary: This study investigated the nasopharynx microbial community of patients with different severity levels of COVID-19, revealing differences in composition of specific OTUs and complexity of co-abundance networks. Taxa with differential abundances could potentially serve as biomarkers for COVID-19 severity, but validation with larger sample sizes is needed.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biology
Fares Z. Najar, Evan Linde, Chelsea L. Murphy, Veniamin A. Borin, Huan Wang, Shozeb Haider, Pratul K. Agarwal
Summary: COVID-19 pandemic caused by rapidly mutating and highly transmissible SARS-CoV-2 virus has underscored the importance of preparedness strategies in responding to current and future outbreaks. Real-time genomic surveillance, particularly through mutation analysis of viral proteins, provides a method for predicting surges in infection cases in advance. This approach, applicable to other pathogens as well, offers valuable insights for effective containment measures.
Article
Virology
Chun Kiat Lee, Jason Wei Ming Tham, Siyu Png, Chean Nee Chai, Shu Chi Ng, Eunice Jia Min Tan, Li Jie Ng, Rui Ping Chua, Musa Sani, Yiqi Seow, Gabriel Yan, Julian Tang
Summary: In nasopharyngeal swab samples, there are variations in the performance of six different assays for detecting SARS-CoV-2, with TaqPath and cobas assays being the most sensitive and ARIES assay being the least sensitive. Further optimization may be required for the ARIES assay before implementation in testing laboratories.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Hamzah Z. Farooq, Emma Davies, Benjamin Brown, Thomas Whitfield, Peter Tilston, Ashley McEwan, Andrew Birtles, Robert O'Hara, Hannah Spencer, Louise Hesketh, Shazaad Ahmad, Malcolm Guiver, Nicholas Machin
Summary: The study presented the results of SARS-CoV-2 surveillance conducted by PHE Manchester during the first wave of the Covid-19 pandemic in the UK, highlighting the highest positivity rate in nasal swabs. This suggests that nasal swabs may be the optimal sample type for detecting SARS-CoV-2 within this dataset. Further research is needed to assess the utility of testing faecal, fluid, and CSF samples.
JOURNAL OF INFECTION
(2021)
Review
Immunology
Jeffrey Cohen, Peter D. Burbelo
Summary: The likelihood and duration of reinfection with SARS-CoV-2 remain uncertain, as current knowledge on this topic is limited. Studies on other respiratory viruses suggest that serum antibodies typically persist for only a few months to a few years, making reinfections common. These findings have implications for vaccine development and the need for continued protective measures.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Muge Cevik, Julia L. Marcus, Caroline Buckee, Tara C. Smith
Summary: Understanding how the virus is transmitted is crucial in identifying high-risk environments and activities for effective preventative measures implementation. Contact tracing and household studies provide robust evidence about transmission parameters. Transmission dynamics should guide policy decisions to target interventions to settings, activities, and socioeconomic factors with the highest risks of transmission.
CLINICAL INFECTIOUS DISEASES
(2021)
