Article
Multidisciplinary Sciences
Hannah Paris Cowley, Michael S. Robinette, Jordan K. Matelsky, Daniel Xenes, Aparajita Kashyap, Nabeela F. Ibrahim, Matthew L. Robinson, Scott Zeger, Brian T. Garibaldi, William Gray-Roncal
Summary: As clinicians are overwhelmed with clinical data, data science provides valuable insights into patient outcomes and aids in the development of new clinical hypotheses. Machine learning can serve as a clinical support tool by connecting care providers with reliable results from big data analysis, identifying previously unnoticed clinical patterns. This study demonstrates the collaboration between clinicians and data scientists during the COVID-19 pandemic, identifying sub-groups of patients and predicting adverse outcomes through classification and clustering methods, which can be applied to future public health crises.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Daniel R. Feikin, Melissa M. Higdon, Laith J. Abu-Raddad, Nick Andrews, Rafael Araos, Yair Goldberg, Michelle J. Groome, Amit Huppert, Katherine L. O'Brien, Peter G. Smith, Annelies Wilder-Smith, Scott Zeger, Maria Deloria Knoll, Minal K. Patel
Summary: This study systematically reviewed the duration of protection provided by COVID-19 vaccines against various clinical outcomes. The findings indicate that the effectiveness or efficacy of the vaccines decreased from 1 to 6 months after full vaccination, but remained high against severe disease. Evaluating the effectiveness or efficacy of vaccines beyond 6 months is crucial for updating vaccine policies.
Review
Immunology
Runzhen Zhao, Zhenlei Su, Andrey A. Komissarov, Shan-Lu Liu, Guohua Yi, Steven Idell, Michael A. Matthay, Hong-Long Ji
Summary: The study revealed the association of plasma D-dimer with various clinical variables in COVID-19 patients through meta-analysis and meta-regression, supporting D-dimer as an independent predictor for mortality and complications. It also identified 22 variables independently correlated with D-dimer level, including respiratory rate and blood test parameters.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Romil Singh, Sawai Singh Rathore, Hira Khan, Smruti Karale, Yogesh Chawla, Kinza Iqbal, Abhishek Bhurwal, Aysun Tekin, Nirpeksh Jain, Ishita Mehra, Sohini Anand, Sanjana Reddy, Nikhil Sharma, Guneet Singh Sidhu, Anastasios Panagopoulos, Vishwanath Pattan, Rahul Kashyap, Vikas Bansal
Summary: The study found a significant association between obesity and increased severity and higher mortality among COVID-19 patients, recommending the inclusion of obesity or its surrogate body mass index in prognostic scores and improvement of guidelines for patient care management.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Infectious Diseases
Marie Deleers, Adrien Breiman, Valery Daubie, Carine Maggetto, Isabelle Barreau, Tatiana Besse, Beatrice Clemenceau, Nathalie Ruvoen-Clouet, Jean-Francois Fils, Evelyne Maillart, Virginie Doyen, Bhavna Mahadeb, Jacques C. Jani, Philippe Van der Linden, Mieke M. Cannie, Nabil Hayef, Francis Corazza, Jacques Le Pendu, Hanane El Kenz
Summary: The study found significantly lower levels of ABO antibodies in COVID-19 patients compared to controls, indicating that patients with low levels of ABO antibodies may be at a higher risk of infection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Yinon M. Bar-On, Yair Goldberg, Micha Mandel, Omri Bodenheimer, Laurence Freedman, Sharon Alroy-Preis, Nachman Ash, Amit Huppert, Ron Milo
Summary: The study shows that receiving a booster dose of the BNT162b2 vaccine can significantly lower the rates of confirmed Covid-19 and severe illness, as well as reduce mortality among individuals aged 60 and above.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Clinical Neurology
Razyeh Bajoulvand, Shima Hashemi, Elaheh Askari, Rasool Mohammadi, Masoud Behzadifar, Mohammad-Hasan Imani-Nasab
Summary: This study aims to investigate the prevalence of Post-Traumatic Stress Disorder (PTSD) in high-risk groups for COVID-19 (HRGs-COVID19) and identify its risk factors. The study found that the pooled prevalence of PTSD in HRGs-COVID19 was 30%, higher than the general population, COVID-19 patients, and healthcare workers. It is recommended to prioritize this subgroup for prevention and treatment of psychological outcomes and implement early psychological interventions, especially among HRGs-COVID19 women.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Biological
Jianghao Wang, Yichun Fan, Juan Palacios, Yuchen Chai, Nicolas Guetta-Jeanrenaud, Nick Obradovich, Chenghu Zhou, Siqi Zheng
Summary: The COVID-19 pandemic has had unprecedented effects on people's physical health and subjective well-being. This study uses social media data and machine learning techniques to develop a global dataset of expressed sentiment indices, allowing for real-time tracking of affective states. The findings show that global sentiment declined sharply during the COVID-19 outbreak and exhibited asymmetric, slower recoveries, while the effects of lockdown policies on sentiment varied greatly across countries.
NATURE HUMAN BEHAVIOUR
(2022)
Article
Multidisciplinary Sciences
Katie L. Kunze, Patrick W. Johnson, Noud van Helmond, Jonathon W. Senefeld, Molly M. Petersen, Stephen A. Klassen, Chad C. Wiggins, Allan M. Klompas, Katelyn A. Bruno, John R. Mills, Elitza S. Theel, Matthew R. Buras, Michael A. Golafshar, Matthew A. Sexton, Juan C. Diaz Soto, Sarah E. Baker, John R. A. Shepherd, Nicole C. Verdun, Peter Marks, Nigel S. Paneth, DeLisa Fairweather, R. Scott Wright, Camille M. van Buskirk, Jeffrey L. Winters, James R. Stubbs, Katherine A. Senese, Michaela C. Pletsch, Zachary A. Buchholtz, Robert F. Rea, Vitaly Herasevich, Emily R. Whelan, Andrew J. Clayburn, Kathryn F. Larson, Juan G. Ripoll, Kylie J. Andersen, Elizabeth R. Lesser, Matthew N. P. Vogt, Joshua J. Dennis, Riley J. Regimbal, Philippe R. Bauer, Janis E. Blair, Arturo Casadevall, Rickey E. Carter, Michael J. Joyner
Summary: Successful COVID-19 therapeutics and vaccines have utilized the immune response to the virus, but locally-evolving variants may impact treatment effectiveness. Near-sourced convalescent plasma has higher efficacy in causing death within 30 days of transfusion.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Xuefeng Gu, Ling Sha, Shaofeng Zhang, Duo Shen, Wei Zhao, Yongxiang Yi
Summary: The study aimed to develop a diagnostic model for asymptomatic and moderate COVID-19 patients based on demographic, clinical, and laboratory variables. Comparing the two groups, it was found that neutrophil count and lymphocyte count were independent predictors for the presence of clinical symptoms after COVID-19 infection, serving as diagnostic predictors of asymptomatic COVID-19.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Virology
Jaskaran Khinda, Naveed Z. Janjua, Shannon Cheng, Edwin R. van den Heuvel, Parveen Bhatti, Maryam Darvishian
Summary: The study found that markers of hyperinflammation, blunted adaptive immune response, and intravascular coagulation play key roles in the pathogenesis of COVID-19, and can help identify patients for early intervention regardless of age or sex in adult patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Immunology
Xiaosheng Liu, Yuelun Zhang, Lianfeng Lu, Xiaodi Li, Yuanni Wu, Yang Yang, Taisheng Li, Wei Cao
Summary: According to a systematic review of 17 studies, high-dose intravenous immunoglobulin (IVIg) treatment for COVID-19 patients shows a potential benefit in reducing the risk of death, particularly for severe cases. However, there is no significant impact of IVIg compared to routine care on overall mortality, hospital stay duration, mechanical ventilation requirement, and incidence of adverse events among all hospitalized patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Mohammed Badedi, Awaji Alnami, Hussain Darraj, Anas Alrajhi, Dhayf-Alrahman Mutawwam, Majed Somaily, Ali Alshareefi, Abdulrahman Muhajir, Yasser Majrabi
Summary: This study assessed ABO blood groups and clinical characteristics among Saudi patients with COVID-19. Blood type O had the highest proportion, followed by blood types A, B, and AB. Men and patients aged 18-44 years had a higher percentage, with the majority experiencing clinical symptoms.
Article
Immunology
Nashwa Shesha, Sami Melebari, Saad Alghamdi, Bassem Refaat, Hind Naffadi, Khalid Alquthami
Summary: This study investigated the potential associations between different blood types and COVID-19 infection, finding no significant correlation between ABO blood groups and Rh types with the severity of illness. However, symptoms such as respiratory distress syndrome, pneumonia, and respiratory failure, as well as underlying conditions like diabetes and hypertension, significantly increased the risk of death from COVID-19. Additionally, deceased patients showed lower rates of fever, cough, and asthma compared to those who recovered.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Kathleen M. Decker, Allison Feely, Oliver Bucher, Piotr Czaykowski, Pamela Hebbard, Julian O. Kim, Marshall Pitz, Harminder Singh, Maclean Thiessen, Pascal Lambert
Summary: There is an association between the COVID-19 pandemic and cancer diagnosis incidence, leading to an initial decrease followed by recovery for most cancer sites. However, some cancers with high fatality still have a cumulative deficit that requires immediate attention.
