Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 26, Issue 61, Pages 13832-13841Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201905083
Keywords
boron neutron capture therapy; cholesterol; closo-dodecaborate; cobalt bis(dicarbollide); iron bis(dicarbollide); liposomes
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Funding
- Russian Foundation for Basic Research [17-53-80099_BRICS]
- Department of Science and Technology, Government of India [DST/IMRCD/BRICS/PilotCall1/BGNCDT/2017 (G)]
- National Natural Science Foundation of China [51761145021]
- Ministry of Science and high Education of the Russian Federation
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A series of boron-containing lipids were prepared by reactions of cyclic oxonium derivatives of polyhedron boranes and metallacarboranes (closo-dodecaborate anion, cobalt and iron bis(dicarbollides)) with amine and carboxylic acids which are derived from cholesterol. Stable liposomal formulations, on the basis of synthesized boron-containing lipids, hydrogenated soybeanl-alpha-phosphatidylcholine and (HSPC) 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG) as excipients, were prepared and then characterized by dynamic light scattering (DLS) that revealed the formation of particles to be smaller than 200 nm in diameter. The resulting liposomal formulations showed moderate to excellent loading and entrapment efficiency, thus justifying the design of the compounds to fit in the lipid bilayer and ensuring ease of in vivo use for future application. The liposomal formulations based on cobalt and iron bis(dicarbollide)-based lipids were found to be nontoxic against both human breast normal epithelial cells MCF-10A and human breast cancer cells MCF-7.
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