Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 77, Issue 24, Pages 5101-5119Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-020-03569-w
Keywords
Glioma; Tumor microenvironment (TME); Metabolism; Cell communication; Tumor initiating cells; Slow-cycling cells; Immune cells
Categories
Funding
- American Brain Tumor Association (ABTA) Discovery Grant - Uncle Kory Foundation
- MRC [MR/S007709/1]
- Florida Center for Brain Tumor Research & Accelerate Brain Cancer Cure [P0058849]
- ABTA Discovery Grant [DG1800014]
- Pray for Dominic St Baldrick's Research Grant [638733]
- UFHCC Cancer Therapeutics & Host Response Research grant [00096885]
- Dana-Farber/Harvard Cancer Center (DF/HCC) SPORE in brain cancer DRP Award
- MRC [MR/S007709/1] Funding Source: UKRI
Ask authors/readers for more resources
The metabolic complexity and flexibility commonly observed in brain tumors, especially glioblastoma, is fundamental for their development and progression. The ability of tumor cells to modify their genetic landscape and adapt metabolically, subverts therapeutic efficacy, and inevitably instigates therapeutic resistance. To overcome these challenges and develop effective therapeutic strategies targeting essential metabolic processes, it is necessary to identify the mechanisms underlying heterogeneity and define metabolic preferences and liabilities of malignant cells. In this review, we will discuss metabolic diversity in brain cancer and highlight the role of cancer stem cells in regulating metabolic heterogeneity. We will also highlight potential therapeutic modalities targeting metabolic vulnerabilities and examine how intercellular metabolic signaling can shape the tumor microenvironment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available