Journal
CANCER CELL
Volume 38, Issue 1, Pages 17-20Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2020.06.009
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Funding
- Australian National Health and Medical Research Council, Australia [1159955]
- Peter and Julie Alston Centenary Fellowship
- National Health and Medical Research Council of Australia [1159955] Funding Source: NHMRC
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Small cell lung cancer (SCLC) is highly heterogeneous. In this issue of Cancer Cell, Ireland et al. demonstrate that MYC mediates neuroendocrine cell plasticity in SCLC by activating NOTCH signaling. This MYC-NOTCH axis controls the dynamic behavior of tumor cells, resulting in the co-existence of SCLC subtypes within individual tumors.
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