Journal
CARBOHYDRATE POLYMERS
Volume 237, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.116114
Keywords
Cellulose-based nanoparticles; Supramolecular nanocarriers; Host-guest interactions; Cyclodextrin; Biocompatibility; Drug delivery
Categories
Funding
- Major Program of National Natural Science Foundation of China [21334005]
- Major International (Regional) Joint Research Project [21620102004]
- Funds for International Cooperation and Exchange of the National Natural Science Foundation of China [21811530006]
- National Natural Science Foundation of China [51873164]
- Health and Medical Research Fund, the Food and Health Bureau, the Government of the Hong Kong Special Administrative Region [04152836]
Ask authors/readers for more resources
To extend the applications of natural products in nanomedicine, novel cellulose-based supramolecular nanoparticles (SNPs) were fabricated via a host-guest driven self-assembly strategy here. The adamantane-grafted carboxyethyl hydroxyethyl cellulose and beta-cyclodextrin-grafted glycerol ethoxylate were synthesized to self-assemble into the SNPs. Furthermore, doxorubicin (DOX)-functionalized beta-cyclodextrin was encapsulated into SNPs via an in situ co-assembly process to generate DOX-loaded SNPs (DOX-SNPs). The SNPs exhibited a quasispherical morphology with an average diameter of similar to 25 nm. The DOX-SNPs with relatively larger diameter possessed a high DOX loading efficiency (similar to 94 %) and the pH-responsive drug release behaviors, which made them suitable as a drug delivery system. In vitro cytotoxicity assays demonstrated the excellent cytocompatibility of SNPs and the efficient inhibition of Hela cell proliferation of DOX-SNPs. Moreover, the DOX-SNPs could effectively enter Hela cells via endocytosis and release DOX under endo/lysosome pH. Thus, this nanocarrier has promising translational potential in cancer therapy and personalized nanomedicine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available