Review
Biochemistry & Molecular Biology
Andres Molero-Chamizo, Michael A. Nitsche, Rafael Tomas Andujar Barroso, Jose R. Alameda Bailen, Jesus Carlos Garcia Palomeque, Guadalupe Nathzidy Rivera-Urbina
Summary: Although fibromyalgia is primarily characterized by muscular pain, it also involves dysfunctions in various bodily systems. Neuromodulatory stimulation techniques have shown potential in treating the neurological symptoms of fibromyalgia. In this review, we discuss the use of non-invasive brain stimulation techniques as therapeutic strategies and their contribution to understanding the neurophysiological characteristics of fibromyalgia. While these approaches do not aim to cure the syndrome, they can significantly improve patients' quality of life by reducing key symptoms.
Article
Clinical Neurology
Tariq Parker, Ashley Raghu, Yongzhi Huang, Martin J. Gillies, James J. FitzGerald, Tipu Aziz, Alexander L. Green
Summary: The study findings suggest that the combination of single-session tDCS with DRGS is safe and significantly reduces pain acutely in neuropathic pain patients.
Article
Medicine, Research & Experimental
Selina Johnson, Anne Marshall, Dyfrig Hughes, Emily Holmes, Florian Henrich, Turo Nurmikko, Manohar Sharma, Bernhard Frank, Paul Bassett, Andrew Marshall, Walter Magerl, Andreas Goebel
Summary: Two interlinked studies examined the therapeutic LTD for chronic peripheral nerve injury pain, with the clinical trial showing non-significant results and the mechanistic study indicating improvement in mechanical hyperalgesia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Medicine, General & Internal
David Fernandez-Hernando, Cristian Justribo Manion, Juan A. Pareja, Francisco J. Garcia-Esteo, Juan A. Mesa-Jimenez
Summary: This study conducted a systematic review on the effectiveness of non-invasive neuromodulation of the vagus nerve in patients with cluster headaches. The results showed that neuromodulation had some positive effects on relieving the frequency and intensity of cluster headaches. However, the limited quantity and heterogeneity of available studies prevented a meta-analysis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Behavioral Sciences
Elisa Tatti, Angela L. Phillips, Rachel Paciorek, Sara M. Romanella, Davide Dettore, Giorgio Di Lorenzo, Giulio Ruffini, Simone Rossi, Emiliano Santarnecchi
Summary: Mental health disorders and substance use disorders pose significant challenges to public health systems. Evidence-based psychotherapy is commonly used to address mental health issues, but treatment adherence, relapses, and practical barriers hinder psychological change. Non-invasive brain stimulation techniques have emerged as promising tools to directly target dysfunctional neural circuitry and promote lasting plastic changes. Combining psychotherapy with brain stimulation may personalize treatment and provide more direct control of neuronal changes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Food Science & Technology
Mariarosaria Valente, Christian Lettieri, Valentina Russo, Francesco Janes, Gian Luigi Gigli
Summary: Chronic pain syndromes lead to changes in cortical excitability and plasticity in patients, as shown in a study using transcranial magnetic stimulation (TMS) in chronic migraine (CM) patients treated with botulinum neurotoxin type A (BoNT/A). Patients with CM showed lower cortical excitability and increased intracortical facilitation (ICF) compared to those with episodic migraine (EM). After BoNT/A treatment, there was a partial reduction in cortical excitability and a significant decrease in MIDAS score, indicating long-term alteration of cortical plasticity in chronic pain.
Review
Neurosciences
Jaya Dilip Badadhe, Hyeonhee Roh, Byung Chul Lee, Jae Hun Kim, Maesoon Im
Summary: Globally, there are over 2.2 billion visually impaired individuals, and ultrasound stimulation can serve as a non-invasive alternative approach to restore vision. Recent studies have demonstrated that ultrasound stimulation can successfully modulate retinal/brain neuronal activities without causing any damage to nerve cells. The superior penetration depth and high spatial resolution of focused ultrasound can open new avenues in neuromodulation research.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Matteo Guidetti, Alessandro Bertini, Francesco Pirone, Gessica Sala, Paola Signorelli, Carlo Ferrarese, Alberto Priori, Tommaso Bocci
Summary: Non-invasive brain stimulation techniques have shown potential in improving symptoms of neurodegenerative diseases, particularly cognitive and motor impairments in Alzheimer's Disease and Parkinson's Disease. However, their effect on disease progression is still unclear, although recent evidence suggests a possible neuroprotective role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Kathleen E. Mantell, Nipun D. Perera, Sina Shirinpour, Oula Puonti, Ting Xu, Jan Zimmermann, Arnaud Falchier, Sarah R. Heilbronner, Axel Thielscher, Alexander Opitz
Summary: The study examined the impact of anatomical details in NHP models on NIBS electric field calculations, highlighting the effects of muscle tissue and head field of view on TES and TMS simulation results. Opposing effects were found between TES and TMS when comparing full head models to cropped head models, with significant changes in electric field strength observed.
Article
Medicine, Research & Experimental
Benjamin H. Natelson, Aaron J. Stegner, Gudrun Lange, Sarah Khan, Michelle Blate, Anays Sotolongo, Michelle DeLuca, William W. Van Doren, Drew A. Helmer
Summary: In a study involving Gulf War Veterans with GWI, non-invasive vagal nerve stimulation did not show significant improvement in widespread pain or migraine frequency compared to sham stimulation. Overall, there were slight improvements in pain ratings and physical function, but no significant differences between active and sham nVNS groups. The open-label follow-up period did not reveal any statistically significant changes in pain, physical function, migraine measures, or impression of change.
Review
Food Science & Technology
Matthew S. Agritelley, Jeffrey J. Goldberger
Summary: Caffeine withdrawal in the hospital setting is often overlooked but can lead to symptoms such as headaches and mood swings. Some studies suggest that caffeine may promote wakefulness post-anesthesia and prevent withdrawal headaches.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Y. Hong, J. Wang, J. Li, Z. Xu, X. Yang, M. Bai, P. Gong, Y. Xie, X. Zhang, P. Xu, X. Chen, R. Li, X. Liu, G. Ruan, G. Xu
Summary: This study explores an alternative strategy of non-invasive brain delivery of nanoparticles and finds that this method can enhance the neural stimulation effects of transcranial magnetic stimulation (TMS). The use of Tat-SPIONs in combination with TMS shows significant improvement in stroke recovery in rats. Mechanistic studies suggest that the neural stimulation enhancement is mediated by neuroplasticity and magnetoelectric effect, primarily through the binding of Tat-SPIONs to neurons' plasma membranes. This research provides a technological platform for the medical applications of nanoparticles in remote brain stimulation for stroke and other neurological disorders.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Aidan Levine, Erika Liktor-Busa, Kelly L. Karlage, Luigi Giancotti, Daniela Salvemini, Todd W. Vanderah, Tally M. Largent-Milnes
Summary: Recent findings suggest that Clinical Endocannabinoid Deficiency is associated with pain disorders, and targeted regulation of the endocannabinoid system may induce headache pain. Inhibition of specific biosynthetic enzymes could lead to headache-like pain and photophobia, providing a valuable addition to headache models.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Ines R. Violante, Ketevan Alania, Antonino M. Cassara, Esra Neufeld, Emma Acerbo, Romain Carron, Adam Williamson, Danielle L. Kurtin, Edward Rhodes, Adam Hampshire, Niels Kuster, Edward S. Boyden, Alvaro Pascual-Leone, Nir Grossman
Summary: This study validates the concept of non-invasive deep brain stimulation (DBS) in humans. Through electric field modeling and measurements, it is shown that DBS can be focused on the hippocampus with minimal exposure to the overlying cortex. Functional magnetic resonance imaging and behavioral experiments demonstrate that DBS can modulate hippocampal activity and enhance episodic memory in healthy individuals.
NATURE NEUROSCIENCE
(2023)
Review
Neurosciences
Wanting Guo, Yuchen He, Wenquan Zhang, Yiwei Sun, Junling Wang, Shuang Liu, Dong Ming
Summary: Neuromodulation technology has great potential in treating neuropsychiatric disorders, but challenges like invasiveness, energy consumption, and public acceptance need to be addressed. Temporally interfering electrical stimulation, using low-frequency envelope waveform, shows promise in targeting specific brain areas without invasive procedures. Recent studies have focused on investigating the stimulation qualities and application of this technique, aiming to provide reference for future research.
FRONTIERS IN NEUROSCIENCE
(2023)
Correction
Clinical Neurology
Edoardo Nicolo Aiello, Sara Rimoldi, Nadia Bolognini, Ildebrando Appollonio, Giorgio Arcara
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Marta Bellofatto, Alessandro Bertini, Irene Tramacere, Fiore Manganelli, Gian Maria Fabrizi, Angelo Schenone, Lucio Santoro, Tiziana Cavallaro, Marina Grandis, Stefano C. Previtali, Isabella Allegri, Luca Padua, Costanza Pazzaglia, Daniela Calabrese, Paola Saveri, Aldo Quattrone, Paola Valentino, Stefano Tozza, Luca Gentile, Massimo Russo, Anna Mazzeo, Giuseppe Vita, Sylvie Piacentini, Chiara Pisciotta, Davide Pareyson
Summary: A significant proportion of Charcot-Marie-Tooth disease (CMT) patients experience general distress and depression, which are correlated with disease severity and medication usage.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Silvia Fenu, Irene Tramacere, Francesca De Giorgi, Davide Pareyson
Summary: Telehealth is a valid tool for monitoring patients with SBMA, as demonstrated by the effective and reliable administration of the AMAT and SBMA-FRS scales remotely.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Mirna Andelic, Erika Salvi, Stefania Marcuzzo, Margherita Marchi, Raffaella Lombardi, Daniele Cartelli, Daniele Cazzato, Elkadia Mehmeti, Andrea Gelemanovic, Matilde Paolini, Carlotta Pardo, Ilaria D'Amato, Janneke G. J. Hoeijmakers, Sulayman Dib-Hajj, Stephen G. Waxman, Catharina G. Faber, Giuseppe Lauria
Summary: Personalized management of neuropathic pain is a clinical need that has not been fulfilled due to various factors. Recent studies on microRNA have provided insights into pain-related mechanisms and identified potential drug candidates. By generating a molecular profile of the epidermis in patients with sodium channel-related painful neuropathy, the researchers identified specific miRNAs and mRNA targets that are involved in peripheral sensory transduction and modulation. The findings suggest a complex interaction between epidermal cells and axons in neuropathy pain. This targeted molecular profiling could advance personalized medicine for neuropathic pain.
Article
Clinical Neurology
Marta Bellofatto, Alessandro Bertini, Irene Tramacere, Fiore Manganelli, Gian Maria Fabrizi, Angelo Schenone, Lucio Santoro, Tiziana Cavallaro, Marina Grandis, Stefano C. Previtali, Yuri Falzone, Isabella Allegri, Luca Padua, Costanza Pazzaglia, Daniela Calabrese, Paola Saveri, Aldo Quattrone, Paola Valentino, Stefano Tozza, Luca Gentile, Massimo Russo, Anna Mazzeo, Giuseppe Vita, Sylvie Piacentini, Chiara Pisciotta, Davide Pareyson
Summary: This study investigated fatigue in CMT patients and found that 36% of the patients experienced abnormal fatigue. Abnormal fatigue was correlated with disease severity, anxiety, depression, sleepiness, and obesity. Therefore, the management of CMT patients should involve treating fatigue and addressing other factors such as anxiety, depression, sleepiness, and obesity.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Food Science & Technology
Angelo Torrente, Laura Pilati, Salvatore Di Marco, Simona Maccora, Paolo Alonge, Lavinia Vassallo, Antonino Lupica, Serena Coppola, Cecilia Camarda, Nadia Bolognini, Filippo Brighina
Summary: This study found that multisensory integration is modified in chronic migraine, and onabotulinumtoxinA is effective in preventing chronic migraine and restoring multisensory processing.
Article
Immunology
Maria Rescigno, Chiara Agrati, Carlo Salvarani, Diana Giannarelli, Massimo Costantini, Alberto Mantovani, Raffaella Massafra, Pier Luigi Zinzani, Aldo Morrone, Stefania Notari, Giulia Matusali, Giuseppe Lauria Pinter, Antonio Uccelli, Gennaro Ciliberto, Fausto Baldanti, Franco Locatelli, Nicola Silvestris, Valentina Sinno, Elena Turola, Maria Teresa Lupo-Stanghellini, Giovanni Apolone
Summary: This study compared the B-cell, T-cell, and neutralizing antibody response to WT and Omicron BA.2 SARS-CoV-2 virus in patients with hematological malignancies, solid tumors, and immune-rheumatological diseases after the fourth dose of mRNA COVID-19 vaccine. The T-cell response was similarly boosted by the fourth dose across different subgroups, while the antibody response was improved only in patients not receiving B-cell targeted therapies. However, a small percentage of patients did not have neutralizing antibodies to either virus variants, making them vulnerable to SARS-CoV-2 infection. The increment of neutralizing antibodies was similar towards Omicron BA.2 and WT virus after the third or fourth dose of vaccine. Additional booster doses are recommended for frail patients to enhance the development of a B-cell response against Omicron and/or to enhance the T-cell response in patients treated with anti-CD20.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Anna Nigri, Eleonora Dalla Bella, Stefania Ferraro, Jean Paul Medina Carrion, Greta Demichelis, Enrica Bersano, Monica Consonni, Antje Bischof, Mario Stanziano, Sara Palermo, Giuseppe Lauria, Maria Grazia Bruzzone, Nico Papinutto
Summary: This study evaluated the degeneration of gray matter and white matter in the cervical spinal cord in amyotrophic lateral sclerosis patients using the King's staging system. The results showed that the pattern of spinal cord atrophy differed in different clinical stages. This study provides important insights into the progression of amyotrophic lateral sclerosis.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Oncology
Paolo Ferroli, Francesco Restelli, Giacomo Bertolini, Emanuele Monti, Jacopo Falco, Giulio Bonomo, Irene Tramacere, Bianca Pollo, Chiara Calatozzolo, Monica Patane, Silvia Schiavolin, Morgan Broggi, Francesco Acerbi, Alessandra Erbetta, Silvia Esposito, Elio Mazzapicchi, Emanuele La Corte, Ignazio Gaspare Vetrano, Giovanni Broggi, Marco Schiariti
Summary: This retrospective study analyzed the associations between possible prognostic factors and survival rate. Surgical resection, tumor volume, histological grade, extent of resection, and 3-month postoperative performance status were identified as important prognostic factors. Surgery for thalamic gliomas improves overall survival, and patients with stable performance status after 3 months have better prognosis. Therefore, accurate evaluation of predictors of 3-month postoperative performance status is crucial in deciding between biopsy or surgical removal.
Article
Clinical Neurology
Stefania Bianchi Marzoli, Lisa Melzi, Paola Ciasca, Alberto Raggi, Anna Bersano, Carlotta Casati, Nadia Bolognini
Summary: This study aimed to quantify the degree of ganglion cell degeneration using SD-OCT in adult patients with post-stroke homonymous visual field defect. The results showed that there were significant differences in pRNFL-AVG, GCC-AVG, GLV, and FLV between stroke patients and controls regardless of stroke type and involved vascular territories. Age and elapsed time from stroke had a significant effect on pRNFL-AVG and GCC-AVG, while visual field defect size was unrelated to SD-OCT measurements.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Simona Maccora, Nadia Bolognini, Carlo Mannina, Angelo Torrente, Luisa Agnello, Bruna Lo Sasso, Marcello Ciaccio, Guido Sireci, Filippo Brighina
Summary: This study aimed to investigate the influence of estradiol on the sound-induced flash illusion (SIFI) and found that high estradiol levels during ovulation led to reduced perception of SIFI in women, indicating an enhanced excitability of the visual cortex. Additionally, migraine women perceived fewer flashes in the illusion compared to controls, independent of the menstrual cycle phase.
NEUROLOGICAL SCIENCES
(2023)
Article
Anesthesiology
Margherita Marchi, Erika Salvi, Mirna Andelic, Elkadia Mehmeti, Ilaria D'Amato, Daniele Cazzato, Federica Chiappori, Raffaella Lombardi, Daniele Cartelli, Grazia Devigili, Eleonora Dalla Bella, Monique Gerrits, Rowida Almomani, Rayaz A. Malik, Milena Sleczkowska, Anna Mazzeo, Luca Gentile, Sulayman Dib-Hajj, Stephen G. Waxman, Catharina G. Faber, Eleonora Vecchio, Marina de Tommaso, Giuseppe Lauria
Summary: This study aimed to identify rare variants associated with chronic neuropathic pain and nociplastic pain by conducting next-generation sequencing and gene-wise aggregation analysis. TRPA1 was found to be the most significant gene, with the frequency of rare variants significantly differentiating chronic pain patients from healthy controls. The study expands the understanding of channelopathy-related chronic pain disorders and contributes to personalized therapies based on patients' molecular profiles.
Correction
Geriatrics & Gerontology
Federico Angelo Cazzaniga, Edoardo Bistaffa, Chiara Maria Giulia De Luca, Sara Maria Portaleone, Marcella Catania, Veronica Redaelli, Irene Tramacere, Giuseppe Bufano, Martina Rossi, Paola Caroppo, Anna Rita Giovagnoli, Pietro Tiraboschi, Giuseppe Di Fede, Roberto Eleopra, Grazia Devigili, Antonio Emanuele Elia, Roberto Cilia, Michele Fiorini, Matilde Bongianni, Giulia Salzano, Luigi Celauro, Federico Giuseppe Quarta, Angela Mammana, Giuseppe Legname, Fabrizio Tagliavini, Piero Parchi, Gianluigi Zanusso, Giorgio Giaccone, Fabio Moda
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Luigi Tesio, Antonio Caronni, Cristina Russo, Giorgio Felisari, Elisabetta Banco, Anna Simone, Stefano Scarano, Nadia Bolognini
Summary: In mirror training (MIT), stroke patients move their hands while looking at the reflected image of the unaffected one, while reversed MIT (REMIT) requires moving hands while looking at the paretic one. This study compared the effects of MIT and REMIT on post-stroke upper-limb recovery and found that both were equally effective, challenging the exclusive role of mirror neurons in rehabilitation.
Article
Psychology, Experimental
Stefano Zago, Alice N. Preti, Teresa Difonzo, Annalisa D'Errico, Giuseppe Sartori, Andrea Zangrossi, Nadia Bolognini
Summary: Amnesia is common in major crimes, with both genuine and malingering cases. Various techniques such as polygraphs, event-related potentials, and facial analysis can assist in determining the credibility of crime-related amnesia. However, there is limited evidence on their usefulness in forensic practice.
TOPICS IN COGNITIVE SCIENCE
(2023)
