Article
Urology & Nephrology
Paul Doan, William Counter, Nathan Papa, Gemma Sheehan-Dare, Bao Ho, Jonathan Lee, Victor Liu, James E. Thompson, Shikha Agrawal, Matthew J. Roberts, James Buteau, Michael S. Hofman, Daniel Moon, Nathan Lawrentschuk, Declan Murphy, Phillip D. Stricker, Louise Emmett
Summary: This study aimed to investigate whether synchronous reading of multiparametric magnetic resonance imaging (mpMRI) and Ga-68-PSMA-11 positron emission tomography (PET)/computed tomography (PSMA-PET) can improve diagnostic performance and certainty compared to independent and synthesized mpMRI/PSMA-PET. Results showed that synchronous reading of mpMRI/PSMA-PET increased sensitivity but did not improve specificity. When mpMRI/PSMA-PET findings were concordant and positive, 95% of patients had clinically significant prostate cancer.
Article
Urology & Nephrology
Anthony Franklin, William J. Yaxley, Sheliyan Raveenthiran, Geoff Coughlin, Troy Gianduzzo, Boon Kua, Lousie McEwan, David Wong, Brett Delahunt, Lars Egevad, Hema Samaratunga, Nicholas Brown, Rob Parkinson, Matthew J. Roberts, John W. Yaxley
Summary: The study evaluated the predictive ability of preoperative mpMRI and Ga-68-PSMA PET/CT scan on pathological outcomes, identifying men with <5% risk of LNM; Ga-68-PSMA PET/CT was more sensitive in LNM detection, and men with negative results had lower risk compared to traditional calculators.
Article
Urology & Nephrology
Dennie Meijer, Rosemarijn H. Ettema, Pim J. van Leeuwen, Theo H. van der Kwast, Henk G. van der Poel, Maarten L. Donswijk, Daniela E. Oprea-Lager, Elise M. Bekers, Andre N. Vis
Summary: This study aimed to evaluate the diagnostic ability of PSMA PET/CT for preoperative pelvic lymph node metastasis and found that suspected metastatic lymph nodes and tumor size were closely associated with postoperative biochemical progression.
Article
Urology & Nephrology
Nattakorn Dhiantravan, Louise Emmett, Anthony M. Joshua, David A. Pattison, Roslyn J. Francis, Scott Williams, Shahneen Sandhu, Ian D. Davis, Ian Vela, Nitika Neha, Mathias Bressel, Declan G. Murphy, Michael S. Hofman, Arun A. Azad
Summary: The study aims to evaluate the activity and safety of Lu-177-PSMA-617 in men with de novo metastatic hormone-naive prostate cancer.
Article
Urology & Nephrology
Jeff Dunn, Anna Green, Nicholas Ralph, Robert U. Newton, Andrew Kneebone, Mark Frydenberg, Suzanne K. Chambers
Summary: The study aimed to develop contemporary and inclusive prostate cancer survivorship guidelines for Australia, involving a diverse expert panel to identify key descriptors of men's current survivorship experience and important elements within survivorship domains. Consensus was high on the essential nature of all identified domains, with feasibility ratings varying. Seven priorities for immediate action were derived from the study results.
Article
Medicine, General & Internal
Manuela A. Hoffmann, Jonas Mueller-Huebenthal, Florian Rosar, Nicolas Fischer, Finn Edler von Eyben, Hans-Georg Buchholz, Helmut J. Wieler, Mathias Schreckenberger
Summary: This study compared the performance of [F-18]PSMA-1007 and [Ga-68]Ga-PSMA-11 positron emission tomography/computed tomography in the initial staging of prostate cancer patients. The results showed that both methods were able to detect PSMA-avid lesions with high concordance to histopathologically proven cancer. There was no superior advantage of either method in diagnosing prostate cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Florian Rosar, Mark Bartholoma, Stephan Maus, Bastiaan M. Prive, Fadi Khreish, Gerben M. Franssen, Yvonne H. W. Derks, James Nagarajah, Samer Ezziddin
Summary: In this study, Ga-68-PSMA-11 PET/CT imaging and additional Zr-89-PSMA-617 PET/CT imaging were performed on a patient, revealing a small local recurrence in the prostate bed. This highlights the potential of Zr-89-labeled PSMA ligands, such as Zr-89-PSMA-617, in identifying the source of biochemical recurrence.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Oncology
Lawrence D. True, Delphine L. Chen
Summary: Current imaging techniques for prostate cancer have limited sensitivity and specificity, but the novel PSMA agent F-18-DCFPyL-PET/CT shows promising performance.
CLINICAL CANCER RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Babak Fallahi, Niloufar Khademi, Najme Karamzade-Ziarati, Armaghan Fard-Esfahani, Alireza Emami-Ardekani, Saeed Farzanefar, Mohammad Eftekhari, Davood Beiki
Summary: In patient-based evaluation, both Tc-99m-PSMA SPECT/CT and Ga-68-PSMA PET/CT scans were positive in 95.45% (21/22) of patients. In region-based evaluation, Ga-68-PSMA PET/CT detected more regions compared to Tc-99m-PSMA SPECT/CT, with lower detection rates in the prostate bed being the main difference. There was a significant correlation between serum prostate-specific antigen level and disease extension detected by both modalities.
CLINICAL NUCLEAR MEDICINE
(2021)
Review
Medicine, General & Internal
Luca Urso, Luca Filippi, Angelo Castello, Maria Cristina Marzola, Mirco Bartolomei, Corrado Cittanti, Luigia Florimonte, Massimo Castellani, Paolo Zucali, Alessio Bruni, Roberto Sabbatini, Massimo Dominici, Stefano Panareo, Laura Evangelista
Summary: PSMA ligand PET has higher detection rates compared to conventional imaging in CRPC patients, reducing the number of M0 CRPC patients. However, its impact on patients' prognosis is still uncertain. Additionally, PSMA ligand PET has sensitivity and specificity limitations in CRPC patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Michael R. Poulson, Samuel A. Helrich, Kelly M. Kenzik, Tracey A. Dechert, Teviah E. Sachs, Mark H. Katz
Summary: This study found that racial residential segregation has a significant impact on Black-White disparities in prostate cancer, particularly in highly segregated areas. White patients have better treatment outcomes at lower levels of segregation, while Black patients face greater risks. No effects of segregation were observed on stage at diagnosis or surgical resection for Black patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Florian Rosar, Fadi Khreish, Robert J. Marlowe, Andrea Schaefer-Schuler, Caroline Burgard, Stephan Maus, Sven Petto, Mark Bartholomae, Samer Ezziddin
Summary: Preliminary data suggest that using Zr-89-labeled PSMA ligand radiotracers may be more effective than using tracers with short-lived radionuclides in detecting suspicious lesions in patients with biochemical recurrence of prostate cancer. In this study, 78% of patients had suspicious lesions detected on 24-h and 48-h scans, with higher detection rates on the 48-h scans. This suggests that imaging at a later time may be preferable.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Urology & Nephrology
Leonie Exterkate, Max Peters, Diederik M. Somford, Henk Vergunst
Summary: Salvage cryosurgery for radiorecurrent prostate cancer shows acceptable oncological outcomes, but serious complications such as urinary incontinence and fistula should not be underestimated.
Article
Urology & Nephrology
David Eldred-Evans, Martin J. Connor, Mariana Bertoncelli Tanaka, Edward Bass, Deepika Reddy, Uma Walters, Luke Stroman, Easter Espinosa, Raj Das, Nalin Khosla, Henry Tam, Elizabeth Pegers, Hasan Qazi, Stephen Gordon, Mathias Winkler, Hashim U. Ahmed
Summary: The RAPID prostate cancer diagnostic pathway allows 43% of men to avoid biopsy while accurately detecting clinically significant cancers and having a low detection rate for insignificant cancers. There are some variations among different centers.
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefano Fanti, Karolien Goffin, Boris A. Hadaschik, Ken Herrmann, Tobias Maurer, Steven MacLennan, Daniela E. Oprea-Lager, Wim J. G. Oyen, Olivier Rouviere, Nicolas Mottet, Anders Bjartell
Summary: PSMA PET/CT can be used to evaluate treatment response in patients with metastatic prostate cancer before and after any local and systemic treatment. Ideally, imaging criteria should categorize patients as responders, patients with stable disease, partial response, and complete response, or as non-responders. Specific clinical scenarios deserve special consideration.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Rhiannon McBean, Annaleis Tatkovic, Robert Edwards, Katrina Newbigin
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Annaleis Tatkovic, Rhiannon McBean, Joseph Schoeman, David Wong
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2020)
Article
Urology & Nephrology
Anthony Franklin, William J. Yaxley, Sheliyan Raveenthiran, Geoff Coughlin, Troy Gianduzzo, Boon Kua, Lousie McEwan, David Wong, Brett Delahunt, Lars Egevad, Hema Samaratunga, Nicholas Brown, Rob Parkinson, Matthew J. Roberts, John W. Yaxley
Summary: The study evaluated the predictive ability of preoperative mpMRI and Ga-68-PSMA PET/CT scan on pathological outcomes, identifying men with <5% risk of LNM; Ga-68-PSMA PET/CT was more sensitive in LNM detection, and men with negative results had lower risk compared to traditional calculators.
Article
Oncology
William John Yaxley, Francois-Xavier Nouhaud, Sheliyan Raveenthiran, Anthony Franklin, Peter Donato, Geoff Coughlin, Boon Kua, Troy Gianduzzo, David Wong, Robert Parkinson, Nicholas Brown, Hemamali Samaratunga, Brett Delahunt, Lars Egevad, Matthew Roberts, John William Yaxley
Summary: This study found that mpMRI underestimates tumor grade and volume, although high-grade cancer is rare. Histopathological analysis of totally embedded normal mpMRI lobes helps reveal the multifocality of prostate cancer. These results suggest the practical utility of systematic biopsy in addition to targeted biopsies when making clinical decisions on prostate cancer management.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Article
Pathology
Anthony Franklin, Brett Delahunt, Lars Egevad, John Yaxley, Shulammite Johannsen, Troy Gianduzzo, Jonathan Ganter, Carla Pecoraro, Michelle Thunders, Hemamali Samaratunga
Summary: This study found that different patterns within Gleason grade 5 prostate cancer, including sheets, comedocarcinoma, single cells and clusters/cords, are associated with aggressive outcomes in terms of tumor characteristics and postoperative recurrence rates.
Article
Radiology, Nuclear Medicine & Medical Imaging
Annaleis Tatkovic, Rhiannon McBean, David Wong
Summary: Radioligand therapies targeting PSMA, like Lutetium-177, have shown promising outcomes in mCRPC patients. Our study found an 18-month overall survival rate of 64% in patients undergoing LuPSMA therapy, with baseline serum PSA, SUVmax, and biochemical response as prognostic markers for increased survival.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Annaleis Tatkovic, Rhiannon McBean, Ebony Perkins, David Wong
Summary: In neuro-oncology imaging, a positive correlation was observed between the maximum standard uptake value (SUV) on F-18-FET PET and the World Health Organization (WHO) grade in glioma. Further studies are recommended to explore this relationship.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Matt Dentry, Rhiannon McBean, Andrea Garrett, Nicholas Brown
Summary: MRGB is an effective method for diagnosing vaginal lesions, providing accurate information for treatment decisions. A multidisciplinary team approach can improve the accuracy and effectiveness of diagnosis and treatment. Regular follow-up can help monitor the patient's condition and adjust treatment plans in a timely manner.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthew J. Roberts, Andrew Morton, Nathan Papa, Anthony Franklin, Sheliyan Raveenthiran, William J. Yaxley, Geoffrey Coughlin, Troy Gianduzzo, Boon Kua, Louise McEwan, David Wong, Brett Delahunt, Lars Egevad, Hemamali Samaratunga, Nicholas Brown, Robert Parkinson, Louise Emmett, John W. Yaxley
Summary: PSMA intensity on PSMA PET/CT is a clinically significant biomarker for predicting oncological outcomes and biochemical recurrence-free survival in patients undergoing radical prostatectomy.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Emergency Medicine
Annaleis Tatkovic, Katie Moore, Jolene C. J. Lim
Summary: This study analyzes data from emergency departments (EDs) in Australia to investigate the differences in utilization, case mix, and performance among different geographical regions. The findings highlight the need to allocate appropriate resources to regional and remote EDs to address inequities and ensure the support of the communities they serve.
EMERGENCY MEDICINE AUSTRALASIA
(2023)
Article
Urology & Nephrology
William John Yaxley, Rhiannon McBean, David Wong, David Grimes, Paul Vasey, Mark Frydenberg, John William Yaxley
Summary: Lu-PSMA RLT shows improved PSA response in men with only lymph node metastasis, especially in the chemotherapy naive cohort. These findings provide important evidence for planning future prospective randomized trials evaluating the role of Lu-PSMA RLT in the early treatment of node metastatic prostate cancer.
INVESTIGATIVE AND CLINICAL UROLOGY
(2021)
Article
Urology & Nephrology
Michael Y. Chen, Jonathan Cho, Rachel Esler
JOURNAL OF CLINICAL UROLOGY
(2021)
Review
Urology & Nephrology
Michael Y. Chen, Jacob Skewes, Maria A. Woodruff, Nicholas J. Rukin
JOURNAL OF CLINICAL UROLOGY
(2021)