Article
Biochemistry & Molecular Biology
Kuo-Hua Lee, Yuan-Chia Chu, Ming-Tsun Tsai, Wei-Cheng Tseng, Yao-Ping Lin, Shuo-Ming Ou, Der-Cherng Tarng
Summary: This study used machine learning to predict the risk of end-stage renal disease (ESRD) in sepsis survivors. The researchers found that estimated glomerular filtration rates, hemoglobin, and proteinuria were important predictors of ESRD development.
Review
Urology & Nephrology
Orlando M. Gutierrez
Summary: Iron deficiency is common in individuals with chronic kidney disease and can lead to the development of anemia. Oral iron agents may not be effective, and consideration should be given to using intravenous formulations. Recent studies suggest that more aggressive repletion of iron may provide benefits for anemia management and severe clinical outcomes such as cardiovascular disease.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Mahmoud M. Zakaria, Safaa A. Derbala, Ayman E. Salem, Amgad E. EL-Agroudy, Fatma M. El-Tantawy
Summary: The study found that ESRD patients have a significantly lower number of T-cell subsets compared to CKD patients, which is related to a higher degree of apoptosis in these cells.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Infectious Diseases
Jose Molto, Fredzzia Graterol, Adrian Curran, Natalia Ramos, Arkaitz Imaz, Diego Sandoval, Francisco Perez, Lucia Bailon, Saye Khoo, Laura Else, Roger Paredes
Summary: This study evaluated the effect of haemodialysis on doravirine concentrations in people living with HIV (PLWH) undergoing routine haemodialysis. The results showed that despite moderate removal of doravirine by haemodialysis, trough doravirine concentrations in plasma after the haemodialysis sessions remained in excess of the protein-binding-adjusted EC50 (5 ng/mL). Therefore, doravirine dosage adjustments are unnecessary in PLWH undergoing intermittent haemodialysis.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Urology & Nephrology
Jonathan G. Amatruda, Ronit Katz, Mark J. Sarnak, Orlando M. Gutierrez, Jason H. Greenberg, Mary Cushman, Sushrut Waikar, Chirag R. Parikh, Jeffrey R. Schelling, Manasi P. Jogalekar, Joseph Bonventre, Ramachandran S. Vasan, Paul L. Kimmel, Michael G. Shlipak, Joachim H. Ix
Summary: For individuals with diabetes and CKD, urine biomarkers of kidney health may provide better understanding of disease progression. This study found that higher levels of urine KIM-1, α-1-microglobulin, and MCP-1 were independently associated with incident ESKD in adults with diabetes and eGFR < 60 ml/min per 1.73 m(2).
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Medicine, General & Internal
Na Ri Kang, Yo Han Ahn, Eujin Park, Keum Hwa Lee, Hee Sun Baek, Seong Heon Kim, Heeyeon Cho, Min Hyun Cho, Jae Il Shin, Joo Hoon Lee, Hae Il Cheong, Hee Gyung Kang, Young Seo Park, Il-Soo Ha, Duk-Soo Moon, Kyoung Hee Han
Summary: This study investigated the intelligence levels and risk factors for low intelligence in children and adolescents with CKD, finding that participants with short stature, failure to thrive, more severe CKD stage, longer duration of CKD, and those who were Medicare or Medicaid beneficiaries had significantly lower intelligence levels. The association between intelligence and longer duration of CKD and growth failure remained significant after controlling for demographic and clinical variables, highlighting the importance of early interventions such as kidney transplantation.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Endocrinology & Metabolism
Rodolfo J. Galindo, Francisco J. Pasquel, Priyathama Vellanki, Cesar Zambrano, Bonnie Albury, Citlalli Perez-Guzman, Zheng Ziduo, Guillermo E. Umpierrez
Summary: This study revealed significant metabolic differences among DKA patients with different levels of renal function, with beta-hydroxybutyrate levels potentially assisting in confirming the diagnosis of DKA in ESKD patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Nikolay K. Sadykhov, Andrey G. Kartuesov, Evgeny E. Borisov, Vasily N. Sukhorukov, Alexander N. Orekhov
Summary: Atherosclerosis is the leading cause of cardiovascular disease worldwide, and it shares several risk factors with chronic kidney disease. Patients with chronic kidney disease are more susceptible to cardiovascular problems.
Article
Cell Biology
Zaipul I. Md Dom, Eiichiro Satake, Jan Skupien, Bozena Krolewski, Kristina O'Neil, Jill A. Willency, Simon T. Dillon, Jonathan M. Wilson, Hiroki Kobayashi, Katsuhito Ihara, Towia A. Libermann, Marlon Pragnell, Kevin L. Duffin, Andrzej S. Krolewski
Summary: This study identified three elevated plasma proteins associated with protection against progressive renal decline and progression to endstage renal disease in individuals with diabetes. These protective proteins may serve as biomarkers for stratifying diabetic individuals by their risk of developing ESRD, and could be explored as potential therapeutics to delay or prevent ESRD onset.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Yinghui Wang, Lu Gao
Summary: Chronic kidney disease and cardiac insufficiency often co-exist, especially in uremic patients on hemodialysis. Impaired renal function is often indicative of poor prognosis in patients with cardiac insufficiency. Inflammation plays a significant role in the development of cardiovascular complications in patients with chronic kidney disease and is indicative of prognosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Lorry Aitkens, Jennifer L. Waller, Stephanie L. Baer, Azeem Mohammed, Sarah Tran, Budder Siddiqui, Sandeep Padala, Lufei Young, Mufaddal Kheda, Wendy B. Bollag
Summary: This study found that psoriasis is protective against pneumonia in patients with end-stage renal disease, with other factors such as the Charlson Comorbidity Index (CCI) and tobacco use being more strongly associated with increased risk for pneumonia.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Review
Medicine, General & Internal
Xu Jing, Wen Zhuyuan, Chen Aijun, Xiong Jianxia, Huang Kun, Wang Ping
Summary: Previous studies have shown that patients with psoriasis are at higher risk of developing CKD and ESRD compared with the general population, but data on the differences in occurrence between psoriasis and non-psoriatic controls are limited and inconsistent. This study conducted a meta-analysis of cohort studies to compare the probability of suffering CKD and ESRD in patients with or without psoriasis.
FRONTIERS IN MEDICINE
(2023)
Article
Clinical Neurology
Chang Min Heo, Won Ho Lee, Bong Soo Park, Yoo Jin Lee, Sihyung Park, Yang Wook Kim, Dong Ah Lee, Byeong Cheol Yoo, Kang Min Park
Summary: This study compares glymphatic dysfunction between patients with end-stage renal disease (ESRD) and healthy controls, and reveals the presence of glymphatic dysfunction in patients with ESRD as demonstrated by the DTI-ALPS index. Additionally, a significant positive correlation is found between the DTI-ALPS index and serum parathyroid hormone levels in ESRD patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Fung-Chang Sung, Ying-Chin Jong, Chih-Hsin Muo, Chih-Cheng Hsu, Wen-Chen Tsai, Yueh-Han Hsu
Summary: Through analyzing insurance claims data from Taiwan, we found that statin therapy may reduce mortality risks for hyperlipidemic patients, especially in those with end-stage renal disease. Hydrophilic statin therapy showed superior effects in reducing all-cause mortality and deaths from cancer.
FRONTIERS IN PHARMACOLOGY
(2022)