Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 17, Issue 8, Pages 799-806Publisher
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/s41423-020-0482-z
Keywords
Genetic variation; Human Leukocyte Antigen; Innate immunity; Killer-cell immunoglobulin-like receptor; Malaria; Natural killer cells
Categories
Funding
- DELTAS Africa Initiative [107743]
- African Academy of Science (AAS)
- Alliance for Accelerating Excellence in Science in Africa
- New Partnership for Africa's Development Planning and Coordinating Agency (NEPAD Agency)
- Wellcome Trust [107743, 200841/Z/16/Z]
- European Research Council under the European Union [695551]
- Centre for Trophoblast Research
- NEPAD Agency
- Wellcome Trust [200841/Z/16/Z] Funding Source: Wellcome Trust
- European Research Council (ERC) [695551] Funding Source: European Research Council (ERC)
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Malaria is one of the deadliest infectious diseases in the world. Immune responses toPlasmodium falciparummalaria vary among individuals and between populations. Human genetic variation in immune system genes is likely to play a role in this heterogeneity. Natural killer (NK) cells produce inflammatory cytokines in response to malaria infection, kill intraerythrocyticPlasmodium falciparumparasites by cytolysis, and participate in the initiation and development of adaptive immune responses to plasmodial infection. These functions are modulated by interactions between killer-cell immunoglobulin-like receptors (KIRs) and human leukocyte antigens (HLAs). Therefore, variations inKIRandHLAgenes can have a direct impact on NK cell functions. Understanding the role of KIRs and HLAs in immunity to malaria can help to better characterize antimalarial immune responses. In this review, we summarize the different KIRs and HLAs associated with immunity to malaria thus far.
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