Journal
CELL
Volume 182, Issue 1, Pages 24-37Publisher
CELL PRESS
DOI: 10.1016/j.cell.2020.06.023
Keywords
-
Categories
Funding
- NIH [R35 GM128625, R01 NS099068, R01 AR073228, R01 GM055479, R01 HG010730, R21 HG008186]
- Cincinnati Children's Hospital Trustee Award
- Cincinnati Children's Hospital Center for Pediatric Genomics Award
- Cincinnati Children's Hospital CCRF Endowed Scholar Award''
Ask authors/readers for more resources
Viral genomes encode transcriptional regulators that alter the expression of viral and host genes. Despite an emerging role in human diseases, a thorough annotation of human viral transcriptional regulators (vTRs) is currently lacking, limiting our understanding of their molecular features and functions. Here, we provide a comprehensive catalog of 419 vTRs belonging to 20 different virus families. Using this catalog, we characterize shared and unique cellular genes, proteins, and pathways targeted by particular vTRs and discuss the role of vTRs in human disease pathogenesis. Our study provides a unique and valuable resource for the fields of virology, genomics, and human disease genetics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available