High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer

The double edge sword of fibrosis in cancer

(2019) Chelsea Chandler et al.   Translational Research

Causes, consequences, and therapy of tumors acidosis

(2019) Smitha R. Pillai et al.   CANCER AND METASTASIS REVIEWS

Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours

(2019) Han Yao et al.   Nature Biomedical Engineering

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer

(2019) Shigeru Hashimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid-Derived Suppressor Cells and Pancreatic Cancer: Implications in Novel Therapeutic Approaches

(2019) Anita Thyagarajan et al.   Cancers

Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe

(2018) Yasuhito Onodera et al.   Nature Communications

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

P53- and mevalonate pathway–driven malignancies require Arf6 for metastasis and drug resistance

(2016) Ari Hashimoto et al.   JOURNAL OF CELL BIOLOGY

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer

(2016) Shigeru Hashimoto et al.   Nature Communications

ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance

(2016) A Hashimoto et al.   Oncogenesis

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy

(2015) Katherine M. Bever et al.   HPB

α-Smooth muscle actin expression and desmoplastic stromal reaction in pancreatic cancer: results from the CONKO-001 study

(2014) M Sinn et al.   BRITISH JOURNAL OF CANCER

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

(2014) Susann Weissmueller et al.   CELL

High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients

(2014) Hiroki Sato et al.   Cell Communication and Signaling

Rab5c promotes AMAP1–PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion

(2012) Yasuhito Onodera et al.   JOURNAL OF CELL BIOLOGY

Engagement of Overexpressed Her2 with GEP100 Induces Autonomous Invasive Activities and Provides a Biomarker for Metastases of Lung Adenocarcinoma

(2011) Toshi Menju et al.   PLoS One

Three-Dimensional Collagen I Promotes Gemcitabine Resistance in Pancreatic Cancer through MT1-MMP-Mediated Expression of HMGA2

(2010) S. Dangi-Garimella et al.   CANCER RESEARCH

The EGFR-GEP100-Arf6-AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis†

(2009) Hisataka Sabe et al.   TRAFFIC

The Activated Stroma Index Is a Novel and Independent Prognostic Marker in Pancreatic Ductal Adenocarcinoma

(2008) Mert Erkan et al.   Clinical Gastroenterology and Hepatology

Focal adhesion kinase as a regulator of cell tension in the progression of cancer

(2007) Robert W. Tilghman et al.   SEMINARS IN CANCER BIOLOGY