Article
Immunology
Na Li, Jiahong Wang, Xianquan Zhan
Summary: This study identified two reliable immune-related gene signature models that were significantly associated with prognosis and tumor microenvironment cell infiltration in LUAD and LUSC, respectively. Evaluation of these models could help predict response to immunotherapy and guide immunotherapy strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Vahide Saeidi, Nicole Doudican, John A. Carucci
Summary: Primary cutaneous squamous cell carcinoma (cSCC) is the second most common human cancer with a rising incidence of about 1.8 million in the United States annually. Surgery is usually curative, but in some cases, cSCC can metastasize and result in death. The introduction of checkpoint inhibitor immunotherapy has significantly improved treatment outcomes for advanced or metastatic cSCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Hui-Shan Chen, Ching-Hsiung Lin, Shiao-Chi Wu, Bing-Yen Wang
Summary: This study compared the survival outcomes of neoadjuvant chemoradiotherapy followed by operation, definitive chemoradiotherapy, and esophagectomy alone in patients with locoregional esophageal squamous cell carcinoma. It found that neoadjuvant chemoradiotherapy followed by operation and esophagectomy alone were associated with better overall survival compared to definitive chemoradiotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Yu-Zhen Zheng, Xiao-Qiang Li, Jun-Ye Wang, Hong Yang, Jing Wen, Wen-Yu Zhai, Lian-Xiong Yuan, Shen-Shen Fu, Hong-Ying Liao, Jian-Hua Fu
Summary: This study suggests that a higher number of examined lymph nodes (ELNs) in patients with esophageal squamous cell carcinoma (ESCC) who underwent right transthoracic esophagectomy is associated with more accurate nodal staging and better long-term survival. The optimal ELN count threshold was found to be 21.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xianfeng Li, Yan Wang, Qingjie Min, Weimin Zhang, Huajing Teng, Chao Li, Kun Zhang, Leisheng Shi, Bin Wang, Qimin Zhan
Summary: In this study, a comprehensive comparison of the transcriptomes of esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) was conducted, revealing shared and distinct transcriptomic signatures between these two cancer subtypes and uncovering possible common and unique mechanisms involved in tumorigenesis.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Oncology
Vishal A. Patel, Catherine McCullum, Andrew D. Sparks, Chrysalyne D. Schmults, Sarah T. Arron, Anokhi Jambusaria-Pahlajani
Summary: This study examines consensus and differences in defining high-risk features, staging methods, and management patterns of cutaneous squamous cell carcinoma (CSCC) among dermatologists and other cancer specialists. The study found that high-risk CSCC is defined as BWH T2b and higher and AJCC T3 and higher, providing a basis for considering treatments beyond surgery in certain cases. Additional research is needed to develop a comprehensive risk-based management approach for CSCC.
Article
Oncology
Fan Yu, Yaozhong Zhang, Haidi Xu, Kuankuan Li, Jingge Gheng, Chenxi Lin, Lei Li, Na Wang, Lei Wang
Summary: This study evaluated and compared the therapeutic effects of Sweet esophagectomy and McKeown Minimally Invasive esophagectomy (McKeown MIE) for middle and lower third esophageal cancer patients receiving neoadjuvant chemotherapy combined with immunotherapy (NACI). The results showed that both Sweet esophagectomy and McKeown MIE were safe and effective for resectable esophageal squamous cell carcinoma (ESCC) patients after NACI therapy, with low operative mortality and morbidity rate. Sweet esophagectomy had a lower incidence of severe complications and shorter hospital stay for patients over 70 years old compared to McKeown MIE.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Simon Mylius Rasmussen, Thomas Nielsen, Sofie Hody, Henrik Hager, Lars Peter Schousboe
Summary: This study introduces a video processing algorithm designed to identify cancer suspicious skin areas, based on remote photoplethysmography signal differences between squamous cell carcinoma and healthy skin. The research shows significant temporal signal changes in cancer areas versus healthy areas, providing valuable insights for further investigation on detailed disease boundary recognition.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Wei Guo, Bolun Zhou, Zhenlin Yang, Xiang Liu, Qilin Huai, Lei Guo, Xuemin Xue, Fengwei Tan, Yin Li, Qi Xue, Shugeng Gao, Jie He
Summary: This study characterized the spatial landscape of different cell subsets within the tumor microenvironment (TME) using single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST). It identified distinct stromal cell populations and their distribution in the TME of esophageal squamous cell carcinoma (ESCC). The study also revealed differences in TME features between metastatic and non-metastatic samples and between the primary and metastatic sites.
Review
Oncology
Leonardo Di Gennaro, Raimondo De Cristofaro, Antonietta Ferretti, Maria Basso, Claudia Riccio, Massimo Cordaro, Carlo Lajolo
Summary: This review discusses the relationship between oral squamous cell carcinoma (OSCC) and venous thromboembolism (VTE). VTE has a significant impact on the mortality rate of cancer patients, and the thrombotic risk in OSCC patients has not been extensively studied, leading to insufficient prevention measures and affecting the effectiveness of oncologic treatment.
Article
Surgery
Bing-Yen Wang, Ching-Hsiung Lin, Shiao-Chi Wu, Hui-Shan Chen
Summary: This retrospective study compared the overall survival between open and thoracoscopic upfront esophagectomy for patients with esophageal squamous cell carcinoma (ESCC) without neoadjuvant chemodatiotherapy (CRT). The study found that thoracoscopic esophagectomy provided better survival than open esophagectomy.
Article
Endocrinology & Metabolism
Na Li, Yalin Li, Peixian Zheng, Xianquan Zhan
Summary: This study established immune-related gene-prognostic models in LUAD and LUSC based on mRNAsi, showing a correlation between tumor stemness index and immune cell infiltration in lung cancer tissues.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Hong Wu, Xuefeng Leng, Qianshi Liu, Tianqin Mao, Tao Jiang, Yiqiang Liu, Feifei Li, Chenhui Cao, Jun Fan, Liang Chen, Yaqi Chen, Quan Yao, Shun Lu, Renchuan Liang, Lanlin Hu, Mingxin Liu, Yejian Wan, Zhaoshen Li, Jun Peng, Qiyu Luo, Hang Zhou, Jun Yin, Ke Xu, Mei Lan, Xinhao Peng, Haitao Lan, Gang Li, Yongtao Han, Xia Zhang, Zhi-Xiong Jim Xiao, Jinyi Lang, Guihua Wang, Chuan Xu
Summary: Analysis of intratumoral microbiota in patients with esophageal cancer reveals a microbiota signature that is associated with chemoimmunotherapy response, showing that Streptococcus stimulates CD8+ T-cell infiltration and induces a favorable response. These findings suggest the potential clinical utility of intratumoral microbiota for cancer immunotherapy.
Article
Oncology
Mingwei Yang, Panpan Hu, Minglun Li, Rui Ding, Yichun Wang, Shuhao Pan, Mei Kang, Weihao Kong, Dandan Du, Fan Wang
Summary: This study retrospectively evaluated the predictive potential of contrast-enhanced CT radiomics in estimating pathological tumor extent in 116 ESCC patients who underwent esophagectomy. The CT radiomics signatures showed favorable predictive performance for T stage and tumor length, indicating potential clinical utility in preoperative assessment of ESCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Ryoma Haneda, Eisuke Booka, Kenjiro Ishii, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Kinji Kamiya, Hirofumi Ogawa, Hirofumi Yasui, Hiroya Takeuchi, Yasuhiro Tsubosa
Summary: Definitive chemoradiotherapy may be a promising alternative therapy comparable with radical esophagectomy in patients with clinical T1bN0M0 esophageal squamous cell carcinoma. Early detection of recurrence by frequent follow-up after definitive chemoradiotherapy is crucial for controlling disease within local recurrence, and salvage therapy for local lesions could contribute to long-term survival.
WORLD JOURNAL OF SURGERY
(2021)