Journal
CELL CALCIUM
Volume 89, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2020.102215
Keywords
Two-pore channel; Ion channel selectivity; Agonist; TMAP; Vesicle motility; Lysosomal exocytosis
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Funding
- Swiss National Science Foundation (NCCR TransCure)
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TPC2-A1-N and TPC2-A1-P, two novel small molecules, differentially activate two-pore channel 2 (TPC2) and mimic the activation of TPC2 with NAADP and PIP2, resulting in distinct ion channel selectivities. These two different modes of TPC2 activity have physiological, and possibly pathophysiological, implications as they can modulate vesicle trafficking and lysosomal exocytosis.
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