Review
Cardiac & Cardiovascular Systems
Gerd Heusch
Summary: This review summarizes the pathophysiology of myocardial stunning and hibernation, emphasizing potential treatments and clinical implications. It is important to have a better understanding of these characteristic reperfusion phenomena to determine the indication for revascularization more precisely and its consequences in patients with chronic coronary syndromes.
NATURE REVIEWS CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Krishna K. Patel, A. Iain Mcghie, Kevin F. Kennedy, Randall C. Thompson, John A. Spertus, Brett W. Sperry, Leslee J. Shaw, Timothy M. Bateman
Summary: PET LVEF-R can be a significant predictor of prognosis in patients with cardiovascular disease. It can identify patients who benefit from revascularization within 90 days and improve survival, especially in the absence of prior myocardial infarction or revascularization.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Mathematical & Computational Biology
Jucheng Zhang, Minwen Ma, Huajun Li, Zhaoxia Pu, Haipeng Liu, Tianhai Huang, Huan Cheng, Yinglan Gong, Yonghua Chu, Zhikang Wang, Jun Jiang, Ling Xia
Summary: This study investigates the diagnostic performance of myocardial contrast echocardiography (MCE) for coronary microvascular dysfunction (CMD). It finds that MCE has high sensitivity and specificity in diagnosing CMD, showing strong agreement with thermodilution. However, the correlation coefficient is not high.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Valeria Gaudieri, Teresa Mannarino, Emilia Zampella, Roberta Assante, Adriana D'Antonio, Carmela Nappi, Valeria Cantoni, Roberta Green, Mario Petretta, Parthiban Arumugam, Alberto Cuocolo, Wanda Acampa
Summary: The study evaluated the association between impaired coronary vascular function and cardiovascular risk in hypertensive patients without overt coronary artery disease. Results showed that patients with resistant hypertension (RH) were older, had a higher prevalence of left ventricular hypertrophy, and lower hyperemic myocardial blood flow compared to those without RH. Multivariable analysis identified age, RH, and reduced myocardial perfusion reserve as independent predictors of cardiovascular events. Patients with RH and reduced myocardial perfusion reserve had the highest risk of events.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Mario D. Gaudino, George J. Dangas, Dominick Angiolillo, Jessica Brodt, Joanna Chikwe, Abe DeAnda, Irbaz L. Hameed, Mary Rodgers, Sigrid Y. Sandner, Louise M. Sun, Celina Yong
Summary: Acute postoperative myocardial ischemia (PMI) is a rare but potentially life-threatening complication after cardiac surgery. Factors associated with acute PMI may vary by the type of surgical procedure performed. The diagnosis of acute PMI lacks universally accepted criteria and the evidence on its management is limited and of low quality. Prompt diagnosis and treatment are crucial once acute PMI is suspected, with options including conservative strategies, percutaneous coronary intervention, and redo coronary artery bypass grafting. A multidisciplinary group of experts in cardiac surgery, cardiology, anesthesiology, and postoperative care provides clinical guidance based on the existing evidence.
Article
Radiology, Nuclear Medicine & Medical Imaging
Keiichiro Kuronuma, Robert J. H. Miller, Serge D. Van Kriekinge, Donghee Han, Ananya Singh, Heidi Gransar, Damini Dey, Daniel S. Berman, Piotr J. Slomka
Summary: PurposePhase analysis can evaluate left ventricular dyssynchrony, but the prognostic value of phase variables over PET-MPI variables has not been studied. This study aimed to explore the prognostic value of phase variables for predicting mortality. A total of 3963 patients who underwent pharmacological stress-rest Rb-82 PET study were enrolled. Cox proportional hazard analyses showed that stress phase entropy was significantly associated with all-cause mortality, and its addition improved the discriminatory power for mortality prediction.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yarong Yu, Lihua Yu, Xu Dai, Jiayin Zhang
Summary: The study investigated the diagnostic performance of CT fractional flow reserve (CT-FFR) for myocardial bridging-related ischemia using dynamic CT myocardial perfusion imaging (CT-MPI) as a reference standard. Delta CT-FFRsystolic showed the largest area under the curve in identifying myocardial bridging-related ischemia, with high sensitivity and negative predictive value. Myocardial bridging showing positive CT-FFR results requires further evaluation.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Nicholas T. Thielen, Adison A. Kleinsasser, Jessica L. Freeling
Summary: This study explored the use of myocardial contrast echocardiography (MCE) to assess myocardial infarction (MI) in mice. The MCE parameters were able to differentiate between MI and sham-operated groups, providing complementary information to conventional methods and additional hemodynamic data.
Review
Cardiac & Cardiovascular Systems
Timothy D. Henry, Matthew I. Tomey, Jacqueline E. Tamis-Holland, Holger Thiele, Sunil V. Rao, Venu Menon, Deborah G. Klein, Yoshifumi Naka, Ileana L. Pina, Navin K. Kapur, George D. Dangas
Summary: CS remains the leading cause of mortality in patients with acute myocardial infarction, and early revascularization has shown survival benefit in treating CS patients. A recent classification scheme and scientific statement have recommended the establishment of CS centers with standardized protocols for diagnosis and management.
Article
Cardiac & Cardiovascular Systems
Itta Kawamura, Toru Tanigaki, Hiroyuki Omori, Takuya Mizukami, Tetsuo Hirata, Jun Kikuchi, Hideaki Ota, Yoshihiro Sobue, Taiji Miyake, Yoshiaki Kawase, Munenori Okubo, Hiroki Kamiya, Masanori Kawasaki, Kunihiko Tsuchiya, Masayasu Nakagawa, Takeshi Kondo, Takahiko Suzuki, Hitoshi Matsuo
Summary: The study found a good correlation between MPI and FFR in detecting myocardial ischemia, but the positive predictive value of FFR in identifying MPI-positive lesions was not high. Some lesions with normal MPI results may also have low FFR values.
CIRCULATION JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Louise A. E. Brown, Gaurav S. Gulsin, Sebastian C. Onciul, David A. Broadbent, Jian L. Yeo, Alice L. Wood, Christopher E. D. Saunderson, Arka Das, Nicholas Jex, Amrit Chowdhary, Sharmaine Thirunavukarasu, Noor Sharrack, Kristopher D. Knott, Eylem Levelt, Peter P. Swoboda, Hui Xue, John P. Greenwood, James C. Moon, David Adlam, Gerry P. McCann, Peter Kellman, Sven Plein
Summary: This study aimed to establish sex- and age-specific normal values for myocardial blood flow (MBF) in healthy volunteers. The results showed differences in MBF between males and females, and a decrease in MBF and myocardial perfusion reserve with advancing age.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Anna Oleksiak, Cezary Kepka, Koen Nieman, Mariusz Debski, Marcin Demkow, Mariusz Kruk
Summary: This study aimed to compare a novel ischemic volume quantification method based on dynamic computed tomography perfusion (VOL CTP) with other CT-based imaging modalities for revascularization prediction. The results showed that VOL CTP performed better in predicting total revascularization compared to other methods.
KARDIOLOGIA POLSKA
(2022)
Article
Cardiac & Cardiovascular Systems
Kurt Ruetzler, Nathaniel R. Smilowitz, Jeffrey S. Berger, P. J. Devereaux, Bradley A. Maron, L. Kristin Newby, Vinicio de Jesus Perez, Daniel Sessler, Duminda N. Wijeysundera
Summary: Myocardial injury after noncardiac surgery is defined by elevated cardiac troponin levels, occurring in about 20% of patients, and independently associated with mortality. Monitoring is recommended for high-risk patients.
Article
Cardiac & Cardiovascular Systems
Roberta Assante, Ciro Gabriele Mainolfi, Emilia Zampella, Valeria Gaudieri, Carmela Nappi, Teresa Mannarino, Adriana D'Antonio, Parthiban Arumugam, Mario Petretta, Alberto Cuocolo, Wanda Acampa
Summary: The study found that diabetic patients with reduced MFR had higher annualized event rate and lower event-free survival compared to those with preserved MFR and nondiabetic patients. Age, BMI, and reduced MFR were identified as independent predictors of events in diabetic patients. Diabetic patients with reduced MFR had lower event-free survival compared to both diabetic patients with normal MFR and nondiabetic patients with reduced MFR.
JOURNAL OF NUCLEAR CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Signe Hojstrup, Kim W. Hansen, Ulrik Talleruphuus, Lisbeth Marner, Soren Galatius, Maira Rauf, Louise H. Bjerking, Lars Jakobsen, Evald H. Christiansen, Kirsten Bouchelouche, Hanne Christensen, Eva I. B. Prescott
Summary: This study is the first large-scale cohort study to establish a link between coronary microvascular disease (CMD) and small vessel disease in the kidney and brain. The data support the hypothesis that CMD is part of a systemic vascular disorder.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Oncology
Diana D. Shi, Kevin X. Liu, Fred Hacker, Glenn J. Hanna, Raymond Y. Kwong, Daniel N. Cagney, Raymond H. Mak, Lisa Singer
Summary: Stereotactic magnetic resonance-guided adaptive radiation therapy offers advantages in treating cardiac metastases, improving tumor visualization, real-time monitoring, and plan adaptation.
PRACTICAL RADIATION ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Qiang Zhang, Konrad Werys, Iulia A. Popescu, Luca Biasiolli, Ntobeko A. B. Ntusi, Milind Desai, Stefan L. Zimmerman, Dipan J. Shah, Kyle Autry, Bette Kim, Han W. Kim, Elizabeth R. Jenista, Steffen Huber, James A. White, Gerry P. McCann, Saidi A. Mohiddin, Redha Boubertakh, Amedeo Chiribiri, David Newby, Sanjay Prasad, Aleksandra Radjenovic, Dana Dawson, Jeanette Schulz-Menger, Heiko Mahrholdt, Iacopo Carbone, Ornella Rimoldi, Stefano Colagrande, Linda Calistri, Michelle Michels, Mark B. M. Hofman, Lisa Anderson, Craig Broberg, Flett Andrew, Javier Sanz, Chiara Bucciarelli-Ducci, Kelvin Chow, David Higgins, David A. Broadbent, Scott Semple, Tarik Hafyane, Joanne Wormleighton, Michael Salerno, Taigang He, Sven Plein, Raymond Y. Kwong, Michael Jerosch-Herold, Christopher M. Kramer, Stefan Neubauer, Vanessa M. Ferreira, Stefan K. Piechnik
Summary: By utilizing MR phantoms manufactured in 2013, including ShMOLLI T1-mapping and reference T1 and T2 protocols, the study investigated the impact of temperature and phantom aging on T1 values. A multiparametric QA model was developed and applied to 78 scans from 28 multinational sites, confirming the accuracy and robustness of the QA program for T1-mapping.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Harmony R. Reynolds, Leslee J. Shaw, James K. Min, Courtney B. Page, Daniel S. Berman, Bernard R. Chaitman, Michael H. Picard, Raymond Y. Kwong, Sean M. O'Brien, Zhen Huang, Daniel B. Mark, Ranjit K. Nath, Sudhanshu K. Dwivedi, Paola E. P. Smanio, Peter H. Stone, Claes Held, Matyas Keltai, Sripal Bangalore, Jonathan D. Newman, John A. Spertus, Gregg W. Stone, David J. Maron, Judith S. Hochman
Summary: The ISCHEMIA trial found that the severity of ischemia was not associated with increased risk after adjustment for CAD severity. More severe CAD was related to increased risk. Invasive management did not lower all-cause mortality at 4 years in any ischemia or CAD subgroup.
Letter
Cardiac & Cardiovascular Systems
Harmony R. Reynolds, Raymond Y. Kwong, Akiko Maehara, Nathaniel R. Smilowitz
Article
Cardiac & Cardiovascular Systems
Sharmila Dorbala, Yukio Ando, Sabahat Bokhari, Angela Dispenzieri, Rodney H. Falk, Victor A. Ferrari, Marianna Fontana, Olivier Gheysens, Julian D. Gillmore, Andor W. J. M. Glaudemans, Mazen A. Hanna, Bouke P. C. Hazenberg, Arnt Kristen, Raymond Y. Kwong, Mathew S. Maurer, Giampaolo Merlini, Edward J. Miller, James C. Moon, Venkatesh L. Murthy, C. Cristina Quarta, Claudio Rapezzi, Frederick L. Ruberg, Sanjiv J. Shah, Riemer H. J. A. Slart, Hein J. Verberne, Jamieson M. Bourque
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Correction
Cardiac & Cardiovascular Systems
Sharmila Dorbala, Yukio Ando, Sabahat Bokhari, Angela Dispenzieri, Rodney H. Falk, Victor A. Ferrari, Marianna Fontana, Olivier Gheysens, Julian D. Gillmore, Andor W. J. M. Glaudemans, Mazen A. Hanna, Bouke P. C. Hazenberg, Arnt V. Kristen, Raymond Y. Kwong, Mathew S. Maurer, Giampaolo Merlini, Edward J. Miller, James C. Moon, Venkatesh L. Murthy, C. Cristina Quarta, Claudio Rapezzi, Frederick L. Ruberg, Sanjiv J. Shah, Riemer H. J. A. Slart, Hein J. Verberne, Jamieson M. Bourque
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Panagiotis Antiochos, Yin Ge, Bobak Heydari, Kevin Steel, Scott Bingham, Shuaib M. Abdullah, J. Ronald Mikolich, Andrew E. Arai, Patricia Bandettini, Amit R. Patel, Afshin Farzaneh-Far, John F. Heitner, Chetan Shenoy, Steve W. Leung, Jorge A. Gonzalez, Dipan J. Shah, Subha Raman, Victor A. Ferrari, Jeanette Schulz-Menger, Matthias Stuber, Orlando P. Simonetti, Raymond Y. Kwong
Summary: Stress CMR-assessed ischemia was strongly associated with MI/CV death and reclassified patient risk beyond CV risk factors, especially in those considered to be at intermediate risk. Absence of ischemia was associated with a <2% annual rate of MI/CV death.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Ayako Seno, Panagiotis Antiochos, Helena Lichtenfeld, Eva Rickers, Iqra Qamar, Yin Ge, Ron Blankstein, Michael Steigner, Ayaz Aghayev, Michael Jerosch-Herold, Raymond Y. Kwong
Summary: Recent research has found that the assessment of extracellular volume fraction (ECV) and global longitudinal strain (GLS) by cardiac magnetic resonance can provide valuable prognostic information for predicting all-cause death or heart failure hospitalizations in patients suspected of heart failure. This incremental prognostic value of ECV and GLS goes beyond traditional markers such as left ventricular ejection fraction (LVEF) and late gadolinium enhancement (LGE). Additionally, the joint assessment of GLS and ECV has been shown to significantly improve model discrimination and risk reclassification for adverse outcomes in this patient population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Raymond Y. Kwong, Rhanderson Cardoso, Michael Jerosch-Herold
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Raymond Y. Kwong, Michael Jerosch-Herold
Editorial Material
Cardiac & Cardiovascular Systems
Toral R. Y. Patel, Todd Villines, Christopher M. Kramer
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Dominik C. Benz, Christoph Grani, Panagiotis Antiochos, Bobak Heydari, Mark Colin Gissler, Yin Ge, Sarah A. M. Cuddy, Sharmila Dorbala, Raymond Y. Kwong
Summary: Cardiac magnetic resonance offers multiple facets in the diagnosis, risk stratification, and management of patients with myocardial diseases. Particularly, its feature to precisely monitor disease activity lends itself to quantify response to novel therapeutics.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Christoph Grani, Marius R. Bigler, Raymond Y. Kwong
Summary: The purpose of this review is to evaluate how noninvasive comprehensive anatomic- and physiologic evaluation can guide patient management for anomalous aortic origin of a coronary artery (AAOCA). The review explores the role of noninvasive multimodality imaging in characterizing AAOCA, with a focus on the pathophysiology of myocardial ischemia and stress testing protocols.
CURRENT CARDIOLOGY REPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Andrew E. Arai, Raymond Y. Kwong, Michael Salerno, John P. Greenwood, Chiara Bucciarelli-Ducci
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2022)
Article
Cardiac & Cardiovascular Systems
Ankur Pandya, Yuan-Jui Yu, Yin Ge, Eike Nagel, Raymond Y. Kwong, Rafidah Abu Bakar, John D. Grizzard, Alexander E. Merkler, Ntobeko Ntusi, Steffen E. Petersen, Nina Rashedi, Juerg Schwitter, Joseph B. Selvanayagam, James A. White, James Carr, Subha V. Raman, Orlando P. Simonetti, Chiara Bucciarelli-Ducci, Lilia M. Sierra-Galan, Victor A. Ferrari, Mona Bhatia, Sebastian Kelle
Summary: Based on the research, cardiovascular magnetic resonance (CMR) is usually a cost-effective option compared to relevant comparators for assessing significant coronary artery disease. The findings suggest that CMR can provide both health benefits and cost savings, making it a favorable choice for evaluating CAD.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2022)