Review
Multidisciplinary Sciences
Yesim Aydinok
Summary: Combination chelation therapy is a viable option for transfusion-dependent thalassemia patients who have not achieved iron balance with monotherapy or need intensified treatment for rapid iron reduction. It allows for a more personalized approach, improving tolerability, adherence, and quality of life. Real-life data highlights the importance of compliance in achieving meaningful reduction in iron overload compared to monotherapy.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Seung Hun Park, Richard S. Kim, Wesley R. Stiles, Minjoo Jo, Lingxue Zeng, Sunghoon Rho, Yoonji Baek, Jonghan Kim, Moon Suk Kim, Homan Kang, Hak Soo Choi
Summary: Deferoxamine (DFO) is an FDA-approved iron-chelating agent with good therapeutic efficacy, but its short blood half-life poses challenges for patients who require frequent administrations. By integrating crosslinked hyaluronic acid and Pluronic F127 into an injectable hydrogel formulation, a prolonged release of DFO nanochelators is achieved, significantly extending the half-life and demonstrating potential for the treatment of iron overload disorders.
Review
Chemistry, Analytical
Giancarla Alberti, Camilla Zanoni, Lisa Rita Magnaghi, Raffaela Biesuz
Summary: Deferoxamine is a versatile siderophore that can strongly bind iron(III), making it suitable for various clinical and analytical applications, especially in the field of iron(III) chelation and recognition.
Review
Medicine, Research & Experimental
Amy Corbin Farr, May P. Xiong
Summary: Deferoxamine mesylate (DFO) is an iron chelator used to alleviate systemic iron burden in thalassemia major and sickle cell patients, with implications for neurodegenerative diseases. However, limitations such as toxicity at high doses and uncertain ability to cross the BBB have hindered its widespread use. Preclinical evidence suggests promising results in improving behavioral outcomes, but standardized dosing regimens and better understanding of brain DFO concentration following administration are needed for successful clinical translation.
MOLECULAR PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Alessandra Di Paola, Chiara Tortora, Maura Argenziano, Maria Maddalena Marrapodi, Francesca Rossi
Summary: Iron is a crucial element for mammalian cells and its alteration could lead to the onset of disorders. Iron chelation has been proposed as a novel therapeutic strategy to counteract inflammation in autoimmune and inflammatory diseases. Several iron chelators, such as deferiprone, deferoxamine, deferasirox, and Dp44mT, have anti-inflammatory effects. Eltrombopag has been reported to reduce inflammation by chelating iron and modulating iron efflux.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Neera Raghav, Chanchal Vashisth, Nitika Mor, Priyanka Arya, Manishita R. Sharma, Ravinder Kaur, Surender P. Bhatti, John F. Kennedy
Summary: Polymers-based drug delivery systems are actively studied in the medicinal and pharmaceutical industries. Properties of polymers have been modified to enhance solubility, release kinetics, targeted action site, absorption, and therapeutic efficacy. Natural polymers are preferred due to their easy availability, accessibility, and non-toxicity. This review focuses on oral drug delivery systems using four natural polymers, cellulose, pectin, carrageenan, and alginate, and provides a concise and tabulated summary of relevant literature from the last five years.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Rui Liu, Alessandro Poma
Summary: Despite significant efforts in the past decades, challenges such as severe side effects and poor bioavailability continue to hinder the clinical translation of drug molecules. As a result, researchers are turning their attention to drug delivery vehicles, with molecularly imprinted polymers (MIPs) showing promise due to their selective recognition, enhanced drug loading, sustained release, and robustness in harsh conditions. This review highlights the design and development of strategies for MIPs used as drug delivery vehicles, focusing on different drug delivery mechanisms, such as rate-programmed, stimuli-responsive, and active targeting, published over the past five years.
Article
Oncology
Takahiro Nomoto, Kana Komoto, Tomoya Nagano, Takuya Ishii, Haochen Guo, Yuto Honda, Shun-ichiro Ogura, Masahiro Ishizuka, Nobuhiro Nishiyama
Summary: This study suggests that the use of a polymeric iron chelator can enhance the effectiveness of 5-ALA-induced photodynamic therapy by modulating the intratumoral iron levels. The polymeric iron chelator effectively deactivates intracellular labile iron and increases the accumulation of PpIX, improving the cytotoxicity upon photoirradiation.
Review
Polymer Science
Md. Harun-Or-Rashid, Most. Nazmin Aktar, Md. Sabbir Hossain, Nadia Sarkar, Md. Rezaul Islam, Md. Easin Arafat, Shukanta Bhowmik, Shin-ichi Yusa
Summary: Polymeric drug delivery technology has advanced significantly in recent decades, allowing medicinal ingredients to enter cells more easily. Natural and synthetic polymers are used in drug delivery systems, and combining synthetic and biological approaches can result in revolutionary drug and gene delivery devices.
Review
Ophthalmology
Mohamed Belmouhand, Christina Eckmann-Hansen, Tomas Ilginis, Eva Birgitte Leinoe, Bo Kok Mortensen, Michael Larsen
Summary: Deferoxamine retinopathy is a pattern of outer retinal degeneration in iron-overloaded chronic anemia patients treated with deferoxamine. The cause of retinal degeneration seems to be insufficient iron chelation rather than deferoxamine itself. Adjusting chelation therapy may not improve visual function, suggesting a role of promoting slow retinal siderosis development.
Review
Pharmacology & Pharmacy
Karen Escobar, Karla A. Garrido-Miranda, Ruth Pulido, Nelson Naveas, Miguel Manso-Silvan, Jacobo Hernandez-Montelongo
Summary: This review comprehensively covers the chemical properties and synthesis routes of CD/CTR cross-linking, as well as their applications as drug-delivery systems on different substrates. The study found that the CD/CTR biopolymers were nontoxic, environmentally friendly, and inexpensive, making them widely used in coating implants and biomedical materials. The importance of pretreatment methods on substrates and the analysis of release mechanisms, including the Korsmeyer-Peppas mathematical model, were also discussed. The flexibility of CD/CTR in hosting a wide variety of drugs, integrating with diverse implantable materials, and controllable release kinetics provide a range of advantages for future uses.
Article
Medicine, General & Internal
Jennifer B. Parker, Michelle F. Griffin, Mauricio A. Downer, Deena Akras, Charlotte E. Berry, Asha C. Cotterell, Geoffrey C. Gurtner, Michael T. Longaker, Derrick C. Wan
Summary: Translating basic science research into clinical practice has benefits, but most therapies fail to gain approval. The gap between basic research and approved treatment continues to grow, with long approval processes. Recent research on DFO shows promise for treating radiation-induced soft tissue injury.
FRONTIERS IN MEDICINE
(2023)
Review
Polymer Science
Louise Van Gheluwe, Igor Chourpa, Coline Gaigne, Emilie Munnier
Summary: Progress in stimuli-responsive polymers has led to advancements in smart drug delivery systems (SDDS) which can address targeted drug delivery and personalized medicine challenges. SDDS, mainly explored in oncology, are now extending to dermatology and cosmetics fields. pH and temperature are the most commonly used stimuli for controlled release of active ingredients.
Article
Chemistry, Multidisciplinary
Gregory Jones, Lingxue Zeng, Jonghan Kim
Summary: Deferoxamine (DFO) has limited use due to off-target toxicities and cumbersome dosage regimen. The development of DFO-based nanochelator (DFO-NP) with selective renal excretion has shown promise in ameliorating iron overload. This study validated the pharmacokinetics of DFO-NPs in mice and predicted their potential in humans.
Review
Chemistry, Multidisciplinary
Muhammad Shafiq, Muhammad Rafique, Yingkun Cui, Li Pan, Chi-Wai Do, Emmanuel A. Ho
Summary: Currently, eye diseases are mainly treated with topical eye drops, but there are challenges such as multiple administrations and poor penetration. Therefore, it is necessary to design ocular drug delivery systems that can penetrate the cornea effectively, have good bioavailability, and can target specific regions. Nanocarriers are a promising choice to overcome these barriers and enhance drug penetration into the eye. They can also be modified to improve targeting and stability through functionalization and cell-mediated approaches.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Aziz Awaad, Hiroyasu Takemoto, Muneaki Iizuka, Koichi Ogi, Yuki Mochida, Abdul-Hackam Ranneh, Masahiro Toyoda, Makoto Matsui, Takahiro Nomoto, Yuto Honda, Kotaro Hayashi, Keishiro Tomoda, Tomoyuki Ohtake, Yutaka Miura, Nobuhiro Nishiyama
Summary: This study demonstrates the use of a shell material based on ethylenediamine-based carboxybetaine to enhance tumor-targeted delivery of nanoparticles, achieving remarkable success by maximizing the EPR effect.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Acoustics
Yuta Kurashina, Risa Asano, Makoto Matsui, Takahiro Nomoto, Keita Ando, Kentaro Nakamura, Nobuhiro Nishiyama, Yoshitaka Kitamoto
Summary: Ultrasound is a promising non-invasive technique for transdermal delivery, and a new device was designed to investigate the mechanism of sonophoresis. The experiments showed that the acoustic pressure and cavitation onset are sensitive to the subcutaneous support material, and the penetration of particles depends on their size, material, and the hardness of the subcutaneous support.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Yi-Jung Sung, Haochen Guo, Aria Ghasemizadeh, Xin Shen, Wanphiwat Chintrakulchai, Motoaki Kobayashi, Masahiro Toyoda, Koichi Ogi, Junya Michinishi, Tomoyuki Ohtake, Makoto Matsui, Yuto Honda, Takahiro Nomoto, Hiroyasu Takemoto, Yutaka Miura, Nobuhiro Nishiyama
Summary: A smart surface modification using charge-switchable polycarboxybetaine has been developed to enhance tumor accumulation and improve nucleic acid delivery efficiency.
Article
Pharmacology & Pharmacy
Xue Xie, Yuta Kurashina, Makoto Matsui, Takahiro Nomoto, Munenari Itoh, Hirotaka J. Okano, Kentaro Nakamura, Nobuhiro Nishiyama, Yoshitaka Kitamoto
Summary: The study proposed a transdermal delivery system using sonophoresis with carboxymethyl chitosan nanocarriers to administer bFGF over a wide area of skin. Through ex vivo experiments, the effectiveness of the delivery system was demonstrated, showing that the penetration of bFGF-loaded carboxymethyl chitosan nanocarriers with ultrasound was significantly higher than ultrasound irradiation alone. This research paves the way for future use of polymeric nanocarriers using sonophoresis for biomacromolecule administration.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yuto Honda, Sayaka Onodera, Hiroyasu Takemoto, Noor Faizah Che Harun, Takahiro Nomoto, Makoto Matsui, Keishiro Tomoda, Yudi Sun, Yutaka Miura, Nobuhiro Nishiyama
Summary: This study aims to develop a technology to control the activity of small interfering RNA (siRNA) in a thermo-responsive manner, even at temperatures close to body temperature. By conjugating siRNA with a thermally responsive copolymer, the activity of siRNA can be enhanced based on temperature changes. This technique offers a promising approach to selectively induce therapeutic effects of siRNA in vivo.
PHARMACEUTICAL RESEARCH
(2023)
Article
Engineering, Biomedical
Haochen Guo, Wen Xu, Takahiro Nomoto, Kaito Kanamori, Yan Ming Voon, Yuto Honda, Naoki Yamada, Hiroyasu Takemoto, Makoto Matsui, Nobuhiro Nishiyama
Summary: Cancer cells overexpress LAT1 to take up neutral amino acids, and targeting LAT1 with drug delivery systems has promising potential for cancer diagnosis and therapy. This study developed polymers with Met or Cys structures to test their affinity with LAT1. The Met-modified polymers exhibited higher cellular uptake efficiency in an LAT1-selective manner and showed tumor-selective accumulation in vivo, suggesting their potential for LAT1-targeting drug delivery systems.
Article
Oncology
Takahiro Nomoto, Kana Komoto, Tomoya Nagano, Takuya Ishii, Haochen Guo, Yuto Honda, Shun-ichiro Ogura, Masahiro Ishizuka, Nobuhiro Nishiyama
Summary: This study suggests that the use of a polymeric iron chelator can enhance the effectiveness of 5-ALA-induced photodynamic therapy by modulating the intratumoral iron levels. The polymeric iron chelator effectively deactivates intracellular labile iron and increases the accumulation of PpIX, improving the cytotoxicity upon photoirradiation.
Review
Chemistry, Analytical
Sjaikhurrizal El Muttaqien, Indra Memdi Khoris, Sabar Pambudi, Enoch Y. Y. Park
Summary: In the past few decades, nanomaterials have been explored in the sensing research field. However, less attention has been given to their application in biosensors for pathogenic virus detection. This review focuses on 3D nanospheres, a type of nanostructured material, and their extensive use in various sensing techniques. Signal amplification strategies using different types of nanospheres are discussed, along with challenges related to toxicity and commercialization in the development of nanosphere-based biosensors.
Article
Chemistry, Multidisciplinary
Shan Gao, Yutaka Miura, Akira Sumiyoshi, Satoshi Ohno, Keisuke Ogata, Takahiro Nomoto, Makoto Matsui, Yuto Honda, Minoru Suzuki, Megumi Iiyama, Kensuke Osada, Ichio Aoki, Nobuhiro Nishiyama
Summary: Nano-sized contrast agents (NCAs) have the potential to enhance tumor contrast during magnetic resonance imaging. This study introduces a novel molecular mechanism to enhance the relaxation of NCAs, resulting in sharp tumor imaging. The self-folding molecular design allows for minimal loading of gadolinium complexes and selective accumulation in tumor tissues, providing effective anti-tumor results through gadolinium neutron capture therapy.
