Article
Multidisciplinary Sciences
Laia Capilla-Perez, Stephanie Durand, Aurelie Hurel, Qichao Lian, Aurelie Chambon, Christelle Taochy, Victor Solier, Mathilde Grelon, Raphael Mercier
Summary: The spatial organization of transverse filaments is essential for CO formation during meiosis, with the absence of ZYP1 leading to an unexpected increase in CO formation. The tripartite synaptonemal complex plays a key role in regulating the number and distribution of COs, affecting CO interference and heterochiasmy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Elena Llano, Alberto M. Pendas
Summary: The synaptonemal complex (SC) forms during meiosis I and is involved in the synapses of homologous chromosomes, repair of double-strand breaks (DSBs), and formation of crossovers (COs). Defects in SC assembly or meiotic recombination machinery can cause meiotic arrest and infertility. Many proteins involved in these processes are meiosis-specific, but some also have roles in somatic DNA repair and are associated with cancer development.
Article
Multidisciplinary Sciences
Talia Feijao, Bruno Marques, Rui D. Silva, Celia Carvalho, Daniel Sobral, Ricardo Matos, Tian Tan, Antonio Pereira, Eurico Morais-de-Sa, Helder Maiato, Steven Z. DeLuca, Rui Goncalo Martinho
Summary: The timely expression of synaptonemal complex (SC) coding genes is essential for successful meiosis, but SC components have a tendency to self-organize into abnormal structures. This study reveals that the Polycomb group protein Sfmbt plays a crucial role in preventing excessive expression of SC genes during prophase I. Depletion of Sfmbt leads to abnormal SC disassembly and the formation of multiple synaptonemal complexes (polycomplexes). Further investigation suggests that other Polycomb group proteins and the overexpression of the SC gene corona are also associated with polycomplex formation during SC disassembly.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Hideo Tsubouchi
Summary: Homologous recombination (HR) is crucial for meiosis and is induced during meiotic prophase. The Hop2-Mnd1 complex, originally identified in budding yeast, is conserved across species and plays an essential role in meiosis. Accumulating evidence suggests that Hop2-Mnd1 promotes RecA-like recombinases for homology search and strand exchange. This review summarizes studies on the mechanism of the Hop2-Mnd1 complex in promoting HR and beyond.
Review
Biochemistry & Molecular Biology
Fengguo Zhang, Mengfei Liu, Jinmin Gao
Summary: Around 10% of reproductive-aged couples suffer from infertility, but the genetic causes of human infertility are largely unknown. Errors in meiosis, the process that produces gametes for fertilization, are associated with infertility in both males and females. Successful meiosis relies on the assembly of the synaptonemal complex (SC) between paired homologous chromosomes. Mutations in SC coding genes have been linked to human infertility, and complex interaction networks associated with SC components have been identified. Further investigations are needed to determine the role of genetic variations and environmental factors in human infertility.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biology
John A. Fozard, Chris Morgan, Martin Howard, Akira Shinohara
Summary: The shuffling of genetic material through meiotic crossovers is vital for genetic variation. By studying Arabidopsis mutants lacking the synaptonemal complex (SC), a protein scaffold, researchers have discovered a coarsening mechanism involving the competition for a limited pool of the pro-crossover factor HEI10. This mechanism explains the crossover patterning in SC-defective mutants and wild-type Arabidopsis, highlighting the importance of regulating crossover events.
Article
Oncology
Rosario Ortiz, Silvia Juarez Chavero, Olga M. Echeverria, Abrahan Hernandez-Hernandez
Summary: The study utilized an ultrastructural DNA staining technique on mouse testis to observe the organization of DNA in the SC. Bubble-like staining patterns were observed in certain regions, indicating that the specific organization of DNA is determined by chromosome synapsis, regardless of homology or partial SC formation.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Genetics & Heredity
Karen Voelkel-Meiman, Ashwini Oke, Arden Feil, Alexander Shames, Jennifer Fung, Amy J. MacQueen
Summary: The study reveals that while the SC proteins are not essential for recombination itself, they promote efficient mismatch repair at interhomolog recombination sites. Failure to repair mismatches leads to the formation of genotypically sectored colonies, with an increased frequency of unrepaired mismatches in cells lacking specific proteins.
Article
Genetics & Heredity
Jing Wang, Wen Wang, Jihong Li, Yirui Zhang, Kaikun Luo, Linmei Han, Caixia Xiang, Mingli Chai, Ziye Luo, Rurong Zhao, Shaojun Liu
Summary: Research shows that in the hybrid clone line of red crucian carp and common carp, there is a failure in chromosome pairing in the fertilized eggs, leading to sterility. However, after a long period of inhibition, the chromosome number doubles and successfully forms paired chromosomes and synaptonemal complex. This study further reveals the mechanisms of meiosis in hybrids.
FRONTIERS IN GENETICS
(2023)
Article
Multidisciplinary Sciences
Martin G. France, Janina Enderle, Sarah Roehrig, Holger Puchta, F. Chris H. Franklin, James D. Higgins
Summary: The study on the function of the synaptonemal complex in Arabidopsis indicates that it limits the formation of Class I crossover interference and disrupts the progressive alignment of chromosome axes in plants.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Michael G. Pollard, Beth Rockmill, Ashwini Oke, Carol M. Anderson, Jennifer C. Fung
Summary: The synaptonemal complex (SC) is a structure formed during meiosis that stabilizes and supports essential processes such as pairing and recombination. This study measured the assembly and disassembly kinetics of the SC protein Zip1 in live cells of S. cerevisiae. It was found that SC assembly occurs with both monophasic and biphasic kinetics, and there are distinct disassembly events termed abortive disassembly. These findings provide new insights into the regulation of SC assembly and disassembly.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Yukiko Imai, Kenji Saito, Kazumasa Takemoto, Fabien Velilla, Toshihiro Kawasaki, Kei-ichiro Ishiguro, Noriyoshi Sakai
Summary: The mutation in the zebrafish gene encoding the transverse filament protein Sycp1 leads to incomplete pairing of homologs in zebrafish meiosis, while not affecting double-strand break formation near telomeres.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Marine & Freshwater Biology
Miao Tian, Xia Cai, Yujie Liu, Mingmei Liucong, Rachel Howard-Till
Summary: Meiosis, a critical cell division program, produces haploid gametes for sexual reproduction. The synaptonemal complex (SC) plays a crucial role in guiding and stabilizing homologous chromosome pairing during meiosis. However, there are organisms that undergo meiosis without a functional SC. Studying the ciliated protozoan Tetrahymena can provide insights into the features and adaptive significance of SC-less meiosis, and possibly reveal novel features in poorly characterized ciliates. A better understanding of SC-less meiosis and its mechanisms can contribute to our knowledge of the SC function and the evolution of meiosis.
MARINE LIFE SCIENCE & TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Svein-Ole Mikalsen, Sunnvor i Kongsstovu, Marni Tausen
Summary: Previous studies have shown that the connexin gene family has similar subfamily structures in several vertebrate groups. However, there is a lack of data between invertebrates and teleosts. The major evolutionary transformations in this gene family are from tunicates to cyclostomes and from cyclostomes to jawed vertebrates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Yukiko Imai, Ivan Olaya, Noriyoshi Sakai, Sean M. Burgess
Summary: Recent studies in zebrafish have provided insights on key features of meiotic chromosome dynamics, such as telomere clustering and homolog alignment. This review discusses the temporal progression of these events and the roles of proteins associated with homologous recombination.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Letter
Microbiology
Monique Aouad, Guillaume Borrel, Celine Brochier-Armanet, Simonetta Gribaldo
NATURE MICROBIOLOGY
(2019)
Article
Microbiology
Alexandre Duprey, Najwa Taib, Simon Leonard, Tiffany Garin, Jean-Pierre Flandrois, William Nasser, Celine Brochier-Armanet, Sylvie Reverchon
ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Microbiology
Lorine Bethencourt, Hasna Boubakri, Najwa Taib, Philippe Normand, Jean Armengaud, Pascale Fournier, Celine Brochier-Armanet, Aude Herrera-Belaroussi
RESEARCH IN MICROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Eaazhisai Kandiah, Diego Carriel, Pierre Simon Garcia, Jan Felix, Manuel Banzhaf, George Kritikos, Maria Bacia-Verloop, Celine Brochier-Armanet, Sylvie Elsen, Irina Gutsche
Editorial Material
Ecology
Simonetta Gribaldo, Celine Brochier-Armanet
NATURE ECOLOGY & EVOLUTION
(2020)
Article
Evolutionary Biology
Irene da Cruz, Celine Brochier-Armanet, Ricardo Benavente
BMC EVOLUTIONARY BIOLOGY
(2020)
Article
Microbiology
Nicole Hugouvieux-Cotte-Pattat, Celine Brochier-Armanet, Jean-Pierre Flandrois, Sylvie Reverchon
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2020)
Article
Microbiology
Sophie S. Abby, Melina Kerou, Christa Schleper
Article
Biochemistry & Molecular Biology
Michel Lecocq, Mathieu Groussin, Manolo Gouy, Celine Brochier-Armanet
Summary: This study used Methanococcales as a model to investigate the impact of environmental temperature on proteome evolution in Bacteria and Archaea. It found that optimal growth temperature is the major factor affecting amino acid frequencies in proteomes, with sequential amino acid substitutions playing a central role in thermoadaptation. Colonization to new thermal niches was not linked to high amounts of horizontal gene transfers, suggesting that sequential amino acid substitutions are the main driving force behind thermoadaptation.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Multidisciplinary Sciences
Jan Felix, Claire Siebert, Julia Novion Ducassou, Jerome Nigou, Pierre Simon Garcia, Angelique Fraudeau, Karine Huard, Caroline Mas, Celine Brochier-Armanet, Yohann Coute, Irina Gutsche, Patricia Renesto
Summary: This study characterized the lysine decarboxylase in F. novicida, demonstrating its involvement in oxidative stress response and identifying it as a potential drug target for survival in host cells. The research also analyzed the impact of ldcF deletion on bacterial growth under different stress conditions and in infected macrophages, revealing key proteins affected by the deletion.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Pierre S. Garcia, Wandrille Duchemin, Jean-Pierre Flandrois, Simonetta Gribaldo, Christophe Grangeasse, Celine Brochier-Armanet
Summary: The study conducted a large-scale in-silico analysis on around 1,000 genomes of the Firmicutes bacterial phylum, revealing substantial differences among clades and evolution hotspots. A functional network was established in the Firmicutes, allowing for the identification of new functional links and new candidates involved in sporulation and cell wall synthesis. The results provide a previously undescribed view on the diversity of the bacterial cell cycle and a methodological framework for analyzing other biological systems.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Plant Sciences
Djivan Prentout, Natasa Stajner, Andreja Cerenak, Theo Tricou, Celine Brochier-Armanet, Jernej Jakse, Jos Kafer, Gabriel A. B. Marais
Summary: A shared sex chromosome system was discovered in Cannabis and Humulus, with recombination suppression beginning 21-25 million years ago, leading to a degenerated Y chromosome.
Article
Biochemistry & Molecular Biology
Celine Brochier-Armanet, Dominique Madern
Summary: Recent research has shown that the LDH/MDH superfamily includes three main families: MDH1, MDH2, and a larger family encompassing MDH3, LDH, and HicDH sequences. Surprisingly, the latter showed unexpected combinations of amino acids, indicating a higher diversity than previously thought. Functional characterization of enzymes from this family revealed mixed properties, blurring the lines between MDH3 and LDH enzymes.
Article
Biochemistry & Molecular Biology
Adeline Y. Robin, Celine Brochier-Armanet, Quentin Bertrand, Caroline Barette, Eric Girard, Dominique Madern
Summary: This study provides a comprehensive understanding of the evolution and structure-function relationships of lactate dehydrogenase (LDH), identifying the link between eukaryotic and cyanobacterial LDHs and characterizing the role of specific amino acid positions in the regulation of LDH activity.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Ecology
Monique Aouad, Jean-Pierre Flandrois, Frederic Jauffrit, Manolo Gouy, Simonetta Gribaldo, Celine Brochier-Armanet
Summary: Recent cultivation-independent genome sequencing has provided valuable material to explore uncharted branches of the Tree of Life, particularly concerning the Archaea. By analyzing subsets of specific taxonomic samples, we successfully resolved the phylogenetic tree of Archaea and identified two main clades. However, further study is needed to understand the fast-evolving nanosized archaeal lineages.
BMC ECOLOGY AND EVOLUTION
(2022)
