Review
Oncology
Felix Boehm, Rene Graesslin, Marie-Nicole Theodoraki, Leon Schild, Jens Greve, Thomas K. Hoffmann, Patrick J. Schuler
Summary: In recent years, therapy for oncologic diseases has advanced with the goal of improving patient survival and quality of life. While robotic technology is widely used in other surgical specialties, its application in head and neck surgery lacks large-scale randomized trials for evaluation. Further research is needed to determine the clinical effectiveness and safety of robot-assisted surgery in this field.
Article
Oncology
Han Yu, Sung Jun Ma, Mark Farrugia, Austin J. Iovoli, Kimberly E. Wooten, Vishal Gupta, Ryan P. McSpadden, Moni A. Kuriakose, Michael R. Markiewicz, Jon M. Chan, Wesley L. Hicks, Mary E. Platek, Anurag K. Singh
Summary: Predicting the overall survival of head and neck squamous cell carcinoma patients remains challenging, but host factors can enhance the performance of prediction models. Proper dimension reduction of host factors before incorporating them into machine learning models is crucial for accurate risk assessment and targeted care for high-risk patients.
Article
Oncology
Alessandra Buja, Claudia Cozzolino, Anna Zanovello, Ruggero Geppini, Andrea Miatton, Manuel Zorzi, Mariagiovanna Manfredi, Emanuela Bovo, Paolo Del Fiore, Saveria Tropea, Luigi dall'Olmo, Carlo Riccardo Rossi, Simone Mocellin, Marco Rastrelli, Massimo Rugge
Summary: The aim of this study was to analyze the cost items of CMM based on stage at diagnosis and other diagnostic and prognostic characteristics. Direct melanoma-related costs per patient were calculated and stratified by cost items. The study found that the highest costs for CMM patients are in the first year after diagnosis, with hospitalization costs being significantly higher compared to subsequent years. Outpatient services and inpatient drug costs decrease gradually over time. The higher expenditure associated with advanced stages of CMM is mainly due to inpatient drug use.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Catherine T. Haring, Lulia A. Kana, Sarah M. Dermody, Collin Brummel, Jonathan B. McHugh, Keith A. Casper, Steven B. Chinn, Kelly M. Malloy, Michelle Mierzwa, Mark E. P. Prince, Andrew J. Rosko, Jennifer Shah, Chaz L. Stucken, Andrew G. Shuman, J. Chad Brenner, Matthew E. Spector, Francis P. Worden, Paul L. Swiecicki
Summary: A retrospective analysis of 447 patients with HNSCC revealed that HPV negativity, high neutrophil/lymphocyte ratio, disease-free interval ≤6 months, and poor performance status were predictors of worse survival. Furthermore, the majority of recurrences and metastases occurred within 6 months to 2 years after treatment completion.
Article
Oncology
Yangmeihui Song, Fang Liu, Weiwei Ruan, Fan Hu, Muhsin H. Younis, Zairong Gao, Jie Ming, Tao Huang, Weibo Cai, Xiaoli Lan
Summary: PET/MR technology, combining MRI and PET capabilities, shows potential in achieving high diagnostic performance for refractory malignancies in DTC patients. Compared to PET/CT, PET/MR demonstrates better detection rates and sensitivity in assessing recurrent DTC lesions and lymph node metastases, providing more precise diagnostic information without additional ionizing radiation. Further studies and economic analysis are needed for scaling-up prospective applications.
Article
Otorhinolaryngology
Philippe Gorphe, Antoine Moya-Plana, Joanne Guerlain, Yungan Tao, France Nguyen, Ingrid Breuskin, Pierre Blanchard, Stephane Temam
Summary: In head and neck carcinoma patients, time to local recurrence is a prognostic variable that can be stratified based on easy-to-use categories, with factors such as patient age, initial disease stage, and time to recurrence being significantly associated with overall survival and post-recurrence survival.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Chemistry, Physical
Claudia Viegas, Daniela S. M. Pereira, Pedro Fonte
Summary: Head and neck cancers, ranking sixth among the most common cancers, have a stagnant survival rate due to late diagnosis and ineffective treatments. Tobacco and alcohol are the main risk factors, while human papillomavirus infection is a secondary risk factor. These cancers affect vital areas for the five senses, making early effective and non-invasive treatment necessary, which is not always possible with conventional treatments. Nanomedicine plays a crucial role in the diagnosis and treatment of head and neck cancers by using nanocarriers to deliver drugs, reducing necessary doses and potential side effects.
Article
Oncology
Shouyi Tang, Li Zhao, Xing-Bo Wu, Zhen Wang, Lu-Yao Cai, Dan Pan, Ying Li, Yu Zhou, Yingqiang Shen
Summary: This study identified a 24-gene signature for predicting the overall survival of head and neck squamous carcinoma (HNSC) patients. The study also found that patients in the high-risk group had worse prognosis compared to the low-risk group. Furthermore, significant differences were observed between the two groups in metabolic pathways and immune microenvironment.
Article
Oncology
Antonio Olry de Labry Lima, Zuzana Spacirova, Silvia Fenix-Caballero, Antonio Matas Hoces, Adrian Sanchez Vegas, Manuel Cardenas Aranzana, Jesus F. Sierra-Sanchez, Maria del Carmen Martinez Diaz, Emilio Jesus Alegre del Rey
Summary: The study analyzed the cost-utility ratio and budgetary impact of talazoparib treatment for breast cancer patients, showing that while talazoparib was more effective, its cost was higher, requiring a price reduction to reach cost-utility thresholds.
Article
Medicine, General & Internal
Lachlan Cook, Charmaine Woods, Tracey Nicholls, Eng H. Ooi
Summary: This study aimed to assess whether head and neck cancer treatment at Flinders Medical Centre in Australia was delivered within the recommended timeframe and identify factors associated with treatment delays. The results showed that delays in treatment initiation were associated with patients undergoing primary radiotherapy treatment and those requiring prophylactic gastrostomy tube insertion. Treatment initiation beyond the recommended timeframe did not significantly impact overall survival or disease-free survival.
MEDICINA-LITHUANIA
(2022)
Article
Nutrition & Dietetics
Merran Findlay, Kathryn White, Natalie Stapleton, Judith Bauer
Summary: This study found that CT-defined sarcopenia is associated with reduced overall survival in patients with head and neck cancer. Both pre- and post-treatment sarcopenia showed similar findings. Consensus and standardization in sarcopenia assessment and definitions are needed, and body composition assessment should be implemented as a clinically meaningful prognostic tool.
CLINICAL NUTRITION
(2021)
Article
Oncology
Alhadi Almangush, Stijn De Keukeleire, Sylvie Rottey, Liesbeth Ferdinande, Tijl Vermassen, Ilmo Leivo, Antti A. Makitie
Summary: Tumor-infiltrating lymphocytes (TILs) play a significant role in predicting the clinical behavior of head and neck cancer. Evaluating TILs as a prognostic biomarker shows promise in aiding clinical decision making, especially in the era of immunotherapy for head and neck cancer.
Article
Oncology
Mehdi Varmaghani, Malihe Amiri, Hossein Ebrahimpour, Roham Salek, Javad Javan-Noughabi
Summary: This study compared the cost-effectiveness of intensity-modulated radiation therapy and three-dimensional conformal radiotherapy for head and neck cancer treatment in east of Iran. The results showed that three-dimensional conformal radiotherapy was more cost-effective and saved more quality-adjusted life years than intensity-modulated radiotherapy.
RADIATION ONCOLOGY
(2023)
Article
Oncology
Matthew Krutz, Pawan Acharya, Geraldine Chissoe, Vijay Raj, Lane Driskill, Greg Krempl, Daniel Zhao, Rachad Mhawej, Lurdes Queimado
Summary: For patients with head and neck squamous cell carcinoma (HNSCC), quitting smoking after diagnosis can lead to better treatment outcomes and long-term survival.
Article
Oncology
Cecilie D. de la Cour, Christian von Buchwald, Christian Dehlendorff, Martin Garset-Zamani, Christian Gronhoj, Amanda-Louise F. Carlander, Soren Friis, Susanne K. Kjaer
Summary: This nationwide cohort study did not find an association between postdiagnostic low-dose aspirin use and cancer-specific mortality in patients with head and neck squamous cell cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Pathology
Sam T. H. Reerds, Maike J. M. Uijen, Adriana C. H. Van Engen-Van Grunsven, Henri A. M. Marres, Carla M. L. van Herpen, Jimmie Honings
Summary: This study evaluated the frequency and results of pathology consultations and revisions for salivary gland neoplasms in the Netherlands. The findings highlight the complexity of the histopathological diagnosis, with a noteworthy rate of revisions and discordant revisions. Increasing consultations may improve the accuracy of initial diagnosis and reduce the need for revisions and discordant revisions.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Oncology
Michelle van den Berg, Suzanne E. J. Kaal, Teska N. Schuurman, Didi D. M. Braat, Caroline M. P. W. Mandigers, Jolien Tol, Jacqueline M. Tromp, Maurice J. D. L. van der Vorst, Catharina C. M. Beerendonk, Rosella P. M. G. Hermens
Summary: A survey study was conducted to assess the current practice of female oncofertility care in cancer patients. The results showed that the quality of care is far from optimal, with low adherence to several key indicators. Improvement strategies tailored to the identified determinants and guideline-specific barriers are needed.
Article
Obstetrics & Gynecology
Malou E. Gelderblom, Veerle Jaspers, Reinier P. Akkermans, Brigitte Slangen, Angele L. M. Oei, Alexandra A. van Ginkel, Huy Ngo, Joanna IntHout, Rosella P. M. G. Hermens, Joanne A. de Hullu, Jurgen M. J. Piek
Summary: This study aimed to determine the implementation of counseling and performance of opportunistic salpingectomy (OS) between 2015 and 2018, and its patient, surgical, physician, and hospital characteristics. The results showed that the proportion of counseling and performance increased over the years, but there were still variations. Therefore, an implementation strategy tailored to associated determinants is recommended.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Oncology
Anna Koot, Paula Soares, Eyal Robenshtok, Laura D. Locati, Christelle de la Fouchardiere, Markus Luster, Massimo Bongiovanni, Rosella Hermens, Petronella Ottevanger, Frans Geenen, Beate Bartes, Harald Rimmele, Cosimo Durante, Els Nieveen-van Dijkum, Peep Stalmeier, Marek Dedecjus, Romana Netea-Maier
Summary: The incidence of differentiated thyroid cancer (DTC) is increasing globally, mainly due to the detection of micro papillary thyroid carcinomas (microPTCs), which often lead to overtreatment without improvement in mortality rate. Less aggressive approaches, such as active surveillance or minimally invasive treatments (MIT), have been suggested as alternatives. Patient participation in decision-making process is crucial. The Endocrine Task Force of the EORTC aims to establish consensus and provide practical suggestions for implementing shared decision making (SDM) based on scientific evidence and patients' needs.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Health Care Sciences & Services
Ellen Marie Sparidaens, Jade G. M. Logger, Willianne L. D. M. Nelen, Didi D. M. Braat, Kathrin Fleischer, Rosella P. M. Hermens
Summary: Through quantitative evaluation using the HOT-fit framework, the myFertiCare app has been proven to be successful in increasing treatment knowledge, improving coping mechanisms, and enhancing patient-centered care. Furthermore, app usage can be improved by increasing publicity.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Oncology
Genevieve I. C. G. Ector, Inge G. P. Geelen, Avinash G. Dinmohamed, Mels Hoogendoorn, Peter E. Westerweel, Rosella P. M. G. Hermens, Nicole M. A. Blijlevens
Summary: This study shows suboptimal adherence to treatment guidelines among chronic myeloid leukemia patients, particularly in monitoring aspects. It highlights the evidence-practice gap, the need for improvement, and emphasizes the importance of real-world data.
LEUKEMIA & LYMPHOMA
(2023)
Article
Oncology
Esther Deuning-Smit, Jose A. E. Custers, Linda Kwakkenbos, Rosella P. M. G. Hermens, Judith B. Prins
Summary: The Distress Thermometer (DT) and its accompanying problem list have limited capacity in detecting fear of cancer recurrence (FCR), indicating a need for more effective measures to improve patient access to psychosocial care in oncology practice.
Article
Oncology
Eline Bouwman, Saskia M. F. Pluijm, Iridi Stollman, Vera Araujo-Soares, Nicole M. A. Blijlevens, Cecilia Follin, Jeanette Falck Winther, Lars Hjorth, Tomas Kepak, Katerina Kepakova, Leontien C. M. Kremer, Monica Muraca, Helena J. H. van der Pal, Carina Schneider, Anne Uyttebroeck, Gertrui Vercruysse, Roderick Skinner, Morven C. Brown, Rosella P. M. G. Hermens, Jacqueline J. Loonen
Summary: This study identified education and training of healthcare professionals (HCPs) as key opportunities to improve health behavior support (HBS) for childhood cancer survivors (CCSs). Survivorship care clinics should work towards establishing well-integrated structured care with internal and external networks, including HBS being part of routine care. Proper understanding of facilitators and barriers should lead to better survivorship care for CCSs.
Review
Oncology
Cilla E. J. Vrinzen, Linn Delfgou, Niek Stadhouders, Rosella P. M. G. Hermens, Matthias A. W. Merkx, Haiko J. Bloemendal, Patrick P. T. Jeurissen
Summary: Comorbidities can greatly affect cancer care, including diagnosis, treatment outcomes, and healthcare costs. Therefore, it is crucial to evaluate the prevalence and trends of comorbidities in cancer patients.
Article
Otorhinolaryngology
Daphne A. J. J. Driessen, Anne I. J. Arens, Tim Dijkema, Willem L. J. Weijs, Lisette C. Draaijer, Guido B. van den Broek, Robert P. Takes, Jimmie Honings, Johannes H. A. M. Kaanders
Summary: The feasibility of flexible endoscopy-guided tracer injection for sentinel lymph node identification in patients with laryngeal and pharyngeal carcinoma was investigated in this study. The results showed a success rate of 94% in tracer injection and visualization of sentinel lymph nodes. The median number of tracer injections was 1 intratumoral and 3 peritumoral.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Cell Biology
Joep M. A. Bogaerts, Majke H. D. van Bommel, Rosella P. M. G. Hermens, Miranda P. Steenbeek, Joanne A. de Hullu, Jeroen A. W. M. van Der Laak, Michiel Simons
Summary: It is crucial to diagnose or exclude serous tubal intraepithelial carcinoma (STIC), a precursor lesion of tubo-ovarian high-grade serous carcinoma (HGSC), in a reliable and safe manner. This study aimed to optimize STIC diagnosis and increase reproducibility through a three-round Delphi study involving an international panel of expert gynecologic pathologists. The resulting consensus statements provide recommendations for more consistent STIC diagnosis.
Article
Oncology
Miranda P. Steenbeek, Majke H. D. van Bommel, Joanna intHout, Christine B. Peterson, Michiel Simons, Kit C. B. Roes, Marleen Kets, Barbara M. Norquist, Elizabeth M. Swisher, Rosella P. M. G. Hermens, Karen H. Lu, Joanne A. de Hullu
Summary: This study aims to investigate whether delayed oophorectomy is non-inferior to standard salpingo-oophorectomy for the prevention of tubo-ovarian cancer among individuals at high inherited risk. It is an international prospective preference trial, where participants can choose between delayed oophorectomy and standard salpingo-oophorectomy. Recruitment is expected to be completed by the end of 2026, and the primary outcome will be available in 2036.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Eline Bouwman, Saskia M. F. Pluijm, Iridi Stollman, Vera Araujo-Soares, Nicole M. A. Blijlevens, Cecilia F. Follin, Jeanette F. Winther, Lars Hjorth, Tomas Kepak, Katerina Kepakova, Leontien C. M. Kremer, Monica Muraca, Helena J. H. van Der Pal, Carina Schneider, Anne Uyttebroeck, Gertrui Vercruysse, Rod C. Skinner, Morven C. Brown, Rosella P. M. G. J. Hermens, Jacqueline Loonen, PanCareFollowUp Consortium
Summary: This study aimed to assess the barriers and facilitators to health behavior adoption and maintenance in childhood cancer survivors. The study found that knowledge, time constraints, and unhealthy environments were common barriers, while education and available professional support were identified as key opportunities to promote health behavior adoption in childhood cancer survivors.
Article
Oncology
Cecile van de Weerd, Tom Ebbers, Donna E. M. Smilde, Julia J. van Tol-Geerdink, Robert P. Takes, Guido B. van den Broek, Rosella P. M. G. Hermens, Rudolf B. Kool
Summary: A remote monitoring app was developed for head and neck cancer follow-up during the SARS-CoV-2 pandemic. The usability and patients' experiences with the app were studied through a mixed-methods approach. The app was found to be user-friendly and made patients feel more in control, but there were some barriers that need to be resolved before it can be used in regular follow-up.
Review
Oncology
Dylan Henssen, Lars Leijten, Frederick J. A. Meijer, Anja van der Kolk, Anne I. J. Arens, Mark ter Laan, Robert J. Smeenk, Anja Gijtenbeek, Elsmarieke M. van de Giessen, Nelleke Tolboom, Daniela E. Oprea-Lager, Marion Smits, James Nagarajah
Summary: Sophisticated imaging techniques have been suggested for distinguishing tumor progression (TP) from treatment-related abnormalities (TRA) in post-treatment surveillance of gliomas. However, it remains unclear if any technique holds diagnostic superiority. This meta-analysis compared the diagnostic accuracy of different imaging techniques and found no superior technique.