4.6 Letter

Towards the rational utilization of SARS-CoV-2 serological tests in clinical practice

Journal

CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Volume 58, Issue 10, Pages E189-E191

Publisher

WALTER DE GRUYTER GMBH
DOI: 10.1515/cclm-2020-0880

Keywords

-

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Medical Laboratory Technology

Seroprevalence of SARS-CoV-2 antibodies in Italy in newborn dried blood spots

Luisa Galla, Chiara Cosma, Michela Bertan, Sara Altinier, Martina Zaninotto, Daniela Basso, Alberto Burlina, Andrea Padoan, Mario Plebani

Summary: This study evaluated the prevalence of SARS-CoV-2 IgG antibodies in dried blood spot (DBS) samples in the Trentino region of Italy. The results showed that DBS is a suitable tool for monitoring the COVID-19 pandemic, especially in newborns and pregnant women. The positivity thresholds in DBS increased according to the epidemiological waves of the pandemic.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

Article Medical Laboratory Technology

New insights into SARS-CoV-2 Lumipulse G salivary antigen testing: accuracy, safety and short TAT enhance surveillance

Ada Aita, Filippo Navaglia, Stefania Moz, Nicole Contran, Francesco Barbaro, Anna Maria Cattelan, Andrea Padoan, Chiara Cosma, Diego Faggian, Mario Plebani, Daniela Basso

Summary: This study confirmed the effectiveness of CLEIA SARS-CoV-2 salivary antigen detection as an alternative to molecular testing, providing accurate, timely, and high-throughput results. Heat treatment had minimal impact on the detection, ensuring a safer work environment.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

Letter Medical Laboratory Technology

Pooled analysis of laboratory-based SARS-CoV-2 antigen immunoassays

Giuseppe Lippi, Brandon M. Henry, Mario Plebani

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

Review Medical Laboratory Technology

Clinical Chemistry and Laboratory Medicine celebrates 60 years - narrative review devoted to the contribution of the journal to the diagnosis of SARS-CoV-2

Julien Favresse, Jonathan Douxfils, Brandon Henry, Giuseppe Lippi, Mario Plebani

Summary: This review highlights the contribution of the journal Clinical Chemistry and Laboratory Medicine (CCLM) in generating knowledge in SARS-CoV-2 diagnosis, with a special focus on COVID-19 research. It emphasizes the importance of the journal in publishing major guidelines related to COVID-19 and its dedication to helping the field better understand and diagnose this emerging disease.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

Letter Medical Laboratory Technology

Pre-analytical variability of the Lumipulse immunoassay for plasma biomarkers of Alzheimer's disease

Giulia Musso, Chiara Cosma, Martina Zaninotto, Carlo Gabelli, Daniela Basso, Mario Plebani

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

Article Medical Laboratory Technology

An overview of the most important preanalytical factors influencing the clinical performance of SARS-CoV-2 antigen rapid diagnostic tests (Ag-RDTs)

Giuseppe Lippi, Brandon M. Henry, Mario Plebani

Summary: Due to technical limitations, the diagnostic testing for SARS-CoV-2 mainly relies on antigen rapid diagnostic tests (Ag-RDTs). However, these tests have limited analytical sensitivity and require manual operation, often performed by unskilled personnel or patients themselves, which may significantly impair their accuracy. This article provides an updated overview of the preanalytical drawbacks that may affect the accuracy of SARS-CoV-2 Ag-RDTs.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

Letter Medical Laboratory Technology

Response to Tony Badrick regarding Letter to the Editor regarding the article by Wayne J. Dimech et al. Time to address quality control processes applied to antibody testing for infectious diseases. Clin Chem Lab Med 2023; 61(2): 205-212 by

Wayne J. Dimech, Giuseppe A. Vincini, Mario Plebani, Giuseppe Lippi, James H. Nichols, Oswald Sonntag

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

Review Medical Laboratory Technology

Why C-reactive protein is one of the most requested tests in clinical laboratories?

Mario Plebani

Summary: C-reactive protein (CRP) is a sensitive systemic marker of inflammation and tissue damage, synthesized by the liver in response to inflammatory cytokines. It is widely used for the diagnosis and monitoring of inflammatory conditions. The advances in analytical methods and automation have increased the demand for CRP measurement in systemic inflammatory diseases and atherothrombotic events, and it has recently gained interest as a biomarker for the severity of COVID-19, requiring further study for improved interpretation of results.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

Editorial Material Medical Laboratory Technology

ChatGPT: Angel or Demond? Critical thinking is still needed

Mario Plebani

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

Article Medical Laboratory Technology

Striving for a pragmatic contribution of biomarkers results to lifelong health care

Simona Ferraro, Cristina Cereda, Gianvincenzo Zuccotti, Santica Marcovina, Mario Plebani, Elia Mario Biganzoli

Summary: The aim of this paper is to explore the practical application of laboratory results in the decision-making process for improving healthcare outcomes, through the collaboration between laboratory professionals and experts in econometric, bioinformatics, and biostatistics. The content focuses on the effectiveness of biomarkers, analytical challenges, lack of result harmonization, and factors limiting healthcare effectiveness in clinical chemistry and newborn screening tests.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

Article Medical Laboratory Technology

Clinical assessment of SNIBE Maglumi SARS-CoV-2 antigen fully-automated chemiluminescent immunoassay

Laura Pighi, Brandon M. Henry, Simone De Nitto, Gianluca Gianfilippi, Gian Luca Salvagno, Mario Plebani, Giuseppe Lippi

Summary: In this study, the clinical performance of the SNIBE Maglumi SARS-CoV-2 antigen fully-automated chemiluminescent immunoassay (MAG-CLIA SARS-CoV-2 Ag) was reported. The results showed satisfactory analytical performance of MAG-CLIA SARS-CoV-2 Ag, which could be used as a surrogate for molecular testing in identifying high viral load samples.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

Article Medical Laboratory Technology

Analytical and clinical evaluations of SNIBE Maglumi chemiluminescent immunoassay for the detection of SARS-CoV-2 antigen in salivary samples

Andrea Padoan, Ilaria Talli, Chiara Cosma, Stefania Moz, Giulia Furlan, Filippo Navaglia, Lucio Marchioro, Martina Zaninotto, Daniela Basso, Mario Plebani

Summary: This study describes the analytical and clinical performances of the SNIBE Maglumi SARS-CoV-2 antigen fully-automated chemiluminescent immunoassay (MAG-CLIA) on salivary samples. The results show satisfactory analytical performance of MAG-CLIA and high specificity in salivary samples.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

Article Medical Laboratory Technology

Machine learning-based nonlinear regression-adjusted real-time quality control modeling: a multi-center study

Yu-fang Liang, Andrea Padoan, Zhe Wang, Chao Chen, Qing-tao Wang, Mario Plebani, Rui Zhou

Summary: The study aims to develop a machine learning-based patient-based real-time quality control method, which can effectively detect errors in different datasets and has wide application value.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

Review Medical Laboratory Technology

Rising adoption of artificial intelligence in scientific publishing: evaluating the role, risks, and ethical implications in paper drafting and review process

Anna Carobene, Andrea Padoan, Federico Cabitza, Giuseppe Banfi, Mario Plebani

Summary: The use of artificial intelligence in scientific publishing offers great potential but also raises significant ethical and operational challenges. Recognizing the importance of human reviewers is crucial to maintain authenticity in an AI-influenced environment.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

No Data Available