Article
Medicine, General & Internal
Peter Pommer, Daniel Oberladstaetter, Christoph J. Schlimp, Johannes Zipperle, Wolfgang Voelckel, Christopher Lockie, Marcin Osuchowski, Herbert Schoechl
Summary: This study found that the pattern of injury does not specifically impact platelet function measurable by MP, and platelet dysfunction measured by MP is not associated with transfusion requirements and mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka Zajda, Joanna Sikora, Kristiina M. Huttunen, Magdalena Markowicz-Piasecka
Summary: This study assessed the effects of eight new sulfonamide-based derivatives of metformin on plasma parameters, vascular hemostasis, and endothelial and smooth muscle cell function. The results showed that three of the compounds had the most desirable properties, including safety and glucose utilization. These compounds also had beneficial effects on coagulation parameters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Lydie Crescence, Roxane Darbousset, Eva Caroff, Francis Hubler, Markus A. Riederer, Laurence Panicot-Dubois, Christophe Dubois
Summary: Through real-time intravital microscopy in mice, it was found that compared to clopidogrel and ticagrelor, Selatogrel has fewer platelet thrombus formations, better stability of hemostatic seals, and does not interfere with endothelial activation, neutrophil function, and fibrin-mediated stabilization of hemostatic seals.
THROMBOSIS RESEARCH
(2021)
Article
Surgery
Federica Branchi, Rolf Klingenberg-Noftz, Kristina Friedrich, Nataly Burgel, Severin Daum, Juliane Buchkremer, Elena Sonnenberg, Michael Schumann, Christoph Treese, Hanno Troger, Donata Lissner, Hans-Jorg Epple, Britta Siegmund, Andrea Stroux, Andreas Adler, Winfried Veltzke-Schlieker, Daniel Autenrieth, Silke Leonhardt, Andreas Fischer, Christian Jurgensen, Ulrich-Frank Pape, Bertram Wiedenmann, Oliver Moschler, Maximilian Schreiner, Mathias Z. Strowski, Volkmar Hempel, Yvonne Huber, Helmut Neumann, Christian Bojarski
Summary: PuraStat gel is an effective tool for treating gastrointestinal bleeding, safely applicable as both primary and secondary therapy, and can serve as a bridge to surgery for temporary haemostasis. It shows high efficacy with low rebleeding rates.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Physiology
Bernd Wallner, Bettina Schenk, Peter Paal, Markus Falk, Giacomo Strapazzon, Wenjun Z. Martini, Hermann Brugger, Dietmar Fries
Summary: Hypothermia prolongs clotting time and decreases clot formation velocity in ROTEM measurements, while also leading to a linear decrease in platelet function with decreasing temperatures.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Engineering, Biomedical
Akriti Nepal, Huong D. N. Tran, Nam-Trung Nguyen, Hang Thu Ta
Summary: In traumatized patients, uncontrollable continuous bleeding and unexpected intraoperative bleeding are the primary causes of mortality, increasing the risk of complications and surgical failure. Haemostatic sponges, with their high liquid absorption ratio, are an effective clinical practice for treating various types of wound bleeding. When in contact with blood, they can cause platelet adhesion, aggregation, and thrombosis, achieving the goal of wound bleeding control.
BIOACTIVE MATERIALS
(2023)
Review
Hematology
Shruti Raghunathan, Julie Rayes, Anirban Sen Gupta
Summary: Platelets, derived from megakaryocytes, play a vital role in hemostasis and can be used as a platform for disease-targeted drug delivery. Platelet defects can lead to bleeding complications, while platelet-inspired technologies have the potential to improve therapeutic efficacy.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
I. Ivanko, I. Celap, S. Margetic, D. Marijancevic, J. Josipovic, P. Gacina
Summary: This study investigated the differences in haemostasis and inflammatory markers in subjects vaccinated with mRNA BNT162b2 and Ad26.CoV2.S vaccines. The results showed a statistically significant increase in CRP levels in the vector group after 7 days of vaccination. Additionally, both vaccine groups had a significant rise in D-dimers between the tested time points, but without clinical implications. Therefore, vaccination with BNT162b2 mRNA and Ad26.CoV2.S vaccines did not significantly disrupt coagulation and inflammatory processes.
THROMBOSIS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Christiane Franz, Lara Bender, Christoph Dorn, Thorsten Sichtermann, Jan Minkenberg, Maximilian Franko, Martin Wiesmann, Andrea Stockero, Omid Nikoubashman, Rebecca May, Hani Ridwan
Summary: Knowledge of platelet function in pigs and the effectiveness of antiplatelet therapy is important for the transferability of animal studies to humans. This study characterized the baseline platelet function of Aachen minipigs, compared it with Gottingen minipigs, and evaluated platelet inhibition after intravenous administration of acetylsalicylic acid (ASA). The results showed differences in baseline platelet function between the two pig breeds and immediate platelet inhibition after ASA administration in Aachen minipigs.
Article
Veterinary Sciences
Rebecca Langhorn, Matilde K. Poulsen, Pernille L. Heidemann, Louise Bochsen, Christian Ritz, Annemarie T. Kristensen, Lise N. Nielsen
Summary: Primary hyperfibrinolysis was identified in dogs with sarcomas through tPA-TEG testing, and in vitro therapeutic concentrations of TXA were established for normalizing clot lysis parameters. Additional clinical studies are needed to determine therapeutic dosages in vivo.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Engineering, Biomedical
Ziyan Wan, Jiahui He, Yutong Yang, Tie Chong, Jiaxin Wang, Baolin Guo, Li Xue
Summary: The study designed a series of injectable adhesive multifunctional biocompatible hydrogels with hemostasis, wound management, and anti-adhesion properties for nephron-sparing surgeries. Results demonstrated that the hydrogel showed excellent hemostasis and wound healing properties in liver injury and nephron-sparing surgery models, with effective anti-adhesion performance in an abdomen-caecum adhesion model.
ACTA BIOMATERIALIA
(2022)
Editorial Material
Medicine, General & Internal
Erika P. Ong, Frances V. Ho
Summary: A young woman from the Philippines developed an itchy rash for 1 day, accompanied by resolved symptoms of fever, myalgias, and headache. Her rash was maculopapular with erythematous patches surrounded by unaffected skin.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Hematology
Hanke M. G. Wiegers, Mirte Schaafsma, Noori A. M. Guman, Hein S. Zelisse, Frits I. Mulder, Saskia Middeldorp, Nick van Es, Constantijne H. Mom
Summary: This study aimed to assess the incidence of VTE and bleeding within 30 days following major surgery in patients with ovarian cancer and evaluate the association between VTE and thromboprophylaxis duration. The study found that the cumulative incidence of VTE was considerable in patients with ovarian cancer following major surgery, but extended thromboprophylaxis did not significantly lower the risk of VTE. Overall, the importance of this article is 7 out of 10.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cardiac & Cardiovascular Systems
Claire S. Whyte, Gael B. Morrow, Julia S. Gauer, Samantha J. Montague, Philip L. R. Nicolson
Summary: The 2023 annual meeting of the British Society for Haemostasis and Thrombosis (BSHT) was held in Birmingham, United Kingdom, focusing on novel therapeutics and emerging technology. This article discusses the exciting research presented at the meeting.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Environmental Sciences
Giuseppe Torzillo, Graziella Chini Zittelli, Bernardo Cicchi, Marcello Diano, Maddalena Parente, Ana Margarita Silva Benavides, Serena Esposito, Eleftherios Touloupakis
Summary: This work analyzes and presents the performance of a vertical multiplate photobioreactor. The study shows that a narrower plate spacing leads to higher light conversion efficiency.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Medicine, General & Internal
Mark N. Polizzotto, Jacqueline Nordwall, Abdel G. Babiker, Andrew Phillips, David M. Vock, Nnakelu Eriobu, Vivian Kwaghe, Roger Paredes, Lourdes Mateu, Srikanth Ramachandruni, Rajeev Narang, Manua K. Jain, Susana M. Lazarte, Jason Baker, Anne E. P. Frosch, Garyfallia Poulakou, Konstantinos N. Syrigos, Gretchen S. Amoczy, Natalie A. McBride, Philip A. Robinson, Farjad Sarafian, Sanjay Bhagani, I. Lassan S. Taha, Thomas Benfield, Sean T. H. Liu, Anastasia Antoniadou, Jens Ulrik Staehr Jensen, Ioannis Kalomenidis, Adityo Susilo, Prasetyo Hariadi, Tomas O. Jensen, Jose Luis Morales-Rull, Marie Helleberg, Sreenath Meegada, Isik S. Johansen, Daniel Canario, Eduardo Fernandez-Cruz, Simeon Metallidis, Amish Shah, Aki Sakurai, Nikolaus G. Koulouris, Robin Trounan, Amy C. Weintrob, Dania Podlekareva, Usman Hadi, Kathryn M. Lloyd, Birgit Thorup Roge, Sho Saito, Kelly Sweenis, Jakob J. Malin, Christoph Luebbert, Jose Munoz, Matthew J. Cummings, Marcelo H. Losso, Dan Turner, Kathryn Shaw-Saliba, Robin Dewar, Helene Highbarger, Pertine Lallemand, Tauseef Rehman, Norman Gerry, Dona Arlinda, Christina C. Chang, Birgit Grund, Michael R. Holbrook, Horace P. Holley, Fleur Hudson, Laura A. McNay, Daniel D. Murray, Sarah L. Pett, Megan Shaughnessy, Mary C. Smolslcis, Giota Touloumi, Mary F. Wright, Mittie K. Doyle, Sharon Popik, Christine Hall, Roshan Ramanathan, Huyen Cao, Elsa Mondou, Todd Willis, Joseph Thakuria, Leman Yel, Elizabeth Liggs, Virginia L. Kan, Jens D. Lundgren, James D. Neaton, H. Clifford Lane
Summary: Passive immunotherapy using hyperimmune intravenous immunoglobulin (hIVIG) derived from recovered donors is a potential therapy for COVID-19. However, this international randomized controlled trial found that hIVIG did not demonstrate efficacy among hospitalized COVID-19 patients when administered with standard care including remdesivir.
Article
Infectious Diseases
Dewi Anggraini, Rahmat Azhari Kemal, Usman Hadi, Kuntaman Kuntaman
Summary: This study found a high prevalence of CNS A. baumannii strains at Arifin Achmad Hospital in Indonesia, with a 50% prevalence rate and a high detection rate (92%) of bla(OXA-23) gene among tested isolates. The proportion of CNS A. baumannii was higher in samples from ICU patients and sputum samples, showing high resistance to most antibiotics but with higher susceptibility to amikacin, tigecycline, and trimethoprim/sulfamethoxazole.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2022)
Article
Microbiology
Minori Takaichi, Kayo Osawa, Ryohei Nomoto, Noriko Nakanishi, Masanori Kameoka, Makiko Miura, Katsumi Shigemura, Shohiro Kinoshita, Koichi Kitagawa, Atsushi Uda, Takayuki Miyara, Ni Made Mertaniasih, Usman Hadi, Dadik Raharjo, Ratna Yulistiani, Masato Fujisawa, Kuntaman Kuntaman, Toshiro Shirakawa
Summary: This study confirms the increase in antibiotic resistance in non-typhoidal Salmonella enterica (NTS) in Indonesia. The NTS strains isolated from chicken meat showed high resistance to multiple antibiotics and had many virulence factors. Particularly, a serotype called S. Schwarzengrund was frequently detected as multi-antimicrobial resistant and had a high prevalence of virulence genes.
Article
Infectious Diseases
Dewi Anggraini, Dewi Santosaningsih, Yulia Rosa Saharman, Pepy Dwi Endraswari, Cahyarini Cahyarini, Leli Saptawati, Zinatul Hayati, Helmia Farida, Cherry Siregar, Munawaroh Pasaribu, Heriyannis Homenta, Enty Tjoa, Novira Jasmin, Rosantia Sarassari, Wahyu Setyarini, Usman Hadi, Kuntaman Kuntaman
Summary: Carbapenem non-susceptible Acinetobacter baumannii (CNSAB) is a significant pathogen causing nosocomial bacteremia among critically ill patients worldwide. This study analyzed the genetic profiles of CNSAB isolates from bacteremia patients in Indonesia and found that they were mostly resistant to multiple antibiotic classes, but susceptible to tigecycline and trimethoprim-sulfamethoxazole. The bla(OXA-23-like) gene was identified as the predominant gene. A national surveillance system is needed to monitor the genetic profiles of CNSAB in Indonesia.
Article
Critical Care Medicine
Tri Pudy Asmarawati, Satriyo Dwi Suryantoro, Alfian Nur Rosyid, Erika Marfiani, Choirina Windradi, Bagus Aulia Mahdi, Heri Sutanto
Summary: This study aimed to evaluate the predictive ability of different scoring models for mortality in COVID-19 patients. The results showed that all scoring models had good predictive values on the 5th day evaluation, with APACHE II score performing the best in predicting mortality and ICU admission rate.
INDIAN JOURNAL OF CRITICAL CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Eric Wibisono, Usman Hadi, Bramantono, Muhammad Vitanata Arfijanto, Musofa Rusli, Brian Eka Rahman, Tri Pudy Asmarawati, Miftahani Leo Choirunnisa, Dwi Retno Puji Rahayu
Summary: This study analyzed the use of the NEWS-2 tool in identifying the risk of death in COVID-19 patients. The findings showed that patients with a NEWS-2 score >5 had a higher mortality rate, and several comorbid diseases were significantly associated with the mortality of COVID-19 patients.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Infectious Diseases
Tri Pudy Asmarawati, Okla Sekar Martani, Bramantono Bramantono, Muhammad Vitanata Arfijanto
Summary: This case report highlights the importance of considering co-infection in COVID-19 patients with fever in order to prevent delayed treatment and worsened disease outcome. During the COVID-19 pandemic, paying attention to travel history, previous malaria infection, and fever patterns in patients is crucial in making a differential diagnosis of malaria infection.
Review
Immunology
David Setyo Budi, Ihsan Fahmi Rofananda, Nando Reza Pratama, Henry Sutanto, Arisvia Sukma Hariftyani, Saskia Ratna Desita, Aulia Zinedinita Rahmasari, Tri Pudy Asmarawati, Langgeng Agung Waskito, Citrawati Dyah Kencono Wungu
Summary: The study evaluated the benefits and side effects of ozone as an adjuvant therapy in COVID-19 patients. The results showed that ozone therapy reduced mortality and improved certain clinical and laboratory outcomes. However, it did not improve other endpoints such as length of hospital stay and ICU admission. Ozone therapy seems to be beneficial in improving laboratory parameters among severe COVID-19 patients and has a high safety profile.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Nando Reza Pratama, Ifan Ali Wafa, David Setyo Budi, Henry Sutanto, Tri Pudy Asmarawati, Gema Barlian Effendi, Citrawati Dyah Kencono Wungu
Summary: Booster vaccination with overall vaccines provides better protection against Omicron infections, especially symptomatic infections. However, the effectiveness of the vaccines declines over time.
Article
Infectious Diseases
Tri Pudy Asmarawati, Tarmono Djojodimedjo, Dimas Panca Andhika, Musofa Rusli, Mariyatul Qibtiyah, Bagus Aulia Mahdi, Dwiki Novendrianto, Okla Sekar Martani, Hari Paraton, Heiman Wertheim, Kuntaman Kuntaman
Summary: Prophylactic antibiotics are essential in urological procedures to prevent postoperative infections. A retrospective study in Surabaya, Indonesia, analyzed the medical records of patients who underwent urologic procedures between 2019 and 2020. The study found that despite low susceptibility, the third-generation cephalosporin ceftriaxone was commonly used in urological procedures, while aminoglycosides were suggested for certain procedures such as prostate and urinary tract stone surgeries. Considering the incision site, procedure type, and bacterial profile in the hospital is crucial in proposing antibiotic prophylaxis guidelines.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2023)
Article
Pathology
Muhammad Vitanata Arfijanto, Tri Pudy Asmarawati, Bramantono Bramantono, Musofa Rusli, Brian Eka Rachman, Bagus Aulia Mahdi, Nasronudin Nasronudin, Usman Hadi
Summary: This study aims to explore the associations between clinical features and the duration of SARS-CoV-2 RNA shedding in hospitalized COVID-19 patients. The results show that disease severity, bilateral lung infiltrates, diabetes mellitus, and antibiotic treatment are all associated with the duration of viral shedding. Therefore, different isolation period estimations should be considered for specific clinical characteristics of COVID-19 patients that affect the duration of SARS-CoV-2 RNA shedding.
Article
Pathology
Choirina Windradi, Tri Pudy Asmarawati, Alfian Nur Rosyid, Erika Marfiani, Bagus Aulia Mahdi, Okla Sekar Martani, Giarena Giarena, Esthiningrum Dewi Agustin, Milanitalia Gadys Rosandy
Summary: The authors attempted to create a new and easy scoring system using mean arterial pressure, PF Ratio or SF ratio-respiration rate, and lymphocyte absolute as predictive factors for mortality within 30 days in COVID-19 patients. They conducted analyses on 96 patients and found that MPL and MSLR scores have potential as predictors for mortality in a resource-limited country.
Review
Medicine, General & Internal
David Setyo Budi, Puguh Oktavian, Tri Pudy Asmarawati, Pudji Lestari, Fauziah Ariviani, Raka Ihsanulhaj, Tamara Tsania, Danise Febiola, Naomi Lesmana Putri
Summary: This study provides an overview of the role of various antiviral therapies in COVID-19 outpatients. Molnupiravir, remdesivir, and nirmatrelvir-ritonavir have shown potential to prevent the progression of COVID-19 in early disease. However, this review was based on very limited data. Therefore, further clinical trials are needed to confirm this finding.
ACTA MEDICA INDONESIANA
(2022)
Article
Infectious Diseases
Dewi Anggraini, Dewi Santosaningsih, Pepy Dwi Endraswari, Novira Jasmin, Fajri Marindra Siregar, Usman Hadi, Kuntaman Kuntaman
Summary: This study identified the risk factors for CNSAB-associated bacteremia and the risk factors for death, which are relevant for appropriate antibiotic therapy, infection control prevention, and prognosis evaluation of patients with bloodstream infections.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
