Journal
CELLULOSE
Volume 27, Issue 13, Pages 7691-7701Publisher
SPRINGER
DOI: 10.1007/s10570-020-03314-3
Keywords
Inkjet printing; Paraffin formulation; Candida albicans; Point-of-care
Funding
- Manipal McGill Centre for Infectious Diseases [MAC ID/SGA/2017/21]
- Vision Group on Science and Technology, Government of Karnataka [KSTePS/VGST/SMYSR-2016-17/GRD-595/2017-18, 711/2017-18]
- Indian Council of Medical Research (ICMR) [5/3/8/91/ITR-F/2020]
- Science and Engineering Research Board (SERB), Department of Science and Technology, Govt of India [PDF/2018/001486]
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We present a high resolution, ultra-frugal printing of paper microfluidic devices using in-house paraffin formulation on a simple filter paper. The patterns printed using an office inkjet printer formed a selective hydrophobic barrier of 4 +/- 1 mu m thickness with a hydrophilic channel width of 275 mu m. These printed patterns effectively confine common aqueous solutions and solvents, which was verified by solvent compatibility studies. SEM analysis reveals that the solvent confinement is due to pore blockage in the filter paper. The fabricated paper-based device was validated for qualitative assessment ofCandida albicans(pathogenic fungi) by using a combination of L-proline beta-naphthylamide as the substrate and cinnamaldehyde as an indicator. Our studies reveal that the pathogenic fungi can be detected within 10 min with the limit of detection (LOD) of 0.86 x 10(6) cfu/mL. Owing to its simplicity, this facile method shows high potential and can be scaled up for developing robust paper-based devices for biomarker detection in resource-limited settings. [GRAPHICS] .
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